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The map label for this gene is clpP

Identifier: 238917377

GI number: 238917377

Start: 1508509

End: 1509090

Strand: Reverse

Name: clpP

Synonym: EUBELI_01454

Alternate gene names: 238917377

Gene position: 1509090-1508509 (Counterclockwise)

Preceding gene: 238917378

Following gene: 238917376

Centisome position: 70.38

GC content: 39.86

Gene sequence:

>582_bases
ATGAGTTTTGTACCTTATGTCATTGAACAGAACAGCAGAGGCGAAAGATCATATGATATTTATTCACGTCTGCTTAAAGA
CAGAATTATATTCTTAGGAGAAGAGGTAACAGATGTTTCTGCTAATCTTGTGGTAGCGCAGATGTTATTCCTTGAAGCAG
AAGATCCGAGCAAGGATATACATTTCTACATTAACAGCCCGGGAGGTTCTGTATCAGCAGGATTTGCTATATATGATACA
ATGCAGTACATCAAGTGTGATGTTTCTACAATCTGTATAGGTATGGCTGCAAGTATGGGTGCATTCCTTCTTTCAGGCGG
TGCTAAGGGAAAGAGACTTGCTCTTCCTAATGCAGAGATTATGATTCATCAGCCATCAGGTGGTGCAAGAGGTCAGGAAA
CTGAAATCAGAATCGTTGCTGAGAATATACTTAAGACAAGAAATAAGTTAAACGAAATACTGGCAGCTAATACTGGCAAG
TCAGTTGAAGAGATTTCACGCGACACAGAGAGAGATAACTATATGACAGCACAGGAAGCTGTTGCATATGGACTTATCGA
CAGTGTTGTAGAGAAGAGATAA

Upstream 100 bases:

>100_bases
AGATCTTGCAATTCAGAAGGCTGTAGATGTTATCGTAGGATCAGTTGTTGAAAAGTAATTGAATCTTAAAGAAACATTTT
AGTATATTGGAGGTTGTGTA

Downstream 100 bases:

>100_bases
TAATTGCTTATGATAAGGAAGATGCCTGCAGATAATACATTTGCAGGTGTCTCCCTTGTTTTTGTGTGATAAGCGAACCT
TTATTTAAAGGATTTATAGT

Product: ATP-dependent Clp protease, protease subunit

Products: NA

Alternate protein names: Endopeptidase Clp

Number of amino acids: Translated: 193; Mature: 192

Protein sequence:

>193_residues
MSFVPYVIEQNSRGERSYDIYSRLLKDRIIFLGEEVTDVSANLVVAQMLFLEAEDPSKDIHFYINSPGGSVSAGFAIYDT
MQYIKCDVSTICIGMAASMGAFLLSGGAKGKRLALPNAEIMIHQPSGGARGQETEIRIVAENILKTRNKLNEILAANTGK
SVEEISRDTERDNYMTAQEAVAYGLIDSVVEKR

Sequences:

>Translated_193_residues
MSFVPYVIEQNSRGERSYDIYSRLLKDRIIFLGEEVTDVSANLVVAQMLFLEAEDPSKDIHFYINSPGGSVSAGFAIYDT
MQYIKCDVSTICIGMAASMGAFLLSGGAKGKRLALPNAEIMIHQPSGGARGQETEIRIVAENILKTRNKLNEILAANTGK
SVEEISRDTERDNYMTAQEAVAYGLIDSVVEKR
>Mature_192_residues
SFVPYVIEQNSRGERSYDIYSRLLKDRIIFLGEEVTDVSANLVVAQMLFLEAEDPSKDIHFYINSPGGSVSAGFAIYDTM
QYIKCDVSTICIGMAASMGAFLLSGGAKGKRLALPNAEIMIHQPSGGARGQETEIRIVAENILKTRNKLNEILAANTGKS
VEEISRDTERDNYMTAQEAVAYGLIDSVVEKR

Specific function: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins

COG id: COG0740

COG function: function code OU; Protease subunit of ATP-dependent Clp proteases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S14 family

Homologues:

Organism=Homo sapiens, GI5174419, Length=190, Percent_Identity=53.6842105263158, Blast_Score=219, Evalue=2e-57,
Organism=Escherichia coli, GI1786641, Length=193, Percent_Identity=65.2849740932643, Blast_Score=275, Evalue=2e-75,
Organism=Caenorhabditis elegans, GI17538017, Length=186, Percent_Identity=53.763440860215, Blast_Score=213, Evalue=5e-56,
Organism=Drosophila melanogaster, GI20129427, Length=191, Percent_Identity=54.9738219895288, Blast_Score=223, Evalue=7e-59,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CLPP_EUBE2 (C4Z1T6)

Other databases:

- EMBL:   CP001104
- RefSeq:   YP_002930894.1
- GeneID:   7957115
- GenomeReviews:   CP001104_GR
- KEGG:   eel:EUBELI_01454
- OMA:   SPMEAQD
- GO:   GO:0005737
- GO:   GO:0006508
- HAMAP:   MF_00444
- InterPro:   IPR001907
- InterPro:   IPR018215
- PANTHER:   PTHR10381
- PRINTS:   PR00127
- TIGRFAMs:   TIGR00493

Pfam domain/function: PF00574 CLP_protease

EC number: =3.4.21.92

Molecular weight: Translated: 21222; Mature: 21091

Theoretical pI: Translated: 4.77; Mature: 4.77

Prosite motif: PS00382 CLP_PROTEASE_HIS; PS00381 CLP_PROTEASE_SER

Important sites: ACT_SITE 98-98 ACT_SITE 123-123

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSFVPYVIEQNSRGERSYDIYSRLLKDRIIFLGEEVTDVSANLVVAQMLFLEAEDPSKDI
CCCCCEEEECCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCEE
HFYINSPGGSVSAGFAIYDTMQYIKCDVSTICIGMAASMGAFLLSGGAKGKRLALPNAEI
EEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCEE
MIHQPSGGARGQETEIRIVAENILKTRNKLNEILAANTGKSVEEISRDTERDNYMTAQEA
EEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCHHHHHH
VAYGLIDSVVEKR
HHHHHHHHHHHCC
>Mature Secondary Structure 
SFVPYVIEQNSRGERSYDIYSRLLKDRIIFLGEEVTDVSANLVVAQMLFLEAEDPSKDI
CCCCEEEECCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCEE
HFYINSPGGSVSAGFAIYDTMQYIKCDVSTICIGMAASMGAFLLSGGAKGKRLALPNAEI
EEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCEE
MIHQPSGGARGQETEIRIVAENILKTRNKLNEILAANTGKSVEEISRDTERDNYMTAQEA
EEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCHHHHHH
VAYGLIDSVVEKR
HHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA