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The map label for this gene is uhpC [H]

Identifier: 238897176

GI number: 238897176

Start: 5175313

End: 5176797

Strand: Reverse

Name: uhpC [H]

Synonym: KP1_5445

Alternate gene names: 238897176

Gene position: 5176797-5175313 (Counterclockwise)

Preceding gene: 238897177

Following gene: 238897175

Centisome position: 98.63

GC content: 62.56

Gene sequence:

>1485_bases
TTGCGGCCTGCCGCCGGGGTCGAATCTGCAGGGGTTCGGCCTGACCGGCATGCGCGAGCGCGTGACCGCCCTGGGCGGCA
CACTGACGATCTCCTGCACCCACGGTACCCGGGTGTGCGTCAATCTACCGCTGCGTTACGCCTGAGAGGATCGCCGATGT
TCGCCTTTTTAAAAGCCCCGCCGGACGCTGCGCCGATTAGCGATAAACGCGAACTTGATGCGCGTTATCGCTACTGGCGT
CGCCATATCCTGTTGACCATCTGGCTGGGCTACGCGCTGTTCTATTTCACCCGCAAAAGCTTTAACGCCGCGGTCCCGGA
AATTCTCGCCAGCAACGTCCTGACCCGCAGCGATATTGGCCTGCTGGCCACGCTGTTCTATATCACCTACGGGCTGTCGA
AATTTTTCTCCGGTATCGTCAGCGACCGCTCCGACGCCCGCTATTTTATGGGGCTGGGGCTTATCGCCACCGGGGTGGTG
AATATTCTGTTCGGTTTTTCTTCCTCACTATGGGCTTTCGCGCTGCTGTGGGCGCTGAATGCCTTCTTCCAGGGCTGGGG
CTCGCCGGTCTGCGCCCGACTGCTGACGGCCTGGTATTCGCGGACCGAGCGCGGCGGCTGGTGGGCGCTATGGAATACGG
CGCATAACGTCGGCGGCGCGCTGATCCCGATGGTGGTGGGAGCGGCGGCGTTGCACTACGGCTGGCGTGCCGGGATGACC
ATTGCCGGCTGTCTGGCGATCCTCGCCGGACTGTATCTGTGCTGGCGGCTGCGCGATCGCCCGCAGGCGGTGGGGTTACC
CGCCGTGGGCGACTGGCGTCACGATGCGCTGGAAATCGCCCAGCAGCAGGAAGGCGCTGGGATGTCTCGTAAAGCGATCC
TGACCCGCTACGTGCTGGCCAATCCCTACATCTGGCTGCTGTCGTTGTGCTATGTGCTGGTGTACGTGGTGCGGGCGGCG
ATTAACGACTGGGGCAATCTGTATATGTCGGAGACGCTCGGCGTCGATCTGGTGACCGCTAACTCGGCGGTGACCATGTT
TGAGCTGGGCGGTTTTATCGGCGCGCTGGTGGCGGGGTGGGGCTCGGATAAGCTGTTTAACGGCAACCGTGGGCCGATGA
ACCTGATTTTCGCCGCCGGAATTTTGCTGTCGGTTGGCGGCCTGTGGCTGATGCCGTTCGCCAGCTATGTCATGCAGGCG
GCCTGCTTCTTCACTACCGGTTTCTTCGTTTTCGGCCCGCAGATGCTGATCGGCATGGCGGCGGCGGAATGTTCGCATAA
AGAAGCCGCCGGGGCGGCAACCGGGTTTGTCGGCCTGTTCGCTTATCTTGGCGCCTCGCTTTCCGGCTGGCCGCTGGCGC
AGGTGATGGATATCTGGCACTGGACCGGATTCTTCGTGGTGATTGCGATTGCCGCCGGCATTTCCGCGCTGCTGCTGCTG
CCGTTTTTAAACGCGCAGGCGCCGCGTACCGCCAGCGAAGCGTGA

Upstream 100 bases:

>100_bases
AGGGGCTGAATAATATCGTCAAGCACGCCAGCGCCAGCGCTGTCACTCTGCAGGGCTGGCAGCAGGATGAGCGACTAATG
CTGGTGCTGGAAGATGACGG

Downstream 100 bases:

>100_bases
TGTAGCTCACCCTTTCGCCGCGAACGGGGCAAAACTAAGAAATTTTCCCGGTTTTACCTGGACGCCGTCTCAGGCCAGAC
GGCGCGCTGGTTTTTACAAT

Product: regulatory protein UhpC

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 494; Mature: 494

Protein sequence:

>494_residues
MRPAAGVESAGVRPDRHARARDRPGRHTDDLLHPRYPGVRQSTAALRLRGSPMFAFLKAPPDAAPISDKRELDARYRYWR
RHILLTIWLGYALFYFTRKSFNAAVPEILASNVLTRSDIGLLATLFYITYGLSKFFSGIVSDRSDARYFMGLGLIATGVV
NILFGFSSSLWAFALLWALNAFFQGWGSPVCARLLTAWYSRTERGGWWALWNTAHNVGGALIPMVVGAAALHYGWRAGMT
IAGCLAILAGLYLCWRLRDRPQAVGLPAVGDWRHDALEIAQQQEGAGMSRKAILTRYVLANPYIWLLSLCYVLVYVVRAA
INDWGNLYMSETLGVDLVTANSAVTMFELGGFIGALVAGWGSDKLFNGNRGPMNLIFAAGILLSVGGLWLMPFASYVMQA
ACFFTTGFFVFGPQMLIGMAAAECSHKEAAGAATGFVGLFAYLGASLSGWPLAQVMDIWHWTGFFVVIAIAAGISALLLL
PFLNAQAPRTASEA

Sequences:

>Translated_494_residues
MRPAAGVESAGVRPDRHARARDRPGRHTDDLLHPRYPGVRQSTAALRLRGSPMFAFLKAPPDAAPISDKRELDARYRYWR
RHILLTIWLGYALFYFTRKSFNAAVPEILASNVLTRSDIGLLATLFYITYGLSKFFSGIVSDRSDARYFMGLGLIATGVV
NILFGFSSSLWAFALLWALNAFFQGWGSPVCARLLTAWYSRTERGGWWALWNTAHNVGGALIPMVVGAAALHYGWRAGMT
IAGCLAILAGLYLCWRLRDRPQAVGLPAVGDWRHDALEIAQQQEGAGMSRKAILTRYVLANPYIWLLSLCYVLVYVVRAA
INDWGNLYMSETLGVDLVTANSAVTMFELGGFIGALVAGWGSDKLFNGNRGPMNLIFAAGILLSVGGLWLMPFASYVMQA
ACFFTTGFFVFGPQMLIGMAAAECSHKEAAGAATGFVGLFAYLGASLSGWPLAQVMDIWHWTGFFVVIAIAAGISALLLL
PFLNAQAPRTASEA
>Mature_494_residues
MRPAAGVESAGVRPDRHARARDRPGRHTDDLLHPRYPGVRQSTAALRLRGSPMFAFLKAPPDAAPISDKRELDARYRYWR
RHILLTIWLGYALFYFTRKSFNAAVPEILASNVLTRSDIGLLATLFYITYGLSKFFSGIVSDRSDARYFMGLGLIATGVV
NILFGFSSSLWAFALLWALNAFFQGWGSPVCARLLTAWYSRTERGGWWALWNTAHNVGGALIPMVVGAAALHYGWRAGMT
IAGCLAILAGLYLCWRLRDRPQAVGLPAVGDWRHDALEIAQQQEGAGMSRKAILTRYVLANPYIWLLSLCYVLVYVVRAA
INDWGNLYMSETLGVDLVTANSAVTMFELGGFIGALVAGWGSDKLFNGNRGPMNLIFAAGILLSVGGLWLMPFASYVMQA
ACFFTTGFFVFGPQMLIGMAAAECSHKEAAGAATGFVGLFAYLGASLSGWPLAQVMDIWHWTGFFVVIAIAAGISALLLL
PFLNAQAPRTASEA

Specific function: UhpC is required for uhpT expression, it may act jointly with the uhpB signaling protein [H]

COG id: COG2271

COG function: function code G; Sugar phosphate permease

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family [H]

Homologues:

Organism=Homo sapiens, GI256219598, Length=440, Percent_Identity=29.3181818181818, Blast_Score=200, Evalue=2e-51,
Organism=Homo sapiens, GI4503847, Length=440, Percent_Identity=29.3181818181818, Blast_Score=200, Evalue=2e-51,
Organism=Homo sapiens, GI256219483, Length=440, Percent_Identity=29.3181818181818, Blast_Score=200, Evalue=2e-51,
Organism=Homo sapiens, GI256219543, Length=454, Percent_Identity=28.4140969162996, Blast_Score=195, Evalue=9e-50,
Organism=Homo sapiens, GI256219564, Length=371, Percent_Identity=28.3018867924528, Blast_Score=149, Evalue=6e-36,
Organism=Homo sapiens, GI46361976, Length=466, Percent_Identity=22.7467811158798, Blast_Score=99, Evalue=9e-21,
Organism=Homo sapiens, GI14150047, Length=367, Percent_Identity=21.7983651226158, Blast_Score=80, Evalue=4e-15,
Organism=Homo sapiens, GI223717983, Length=469, Percent_Identity=24.7334754797441, Blast_Score=69, Evalue=1e-11,
Organism=Homo sapiens, GI38093649, Length=469, Percent_Identity=24.7334754797441, Blast_Score=68, Evalue=2e-11,
Organism=Escherichia coli, GI87082310, Length=439, Percent_Identity=88.6104783599089, Blast_Score=802, Evalue=0.0,
Organism=Escherichia coli, GI1788573, Length=435, Percent_Identity=35.8620689655172, Blast_Score=261, Evalue=1e-70,
Organism=Escherichia coli, GI2367259, Length=439, Percent_Identity=31.4350797266515, Blast_Score=174, Evalue=1e-44,
Organism=Escherichia coli, GI2367379, Length=364, Percent_Identity=22.5274725274725, Blast_Score=78, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI133901854, Length=444, Percent_Identity=22.5225225225225, Blast_Score=94, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI133901856, Length=444, Percent_Identity=22.5225225225225, Blast_Score=94, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI133930953, Length=461, Percent_Identity=20.824295010846, Blast_Score=87, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17542316, Length=470, Percent_Identity=22.5531914893617, Blast_Score=87, Evalue=3e-17,
Organism=Drosophila melanogaster, GI24656861, Length=474, Percent_Identity=25.3164556962025, Blast_Score=104, Evalue=1e-22,
Organism=Drosophila melanogaster, GI24656866, Length=473, Percent_Identity=25.369978858351, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI45550478, Length=473, Percent_Identity=25.369978858351, Blast_Score=103, Evalue=2e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000849
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR021159 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 53964; Mature: 53964

Theoretical pI: Translated: 9.68; Mature: 9.68

Prosite motif: PS50850 MFS ; PS00942 GLPT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRPAAGVESAGVRPDRHARARDRPGRHTDDLLHPRYPGVRQSTAALRLRGSPMFAFLKAP
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHEEECCCCEEEEEECC
PDAAPISDKRELDARYRYWRRHILLTIWLGYALFYFTRKSFNAAVPEILASNVLTRSDIG
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LLATLFYITYGLSKFFSGIVSDRSDARYFMGLGLIATGVVNILFGFSSSLWAFALLWALN
HHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHH
AFFQGWGSPVCARLLTAWYSRTERGGWWALWNTAHNVGGALIPMVVGAAALHYGWRAGMT
HHHHCCCCHHHHHHHHHHHHHCCCCCEEEEECCHHHCCHHHHHHHHHHHHHHHHHHCCHH
IAGCLAILAGLYLCWRLRDRPQAVGLPAVGDWRHDALEIAQQQEGAGMSRKAILTRYVLA
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHH
NPYIWLLSLCYVLVYVVRAAINDWGNLYMSETLGVDLVTANSAVTMFELGGFIGALVAGW
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCHHHHHHHHHHHHHHHHCC
GSDKLFNGNRGPMNLIFAAGILLSVGGLWLMPFASYVMQAACFFTTGFFVFGPQMLIGMA
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AAECSHKEAAGAATGFVGLFAYLGASLSGWPLAQVMDIWHWTGFFVVIAIAAGISALLLL
HHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
PFLNAQAPRTASEA
HHHCCCCCCCCCCC
>Mature Secondary Structure
MRPAAGVESAGVRPDRHARARDRPGRHTDDLLHPRYPGVRQSTAALRLRGSPMFAFLKAP
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHEEECCCCEEEEEECC
PDAAPISDKRELDARYRYWRRHILLTIWLGYALFYFTRKSFNAAVPEILASNVLTRSDIG
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LLATLFYITYGLSKFFSGIVSDRSDARYFMGLGLIATGVVNILFGFSSSLWAFALLWALN
HHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHH
AFFQGWGSPVCARLLTAWYSRTERGGWWALWNTAHNVGGALIPMVVGAAALHYGWRAGMT
HHHHCCCCHHHHHHHHHHHHHCCCCCEEEEECCHHHCCHHHHHHHHHHHHHHHHHHCCHH
IAGCLAILAGLYLCWRLRDRPQAVGLPAVGDWRHDALEIAQQQEGAGMSRKAILTRYVLA
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHH
NPYIWLLSLCYVLVYVVRAAINDWGNLYMSETLGVDLVTANSAVTMFELGGFIGALVAGW
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCHHHHHHHHHHHHHHHHCC
GSDKLFNGNRGPMNLIFAAGILLSVGGLWLMPFASYVMQAACFFTTGFFVFGPQMLIGMA
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AAECSHKEAAGAATGFVGLFAYLGASLSGWPLAQVMDIWHWTGFFVVIAIAAGISALLLL
HHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
PFLNAQAPRTASEA
HHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1569007; 11677609 [H]