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The map label for this gene is uhpT [H]

Identifier: 238897175

GI number: 238897175

Start: 5173776

End: 5175167

Strand: Reverse

Name: uhpT [H]

Synonym: KP1_5444

Alternate gene names: 238897175

Gene position: 5175167-5173776 (Counterclockwise)

Preceding gene: 238897176

Following gene: 238897174

Centisome position: 98.6

GC content: 58.41

Gene sequence:

>1392_bases
ATGCTGGCCTTTCTGAATCAGGTGCGCAAGCCGACCCTGGATCTGCCGCTCGATGTGCGGCGCAAAATGTGGTTCAAACC
TTTCATGCAGTCCTATCTGGTGGTTTTCATCGGCTACCTGACCATGTACCTGATCCGCAAGAACTTTAACATCGCGCAGA
ACGACATGATCTCCACCTACGGGCTGAGCATGACCCAGCTGGGGATGATTGGCCTGGGCTTCTCCATCACCTACGGCGTG
GGCAAGACGCTGGTCTCTTATTATGCCGACGGTAAAAATACCAAGCAGTTCCTGCCGTTTATGCTGATCCTCTCCGCCAT
CTGTATGCTGGGCTTTAGCGCCAGCATGGGGGCGGGTTCTACCAGCCTGTTCCTGATGATCGCCTTCTATGCGCTGAGCG
GTTTCTTCCAGAGCACCGGCGGCTCGTGCAGCTATTCCACCATCACCAAGTGGACGCCCAGACGCAAACGCGGCACTTTC
CTCGGCTTCTGGAATATCTCCCACAACCTCGGCGGCGCGGGCGCGGCGGGCGTGGCGCTGTTTGGCGCCAACTATCTGTT
CGACGGCCATGTGATCGGCATGTTTATCTTCCCGTCGATTATTGCGCTGATCGTTGGCTTTATCGGCCTGCGCTACGGTA
GCGACTCTCCGGAATCCTACGGCCTCGGCACGGCGGAAGAGCTGTTTGGCGAAGCGATCAGCGAAGAGGACAAAGAGACC
GAAGAAAATGCGATGACCAAGTGGCAGATCTTTGTCGAGTACGTGCTGAAAAACAAAGTGATCTGGCTGCTGTGCTTCTC
CAACATCTTCCTCTACGTGGTGCGTATCGGTATCGATCAGTGGTCCACCGTGTACGCCTTCCAGGAGCTGAAGCTGTCGA
AAGAGGTGGCGATTCAGGGCTTTACCCTGTTTGAGGTCGGCGCGCTGGTCGGCACGCTGCTGTGGGGCTGGCTGTCGGAT
CTGGCCAACGGCCGCCGCGCGCTGGTGGCCTGCATCGCGCTGGCGCTGATTATCGCCACCCTCGGGGTTTACCAACATGC
CAGCAACCAGTACGTCTATCTGGCCTCGTTGTTTGCGCTGGGCTTCCTGGTGTTTGGTCCGCAGCTGTTGATCGGCGTCG
CCGCCGTCGGTTTCGTACCGAAAAAAGCGATCGGCGCCGCCGATGGAATCAAGGGCACCTTCGCCTATCTGATCGGCGAT
AGCTTCGCCAAACTGGGTCTTGGGATGATCGCCGACGGCACCCCGGTCTTCGGCCTGACCGGCTGGGCCGGCACCTTTGC
GGCGCTGGACGCCGCCGCCGTCGGCTGTATCTGCCTGATGGCCATCGTGGCTATCTTTGAAGAGCGTAAAATTCGCCGCG
AGAAAAAGAACCGTATTTTGCAGACCGCCTGA

Upstream 100 bases:

>100_bases
TCCCGGTTTTACCTGGACGCCGTCTCAGGCCAGACGGCGCGCTGGTTTTTACAATGCCTGGTTATTACGCAGGCATAAAA
AATCAGCTCAGGAGATACCC

Downstream 100 bases:

>100_bases
TTCACCAGGTATTTGGTAACCTTGCCCGGCCTTCGCGCCGGGCTTTTTTATTTCTTGCGCATTATGCCAGGTCCGACAGT
CGACAGCAGGCAAATTCCCA

Product: sugar phosphate antiporter

Products: Proton [Cytoplasm]; glucose-6-phosphate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 463; Mature: 463

Protein sequence:

>463_residues
MLAFLNQVRKPTLDLPLDVRRKMWFKPFMQSYLVVFIGYLTMYLIRKNFNIAQNDMISTYGLSMTQLGMIGLGFSITYGV
GKTLVSYYADGKNTKQFLPFMLILSAICMLGFSASMGAGSTSLFLMIAFYALSGFFQSTGGSCSYSTITKWTPRRKRGTF
LGFWNISHNLGGAGAAGVALFGANYLFDGHVIGMFIFPSIIALIVGFIGLRYGSDSPESYGLGTAEELFGEAISEEDKET
EENAMTKWQIFVEYVLKNKVIWLLCFSNIFLYVVRIGIDQWSTVYAFQELKLSKEVAIQGFTLFEVGALVGTLLWGWLSD
LANGRRALVACIALALIIATLGVYQHASNQYVYLASLFALGFLVFGPQLLIGVAAVGFVPKKAIGAADGIKGTFAYLIGD
SFAKLGLGMIADGTPVFGLTGWAGTFAALDAAAVGCICLMAIVAIFEERKIRREKKNRILQTA

Sequences:

>Translated_463_residues
MLAFLNQVRKPTLDLPLDVRRKMWFKPFMQSYLVVFIGYLTMYLIRKNFNIAQNDMISTYGLSMTQLGMIGLGFSITYGV
GKTLVSYYADGKNTKQFLPFMLILSAICMLGFSASMGAGSTSLFLMIAFYALSGFFQSTGGSCSYSTITKWTPRRKRGTF
LGFWNISHNLGGAGAAGVALFGANYLFDGHVIGMFIFPSIIALIVGFIGLRYGSDSPESYGLGTAEELFGEAISEEDKET
EENAMTKWQIFVEYVLKNKVIWLLCFSNIFLYVVRIGIDQWSTVYAFQELKLSKEVAIQGFTLFEVGALVGTLLWGWLSD
LANGRRALVACIALALIIATLGVYQHASNQYVYLASLFALGFLVFGPQLLIGVAAVGFVPKKAIGAADGIKGTFAYLIGD
SFAKLGLGMIADGTPVFGLTGWAGTFAALDAAAVGCICLMAIVAIFEERKIRREKKNRILQTA
>Mature_463_residues
MLAFLNQVRKPTLDLPLDVRRKMWFKPFMQSYLVVFIGYLTMYLIRKNFNIAQNDMISTYGLSMTQLGMIGLGFSITYGV
GKTLVSYYADGKNTKQFLPFMLILSAICMLGFSASMGAGSTSLFLMIAFYALSGFFQSTGGSCSYSTITKWTPRRKRGTF
LGFWNISHNLGGAGAAGVALFGANYLFDGHVIGMFIFPSIIALIVGFIGLRYGSDSPESYGLGTAEELFGEAISEEDKET
EENAMTKWQIFVEYVLKNKVIWLLCFSNIFLYVVRIGIDQWSTVYAFQELKLSKEVAIQGFTLFEVGALVGTLLWGWLSD
LANGRRALVACIALALIIATLGVYQHASNQYVYLASLFALGFLVFGPQLLIGVAAVGFVPKKAIGAADGIKGTFAYLIGD
SFAKLGLGMIADGTPVFGLTGWAGTFAALDAAAVGCICLMAIVAIFEERKIRREKKNRILQTA

Specific function: Transport protein for sugar phosphate uptake [H]

COG id: COG2271

COG function: function code G; Sugar phosphate permease

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family [H]

Homologues:

Organism=Homo sapiens, GI256219598, Length=445, Percent_Identity=23.1460674157303, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI4503847, Length=445, Percent_Identity=23.1460674157303, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI256219483, Length=445, Percent_Identity=23.1460674157303, Blast_Score=72, Evalue=1e-12,
Organism=Escherichia coli, GI2367259, Length=463, Percent_Identity=95.0323974082073, Blast_Score=864, Evalue=0.0,
Organism=Escherichia coli, GI1788573, Length=456, Percent_Identity=31.359649122807, Blast_Score=218, Evalue=5e-58,
Organism=Escherichia coli, GI87082310, Length=445, Percent_Identity=34.1573033707865, Blast_Score=192, Evalue=5e-50,
Organism=Caenorhabditis elegans, GI133930953, Length=476, Percent_Identity=21.0084033613445, Blast_Score=65, Evalue=6e-11,
Organism=Drosophila melanogaster, GI24656866, Length=497, Percent_Identity=22.3340040241449, Blast_Score=75, Evalue=1e-13,
Organism=Drosophila melanogaster, GI45550478, Length=497, Percent_Identity=22.3340040241449, Blast_Score=75, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24656861, Length=497, Percent_Identity=22.3340040241449, Blast_Score=74, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000849
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR021159 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 50623; Mature: 50623

Theoretical pI: Translated: 9.14; Mature: 9.14

Prosite motif: PS50850 MFS ; PS00942 GLPT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLAFLNQVRKPTLDLPLDVRRKMWFKPFMQSYLVVFIGYLTMYLIRKNFNIAQNDMISTY
CCHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHCHHHHH
GLSMTQLGMIGLGFSITYGVGKTLVSYYADGKNTKQFLPFMLILSAICMLGFSASMGAGS
CCCHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCH
TSLFLMIAFYALSGFFQSTGGSCSYSTITKWTPRRKRGTFLGFWNISHNLGGAGAAGVAL
HHHHHHHHHHHHHHHHHCCCCCCCCCHHCCCCCCCCCCCEEEEEECCCCCCCCCHHHHHH
FGANYLFDGHVIGMFIFPSIIALIVGFIGLRYGSDSPESYGLGTAEELFGEAISEEDKET
HCCCCEECCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHCCCHHHH
EENAMTKWQIFVEYVLKNKVIWLLCFSNIFLYVVRIGIDQWSTVYAFQELKLSKEVAIQG
HHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCC
FTLFEVGALVGTLLWGWLSDLANGRRALVACIALALIIATLGVYQHASNQYVYLASLFAL
CHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEHHHHHHHH
GFLVFGPQLLIGVAAVGFVPKKAIGAADGIKGTFAYLIGDSFAKLGLGMIADGTPVFGLT
HHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCEECC
GWAGTFAALDAAAVGCICLMAIVAIFEERKIRREKKNRILQTA
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MLAFLNQVRKPTLDLPLDVRRKMWFKPFMQSYLVVFIGYLTMYLIRKNFNIAQNDMISTY
CCHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHCHHHHH
GLSMTQLGMIGLGFSITYGVGKTLVSYYADGKNTKQFLPFMLILSAICMLGFSASMGAGS
CCCHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCH
TSLFLMIAFYALSGFFQSTGGSCSYSTITKWTPRRKRGTFLGFWNISHNLGGAGAAGVAL
HHHHHHHHHHHHHHHHHCCCCCCCCCHHCCCCCCCCCCCEEEEEECCCCCCCCCHHHHHH
FGANYLFDGHVIGMFIFPSIIALIVGFIGLRYGSDSPESYGLGTAEELFGEAISEEDKET
HCCCCEECCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHCCCHHHH
EENAMTKWQIFVEYVLKNKVIWLLCFSNIFLYVVRIGIDQWSTVYAFQELKLSKEVAIQG
HHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCC
FTLFEVGALVGTLLWGWLSDLANGRRALVACIALALIIATLGVYQHASNQYVYLASLFAL
CHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEHHHHHHHH
GFLVFGPQLLIGVAAVGFVPKKAIGAADGIKGTFAYLIGDSFAKLGLGMIADGTPVFGLT
HHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCEECC
GWAGTFAALDAAAVGCICLMAIVAIFEERKIRREKKNRILQTA
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; glucose-6-phosphate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + glucose-6-phosphate [Periplasm] = Proton [Cytoplasm] + glucose-6-phosphate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]