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The map label for this gene is uhpB [H]

Identifier: 238897177

GI number: 238897177

Start: 5176653

End: 5178155

Strand: Reverse

Name: uhpB [H]

Synonym: KP1_5446

Alternate gene names: 238897177

Gene position: 5178155-5176653 (Counterclockwise)

Preceding gene: 238897178

Following gene: 238897176

Centisome position: 98.66

GC content: 64.4

Gene sequence:

>1503_bases
ATGAAGGCCGTCGTCTCACGATTGCTGTCGGTCATCGGCTGCGCCTTTATCTTCGCGGCCGCCTGGTTCTGCCTGTGGAG
CATCAGTCTGCATCTGGTGGAACGCGCGGATTTAGCGGTGCTGCTGTTTCCCTTTGGCCTGCGGCTGGGGTTAATGCTGC
AATGCCCCCGCGGCTACTGGCCAGTGCTGCTGGGAACCGAGTGGCTGCTTATCTTATGGCTGGCGCAGGAGGTGGCGCTG
GCGCACCCGATAATTTTGATGACCGGAAGCCTGCTGACTCTGCTGCCGGTGGCGTTGATCTCGCGCTACCGGCAGCAGCG
CGACTGGCTGACGCTGCTGCGTCAGGGCGGGGCGTTAATGGCCGCCGCGCTGCTGCAATCGCTGCCGTGGCTGGCGGAGG
GGGACGAGGGGCTTAACGCCCTGCTGTTGACGCTGACCGGCGGCCTGACGCTGGCGCCGACCTGCCTGGTTTTCTGGCAC
TATCTTACCAGCACCGTCTGGCGGCCGCTGGGGCCGGCGCTGGTGGCGCAGCCGGTTAACTGGCGCGGGCGGCATCTGAT
CTGGTATCTGCTGTTATTCACCATTAGCCTGTGGCTGCAGCTTGGCCTGCCCGCCGAGCTCTCCCGCTTTACCCCGTTTT
GTCTGGCGCTGCCGATTATCGCCCTCGCCTGGCACTACGGCTGGCAGGGAGCGCTGATCGCCACCCTGATGAACGCTATC
GCCTTGATTGCCAGTCAGACCTGGCACGATCACCCGGTCGATTTATTGCTTTCCCTGCTGGCACAGAGCCTCACCGGGCT
GCTGTTGGGGGCGGGGATCCAGCGGCTACGCGAGCTGAACCAGTCATTACAAAGCGAGCTGGCGCGTAATCGTCGGCTGG
CGGAACGCCTGCTGGAGACCGAAGAGAGCGTGCGGCGAGACGTCGCCCGCGAGCTCCATGATGATATCGGCCAGACCATC
ACCGCGATCCGCACCCAGGCCGGGATCGTACAGCGGCTGGCGCCGGACAATGCCAGCGTGCGCCAGAGCGGTCAGCTGAT
AGAACAGCTGTCGCTGGGAGTTTACGACTCGGTGCGTAGACTGCTGGGCCGTCTGCGTCCGCGTCAGCTCGACGACCTGC
CGCTGGAGCAGGCGGTACGTTCGTTGATGCGCGAGATGGAGCTGGAGGACCGCGGCATTGTCAGCCATCTCGACTGGCGG
ATTAACGAGGCGGGACTGAGCGAGAACCAGCGCGTGACGCTGTTTCGCGTTTGCCAGGAGGGGCTGAATAATATCGTCAA
GCACGCCAGCGCCAGCGCTGTCACTCTGCAGGGCTGGCAGCAGGATGAGCGACTAATGCTGGTGCTGGAAGATGACGGTT
GCGGCCTGCCGCCGGGGTCGAATCTGCAGGGGTTCGGCCTGACCGGCATGCGCGAGCGCGTGACCGCCCTGGGCGGCACA
CTGACGATCTCCTGCACCCACGGTACCCGGGTGTGCGTCAATCTACCGCTGCGTTACGCCTGA

Upstream 100 bases:

>100_bases
TGTCGCCGAAAACCGTCCACGTACACCGCGCCAACCTGCTGGAAAAGCTGGGCGTCAGCAACGACGTTGAGCTGGCGCGC
CGCATGTTCGATAGCTGGCA

Downstream 100 bases:

>100_bases
GAGGATCGCCGATGTTCGCCTTTTTAAAAGCCCCGCCGGACGCTGCGCCGATTAGCGATAAACGCGAACTTGATGCGCGT
TATCGCTACTGGCGTCGCCA

Product: sensory histidine kinase UhpB

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 500; Mature: 500

Protein sequence:

>500_residues
MKAVVSRLLSVIGCAFIFAAAWFCLWSISLHLVERADLAVLLFPFGLRLGLMLQCPRGYWPVLLGTEWLLILWLAQEVAL
AHPIILMTGSLLTLLPVALISRYRQQRDWLTLLRQGGALMAAALLQSLPWLAEGDEGLNALLLTLTGGLTLAPTCLVFWH
YLTSTVWRPLGPALVAQPVNWRGRHLIWYLLLFTISLWLQLGLPAELSRFTPFCLALPIIALAWHYGWQGALIATLMNAI
ALIASQTWHDHPVDLLLSLLAQSLTGLLLGAGIQRLRELNQSLQSELARNRRLAERLLETEESVRRDVARELHDDIGQTI
TAIRTQAGIVQRLAPDNASVRQSGQLIEQLSLGVYDSVRRLLGRLRPRQLDDLPLEQAVRSLMREMELEDRGIVSHLDWR
INEAGLSENQRVTLFRVCQEGLNNIVKHASASAVTLQGWQQDERLMLVLEDDGCGLPPGSNLQGFGLTGMRERVTALGGT
LTISCTHGTRVCVNLPLRYA

Sequences:

>Translated_500_residues
MKAVVSRLLSVIGCAFIFAAAWFCLWSISLHLVERADLAVLLFPFGLRLGLMLQCPRGYWPVLLGTEWLLILWLAQEVAL
AHPIILMTGSLLTLLPVALISRYRQQRDWLTLLRQGGALMAAALLQSLPWLAEGDEGLNALLLTLTGGLTLAPTCLVFWH
YLTSTVWRPLGPALVAQPVNWRGRHLIWYLLLFTISLWLQLGLPAELSRFTPFCLALPIIALAWHYGWQGALIATLMNAI
ALIASQTWHDHPVDLLLSLLAQSLTGLLLGAGIQRLRELNQSLQSELARNRRLAERLLETEESVRRDVARELHDDIGQTI
TAIRTQAGIVQRLAPDNASVRQSGQLIEQLSLGVYDSVRRLLGRLRPRQLDDLPLEQAVRSLMREMELEDRGIVSHLDWR
INEAGLSENQRVTLFRVCQEGLNNIVKHASASAVTLQGWQQDERLMLVLEDDGCGLPPGSNLQGFGLTGMRERVTALGGT
LTISCTHGTRVCVNLPLRYA
>Mature_500_residues
MKAVVSRLLSVIGCAFIFAAAWFCLWSISLHLVERADLAVLLFPFGLRLGLMLQCPRGYWPVLLGTEWLLILWLAQEVAL
AHPIILMTGSLLTLLPVALISRYRQQRDWLTLLRQGGALMAAALLQSLPWLAEGDEGLNALLLTLTGGLTLAPTCLVFWH
YLTSTVWRPLGPALVAQPVNWRGRHLIWYLLLFTISLWLQLGLPAELSRFTPFCLALPIIALAWHYGWQGALIATLMNAI
ALIASQTWHDHPVDLLLSLLAQSLTGLLLGAGIQRLRELNQSLQSELARNRRLAERLLETEESVRRDVARELHDDIGQTI
TAIRTQAGIVQRLAPDNASVRQSGQLIEQLSLGVYDSVRRLLGRLRPRQLDDLPLEQAVRSLMREMELEDRGIVSHLDWR
INEAGLSENQRVTLFRVCQEGLNNIVKHASASAVTLQGWQQDERLMLVLEDDGCGLPPGSNLQGFGLTGMRERVTALGGT
LTISCTHGTRVCVNLPLRYA

Specific function: Member of the two-component regulatory system uhpB/uhpA involved in the regulation of the uptake of hexose phosphates. UhpB functions as a membrane-associated protein kinase that phosphorylates uhpA in response to environmental signals [H]

COG id: COG3851

COG function: function code T; Signal transduction histidine kinase, glucose-6-phosphate specific

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI87082311, Length=499, Percent_Identity=86.5731462925852, Blast_Score=764, Evalue=0.0,
Organism=Escherichia coli, GI1788812, Length=210, Percent_Identity=31.4285714285714, Blast_Score=79, Evalue=7e-16,
Organism=Escherichia coli, GI1787474, Length=215, Percent_Identity=28.3720930232558, Blast_Score=71, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR007895
- InterPro:   IPR011712
- InterPro:   IPR005467 [H]

Pfam domain/function: PF02518 HATPase_c; PF07730 HisKA_3; PF05231 MASE1 [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 55715; Mature: 55715

Theoretical pI: Translated: 7.77; Mature: 7.77

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAVVSRLLSVIGCAFIFAAAWFCLWSISLHLVERADLAVLLFPFGLRLGLMLQCPRGYW
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHEECCCCCC
PVLLGTEWLLILWLAQEVALAHPIILMTGSLLTLLPVALISRYRQQRDWLTLLRQGGALM
CHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHH
AAALLQSLPWLAEGDEGLNALLLTLTGGLTLAPTCLVFWHYLTSTVWRPLGPALVAQPVN
HHHHHHHCCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCC
WRGRHLIWYLLLFTISLWLQLGLPAELSRFTPFCLALPIIALAWHYGWQGALIATLMNAI
CCCHHHHHHHHHHHHHHHHHCCCCHHHHHCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
ALIASQTWHDHPVDLLLSLLAQSLTGLLLGAGIQRLRELNQSLQSELARNRRLAERLLET
HHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EESVRRDVARELHDDIGQTITAIRTQAGIVQRLAPDNASVRQSGQLIEQLSLGVYDSVRR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCHHHHHHH
LLGRLRPRQLDDLPLEQAVRSLMREMELEDRGIVSHLDWRINEAGLSENQRVTLFRVCQE
HHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHCCCCCCCCCCCCCCHHHHHHHHH
GLNNIVKHASASAVTLQGWQQDERLMLVLEDDGCGLPPGSNLQGFGLTGMRERVTALGGT
HHHHHHHHCCCCEEEECCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHCCCE
LTISCTHGTRVCVNLPLRYA
EEEEECCCCEEEEECCCCCC
>Mature Secondary Structure
MKAVVSRLLSVIGCAFIFAAAWFCLWSISLHLVERADLAVLLFPFGLRLGLMLQCPRGYW
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHEECCCCCC
PVLLGTEWLLILWLAQEVALAHPIILMTGSLLTLLPVALISRYRQQRDWLTLLRQGGALM
CHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHH
AAALLQSLPWLAEGDEGLNALLLTLTGGLTLAPTCLVFWHYLTSTVWRPLGPALVAQPVN
HHHHHHHCCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCC
WRGRHLIWYLLLFTISLWLQLGLPAELSRFTPFCLALPIIALAWHYGWQGALIATLMNAI
CCCHHHHHHHHHHHHHHHHHCCCCHHHHHCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
ALIASQTWHDHPVDLLLSLLAQSLTGLLLGAGIQRLRELNQSLQSELARNRRLAERLLET
HHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EESVRRDVARELHDDIGQTITAIRTQAGIVQRLAPDNASVRQSGQLIEQLSLGVYDSVRR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCHHHHHHH
LLGRLRPRQLDDLPLEQAVRSLMREMELEDRGIVSHLDWRINEAGLSENQRVTLFRVCQE
HHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHCCCCCCCCCCCCCCHHHHHHHHH
GLNNIVKHASASAVTLQGWQQDERLMLVLEDDGCGLPPGSNLQGFGLTGMRERVTALGGT
HHHHHHHHCCCCEEEECCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHCCCE
LTISCTHGTRVCVNLPLRYA
EEEEECCCCEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3301805; 1569007; 7686882; 9278503 [H]