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The map label for this gene is arnA [H]

Identifier: 238896942

GI number: 238896942

Start: 4914760

End: 4916745

Strand: Reverse

Name: arnA [H]

Synonym: KP1_5182

Alternate gene names: 238896942

Gene position: 4916745-4914760 (Counterclockwise)

Preceding gene: 238896943

Following gene: 238896941

Centisome position: 93.68

GC content: 60.32

Gene sequence:

>1986_bases
ATGAAAGCCGTAGTCTTCGCTTATCACGATATGGGCTGCACCGGTATCCAGTCCCTGCTGGACGCCGGGTATGATATCGC
TGCTATTTTCACCCACCCGGATAACCCTGGCGAAAACCATTTCTTTGGCTCCGTGGCGCGCCTTGCCGCCGAGCAGGGTA
TTCCGGTGTGGGCGCCGGAAGACGTGAACCATCCGCTGTGGATTGAGCGTATCCGCGAGATGAAGCCGGACGTGCTGTTC
TCCTTCTACTATCGCAACCTGCTGGGCGATGAGATCCTCAATCTGGCGCCGAAAGGGGCGTTCAACCTGCACGGTTCGCT
GCTGCCAAAATATCGCGGCCGCGCGCCGCTGAACTGGGTGCTGGTCAATGGCGAAAGCGAAACCGGCGTCACCCTGCACC
GGATGGTGAACCGCGCAGACGCTGGCGATATCGTCGCCCAGCAGGCCGTGGCGATTGGCGCGGATGACGCCGCCCTGACG
CTGCATCGTAAGCTGTGCGCCGCCGCCACTGAGCTGCTGAGCCGGGCGCTGCCGGCGATCCTCGCCGGCACCACCGATGA
GCGTCCGCAGGATCACAGCCAGGCAACCTATGTGGGGCGTCGTACCCCGGAAGATGGCCGGCTGGACTGGGAGCTGCCGG
CGCAGACCCTGCACAATCTGGTGCGTGCGGTCTCGGATCCGTGGCCGGGCGCCTTCGGCTACGCCGGAGCGAACAAGTTT
ATCGTCTGGAAATCCCGCGTTCGCCACGATTTGCCAGCAGCTAAACCGGGCACCGTGATCTCCATTGCGCCGCTGATCGT
CGCGTGCCAGGACGGGGCGCTGGAGATTGTCACCGGCCAGACCGAACGCGGCGTGTACATGCAGGGCGCTCAGCTGGCGC
AGGCGCTGGGCCTGGTGTCCGGGGCGGTGATCAGCAGCAAACCGGTGGTGGCGATTAAGCGTCGCACCCGGGTGCTGATC
CTCGGCGTCAACGGCTTTATCGGTAACCACCTGACCGAGCGCCTGCTGCAGGACGACAACTATGAGATTTACGGTCTGGA
TATCGGCTCCGACGCCATCAGCCGTTTTCTCGACTGTCCGCGTTTCCACTTTGTGGAAGGCGATATCAGCATTCACTCCG
AGTGGATCGAGTATCACATTAAGAAATGCGACGTGGTGCTGCCGCTGGTGGCCATCGCCACGCCTATCGAATACACCCGC
AACCCGCTGCGCGTGTTCGAGCTGGATTTCGAAGAGAACCTGAAAATCATCCGCGACTGCGTGAAATACAATAAGCGCAT
TATCTTCCCGTCGACCTCGGAAGTGTACGGCATGTGCACCGACAATAACTTCGACGAAGATAGCTCCAACCTGGTGGTGG
GGCCGATCAACAAACAGCGCTGGATCTACTCGGTCTCCAAGCAGCTGCTCGATCGCGTGATCTGGGCCTATGGCGATAAG
AACGGCCTGAAGTTCACCCTGTTCCGTCCGTTCAACTGGATGGGGCCGCGGCTGGATAACCTCAACGCCGCGCGTATCGG
CAGCTCCCGCGCTATCACCCAGCTGATCCTCAACCTGGTGGAAGGGTCGCCGATCAAGCTTATCGAAGGCGGCAAGCAGA
AGCGCTGTTTCACCGACATCAGCGACGGTATCGAAGCGCTGTTCCGCATCATCGAGAACAAAGACGGCCGCTGCGACGGG
CAGATCATTAACATCGGCAACCCGGATAACGAAGCGAGCATCAAAGAGCTGGCCGAAATGCTGCTCGCCTGCTTCGAACG
TCATCCGCTGCGCGATCGCTTCCCGCCGTTCGCCGGCTTCCGTGAAGTGGAAAGCAGCGATTACTACGGAAAGGGCTACC
AGGACGTTGAGCATCGTAAGCCGAGCATCCGCAACGCCAAACGCTGCCTGAACTGGGAGCCGAAGGTGGAGATGGAAGAA
ACGGTCGAACACACGCTGGACTTCTTCCTGCGCACGGTTGAACTGGTGGACGATAAAAATCCATGA

Upstream 100 bases:

>100_bases
ATATCGGCCGCATCTATAACGACGTGCGCGCCCGCCCCCGCTACTTTATTCAACGTGTTGTTCGCCAGCCGGAAACGGCA
TCTAAAGAGGAAGATCGTTC

Downstream 100 bases:

>100_bases
AACAGGTCGGCTTACGCATAGATGTCGATACCTTTCGCGGCACGCGGGACGGCGTTCCGCGGCTGCTGGAGCTGCTGGGC
CGGCATGGGATCCAGGCAAG

Product: bifunctional UDP-glucuronic acid decarboxylase/UDP-4-amino-4-deoxy-L-arabinose formyltransferase

Products: NA

Alternate protein names: UDP-4-amino-4-deoxy-L-arabinose formyltransferase; ArnAFT; UDP-L-Ara4N formyltransferase; UDP-glucuronic acid oxidase, UDP-4-keto-hexauronic acid decarboxylating; ArnADH; UDP-GlcUA decarboxylase; UDP-glucuronic acid dehydrogenase [H]

Number of amino acids: Translated: 661; Mature: 661

Protein sequence:

>661_residues
MKAVVFAYHDMGCTGIQSLLDAGYDIAAIFTHPDNPGENHFFGSVARLAAEQGIPVWAPEDVNHPLWIERIREMKPDVLF
SFYYRNLLGDEILNLAPKGAFNLHGSLLPKYRGRAPLNWVLVNGESETGVTLHRMVNRADAGDIVAQQAVAIGADDAALT
LHRKLCAAATELLSRALPAILAGTTDERPQDHSQATYVGRRTPEDGRLDWELPAQTLHNLVRAVSDPWPGAFGYAGANKF
IVWKSRVRHDLPAAKPGTVISIAPLIVACQDGALEIVTGQTERGVYMQGAQLAQALGLVSGAVISSKPVVAIKRRTRVLI
LGVNGFIGNHLTERLLQDDNYEIYGLDIGSDAISRFLDCPRFHFVEGDISIHSEWIEYHIKKCDVVLPLVAIATPIEYTR
NPLRVFELDFEENLKIIRDCVKYNKRIIFPSTSEVYGMCTDNNFDEDSSNLVVGPINKQRWIYSVSKQLLDRVIWAYGDK
NGLKFTLFRPFNWMGPRLDNLNAARIGSSRAITQLILNLVEGSPIKLIEGGKQKRCFTDISDGIEALFRIIENKDGRCDG
QIINIGNPDNEASIKELAEMLLACFERHPLRDRFPPFAGFREVESSDYYGKGYQDVEHRKPSIRNAKRCLNWEPKVEMEE
TVEHTLDFFLRTVELVDDKNP

Sequences:

>Translated_661_residues
MKAVVFAYHDMGCTGIQSLLDAGYDIAAIFTHPDNPGENHFFGSVARLAAEQGIPVWAPEDVNHPLWIERIREMKPDVLF
SFYYRNLLGDEILNLAPKGAFNLHGSLLPKYRGRAPLNWVLVNGESETGVTLHRMVNRADAGDIVAQQAVAIGADDAALT
LHRKLCAAATELLSRALPAILAGTTDERPQDHSQATYVGRRTPEDGRLDWELPAQTLHNLVRAVSDPWPGAFGYAGANKF
IVWKSRVRHDLPAAKPGTVISIAPLIVACQDGALEIVTGQTERGVYMQGAQLAQALGLVSGAVISSKPVVAIKRRTRVLI
LGVNGFIGNHLTERLLQDDNYEIYGLDIGSDAISRFLDCPRFHFVEGDISIHSEWIEYHIKKCDVVLPLVAIATPIEYTR
NPLRVFELDFEENLKIIRDCVKYNKRIIFPSTSEVYGMCTDNNFDEDSSNLVVGPINKQRWIYSVSKQLLDRVIWAYGDK
NGLKFTLFRPFNWMGPRLDNLNAARIGSSRAITQLILNLVEGSPIKLIEGGKQKRCFTDISDGIEALFRIIENKDGRCDG
QIINIGNPDNEASIKELAEMLLACFERHPLRDRFPPFAGFREVESSDYYGKGYQDVEHRKPSIRNAKRCLNWEPKVEMEE
TVEHTLDFFLRTVELVDDKNP
>Mature_661_residues
MKAVVFAYHDMGCTGIQSLLDAGYDIAAIFTHPDNPGENHFFGSVARLAAEQGIPVWAPEDVNHPLWIERIREMKPDVLF
SFYYRNLLGDEILNLAPKGAFNLHGSLLPKYRGRAPLNWVLVNGESETGVTLHRMVNRADAGDIVAQQAVAIGADDAALT
LHRKLCAAATELLSRALPAILAGTTDERPQDHSQATYVGRRTPEDGRLDWELPAQTLHNLVRAVSDPWPGAFGYAGANKF
IVWKSRVRHDLPAAKPGTVISIAPLIVACQDGALEIVTGQTERGVYMQGAQLAQALGLVSGAVISSKPVVAIKRRTRVLI
LGVNGFIGNHLTERLLQDDNYEIYGLDIGSDAISRFLDCPRFHFVEGDISIHSEWIEYHIKKCDVVLPLVAIATPIEYTR
NPLRVFELDFEENLKIIRDCVKYNKRIIFPSTSEVYGMCTDNNFDEDSSNLVVGPINKQRWIYSVSKQLLDRVIWAYGDK
NGLKFTLFRPFNWMGPRLDNLNAARIGSSRAITQLILNLVEGSPIKLIEGGKQKRCFTDISDGIEALFRIIENKDGRCDG
QIINIGNPDNEASIKELAEMLLACFERHPLRDRFPPFAGFREVESSDYYGKGYQDVEHRKPSIRNAKRCLNWEPKVEMEE
TVEHTLDFFLRTVELVDDKNP

Specific function: Bifunctional enzyme that catalyzes the oxidative decarboxylation of UDP-glucuronic acid (UDP-GlcUA) to UDP-4-keto- arabinose (UDP-Ara4O) and the addition of a formyl group to UDP-4- amino-4-deoxy-L-arabinose (UDP-L-Ara4N) to form UDP-L-4-formamido- arabin

COG id: COG0451

COG function: function code MG; Nucleoside-diphosphate-sugar epimerases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the sugar epimerase family. UDP-glucuronic acid decarboxylase subfamily [H]

Homologues:

Organism=Homo sapiens, GI42516563, Length=348, Percent_Identity=26.1494252873563, Blast_Score=117, Evalue=3e-26,
Organism=Homo sapiens, GI21614513, Length=429, Percent_Identity=24.2424242424242, Blast_Score=100, Evalue=3e-21,
Organism=Homo sapiens, GI238814322, Length=289, Percent_Identity=23.8754325259516, Blast_Score=79, Evalue=1e-14,
Organism=Escherichia coli, GI1788589, Length=657, Percent_Identity=77.3211567732116, Blast_Score=1074, Evalue=0.0,
Organism=Escherichia coli, GI1789683, Length=283, Percent_Identity=31.8021201413428, Blast_Score=143, Evalue=3e-35,
Organism=Caenorhabditis elegans, GI17539532, Length=342, Percent_Identity=25.1461988304094, Blast_Score=108, Evalue=6e-24,
Organism=Caenorhabditis elegans, GI133930964, Length=261, Percent_Identity=24.904214559387, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI21356223, Length=343, Percent_Identity=25.9475218658892, Blast_Score=104, Evalue=2e-22,
Organism=Drosophila melanogaster, GI45550868, Length=205, Percent_Identity=29.2682926829268, Blast_Score=88, Evalue=2e-17,
Organism=Drosophila melanogaster, GI28571984, Length=205, Percent_Identity=29.2682926829268, Blast_Score=87, Evalue=3e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR021168
- InterPro:   IPR001509
- InterPro:   IPR005793
- InterPro:   IPR002376
- InterPro:   IPR011034
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01370 Epimerase; PF02911 Formyl_trans_C; PF00551 Formyl_trans_N [H]

EC number: =2.1.2.13; =1.1.1.305 [H]

Molecular weight: Translated: 74047; Mature: 74047

Theoretical pI: Translated: 6.18; Mature: 6.18

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAVVFAYHDMGCTGIQSLLDAGYDIAAIFTHPDNPGENHFFGSVARLAAEQGIPVWAPE
CCEEEEEECCCCHHHHHHHHHCCCCEEEEEECCCCCCCCCHHHHHHHHHHHCCCCEECCC
DVNHPLWIERIREMKPDVLFSFYYRNLLGDEILNLAPKGAFNLHGSLLPKYRGRAPLNWV
CCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCEEEE
LVNGESETGVTLHRMVNRADAGDIVAQQAVAIGADDAALTLHRKLCAAATELLSRALPAI
EEECCCCCCHHHHHHHCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
LAGTTDERPQDHSQATYVGRRTPEDGRLDWELPAQTLHNLVRAVSDPWPGAFGYAGANKF
HCCCCCCCCCCCCHHHEECCCCCCCCCEECCCCHHHHHHHHHHHCCCCCCCCCCCCCCEE
IVWKSRVRHDLPAAKPGTVISIAPLIVACQDGALEIVTGQTERGVYMQGAQLAQALGLVS
EEEHHHHHHCCCCCCCCCEEEECCEEEEECCCCEEEEECCCCCCEEECHHHHHHHHHHHH
GAVISSKPVVAIKRRTRVLILGVNGFIGNHLTERLLQDDNYEIYGLDIGSDAISRFLDCP
CCCCCCCCEEEEECCCEEEEEECCCHHHHHHHHHHHCCCCCEEEEEECCHHHHHHHHCCC
RFHFVEGDISIHSEWIEYHIKKCDVVLPLVAIATPIEYTRNPLRVFELDFEENLKIIRDC
CEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCEEEEEECHHHHHHHHHHH
VKYNKRIIFPSTSEVYGMCTDNNFDEDSSNLVVGPINKQRWIYSVSKQLLDRVIWAYGDK
HHHCCEEEECCCCCEEEEECCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHCCCC
NGLKFTLFRPFNWMGPRLDNLNAARIGSSRAITQLILNLVEGSPIKLIEGGKQKRCFTDI
CCCEEEEECCCCCCCCCCCCCCHHHCCCHHHHHHHHHHHHCCCCEEEECCCCCCHHHHHH
SDGIEALFRIIENKDGRCDGQIINIGNPDNEASIKELAEMLLACFERHPLRDRFPPFAGF
HHHHHHHHHHHCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHCCCCHHCCCCCCCC
REVESSDYYGKGYQDVEHRKPSIRNAKRCLNWEPKVEMEETVEHTLDFFLRTVELVDDKN
HHCCCCCCCCCCCCHHHHCCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCC
P
C
>Mature Secondary Structure
MKAVVFAYHDMGCTGIQSLLDAGYDIAAIFTHPDNPGENHFFGSVARLAAEQGIPVWAPE
CCEEEEEECCCCHHHHHHHHHCCCCEEEEEECCCCCCCCCHHHHHHHHHHHCCCCEECCC
DVNHPLWIERIREMKPDVLFSFYYRNLLGDEILNLAPKGAFNLHGSLLPKYRGRAPLNWV
CCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCEEEE
LVNGESETGVTLHRMVNRADAGDIVAQQAVAIGADDAALTLHRKLCAAATELLSRALPAI
EEECCCCCCHHHHHHHCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
LAGTTDERPQDHSQATYVGRRTPEDGRLDWELPAQTLHNLVRAVSDPWPGAFGYAGANKF
HCCCCCCCCCCCCHHHEECCCCCCCCCEECCCCHHHHHHHHHHHCCCCCCCCCCCCCCEE
IVWKSRVRHDLPAAKPGTVISIAPLIVACQDGALEIVTGQTERGVYMQGAQLAQALGLVS
EEEHHHHHHCCCCCCCCCEEEECCEEEEECCCCEEEEECCCCCCEEECHHHHHHHHHHHH
GAVISSKPVVAIKRRTRVLILGVNGFIGNHLTERLLQDDNYEIYGLDIGSDAISRFLDCP
CCCCCCCCEEEEECCCEEEEEECCCHHHHHHHHHHHCCCCCEEEEEECCHHHHHHHHCCC
RFHFVEGDISIHSEWIEYHIKKCDVVLPLVAIATPIEYTRNPLRVFELDFEENLKIIRDC
CEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCEEEEEECHHHHHHHHHHH
VKYNKRIIFPSTSEVYGMCTDNNFDEDSSNLVVGPINKQRWIYSVSKQLLDRVIWAYGDK
HHHCCEEEECCCCCEEEEECCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHCCCC
NGLKFTLFRPFNWMGPRLDNLNAARIGSSRAITQLILNLVEGSPIKLIEGGKQKRCFTDI
CCCEEEEECCCCCCCCCCCCCCHHHCCCHHHHHHHHHHHHCCCCEEEECCCCCCHHHHHH
SDGIEALFRIIENKDGRCDGQIINIGNPDNEASIKELAEMLLACFERHPLRDRFPPFAGF
HHHHHHHHHHHCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHCCCCHHCCCCCCCC
REVESSDYYGKGYQDVEHRKPSIRNAKRCLNWEPKVEMEETVEHTLDFFLRTVELVDDKN
HHCCCCCCCCCCCCHHHHCCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCC
P
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA