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The map label for this gene is ghrA [H]

Identifier: 238896100

GI number: 238896100

Start: 4071182

End: 4072114

Strand: Direct

Name: ghrA [H]

Synonym: KP1_4239

Alternate gene names: 238896100

Gene position: 4071182-4072114 (Clockwise)

Preceding gene: 238896099

Following gene: 238896101

Centisome position: 77.57

GC content: 65.81

Gene sequence:

>933_bases
ATGTCTGATATCACTATCGTGGTGGATTGTAACGACGCGGATTTCGCCCGCGATATCTGCGCCGCCCTGCAGCAGTTTCC
CGACGTCACGGCGCTTCTGCCCCATCACCAGGCGGCGCGCGACGCCCAGTACGCCAGCTGCTGGTTCCCGGACCCGCAGC
TGTTGACCCGTTCGCCGGGGCTGAAGCTGATCCAGGCCGCGTCCGCCGGGGTCGATCATCTGCCGCCCGCGCTGTTCGCC
AGCGAGATCCCGCTGTGCCGGGTGATCGATGAAGATTTTCGCCACGGCATGTTCGAATATGCCCTGTGGAGCGTCCTGTG
GTTTCAGCGCCATTTCGACCGGGCGCTGGCCCACCAGCAAACCCAAACCTGGAAGCTCTATCCCCAGCGCGCCGCCGCCG
ACTTCCATATCGGCATTATGGGGCTCGGCGAAATTGGCGGCTATATCGCCGACCAGCTGGCCCGCCTCGGCTATCGGGTC
TCCGGCTGGTCGCGCAGTGAAAAGCAGCTGGCTGGCGTCACCTGCTATCGCGGCGAGGAGGCGCTCGACAGCTTCCTCGG
GTCGCTTGACGGGCTGATTAACCTCCTGCCGCTCACCGCGCAGACCCGGGGTATCCTCGCCGCGCCGCTGTTCAGCCGGC
TACCCGCCGGGGCGGTGTTGATCAATTGCGGCCGCGGGGAGCATATGGTCAATGAGGATGTGCTGGCGGCGCTGGAGAGC
GGCCAGCTCGCCGGGGCGGTGCTCGACGTCTTCCCGCAGGAGCCATTGCCGGCGGACGATCCGCTGTGGCGCCATCCGCA
GGTGGTCATCACCCCACATATGGCCTCTGCGGCCTCTGCCGAGGTGATCGCCCGCCAGTTGCTGGAGAACATTCAGCGCC
AGCGCCGCGGGCTGCCGCTGAAGAACCTGGTCAATAAGCACGCCGGTTACTGA

Upstream 100 bases:

>100_bases
GCGAGCAGCTGATGGGCGTGGAGCATGAACGTCAACAGGTCTGGCAGGCGTGGCTGCGCCGTCTTGACCGTCTCGATACC
TCTTACAAAGACTAACGCCT

Downstream 100 bases:

>100_bases
TCCCCGGCTATATCGCCGCTGCTACGCTTAATAGGAGATCCACAACCAGAAGGCAGGAACATGAAGATTGATTTAGCGGG
AAAAGTCGCGCTGGTCACCG

Product: 2-ketoacid reductase

Products: NA

Alternate protein names: 2-ketoacid reductase [H]

Number of amino acids: Translated: 310; Mature: 309

Protein sequence:

>310_residues
MSDITIVVDCNDADFARDICAALQQFPDVTALLPHHQAARDAQYASCWFPDPQLLTRSPGLKLIQAASAGVDHLPPALFA
SEIPLCRVIDEDFRHGMFEYALWSVLWFQRHFDRALAHQQTQTWKLYPQRAAADFHIGIMGLGEIGGYIADQLARLGYRV
SGWSRSEKQLAGVTCYRGEEALDSFLGSLDGLINLLPLTAQTRGILAAPLFSRLPAGAVLINCGRGEHMVNEDVLAALES
GQLAGAVLDVFPQEPLPADDPLWRHPQVVITPHMASAASAEVIARQLLENIQRQRRGLPLKNLVNKHAGY

Sequences:

>Translated_310_residues
MSDITIVVDCNDADFARDICAALQQFPDVTALLPHHQAARDAQYASCWFPDPQLLTRSPGLKLIQAASAGVDHLPPALFA
SEIPLCRVIDEDFRHGMFEYALWSVLWFQRHFDRALAHQQTQTWKLYPQRAAADFHIGIMGLGEIGGYIADQLARLGYRV
SGWSRSEKQLAGVTCYRGEEALDSFLGSLDGLINLLPLTAQTRGILAAPLFSRLPAGAVLINCGRGEHMVNEDVLAALES
GQLAGAVLDVFPQEPLPADDPLWRHPQVVITPHMASAASAEVIARQLLENIQRQRRGLPLKNLVNKHAGY
>Mature_309_residues
SDITIVVDCNDADFARDICAALQQFPDVTALLPHHQAARDAQYASCWFPDPQLLTRSPGLKLIQAASAGVDHLPPALFAS
EIPLCRVIDEDFRHGMFEYALWSVLWFQRHFDRALAHQQTQTWKLYPQRAAADFHIGIMGLGEIGGYIADQLARLGYRVS
GWSRSEKQLAGVTCYRGEEALDSFLGSLDGLINLLPLTAQTRGILAAPLFSRLPAGAVLINCGRGEHMVNEDVLAALESG
QLAGAVLDVFPQEPLPADDPLWRHPQVVITPHMASAASAEVIARQLLENIQRQRRGLPLKNLVNKHAGY

Specific function: Catalyzes the NADPH-dependent reduction of glyoxylate and hydroxypyruvate into glycolate and glycerate, respectively [H]

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GhrA subfamily [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=218, Percent_Identity=27.5229357798165, Blast_Score=75, Evalue=6e-14,
Organism=Homo sapiens, GI6912396, Length=248, Percent_Identity=26.6129032258064, Blast_Score=74, Evalue=1e-13,
Organism=Escherichia coli, GI87081824, Length=275, Percent_Identity=38.1818181818182, Blast_Score=181, Evalue=5e-47,
Organism=Escherichia coli, GI87082289, Length=270, Percent_Identity=29.6296296296296, Blast_Score=89, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17532191, Length=290, Percent_Identity=28.2758620689655, Blast_Score=87, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6320925, Length=195, Percent_Identity=26.6666666666667, Blast_Score=64, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6322116, Length=195, Percent_Identity=26.6666666666667, Blast_Score=63, Evalue=5e-11,
Organism=Drosophila melanogaster, GI28574286, Length=248, Percent_Identity=27.4193548387097, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI19921140, Length=233, Percent_Identity=28.3261802575107, Blast_Score=79, Evalue=4e-15,
Organism=Drosophila melanogaster, GI24585516, Length=254, Percent_Identity=27.5590551181102, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI45552429, Length=232, Percent_Identity=27.1551724137931, Blast_Score=76, Evalue=3e-14,
Organism=Drosophila melanogaster, GI45551003, Length=232, Percent_Identity=27.1551724137931, Blast_Score=76, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24585514, Length=232, Percent_Identity=27.1551724137931, Blast_Score=76, Evalue=3e-14,
Organism=Drosophila melanogaster, GI28574282, Length=232, Percent_Identity=27.1551724137931, Blast_Score=76, Evalue=3e-14,
Organism=Drosophila melanogaster, GI28574284, Length=232, Percent_Identity=27.1551724137931, Blast_Score=75, Evalue=5e-14,
Organism=Drosophila melanogaster, GI28571528, Length=143, Percent_Identity=30.7692307692308, Blast_Score=71, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02826 2-Hacid_dh_C [H]

EC number: =1.1.1.79; =1.1.1.81 [H]

Molecular weight: Translated: 34115; Mature: 33984

Theoretical pI: Translated: 6.12; Mature: 6.12

Prosite motif: PS00671 D_2_HYDROXYACID_DH_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDITIVVDCNDADFARDICAALQQFPDVTALLPHHQAARDAQYASCWFPDPQLLTRSPG
CCCEEEEEECCCCHHHHHHHHHHHHCCCHHHHCCCHHHHHCCCCCEECCCCHHHHHCCCC
LKLIQAASAGVDHLPPALFASEIPLCRVIDEDFRHGMFEYALWSVLWFQRHFDRALAHQQ
HHHHHHHHCCCCCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
TQTWKLYPQRAAADFHIGIMGLGEIGGYIADQLARLGYRVSGWSRSEKQLAGVTCYRGEE
CCCEEECHHHCCCCEEEEEEEHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHCEEEECCHH
ALDSFLGSLDGLINLLPLTAQTRGILAAPLFSRLPAGAVLINCGRGEHMVNEDVLAALES
HHHHHHHHHHHHHHHHCCCHHHCCHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHC
GQLAGAVLDVFPQEPLPADDPLWRHPQVVITPHMASAASAEVIARQLLENIQRQRRGLPL
CCHHHHHHHHCCCCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCH
KNLVNKHAGY
HHHHHHHCCC
>Mature Secondary Structure 
SDITIVVDCNDADFARDICAALQQFPDVTALLPHHQAARDAQYASCWFPDPQLLTRSPG
CCEEEEEECCCCHHHHHHHHHHHHCCCHHHHCCCHHHHHCCCCCEECCCCHHHHHCCCC
LKLIQAASAGVDHLPPALFASEIPLCRVIDEDFRHGMFEYALWSVLWFQRHFDRALAHQQ
HHHHHHHHCCCCCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
TQTWKLYPQRAAADFHIGIMGLGEIGGYIADQLARLGYRVSGWSRSEKQLAGVTCYRGEE
CCCEEECHHHCCCCEEEEEEEHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHCEEEECCHH
ALDSFLGSLDGLINLLPLTAQTRGILAAPLFSRLPAGAVLINCGRGEHMVNEDVLAALES
HHHHHHHHHHHHHHHHCCCHHHCCHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHC
GQLAGAVLDVFPQEPLPADDPLWRHPQVVITPHMASAASAEVIARQLLENIQRQRRGLPL
CCHHHHHHHHCCCCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCH
KNLVNKHAGY
HHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA