BacMap

Definition	Klebsiella pneumoniae NTUH-K2044 chromosome, complete genome.
Accession	NC_012731
Length	5,248,520

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The map label for this gene is yvaG [H]

Identifier: 238896101

GI number: 238896101

Start: 4072175

End: 4072969

Strand: Direct

Name: yvaG [H]

Synonym: KP1_4240

Alternate gene names: 238896101

Gene position: 4072175-4072969 (Clockwise)

Preceding gene: 238896100

Following gene: 238896102

Centisome position: 77.59

GC content: 64.4

Gene sequence:

>795_bases
ATGAAGATTGATTTAGCGGGAAAAGTCGCGCTGGTCACCGCCTCCACGGCGGGTATTGGCTTCGCCATCGCCAAAGGCCT
GGCGGAGAGCGGCGCAGAGGTCATCCTTAACGGGCGCAGCGAGCAGAGCGTGAACGCCGCGATCGCCCGGCTGCAAAATG
AGGTGCCGGGCGCGAAGGCGCGCCCCGCCATCGCCGACCTCAGCGACGCCGACGGCGCAGCGCAGCTGCTGCGGGCCGTG
ACCGGCGTCGATATTCTGGTCAATAACGCCGGGATCTATGGCCCGCAGGATTTCTACGCCACCGACGACGCGACCTGGGA
CAACTACTGGCAGACCAACGTCATGTCCGGCGTGCGCCTGTCGCGAGGGCTGCTCCCGGCGATGGTCAACAAAGGCTGGG
GGCGGGTGGTGTTTATCTCCTCGGAATCGGCGCGCAATATCCCGGCGGACATGATCCACTATGGCGTCACCAAGACCGCG
CAGCTGTCGCTGGCCCGCGGCCTGGCGAAATATGTCGCAGGCAGCGGAGTGACCGTTAACAGCGTTCTGCCAGGGCCAAC
GATTTCCGACGGCTTTGCCGAAATGCTGAAAGACGACGTGGCGAAAACCGGTCAGTCGCTGGAGGAACTGGCGAAAGCGT
TTGTCATGACCCATCGTCCGAGCTCGGTGATCCAGCGGGCGGCCTCGGTGGCAGAGGTCGCCAATATGGTGGTCTACGTC
TGCTCGCCGCAGGCGTCAGCCACCTCCGGCGCCGCGCTGCGCGTCGATGGCGGCGTGGTGGATGATATTCTCTGA

Upstream 100 bases:

>100_bases
GCCGCTGAAGAACCTGGTCAATAAGCACGCCGGTTACTGATCCCCGGCTATATCGCCGCTGCTACGCTTAATAGGAGATC
CACAACCAGAAGGCAGGAAC

Downstream 100 bases:

>100_bases
ATCCCCTTTATGCAGGGGAGCCCCCTCCCCTGCCGCCTTCCCGGGCGCTAAAAAGCGCAAAATGTTAAAAAACAGCCGCA
AAGTCGCACAAAGTGAACAG

Product: putative short-chain dehydrogenase/reductase

Products: (3R)-hydroxyacyl-[acyl-carrier-protein]; NADP; NADPH; Proton; beta-ketoacyl-ACP [C]

Alternate protein names: NA

Number of amino acids: Translated: 264; Mature: 264

Protein sequence:

>264_residues
MKIDLAGKVALVTASTAGIGFAIAKGLAESGAEVILNGRSEQSVNAAIARLQNEVPGAKARPAIADLSDADGAAQLLRAV
TGVDILVNNAGIYGPQDFYATDDATWDNYWQTNVMSGVRLSRGLLPAMVNKGWGRVVFISSESARNIPADMIHYGVTKTA
QLSLARGLAKYVAGSGVTVNSVLPGPTISDGFAEMLKDDVAKTGQSLEELAKAFVMTHRPSSVIQRAASVAEVANMVVYV
CSPQASATSGAALRVDGGVVDDIL

Sequences:

>Translated_264_residues
MKIDLAGKVALVTASTAGIGFAIAKGLAESGAEVILNGRSEQSVNAAIARLQNEVPGAKARPAIADLSDADGAAQLLRAV
TGVDILVNNAGIYGPQDFYATDDATWDNYWQTNVMSGVRLSRGLLPAMVNKGWGRVVFISSESARNIPADMIHYGVTKTA
QLSLARGLAKYVAGSGVTVNSVLPGPTISDGFAEMLKDDVAKTGQSLEELAKAFVMTHRPSSVIQRAASVAEVANMVVYV
CSPQASATSGAALRVDGGVVDDIL
>Mature_264_residues
MKIDLAGKVALVTASTAGIGFAIAKGLAESGAEVILNGRSEQSVNAAIARLQNEVPGAKARPAIADLSDADGAAQLLRAV
TGVDILVNNAGIYGPQDFYATDDATWDNYWQTNVMSGVRLSRGLLPAMVNKGWGRVVFISSESARNIPADMIHYGVTKTA
QLSLARGLAKYVAGSGVTVNSVLPGPTISDGFAEMLKDDVAKTGQSLEELAKAFVMTHRPSSVIQRAASVAEVANMVVYV
CSPQASATSGAALRVDGGVVDDIL

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: COG1028

COG function: function code IQR; Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI5031737, Length=259, Percent_Identity=36.6795366795367, Blast_Score=125, Evalue=3e-29,
Organism=Homo sapiens, GI32483357, Length=262, Percent_Identity=33.969465648855, Blast_Score=120, Evalue=2e-27,
Organism=Homo sapiens, GI33667109, Length=199, Percent_Identity=38.6934673366834, Blast_Score=104, Evalue=8e-23,
Organism=Homo sapiens, GI126723191, Length=186, Percent_Identity=34.9462365591398, Blast_Score=92, Evalue=6e-19,
Organism=Homo sapiens, GI126723750, Length=264, Percent_Identity=31.8181818181818, Blast_Score=90, Evalue=2e-18,
Organism=Homo sapiens, GI7705925, Length=260, Percent_Identity=26.9230769230769, Blast_Score=77, Evalue=1e-14,
Organism=Homo sapiens, GI19923817, Length=263, Percent_Identity=26.2357414448669, Blast_Score=76, Evalue=4e-14,
Organism=Homo sapiens, GI109715829, Length=215, Percent_Identity=27.4418604651163, Blast_Score=68, Evalue=9e-12,
Organism=Homo sapiens, GI7705855, Length=185, Percent_Identity=29.7297297297297, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI142976729, Length=211, Percent_Identity=25.5924170616114, Blast_Score=66, Evalue=3e-11,
Organism=Homo sapiens, GI66933014, Length=256, Percent_Identity=26.171875, Blast_Score=66, Evalue=3e-11,
Organism=Homo sapiens, GI10190704, Length=264, Percent_Identity=27.6515151515151, Blast_Score=65, Evalue=6e-11,
Organism=Escherichia coli, GI1787335, Length=261, Percent_Identity=31.8007662835249, Blast_Score=108, Evalue=5e-25,
Organism=Escherichia coli, GI1787905, Length=266, Percent_Identity=28.9473684210526, Blast_Score=95, Evalue=5e-21,
Organism=Escherichia coli, GI87082100, Length=267, Percent_Identity=30.7116104868914, Blast_Score=92, Evalue=3e-20,
Organism=Escherichia coli, GI1790717, Length=258, Percent_Identity=27.1317829457364, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1786812, Length=262, Percent_Identity=29.7709923664122, Blast_Score=75, Evalue=3e-15,
Organism=Escherichia coli, GI2367365, Length=256, Percent_Identity=28.90625, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1788459, Length=260, Percent_Identity=28.4615384615385, Blast_Score=72, Evalue=4e-14,
Organism=Escherichia coli, GI1789378, Length=268, Percent_Identity=30.2238805970149, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI1789208, Length=259, Percent_Identity=25.4826254826255, Blast_Score=66, Evalue=3e-12,
Organism=Escherichia coli, GI1787820, Length=187, Percent_Identity=28.8770053475936, Blast_Score=62, Evalue=3e-11,
Organism=Escherichia coli, GI2367175, Length=261, Percent_Identity=29.8850574712644, Blast_Score=62, Evalue=5e-11,
Organism=Escherichia coli, GI1789057, Length=263, Percent_Identity=26.2357414448669, Blast_Score=61, Evalue=7e-11,
Organism=Caenorhabditis elegans, GI17560676, Length=260, Percent_Identity=33.4615384615385, Blast_Score=113, Evalue=8e-26,
Organism=Caenorhabditis elegans, GI17561402, Length=266, Percent_Identity=31.5789473684211, Blast_Score=109, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI17531453, Length=266, Percent_Identity=30.8270676691729, Blast_Score=84, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI193204405, Length=265, Percent_Identity=31.3207547169811, Blast_Score=83, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17562910, Length=267, Percent_Identity=28.4644194756554, Blast_Score=80, Evalue=7e-16,
Organism=Caenorhabditis elegans, GI71994604, Length=263, Percent_Identity=26.9961977186312, Blast_Score=80, Evalue=9e-16,
Organism=Caenorhabditis elegans, GI17544670, Length=271, Percent_Identity=28.0442804428044, Blast_Score=79, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI71994600, Length=256, Percent_Identity=26.171875, Blast_Score=78, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI17558006, Length=205, Percent_Identity=31.219512195122, Blast_Score=74, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI17562904, Length=265, Percent_Identity=27.1698113207547, Blast_Score=73, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI25147288, Length=262, Percent_Identity=28.2442748091603, Blast_Score=71, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI17562908, Length=267, Percent_Identity=30.3370786516854, Blast_Score=71, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI115534694, Length=262, Percent_Identity=29.0076335877863, Blast_Score=70, Evalue=9e-13,
Organism=Caenorhabditis elegans, GI17560220, Length=203, Percent_Identity=32.0197044334975, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17562906, Length=269, Percent_Identity=30.4832713754647, Blast_Score=70, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17562990, Length=268, Percent_Identity=27.6119402985075, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17559104, Length=273, Percent_Identity=29.3040293040293, Blast_Score=65, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17538480, Length=220, Percent_Identity=30, Blast_Score=65, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17568967, Length=193, Percent_Identity=25.3886010362694, Blast_Score=65, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI71992402, Length=208, Percent_Identity=27.8846153846154, Blast_Score=64, Evalue=7e-11,
Organism=Drosophila melanogaster, GI23397609, Length=258, Percent_Identity=32.1705426356589, Blast_Score=102, Evalue=3e-22,
Organism=Drosophila melanogaster, GI21355319, Length=264, Percent_Identity=31.8181818181818, Blast_Score=101, Evalue=5e-22,
Organism=Drosophila melanogaster, GI24644339, Length=263, Percent_Identity=30.0380228136882, Blast_Score=92, Evalue=4e-19,
Organism=Drosophila melanogaster, GI28571526, Length=257, Percent_Identity=31.1284046692607, Blast_Score=88, Evalue=5e-18,
Organism=Drosophila melanogaster, GI24643142, Length=258, Percent_Identity=29.8449612403101, Blast_Score=82, Evalue=3e-16,
Organism=Drosophila melanogaster, GI21357041, Length=256, Percent_Identity=30.859375, Blast_Score=81, Evalue=6e-16,
Organism=Drosophila melanogaster, GI20129347, Length=210, Percent_Identity=29.5238095238095, Blast_Score=81, Evalue=7e-16,
Organism=Drosophila melanogaster, GI24639444, Length=262, Percent_Identity=27.8625954198473, Blast_Score=72, Evalue=4e-13,
Organism=Drosophila melanogaster, GI21358495, Length=191, Percent_Identity=29.3193717277487, Blast_Score=72, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24584748, Length=183, Percent_Identity=29.5081967213115, Blast_Score=68, Evalue=6e-12,
Organism=Drosophila melanogaster, GI161076933, Length=183, Percent_Identity=29.5081967213115, Blast_Score=68, Evalue=6e-12,
Organism=Drosophila melanogaster, GI45553409, Length=198, Percent_Identity=28.2828282828283, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24647948, Length=198, Percent_Identity=28.2828282828283, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24647946, Length=198, Percent_Identity=28.2828282828283, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24640442, Length=194, Percent_Identity=31.9587628865979, Blast_Score=65, Evalue=5e-11,
Organism=Drosophila melanogaster, GI18859837, Length=196, Percent_Identity=28.0612244897959, Blast_Score=64, Evalue=8e-11,
Organism=Drosophila melanogaster, GI24644337, Length=261, Percent_Identity=27.5862068965517, Blast_Score=64, Evalue=1e-10,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.100 [C]

Molecular weight: Translated: 27348; Mature: 27348

Theoretical pI: Translated: 5.32; Mature: 5.32

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIDLAGKVALVTASTAGIGFAIAKGLAESGAEVILNGRSEQSVNAAIARLQNEVPGAKA
CEECCCCCEEEEEECCCCHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHHCCCCCC
RPAIADLSDADGAAQLLRAVTGVDILVNNAGIYGPQDFYATDDATWDNYWQTNVMSGVRL
CCCCCCCCCCCHHHHHHHHHHCHHEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHH
SRGLLPAMVNKGWGRVVFISSESARNIPADMIHYGVTKTAQLSLARGLAKYVAGSGVTVN
HHCHHHHHHCCCCCEEEEEECCCCCCCCHHHHHHCCCHHHHHHHHHHHHHHHCCCCCEEE
SVLPGPTISDGFAEMLKDDVAKTGQSLEELAKAFVMTHRPSSVIQRAASVAEVANMVVYV
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHEEEEE
CSPQASATSGAALRVDGGVVDDIL
ECCCCCCCCCCEEEECCCHHHHCC
>Mature Secondary Structure
MKIDLAGKVALVTASTAGIGFAIAKGLAESGAEVILNGRSEQSVNAAIARLQNEVPGAKA
CEECCCCCEEEEEECCCCHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHHCCCCCC
RPAIADLSDADGAAQLLRAVTGVDILVNNAGIYGPQDFYATDDATWDNYWQTNVMSGVRL
CCCCCCCCCCCHHHHHHHHHHCHHEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHH
SRGLLPAMVNKGWGRVVFISSESARNIPADMIHYGVTKTAQLSLARGLAKYVAGSGVTVN
HHCHHHHHHCCCCCEEEEEECCCCCCCCHHHHHHCCCHHHHHHHHHHHHHHHCCCCCEEE
SVLPGPTISDGFAEMLKDDVAKTGQSLEELAKAFVMTHRPSSVIQRAASVAEVANMVVYV
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHEEEEE
CSPQASATSGAALRVDGGVVDDIL
ECCCCCCCCCCEEEECCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Oxoacyl-[acyl-carrier-protein]; NADPH; D-3-hydroxy-acyl-ACP; NADP [C]

Specific reaction: Oxoacyl-[acyl-carrier-protein] + NADPH = (3R)-hydroxyacyl-[acyl-carrier-protein] + NADP+ D-3-hydroxy-acyl-ACP + NADP = NADPH + Proton + beta-ketoacyl-ACP [C]

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]