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The map label for this gene is fucA [C]

Identifier: 238896099

GI number: 238896099

Start: 4070448

End: 4071176

Strand: Direct

Name: fucA [C]

Synonym: KP1_4238

Alternate gene names: 238896099

Gene position: 4070448-4071176 (Clockwise)

Preceding gene: 238896098

Following gene: 238896100

Centisome position: 77.55

GC content: 62.83

Gene sequence:

>729_bases
ATGGCAACTGAGCAACACCTGCGCCAGCAGCTGGCCGCCGCCTACCGGCTGGCGGCGCTGTTCGGCTGGGAGGATACCCT
CTACACTCACTTCTCCGTGCGCCTGCCCGGCGACGGCGAGCCGCGTTTTTTAATTAATCCCTTCGGCATGATGTTTGACG
AAGTCACCGCCAGCAACCTGATCGTAGTGGATATGCAGGGCAAGGTCGTAGCGGGCGACGCGCCGGCTAACTCGGCGGGC
TTTACCATCCATAGCGCGGTGCATATGGCCCGGGAAGACGCCCACTGCGTGATCCACACCCATACGCTGCCGGGGATGGC
GGTGGCCGCCTGCGAGGATGGCCTGCTGCAGCTCAACCAGATCAGCACCGAGTTTTACCAGCGCGTCGGCTACCATCCCT
ATGAAGGGGTGGCCTTTGACCTCGACGAACGGGCGCGTATCCAGCGCTCGCTGGGGAATAATATCGCCATGATCTTGCAG
AGCCACGGCCTGCTGTCGGTGGGCCGCACCGTGGCTGACGCGTTTTACATCATGTACTACCTGAACCGCGCCTGCGAAAT
CCAGATGGCCGCCGCCCAGCTGGCGGCCCTCAGCCCGATCCACACCATCGCCCCGCACCTCAGCCAGCACGCCTGCGAGC
AGCTGATGGGCGTGGAGCATGAACGTCAACAGGTCTGGCAGGCGTGGCTGCGCCGTCTTGACCGTCTCGATACCTCTTAC
AAAGACTAA

Upstream 100 bases:

>100_bases
GAACGGCGTGGTGCAGGCCGATATCGCCCCGCAGGTGATCCGCAGCCCGCTGGAGGCGCCTTCTCTGCAACGAATCCGTG
AATTTATGGGAGTACGCTAA

Downstream 100 bases:

>100_bases
CGCCTATGTCTGATATCACTATCGTGGTGGATTGTAACGACGCGGATTTCGCCCGCGATATCTGCGCCGCCCTGCAGCAG
TTTCCCGACGTCACGGCGCT

Product: L-fuculose phosphate aldolase

Products: Dihydroxyacetone phosphate; L-Lactaldehyde [C]

Alternate protein names: NA

Number of amino acids: Translated: 242; Mature: 241

Protein sequence:

>242_residues
MATEQHLRQQLAAAYRLAALFGWEDTLYTHFSVRLPGDGEPRFLINPFGMMFDEVTASNLIVVDMQGKVVAGDAPANSAG
FTIHSAVHMAREDAHCVIHTHTLPGMAVAACEDGLLQLNQISTEFYQRVGYHPYEGVAFDLDERARIQRSLGNNIAMILQ
SHGLLSVGRTVADAFYIMYYLNRACEIQMAAAQLAALSPIHTIAPHLSQHACEQLMGVEHERQQVWQAWLRRLDRLDTSY
KD

Sequences:

>Translated_242_residues
MATEQHLRQQLAAAYRLAALFGWEDTLYTHFSVRLPGDGEPRFLINPFGMMFDEVTASNLIVVDMQGKVVAGDAPANSAG
FTIHSAVHMAREDAHCVIHTHTLPGMAVAACEDGLLQLNQISTEFYQRVGYHPYEGVAFDLDERARIQRSLGNNIAMILQ
SHGLLSVGRTVADAFYIMYYLNRACEIQMAAAQLAALSPIHTIAPHLSQHACEQLMGVEHERQQVWQAWLRRLDRLDTSY
KD
>Mature_241_residues
ATEQHLRQQLAAAYRLAALFGWEDTLYTHFSVRLPGDGEPRFLINPFGMMFDEVTASNLIVVDMQGKVVAGDAPANSAGF
TIHSAVHMAREDAHCVIHTHTLPGMAVAACEDGLLQLNQISTEFYQRVGYHPYEGVAFDLDERARIQRSLGNNIAMILQS
HGLLSVGRTVADAFYIMYYLNRACEIQMAAAQLAALSPIHTIAPHLSQHACEQLMGVEHERQQVWQAWLRRLDRLDTSYK
D

Specific function: Fucose metabolism; third step. [C]

COG id: COG0235

COG function: function code G; Ribulose-5-phosphate 4-epimerase and related epimerases and aldolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aldolase class II family [H]

Homologues:

Organism=Homo sapiens, GI29826321, Length=190, Percent_Identity=44.7368421052632, Blast_Score=164, Evalue=9e-41,
Organism=Homo sapiens, GI29826319, Length=190, Percent_Identity=44.7368421052632, Blast_Score=163, Evalue=1e-40,
Organism=Homo sapiens, GI29826325, Length=190, Percent_Identity=44.7368421052632, Blast_Score=162, Evalue=3e-40,
Organism=Homo sapiens, GI29826323, Length=190, Percent_Identity=44.7368421052632, Blast_Score=162, Evalue=4e-40,
Organism=Homo sapiens, GI9943848, Length=192, Percent_Identity=36.4583333333333, Blast_Score=125, Evalue=4e-29,
Organism=Homo sapiens, GI9951927, Length=192, Percent_Identity=36.4583333333333, Blast_Score=125, Evalue=5e-29,
Organism=Homo sapiens, GI62912453, Length=192, Percent_Identity=36.4583333333333, Blast_Score=125, Evalue=5e-29,
Organism=Homo sapiens, GI9257190, Length=192, Percent_Identity=35.4166666666667, Blast_Score=122, Evalue=2e-28,
Organism=Homo sapiens, GI89276787, Length=192, Percent_Identity=35.4166666666667, Blast_Score=122, Evalue=2e-28,
Organism=Homo sapiens, GI297307160, Length=192, Percent_Identity=35.4166666666667, Blast_Score=122, Evalue=3e-28,
Organism=Homo sapiens, GI297307158, Length=192, Percent_Identity=35.4166666666667, Blast_Score=122, Evalue=3e-28,
Organism=Homo sapiens, GI9257192, Length=192, Percent_Identity=35.4166666666667, Blast_Score=122, Evalue=3e-28,
Organism=Caenorhabditis elegans, GI115533216, Length=249, Percent_Identity=36.144578313253, Blast_Score=146, Evalue=8e-36,
Organism=Caenorhabditis elegans, GI115533218, Length=249, Percent_Identity=36.144578313253, Blast_Score=145, Evalue=1e-35,
Organism=Caenorhabditis elegans, GI71989550, Length=244, Percent_Identity=30.327868852459, Blast_Score=108, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI71989560, Length=244, Percent_Identity=30.327868852459, Blast_Score=108, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI71989555, Length=244, Percent_Identity=30.327868852459, Blast_Score=108, Evalue=3e-24,
Organism=Caenorhabditis elegans, GI71989541, Length=244, Percent_Identity=30.327868852459, Blast_Score=108, Evalue=3e-24,
Organism=Caenorhabditis elegans, GI71989544, Length=244, Percent_Identity=30.327868852459, Blast_Score=108, Evalue=4e-24,
Organism=Drosophila melanogaster, GI281363755, Length=190, Percent_Identity=39.4736842105263, Blast_Score=129, Evalue=1e-30,
Organism=Drosophila melanogaster, GI281363751, Length=190, Percent_Identity=39.4736842105263, Blast_Score=129, Evalue=1e-30,
Organism=Drosophila melanogaster, GI24655690, Length=190, Percent_Identity=39.4736842105263, Blast_Score=129, Evalue=1e-30,
Organism=Drosophila melanogaster, GI24655685, Length=190, Percent_Identity=39.4736842105263, Blast_Score=129, Evalue=1e-30,
Organism=Drosophila melanogaster, GI281363761, Length=190, Percent_Identity=39.4736842105263, Blast_Score=129, Evalue=2e-30,
Organism=Drosophila melanogaster, GI281363759, Length=190, Percent_Identity=39.4736842105263, Blast_Score=129, Evalue=2e-30,
Organism=Drosophila melanogaster, GI281363753, Length=190, Percent_Identity=39.4736842105263, Blast_Score=129, Evalue=2e-30,
Organism=Drosophila melanogaster, GI281363763, Length=190, Percent_Identity=38.9473684210526, Blast_Score=128, Evalue=3e-30,
Organism=Drosophila melanogaster, GI281363757, Length=190, Percent_Identity=38.9473684210526, Blast_Score=128, Evalue=3e-30,
Organism=Drosophila melanogaster, GI17136738, Length=190, Percent_Identity=38.9473684210526, Blast_Score=128, Evalue=3e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001303 [H]

Pfam domain/function: PF00596 Aldolase_II [H]

EC number: 4.1.2.17 [C]

Molecular weight: Translated: 27080; Mature: 26949

Theoretical pI: Translated: 6.17; Mature: 6.17

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATEQHLRQQLAAAYRLAALFGWEDTLYTHFSVRLPGDGEPRFLINPFGMMFDEVTASNL
CCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEECCCCCCCEEECHHHHHHHHHCCCCE
IVVDMQGKVVAGDAPANSAGFTIHSAVHMAREDAHCVIHTHTLPGMAVAACEDGLLQLNQ
EEEEECCEEEECCCCCCCCCCHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHCCHHHHHH
ISTEFYQRVGYHPYEGVAFDLDERARIQRSLGNNIAMILQSHGLLSVGRTVADAFYIMYY
HHHHHHHHCCCCCCCCEEECCHHHHHHHHHHCCCCEEEHHHCCCHHHHHHHHHHHHHHHH
LNRACEIQMAAAQLAALSPIHTIAPHLSQHACEQLMGVEHERQQVWQAWLRRLDRLDTSY
HHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCC
KD
CC
>Mature Secondary Structure 
ATEQHLRQQLAAAYRLAALFGWEDTLYTHFSVRLPGDGEPRFLINPFGMMFDEVTASNL
CCHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEECCCCCCCEEECHHHHHHHHHCCCCE
IVVDMQGKVVAGDAPANSAGFTIHSAVHMAREDAHCVIHTHTLPGMAVAACEDGLLQLNQ
EEEEECCEEEECCCCCCCCCCHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHCCHHHHHH
ISTEFYQRVGYHPYEGVAFDLDERARIQRSLGNNIAMILQSHGLLSVGRTVADAFYIMYY
HHHHHHHHCCCCCCCCEEECCHHHHHHHHHHCCCCEEEHHHCCCHHHHHHHHHHHHHHHH
LNRACEIQMAAAQLAALSPIHTIAPHLSQHACEQLMGVEHERQQVWQAWLRRLDRLDTSY
HHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCC
KD
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: Ca2+; Co2+; Mg2+; Mn2+; Zn2+ [C]

Kcat value (1/min): 19.3 [C]

Specific activity: 21.0

Km value (mM): 0.7 {L-fuculose} [C]

Substrates: L-Fuculose 1-phosphate [C]

Specific reaction: L-Fuculose 1-phosphate <==> Dihydroxyacetone phosphate + L-Lactaldehyde [C]

General reaction: Elimination of an aldehyde C-C bond; Cleavage [C]

Inhibitor: EDTA; Phosphoglycolohydroxamate [C]

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]