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The map label for this gene is livH [H]

Identifier: 238895344

GI number: 238895344

Start: 3228487

End: 3229401

Strand: Reverse

Name: livH [H]

Synonym: KP1_3406

Alternate gene names: 238895344

Gene position: 3229401-3228487 (Counterclockwise)

Preceding gene: 238895345

Following gene: 238895343

Centisome position: 61.53

GC content: 61.31

Gene sequence:

>915_bases
ATGACGGCGTTTTTTCTGCAACAACTGATCAATGGGCTGACGCTGGGCGCAGTGTACGGCTTAATCGCCATCGGCTACAC
CATGGTGTATGGGATCATCGGCATGATCAACTTCGCCCACGGCGAGGTGTATATGGTCTCCGCCTACCTGTGCGCCATCG
GTCTGGCGCTGCTCTCTTTCTTCGGGATCCACTCCTTTCCGCTGCTGATTTTCGCCACTCTGGTGTTCACCATCGTGGTC
ACCGGCGTATACGGCTGGGCGATCGAGCGCATCGCCTACCGGCCGCTGCGCAACTCGACGCGGCTGGCGCCGCTGATCTC
GGCTATCGGGATGTCGCTGATCCTGCAGAACTATGTCCAGCTGAGCCAGGGGCCGAACCAGCAGGGGATCCCGACGCTGC
TTAGCGGCGCTCTGCGCATGACGGTGGGCGACGGGGTGGTGCAGATCACCTGGACCAAGGTGTTTATTCTCGTCGCGGCG
CTGGTGGGGATGCTGATCCTGACCTGGATTATTCAGTATACCCGGCTGGGGCGCATCTGCCGCGCCACCCAGCAGGACCG
GCGCATGGCGGCGATCCTTGGCATCAATACCGACCGGGTGATCTCCCTGGTGTTTGTCATCGGCGCGGCGATGGCCGGTC
TGGCCGGCGTGCTGGTGACCATGAACTACGGCACCTTCGACTTCTATATCGGATTTATTATCGGCATCAAAGCCTTCACC
GCCGCGGTGCTGGGCGGGATCGGCTCGCTGCCTGGCGCGATGCTGGGTGGTCTGCTGCTTGGGGTGGCCGAAGCCCAGTT
CGCCGGGCTGGTGAATTCGGATTACAAAGATGTCTTTTCCTTTGCGCTGCTGGTGGCGATCCTGATTTTTCGCCCGCAGG
GGCTGTTGGGACGTCCGCTGGTGGCCAAGGTCTAA

Upstream 100 bases:

>100_bases
ACCTGAGGACGCTCTGTCCTTTTGACTTGCGAATTGTCACATGACGGCGGTTGACCGGGAACGGAACCCGGCGGCCGTCT
GCCTGGCGGCTGGAGGGGCT

Downstream 100 bases:

>100_bases
GGAGGCTTTATGGGTGAAATTACGCGCCAGCCTGCGCGGGCTATCCAAAACGCGCTGATCGACAGCGTACTGGCCGGCCT
TTGCGCGTTAATTGTCTTTG

Product: ABC-type high-affinity branched-chain amino acid transport system permease component

Products: ADP; phosphate; L-valine [Cytoplasm]; ADP; L-iso-leucine [Cytoplasm]; L-leucine [Cytoplasm] [C]

Alternate protein names: LIV-I protein H [H]

Number of amino acids: Translated: 304; Mature: 303

Protein sequence:

>304_residues
MTAFFLQQLINGLTLGAVYGLIAIGYTMVYGIIGMINFAHGEVYMVSAYLCAIGLALLSFFGIHSFPLLIFATLVFTIVV
TGVYGWAIERIAYRPLRNSTRLAPLISAIGMSLILQNYVQLSQGPNQQGIPTLLSGALRMTVGDGVVQITWTKVFILVAA
LVGMLILTWIIQYTRLGRICRATQQDRRMAAILGINTDRVISLVFVIGAAMAGLAGVLVTMNYGTFDFYIGFIIGIKAFT
AAVLGGIGSLPGAMLGGLLLGVAEAQFAGLVNSDYKDVFSFALLVAILIFRPQGLLGRPLVAKV

Sequences:

>Translated_304_residues
MTAFFLQQLINGLTLGAVYGLIAIGYTMVYGIIGMINFAHGEVYMVSAYLCAIGLALLSFFGIHSFPLLIFATLVFTIVV
TGVYGWAIERIAYRPLRNSTRLAPLISAIGMSLILQNYVQLSQGPNQQGIPTLLSGALRMTVGDGVVQITWTKVFILVAA
LVGMLILTWIIQYTRLGRICRATQQDRRMAAILGINTDRVISLVFVIGAAMAGLAGVLVTMNYGTFDFYIGFIIGIKAFT
AAVLGGIGSLPGAMLGGLLLGVAEAQFAGLVNSDYKDVFSFALLVAILIFRPQGLLGRPLVAKV
>Mature_303_residues
TAFFLQQLINGLTLGAVYGLIAIGYTMVYGIIGMINFAHGEVYMVSAYLCAIGLALLSFFGIHSFPLLIFATLVFTIVVT
GVYGWAIERIAYRPLRNSTRLAPLISAIGMSLILQNYVQLSQGPNQQGIPTLLSGALRMTVGDGVVQITWTKVFILVAAL
VGMLILTWIIQYTRLGRICRATQQDRRMAAILGINTDRVISLVFVIGAAMAGLAGVLVTMNYGTFDFYIGFIIGIKAFTA
AVLGGIGSLPGAMLGGLLLGVAEAQFAGLVNSDYKDVFSFALLVAILIFRPQGLLGRPLVAKV

Specific function: Part of the binding-protein-dependent transport system for branched-chain amino acids. Probably responsible for the translocation of the substrates across the membrane [H]

COG id: COG0559

COG function: function code E; Branched-chain amino acid ABC-type transport system, permease components

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. LivHM subfamily [H]

Homologues:

Organism=Escherichia coli, GI1789866, Length=304, Percent_Identity=56.578947368421, Blast_Score=310, Evalue=6e-86,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001851 [H]

Pfam domain/function: PF02653 BPD_transp_2 [H]

EC number: NA

Molecular weight: Translated: 32555; Mature: 32423

Theoretical pI: Translated: 9.90; Mature: 9.90

Prosite motif: PS00041 HTH_ARAC_FAMILY_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAFFLQQLINGLTLGAVYGLIAIGYTMVYGIIGMINFAHGEVYMVSAYLCAIGLALLSF
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
FGIHSFPLLIFATLVFTIVVTGVYGWAIERIAYRPLRNSTRLAPLISAIGMSLILQNYVQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHH
LSQGPNQQGIPTLLSGALRMTVGDGVVQITWTKVFILVAALVGMLILTWIIQYTRLGRIC
HHCCCCCCCCHHHHHHHHHHEECCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RATQQDRRMAAILGINTDRVISLVFVIGAAMAGLAGVLVTMNYGTFDFYIGFIIGIKAFT
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
AAVLGGIGSLPGAMLGGLLLGVAEAQFAGLVNSDYKDVFSFALLVAILIFRPQGLLGRPL
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCH
VAKV
HCCC
>Mature Secondary Structure 
TAFFLQQLINGLTLGAVYGLIAIGYTMVYGIIGMINFAHGEVYMVSAYLCAIGLALLSF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH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HCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; L-valine [Periplasm]; H2O; ATP; L-iso-leucine [Periplasm]; L-leucine [Periplasm] [C]

Specific reaction: ATP + L-valine [Periplasm] + H2O = ADP + phosphate + L-valine [Cytoplasm] ATP + L-iso-leucine [Periplasm] + H2O = ADP + phosphate + L-iso-leucine [Cytoplasm] ATP + L-leucine [Periplasm] + H2O = ADP + phosphate + L-leucine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]