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The map label for this gene is livM [H]

Identifier: 238895343

GI number: 238895343

Start: 3227191

End: 3228477

Strand: Reverse

Name: livM [H]

Synonym: KP1_3404

Alternate gene names: 238895343

Gene position: 3228477-3227191 (Counterclockwise)

Preceding gene: 238895344

Following gene: 238895342

Centisome position: 61.51

GC content: 62.47

Gene sequence:

>1287_bases
ATGGGTGAAATTACGCGCCAGCCTGCGCGGGCTATCCAAAACGCGCTGATCGACAGCGTACTGGCCGGCCTTTGCGCGTT
AATTGTCTTTGGCCCGATCGTCGGCGTGGTGCTCAAAGGGTATGGTTTTACCCTCGCGCCTGCGCGGGTGGCGATTCTGG
TGGCGGTGGTGATGGCCGGCAGGCTGGCGCTCAGTCTGCTGCTGCAGAGCCACAGGGGAAAAGCCTTTATTGCCCGCTTT
GAGGGGGCGGATGACGGGGTATACGTCCGGCCGCCGGGCTACCGCTCGCGGCTGCGCTGGATAATACCGCTGCTGGTGGG
GCTGGCCATTGTCTTTCCGTTTCTCGCCACAAAATATCTGCTGACCGTGGCCATTCTTGGGCTGATCTACGTTCTGCTTG
GCCTGGGGTTGAATATTGTGGTGGGCCTCGCGGGCCTGCTCGATCTGGGCTATGTGGCGTTTTACGCCATCGGCGCCTAC
GGCCTGGCGCTGGGCTACCAGTACCTGGGCCTCGGCTTCTGGGCGATGCTGCCGCTGGGGGCGGTGATGGCGGCCCTCGC
CGGGGCGTTGCTGGGCTTTCCGGTGCTGCGTATGCATGGCGACTATCTGGCCATCGTCACCCTTGGCTTTGGCGAAATTA
TCCGCCTGGTGCTTAACAACTGGGTGAGCTTCACCGGCGGCCCTAACGGCGTACCGGTGCCATCCCCCACGCTGTTTGGC
CTCGAGTTTACCCGCCGGGCGAAAGATGGCGGCATCCCCATCCATGAGTTTTTCCACGTCAGCTACAACCCCAACCTGAA
ATTCATCTTTCTCTACGCCGTGCTGTGTCTGGTGGTGATGCTGGTTCTGCTGGTGAAGCATCGCCTGACGCGGATGCCCA
TCGGCCGCGCCTGGGAGGCGCTGCGCGAGGATGAGATCGCCTGTCGGGCGATGGGGCTCAATCACGTACTGGTGAAGCTC
TCGGCGTTTATGCTCGGCGCGTCGACGGCCGGCATCGCCGGGGTGTTCTTCGCCAGCTATCAGGGGTTTGTTAACCCGAC
GTCGTTCACCTTTTTTGAGTCGGCGCTGATCCTGGCGATTGTGGTGCTCGGGGGAATGGGCTCCACCCTGGGAGTGGTAC
TGGCGGCGTTTGTTCTGACGGTCACCCCGGAGCTGCTGCGCGGTTTTGACGAATATCGGGTGCTGCTGTTCGGCGTGCTG
ATGGTGATGATGATGATCTGGCGGCCGCGCGGCCTGGTGCGCACCAGCCGCAGCGGGGTTGCGTTGCGAAAAGGAGTCGC
GCCATGA

Upstream 100 bases:

>100_bases
CAAAGATGTCTTTTCCTTTGCGCTGCTGGTGGCGATCCTGATTTTTCGCCCGCAGGGGCTGTTGGGACGTCCGCTGGTGG
CCAAGGTCTAAGGAGGCTTT

Downstream 100 bases:

>100_bases
CCGACAGCATCTTACGCGTTGAGCATCTGATGATGCATTTCGGCGGCATCAAAGCGCTGAATGATGTCAATCTGGAGGTG
GAGCGGGGGTCGATCACCGC

Product: ABC-type high-affinity branched-chain amino acid transport system permease component

Products: ADP; phosphate; L-valine [Cytoplasm]; ADP; L-iso-leucine [Cytoplasm]; L-leucine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 428; Mature: 427

Protein sequence:

>428_residues
MGEITRQPARAIQNALIDSVLAGLCALIVFGPIVGVVLKGYGFTLAPARVAILVAVVMAGRLALSLLLQSHRGKAFIARF
EGADDGVYVRPPGYRSRLRWIIPLLVGLAIVFPFLATKYLLTVAILGLIYVLLGLGLNIVVGLAGLLDLGYVAFYAIGAY
GLALGYQYLGLGFWAMLPLGAVMAALAGALLGFPVLRMHGDYLAIVTLGFGEIIRLVLNNWVSFTGGPNGVPVPSPTLFG
LEFTRRAKDGGIPIHEFFHVSYNPNLKFIFLYAVLCLVVMLVLLVKHRLTRMPIGRAWEALREDEIACRAMGLNHVLVKL
SAFMLGASTAGIAGVFFASYQGFVNPTSFTFFESALILAIVVLGGMGSTLGVVLAAFVLTVTPELLRGFDEYRVLLFGVL
MVMMMIWRPRGLVRTSRSGVALRKGVAP

Sequences:

>Translated_428_residues
MGEITRQPARAIQNALIDSVLAGLCALIVFGPIVGVVLKGYGFTLAPARVAILVAVVMAGRLALSLLLQSHRGKAFIARF
EGADDGVYVRPPGYRSRLRWIIPLLVGLAIVFPFLATKYLLTVAILGLIYVLLGLGLNIVVGLAGLLDLGYVAFYAIGAY
GLALGYQYLGLGFWAMLPLGAVMAALAGALLGFPVLRMHGDYLAIVTLGFGEIIRLVLNNWVSFTGGPNGVPVPSPTLFG
LEFTRRAKDGGIPIHEFFHVSYNPNLKFIFLYAVLCLVVMLVLLVKHRLTRMPIGRAWEALREDEIACRAMGLNHVLVKL
SAFMLGASTAGIAGVFFASYQGFVNPTSFTFFESALILAIVVLGGMGSTLGVVLAAFVLTVTPELLRGFDEYRVLLFGVL
MVMMMIWRPRGLVRTSRSGVALRKGVAP
>Mature_427_residues
GEITRQPARAIQNALIDSVLAGLCALIVFGPIVGVVLKGYGFTLAPARVAILVAVVMAGRLALSLLLQSHRGKAFIARFE
GADDGVYVRPPGYRSRLRWIIPLLVGLAIVFPFLATKYLLTVAILGLIYVLLGLGLNIVVGLAGLLDLGYVAFYAIGAYG
LALGYQYLGLGFWAMLPLGAVMAALAGALLGFPVLRMHGDYLAIVTLGFGEIIRLVLNNWVSFTGGPNGVPVPSPTLFGL
EFTRRAKDGGIPIHEFFHVSYNPNLKFIFLYAVLCLVVMLVLLVKHRLTRMPIGRAWEALREDEIACRAMGLNHVLVKLS
AFMLGASTAGIAGVFFASYQGFVNPTSFTFFESALILAIVVLGGMGSTLGVVLAAFVLTVTPELLRGFDEYRVLLFGVLM
VMMMIWRPRGLVRTSRSGVALRKGVAP

Specific function: Component of the high affinity leucine, isoleucine, valine, transport system (LIV-I), which is operative without Na(+) and is specific for alanine and threonine, in addition to branched-chain amino acids [H]

COG id: COG4177

COG function: function code E; ABC-type branched-chain amino acid transport system, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. LivHM subfamily [H]

Homologues:

Organism=Escherichia coli, GI1789865, Length=318, Percent_Identity=58.8050314465409, Blast_Score=345, Evalue=3e-96,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001851
- InterPro:   IPR021807 [H]

Pfam domain/function: PF02653 BPD_transp_2; PF11862 DUF3382 [H]

EC number: NA

Molecular weight: Translated: 46059; Mature: 45928

Theoretical pI: Translated: 10.28; Mature: 10.28

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGEITRQPARAIQNALIDSVLAGLCALIVFGPIVGVVLKGYGFTLAPARVAILVAVVMAG
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHH
RLALSLLLQSHRGKAFIARFEGADDGVYVRPPGYRSRLRWIIPLLVGLAIVFPFLATKYL
HHHHHHHHHHCCCCEEEEEECCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
LTVAILGLIYVLLGLGLNIVVGLAGLLDLGYVAFYAIGAYGLALGYQYLGLGFWAMLPLG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AVMAALAGALLGFPVLRMHGDYLAIVTLGFGEIIRLVLNNWVSFTGGPNGVPVPSPTLFG
HHHHHHHHHHHHHHHHHHCCCEEEEEEHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEC
LEFTRRAKDGGIPIHEFFHVSYNPNLKFIFLYAVLCLVVMLVLLVKHRLTRMPIGRAWEA
HHHHHHCCCCCCCHHHEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
LREDEIACRAMGLNHVLVKLSAFMLGASTAGIAGVFFASYQGFVNPTSFTFFESALILAI
HHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHH
VVLGGMGSTLGVVLAAFVLTVTPELLRGFDEYRVLLFGVLMVMMMIWRPRGLVRTSRSGV
HHHCCCCHHHHHHHHHHHHHHCHHHHHCHHHHHHHHHHHHHHHHHHHCCCCCHHCCCCCC
ALRKGVAP
HHHCCCCC
>Mature Secondary Structure 
GEITRQPARAIQNALIDSVLAGLCALIVFGPIVGVVLKGYGFTLAPARVAILVAVVMAG
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHH
RLALSLLLQSHRGKAFIARFEGADDGVYVRPPGYRSRLRWIIPLLVGLAIVFPFLATKYL
HHHHHHHHHHCCCCEEEEEECCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
LTVAILGLIYVLLGLGLNIVVGLAGLLDLGYVAFYAIGAYGLALGYQYLGLGFWAMLPLG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AVMAALAGALLGFPVLRMHGDYLAIVTLGFGEIIRLVLNNWVSFTGGPNGVPVPSPTLFG
HHHHHHHHHHHHHHHHHHCCCEEEEEEHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEC
LEFTRRAKDGGIPIHEFFHVSYNPNLKFIFLYAVLCLVVMLVLLVKHRLTRMPIGRAWEA
HHHHHHCCCCCCCHHHEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
LREDEIACRAMGLNHVLVKLSAFMLGASTAGIAGVFFASYQGFVNPTSFTFFESALILAI
HHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHH
VVLGGMGSTLGVVLAAFVLTVTPELLRGFDEYRVLLFGVLMVMMMIWRPRGLVRTSRSGV
HHHCCCCHHHHHHHHHHHHHHCHHHHHCHHHHHHHHHHHHHHHHHHHCCCCCHHCCCCCC
ALRKGVAP
HHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; L-valine [Periplasm]; H2O; ATP; L-iso-leucine [Periplasm]; L-leucine [Periplasm] [C]

Specific reaction: ATP + L-valine [Periplasm] + H2O = ADP + phosphate + L-valine [Cytoplasm] ATP + L-iso-leucine [Periplasm] + H2O = ADP + phosphate + L-iso-leucine [Cytoplasm] ATP + L-leucine [Periplasm] + H2O = ADP + phosphate + L-leucine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2120183; 10984043 [H]