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The map label for this gene is livH [H]

Identifier: 238893285

GI number: 238893285

Start: 1126910

End: 1127809

Strand: Reverse

Name: livH [H]

Synonym: KP1_1160

Alternate gene names: 238893285

Gene position: 1127809-1126910 (Counterclockwise)

Preceding gene: 238893286

Following gene: 238893284

Centisome position: 21.49

GC content: 59.44

Gene sequence:

>900_bases
ATGGACGGCGCCATTTTTCTCCAGCAAGTGGTCAATGGAATGAGTCTTGGGGGCATGTACGCCCTGATTGCCATCGGTTA
TACGATGGTTTATGGCGTGCTGCGGCTGATCAACTTCGCCCATGCGGACGTGATGATGGTCGGCGCGTTTAGTACGCTGT
TTTTATTTTCTTCGGTTGGGCTACCCTTCGGGGTAGCCGTTTTCCTGACCCTCGGGCTGTGCGGCCTGTTTGGTATGCTG
ATTGACCGGGTCGCCTATCGTCCGCTGCGTCAGGCCTCGAAAATCTCCATGCTGATCACCGCCATCGGCGTCAGCTTCTT
TCTCGAAAACCTGTTTAACGTACTGTTTGGCGGCAGCTCGCGCTTCTTCTCCGCACCTGACTTTTTCAACCAGACCCGGG
CCTTCGGCAGCGTCATCATTACCAACGTGGCGTGGATTGTGCCGCTGATCACCGTCCTGCTGCTGCTGGCGATCCTCTGG
CTGCTGTACCGCACCCGCTATGGGATGGCGATCCGCGCGGTGGCCTTTGACGTCAACACCGTGCGCCTGATGGGCATTGA
CGCCAACCGGATCATCTCCCTGGTCTTCGCCCTCGGCAGTAGTCTCGCGGCGCTCGGCGGCGTGTTCTACTCCATCAGCT
ACCCGACGATCGATCCCCTGATGGGCGTGCTTATCGGCCTGAAGGCCTTCGCCGCCGCCGTGCTGGGCGGGATCGGCAGC
GTCACCGGCGCGGTGCTGGGCGGCTTTATCCTCGGTTTTACCGAAGTGGTCGCCGTGGCGATCTTCCCCGAACTGGGCGG
CTATAAAGACGCTTTCGCCTTCCTGTTCTTGATTCTGGTCCTCTTGTTCCGCCCGGTCGGCATTATGGGCGACGAACGTC
TGGAAAGGAGCCGTTTCTGA

Upstream 100 bases:

>100_bases
AACGGCGACGCCATTCGCAGCGCGGTCATCAACGAAGTGAAAGATGGCAAGCTGGCGTTTCGTACCGTGGTTAACCCTTA
AGTTGTGACGAGGCTACAAA

Downstream 100 bases:

>100_bases
TGCTCAACGCGACGACGACCGCCGGGGCGCAGCTGCGCAACCTGGTAATTATTGTCATCTGTATCGCGCTGCTGGCCGGA
ATCAACGTGGTTTTCAATGA

Product: ABC transport system permease component

Products: ADP; phosphate; L-valine [Cytoplasm]; ADP; L-iso-leucine [Cytoplasm]; L-leucine [Cytoplasm] [C]

Alternate protein names: LIV-I protein H [H]

Number of amino acids: Translated: 299; Mature: 299

Protein sequence:

>299_residues
MDGAIFLQQVVNGMSLGGMYALIAIGYTMVYGVLRLINFAHADVMMVGAFSTLFLFSSVGLPFGVAVFLTLGLCGLFGML
IDRVAYRPLRQASKISMLITAIGVSFFLENLFNVLFGGSSRFFSAPDFFNQTRAFGSVIITNVAWIVPLITVLLLLAILW
LLYRTRYGMAIRAVAFDVNTVRLMGIDANRIISLVFALGSSLAALGGVFYSISYPTIDPLMGVLIGLKAFAAAVLGGIGS
VTGAVLGGFILGFTEVVAVAIFPELGGYKDAFAFLFLILVLLFRPVGIMGDERLERSRF

Sequences:

>Translated_299_residues
MDGAIFLQQVVNGMSLGGMYALIAIGYTMVYGVLRLINFAHADVMMVGAFSTLFLFSSVGLPFGVAVFLTLGLCGLFGML
IDRVAYRPLRQASKISMLITAIGVSFFLENLFNVLFGGSSRFFSAPDFFNQTRAFGSVIITNVAWIVPLITVLLLLAILW
LLYRTRYGMAIRAVAFDVNTVRLMGIDANRIISLVFALGSSLAALGGVFYSISYPTIDPLMGVLIGLKAFAAAVLGGIGS
VTGAVLGGFILGFTEVVAVAIFPELGGYKDAFAFLFLILVLLFRPVGIMGDERLERSRF
>Mature_299_residues
MDGAIFLQQVVNGMSLGGMYALIAIGYTMVYGVLRLINFAHADVMMVGAFSTLFLFSSVGLPFGVAVFLTLGLCGLFGML
IDRVAYRPLRQASKISMLITAIGVSFFLENLFNVLFGGSSRFFSAPDFFNQTRAFGSVIITNVAWIVPLITVLLLLAILW
LLYRTRYGMAIRAVAFDVNTVRLMGIDANRIISLVFALGSSLAALGGVFYSISYPTIDPLMGVLIGLKAFAAAVLGGIGS
VTGAVLGGFILGFTEVVAVAIFPELGGYKDAFAFLFLILVLLFRPVGIMGDERLERSRF

Specific function: Part of the binding-protein-dependent transport system for branched-chain amino acids. Probably responsible for the translocation of the substrates across the membrane [H]

COG id: COG0559

COG function: function code E; Branched-chain amino acid ABC-type transport system, permease components

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. LivHM subfamily [H]

Homologues:

Organism=Escherichia coli, GI1789866, Length=305, Percent_Identity=40.9836065573771, Blast_Score=194, Evalue=9e-51,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001851 [H]

Pfam domain/function: PF02653 BPD_transp_2 [H]

EC number: NA

Molecular weight: Translated: 32188; Mature: 32188

Theoretical pI: Translated: 9.55; Mature: 9.55

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDGAIFLQQVVNGMSLGGMYALIAIGYTMVYGVLRLINFAHADVMMVGAFSTLFLFSSVG
CCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
LPFGVAVFLTLGLCGLFGMLIDRVAYRPLRQASKISMLITAIGVSFFLENLFNVLFGGSS
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
RFFSAPDFFNQTRAFGSVIITNVAWIVPLITVLLLLAILWLLYRTRYGMAIRAVAFDVNT
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHEEECCE
VRLMGIDANRIISLVFALGSSLAALGGVFYSISYPTIDPLMGVLIGLKAFAAAVLGGIGS
EEEEECCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
VTGAVLGGFILGFTEVVAVAIFPELGGYKDAFAFLFLILVLLFRPVGIMGDERLERSRF
HHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHCCC
>Mature Secondary Structure
MDGAIFLQQVVNGMSLGGMYALIAIGYTMVYGVLRLINFAHADVMMVGAFSTLFLFSSVG
CCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
LPFGVAVFLTLGLCGLFGMLIDRVAYRPLRQASKISMLITAIGVSFFLENLFNVLFGGSS
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
RFFSAPDFFNQTRAFGSVIITNVAWIVPLITVLLLLAILWLLYRTRYGMAIRAVAFDVNT
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHEEECCE
VRLMGIDANRIISLVFALGSSLAALGGVFYSISYPTIDPLMGVLIGLKAFAAAVLGGIGS
EEEEECCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
VTGAVLGGFILGFTEVVAVAIFPELGGYKDAFAFLFLILVLLFRPVGIMGDERLERSRF
HHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; L-valine [Periplasm]; H2O; ATP; L-iso-leucine [Periplasm]; L-leucine [Periplasm] [C]

Specific reaction: ATP + L-valine [Periplasm] + H2O = ADP + phosphate + L-valine [Cytoplasm] ATP + L-iso-leucine [Periplasm] + H2O = ADP + phosphate + L-iso-leucine [Cytoplasm] ATP + L-leucine [Periplasm] + H2O = ADP + phosphate + L-leucine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]