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The map label for this gene is livM [H]

Identifier: 238893284

GI number: 238893284

Start: 1125861

End: 1126910

Strand: Reverse

Name: livM [H]

Synonym: KP1_1159

Alternate gene names: 238893284

Gene position: 1126910-1125861 (Counterclockwise)

Preceding gene: 238893285

Following gene: 238893283

Centisome position: 21.47

GC content: 60.67

Gene sequence:

>1050_bases
ATGCTCAACGCGACGACGACCGCCGGGGCGCAGCTGCGCAACCTGGTAATTATTGTCATCTGTATCGCGCTGCTGGCCGG
AATCAACGTGGTTTTCAATGACTACATTGTTCGTGTCATCAGCACCATTTTTATCTTTATGATCCTCGCGGTCAGCTACA
ACCTGATCAACGGCGTGACCGGCCAGCTGTCGCTGGAGCCGAACGGCTTCGTGGCGGTGGGCGCCTACGTCACCGCCCTG
CTGATCCTCTCCAGCGACAGCAAGGTAGACATGTTTGAAATGGCCGCCCCCAGCCCGTGGATCCTCAGCCTGCACGCGGG
CTTCCTCCCTGCCCTGCTGATAAGCGGCCTGTGCGCGGCGGCGCTGGCGGTGTGCCTCGCCGTGCCGGTCTTCCGGGTAC
GTGGCGACTACCTGGCCATTGTCACCCTCGGCTTTGGGTTTATCATCAAGATCCTCGCCATTAACAACCCGCAAATCACC
AACGGCGCCATCGGGCTGAACGATATTCCGCAGCAGCCGCATCTCCTGTTCTGGTGCGGGCTGTTCGCCCTGCTGGCCAC
CGGCATGATCCTCCAGCTGGTGTGGTCGAAGTATGGCCGGATGATGAAAGCTATTCGCGACGATGAAGATGCGGCGATCG
CCATGGGGGTCAACACCTTCCGCATTAAAACCTGCGCCTTCGCCACCAGCGCCTTCTTCGAAGGGATCGGCGGCGGTCTG
CTGGCTTCCCTGCTGACCACCATTTCCCCAGGGCTGTTCGACTTTATGCTCACCTTCCAGCTGCTGATTATTATCGTCCT
CGGCGGGCTCGGCAGCACCACCGGCGCCCTGCTCGGCACCGTGCTGGTGGTCGGCAGCGGCGAGTGGCTGCGCTTCCTCG
ATCAGCCGCTGCAGTTCTTCGGTCACGATCTCGGCGCGTACCCGGGCCTGCGAATGGTGGTCTTCTCCCTGCTGTTGCTG
ATTATCATGCTCTTCGCCCGCGAGGGGCTGTTGGGGAAAAAAGAGATTTGGCAGACCGGAAGAAGGAGCGGCGGCTATGG
CGGAAAATAA

Upstream 100 bases:

>100_bases
GCTATAAAGACGCTTTCGCCTTCCTGTTCTTGATTCTGGTCCTCTTGTTCCGCCCGGTCGGCATTATGGGCGACGAACGT
CTGGAAAGGAGCCGTTTCTG

Downstream 100 bases:

>100_bases
CGTTATCCTGCAGGTGCAGGACGTCACCATGCAGTTCGGCGGCCTGCGGGCCATCGACAACGTCAGCTTCCATGTTGACG
AGGCGGAGATCTTTGGCCTT

Product: ABC transport system permease component

Products: ADP; phosphate; L-valine [Cytoplasm]; ADP; L-iso-leucine [Cytoplasm]; L-leucine [Cytoplasm] [C]

Alternate protein names: LIV-I protein M [H]

Number of amino acids: Translated: 349; Mature: 349

Protein sequence:

>349_residues
MLNATTTAGAQLRNLVIIVICIALLAGINVVFNDYIVRVISTIFIFMILAVSYNLINGVTGQLSLEPNGFVAVGAYVTAL
LILSSDSKVDMFEMAAPSPWILSLHAGFLPALLISGLCAAALAVCLAVPVFRVRGDYLAIVTLGFGFIIKILAINNPQIT
NGAIGLNDIPQQPHLLFWCGLFALLATGMILQLVWSKYGRMMKAIRDDEDAAIAMGVNTFRIKTCAFATSAFFEGIGGGL
LASLLTTISPGLFDFMLTFQLLIIIVLGGLGSTTGALLGTVLVVGSGEWLRFLDQPLQFFGHDLGAYPGLRMVVFSLLLL
IIMLFAREGLLGKKEIWQTGRRSGGYGGK

Sequences:

>Translated_349_residues
MLNATTTAGAQLRNLVIIVICIALLAGINVVFNDYIVRVISTIFIFMILAVSYNLINGVTGQLSLEPNGFVAVGAYVTAL
LILSSDSKVDMFEMAAPSPWILSLHAGFLPALLISGLCAAALAVCLAVPVFRVRGDYLAIVTLGFGFIIKILAINNPQIT
NGAIGLNDIPQQPHLLFWCGLFALLATGMILQLVWSKYGRMMKAIRDDEDAAIAMGVNTFRIKTCAFATSAFFEGIGGGL
LASLLTTISPGLFDFMLTFQLLIIIVLGGLGSTTGALLGTVLVVGSGEWLRFLDQPLQFFGHDLGAYPGLRMVVFSLLLL
IIMLFAREGLLGKKEIWQTGRRSGGYGGK
>Mature_349_residues
MLNATTTAGAQLRNLVIIVICIALLAGINVVFNDYIVRVISTIFIFMILAVSYNLINGVTGQLSLEPNGFVAVGAYVTAL
LILSSDSKVDMFEMAAPSPWILSLHAGFLPALLISGLCAAALAVCLAVPVFRVRGDYLAIVTLGFGFIIKILAINNPQIT
NGAIGLNDIPQQPHLLFWCGLFALLATGMILQLVWSKYGRMMKAIRDDEDAAIAMGVNTFRIKTCAFATSAFFEGIGGGL
LASLLTTISPGLFDFMLTFQLLIIIVLGGLGSTTGALLGTVLVVGSGEWLRFLDQPLQFFGHDLGAYPGLRMVVFSLLLL
IIMLFAREGLLGKKEIWQTGRRSGGYGGK

Specific function: Part of the binding-protein-dependent transport system for branched-chain amino acids. Probably responsible for the translocation of the substrates across the membrane [H]

COG id: COG4177

COG function: function code E; ABC-type branched-chain amino acid transport system, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. LivHM subfamily [H]

Homologues:

Organism=Escherichia coli, GI1789865, Length=329, Percent_Identity=32.8267477203647, Blast_Score=122, Evalue=3e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001851
- InterPro:   IPR021807 [H]

Pfam domain/function: PF02653 BPD_transp_2; PF11862 DUF3382 [H]

EC number: NA

Molecular weight: Translated: 37341; Mature: 37341

Theoretical pI: Translated: 8.20; Mature: 8.20

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLNATTTAGAQLRNLVIIVICIALLAGINVVFNDYIVRVISTIFIFMILAVSYNLINGVT
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
GQLSLEPNGFVAVGAYVTALLILSSDSKVDMFEMAAPSPWILSLHAGFLPALLISGLCAA
CEEEECCCCCEEHHHHHHHHHHHCCCCCCCHHHHCCCCCCEEHHHHHHHHHHHHHHHHHH
ALAVCLAVPVFRVRGDYLAIVTLGFGFIIKILAINNPQITNGAIGLNDIPQQPHLLFWCG
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHH
LFALLATGMILQLVWSKYGRMMKAIRDDEDAAIAMGVNTFRIKTCAFATSAFFEGIGGGL
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCHHHHHHHHHHHHHHHHHCCHHH
LASLLTTISPGLFDFMLTFQLLIIIVLGGLGSTTGALLGTVLVVGSGEWLRFLDQPLQFF
HHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHH
GHDLGAYPGLRMVVFSLLLLIIMLFAREGLLGKKEIWQTGRRSGGYGGK
HHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCCCCCCC
>Mature Secondary Structure
MLNATTTAGAQLRNLVIIVICIALLAGINVVFNDYIVRVISTIFIFMILAVSYNLINGVT
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
GQLSLEPNGFVAVGAYVTALLILSSDSKVDMFEMAAPSPWILSLHAGFLPALLISGLCAA
CEEEECCCCCEEHHHHHHHHHHHCCCCCCCHHHHCCCCCCEEHHHHHHHHHHHHHHHHHH
ALAVCLAVPVFRVRGDYLAIVTLGFGFIIKILAINNPQITNGAIGLNDIPQQPHLLFWCG
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHH
LFALLATGMILQLVWSKYGRMMKAIRDDEDAAIAMGVNTFRIKTCAFATSAFFEGIGGGL
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCHHHHHHHHHHHHHHHHHCCHHH
LASLLTTISPGLFDFMLTFQLLIIIVLGGLGSTTGALLGTVLVVGSGEWLRFLDQPLQFF
HHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHH
GHDLGAYPGLRMVVFSLLLLIIMLFAREGLLGKKEIWQTGRRSGGYGGK
HHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; L-valine [Periplasm]; H2O; ATP; L-iso-leucine [Periplasm]; L-leucine [Periplasm] [C]

Specific reaction: ATP + L-valine [Periplasm] + H2O = ADP + phosphate + L-valine [Cytoplasm] ATP + L-iso-leucine [Periplasm] + H2O = ADP + phosphate + L-iso-leucine [Cytoplasm] ATP + L-leucine [Periplasm] + H2O = ADP + phosphate + L-leucine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 2195019; 8041620; 9278503 [H]