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The map label for this gene is ispH [H]

Identifier: 238893010

GI number: 238893010

Start: 822165

End: 823160

Strand: Direct

Name: ispH [H]

Synonym: KP1_0845

Alternate gene names: 238893010

Gene position: 822165-823160 (Clockwise)

Preceding gene: 238893009

Following gene: 238893011

Centisome position: 15.66

GC content: 59.94

Gene sequence:

>996_bases
TTGATATTGAAGTGCTGGAGATCGATCCGGCGCTGGAGGAGTAACATGCAGATCCTGTTGGCTAACCCGCGCGGTTTTTG
CGCTGGCGTTGACCGCGCTATCAGCATTGTAGAAAACGCGCTGACGCTGTATGGCGCACCGATCTATGTTCGTCATGAAG
TGGTGCACAACCGCTATGTGGTGGATAGCCTGCGCAAGCGTGGCGCCATTTTTATCGAACAGATCAGCGAAGTGCCGGAC
GGCGCGATCCTGATTTTCTCCGCCCACGGCGTGTCGCAGGCGGTACGCAACGAAGCGAAGAGCCGCGACCTGACGGTATT
CGATGCCACCTGTCCGCTGGTGACCAAAGTCCATATGGAAGTCGCCCGCGCCAGCCGCCGCGGCGAAGAGTCGATTCTGA
TTGGCCATGCCGGCCATCCGGAAGTCGAAGGCACCATGGGACAGTACAACAACCCGCAAGGGGGGATGTACCTGGTCGAG
TCGCCGGAAGACGTGCTGAAGCTGGAAGTGAAAAATGACGCCCGGCTGTCGTTTATGACCCAGACCACGCTCTCCGTCGA
CGATACCTCGGATGTGATTGACGCCCTGCGCGCGCGTTTTCCGAAAATCGTCGGCCCGCGCAAAGACGACATTTGCTATG
CCACCACTAACCGTCAGGAAGCCGTGCGCGCGCTGGCGGAGAAGGCTGACGTAGTGCTGGTGGTCGGGTCGAAAAACTCC
TCCAACTCTAACCGCCTCGCCGAGCTGGCGCAGCGGATGGGCAAAGCGGCTTACCTGATTGACGACGCCTCCGATATTCA
GGAAGCGTGGGTCAAGGATGCGGCCTGCGTCGGCGTGACGGCGGGCGCGTCGGCGCCGGATATTCTGGTGCAGAACGTCA
TTACCCGCCTGCAGGAGCTGGGCGGCGGCGAAGCCGTGCCGCTGGAAGGCCGGGAAGAGAATATCGTCTTTGAAGTGCCG
AAAGAGCTGCGTGTGGATGTCCGTGAAGTAGAGTAA

Upstream 100 bases:

>100_bases
GCAATGGATGGCAGCGAAATGCCTGGCGTGATCCGCGAAGTGAACGGCGATTCCATCACCGTTGACTTCAACCATCCGCT
GGCCGGGCGCACTGTTCATT

Downstream 100 bases:

>100_bases
GTTCTTTCCTCCAGCAGTATGAGAAGATGCCAGACTTAACGTCTGGCATTTTTTTAGGGAGAAACCATGCGCTTACCAAT
CATTCTTGATACCGATCCGG

Product: 4-hydroxy-3-methylbut-2-enyl diphosphate reductase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 331; Mature: 331

Protein sequence:

>331_residues
MILKCWRSIRRWRSNMQILLANPRGFCAGVDRAISIVENALTLYGAPIYVRHEVVHNRYVVDSLRKRGAIFIEQISEVPD
GAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILIGHAGHPEVEGTMGQYNNPQGGMYLVE
SPEDVLKLEVKNDARLSFMTQTTLSVDDTSDVIDALRARFPKIVGPRKDDICYATTNRQEAVRALAEKADVVLVVGSKNS
SNSNRLAELAQRMGKAAYLIDDASDIQEAWVKDAACVGVTAGASAPDILVQNVITRLQELGGGEAVPLEGREENIVFEVP
KELRVDVREVE

Sequences:

>Translated_331_residues
MILKCWRSIRRWRSNMQILLANPRGFCAGVDRAISIVENALTLYGAPIYVRHEVVHNRYVVDSLRKRGAIFIEQISEVPD
GAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILIGHAGHPEVEGTMGQYNNPQGGMYLVE
SPEDVLKLEVKNDARLSFMTQTTLSVDDTSDVIDALRARFPKIVGPRKDDICYATTNRQEAVRALAEKADVVLVVGSKNS
SNSNRLAELAQRMGKAAYLIDDASDIQEAWVKDAACVGVTAGASAPDILVQNVITRLQELGGGEAVPLEGREENIVFEVP
KELRVDVREVE
>Mature_331_residues
MILKCWRSIRRWRSNMQILLANPRGFCAGVDRAISIVENALTLYGAPIYVRHEVVHNRYVVDSLRKRGAIFIEQISEVPD
GAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILIGHAGHPEVEGTMGQYNNPQGGMYLVE
SPEDVLKLEVKNDARLSFMTQTTLSVDDTSDVIDALRARFPKIVGPRKDDICYATTNRQEAVRALAEKADVVLVVGSKNS
SNSNRLAELAQRMGKAAYLIDDASDIQEAWVKDAACVGVTAGASAPDILVQNVITRLQELGGGEAVPLEGREENIVFEVP
KELRVDVREVE

Specific function: Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) [H]

COG id: COG0761

COG function: function code IM; Penicillin tolerance protein

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ispH family [H]

Homologues:

Organism=Escherichia coli, GI1786212, Length=316, Percent_Identity=91.4556962025316, Blast_Score=598, Evalue=1e-172,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003451 [H]

Pfam domain/function: PF02401 LYTB [H]

EC number: =1.17.1.2 [H]

Molecular weight: Translated: 36435; Mature: 36435

Theoretical pI: Translated: 5.73; Mature: 5.73

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MILKCWRSIRRWRSNMQILLANPRGFCAGVDRAISIVENALTLYGAPIYVRHEVVHNRYV
CHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCEEEEHHHHHHHHH
VDSLRKRGAIFIEQISEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHME
HHHHHHCCCHHHHHHHHCCCCEEEEEECCCHHHHHHHHHCCCCEEEEECCCCHHHHHHHH
VARASRRGEESILIGHAGHPEVEGTMGQYNNPQGGMYLVESPEDVLKLEVKNDARLSFMT
HHHHHCCCCCEEEEECCCCCCCCCCCCCCCCCCCCEEEEECCCCEEEEEECCCCEEEEEE
QTTLSVDDTSDVIDALRARFPKIVGPRKDDICYATTNRQEAVRALAEKADVVLVVGSKNS
EEEECCCCHHHHHHHHHHHCCHHCCCCCCCEEEEECCHHHHHHHHHHCCCEEEEEECCCC
SNSNRLAELAQRMGKAAYLIDDASDIQEAWVKDAACVGVTAGASAPDILVQNVITRLQEL
CCHHHHHHHHHHHCCEEEEECCHHHHHHHHHCCCHHEEEECCCCCHHHHHHHHHHHHHHC
GGGEAVPLEGREENIVFEVPKELRVDVREVE
CCCCEECCCCCCCCEEEECCHHHCCHHHCCC
>Mature Secondary Structure
MILKCWRSIRRWRSNMQILLANPRGFCAGVDRAISIVENALTLYGAPIYVRHEVVHNRYV
CHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCEEEEHHHHHHHHH
VDSLRKRGAIFIEQISEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHME
HHHHHHCCCHHHHHHHHCCCCEEEEEECCCHHHHHHHHHCCCCEEEEECCCCHHHHHHHH
VARASRRGEESILIGHAGHPEVEGTMGQYNNPQGGMYLVESPEDVLKLEVKNDARLSFMT
HHHHHCCCCCEEEEECCCCCCCCCCCCCCCCCCCCEEEEECCCCEEEEEECCCCEEEEEE
QTTLSVDDTSDVIDALRARFPKIVGPRKDDICYATTNRQEAVRALAEKADVVLVVGSKNS
EEEECCCCHHHHHHHHHHHCCHHCCCCCCCEEEEECCHHHHHHHHHHCCCEEEEEECCCC
SNSNRLAELAQRMGKAAYLIDDASDIQEAWVKDAACVGVTAGASAPDILVQNVITRLQEL
CCHHHHHHHHHHHCCEEEEECCHHHHHHHHHCCCHHEEEECCCCCHHHHHHHHHHHHHHC
GGGEAVPLEGREENIVFEVPKELRVDVREVE
CCCCEECCCCCCCCEEEECCHHHCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA