Click here to switch to the map view.

The map label for this gene is fkpB [H]

Identifier: 238893009

GI number: 238893009

Start: 821759

End: 822208

Strand: Direct

Name: fkpB [H]

Synonym: KP1_0844

Alternate gene names: 238893009

Gene position: 821759-822208 (Clockwise)

Preceding gene: 238893008

Following gene: 238893010

Centisome position: 15.66

GC content: 57.33

Gene sequence:

>450_bases
ATGTCTAAATCCGTACAGAGCAACAGCGCGGTACTGGTGCACTTCACTCTGAAACTGGACGACGGCTCCACTGCCGAGTC
CACCCGCAGCAACGGCAAACCGGCGCTGTTTCGCCTCGGCGACACCTCTTTGTCTGAAGGGCTGGAGCAACAGCTTCTCG
GTTTGAAAGAGGGGGAGAAAAAGGCCTTTTCGCTGGAGCCTGACGCCGCCTTTGGCGTACCCAGCCCGGACCTGATTCAG
TATTTCTCTCGCCGCGAGTTTATCGACGCTGGCGAGCCGGAGATCGGCGCGATTATGCTCTTTACCGCAATGGATGGCAG
CGAAATGCCTGGCGTGATCCGCGAAGTGAACGGCGATTCCATCACCGTTGACTTCAACCATCCGCTGGCCGGGCGCACTG
TTCATTTTGATATTGAAGTGCTGGAGATCGATCCGGCGCTGGAGGAGTAA

Upstream 100 bases:

>100_bases
GACGTGACGCTTACCCGGCCTACAGAATTTTTGGCCCCCGTAGGCTCGGTAAGCGTAATGCCGCCGGGCACCGGGTGACC
TAAACAAGCGAGCAATTTGC

Downstream 100 bases:

>100_bases
CATGCAGATCCTGTTGGCTAACCCGCGCGGTTTTTGCGCTGGCGTTGACCGCGCTATCAGCATTGTAGAAAACGCGCTGA
CGCTGTATGGCGCACCGATC

Product: FKBP-type peptidyl-prolyl cis-trans isomerase

Products: NA

Alternate protein names: PPIase; Rotamase [H]

Number of amino acids: Translated: 149; Mature: 148

Protein sequence:

>149_residues
MSKSVQSNSAVLVHFTLKLDDGSTAESTRSNGKPALFRLGDTSLSEGLEQQLLGLKEGEKKAFSLEPDAAFGVPSPDLIQ
YFSRREFIDAGEPEIGAIMLFTAMDGSEMPGVIREVNGDSITVDFNHPLAGRTVHFDIEVLEIDPALEE

Sequences:

>Translated_149_residues
MSKSVQSNSAVLVHFTLKLDDGSTAESTRSNGKPALFRLGDTSLSEGLEQQLLGLKEGEKKAFSLEPDAAFGVPSPDLIQ
YFSRREFIDAGEPEIGAIMLFTAMDGSEMPGVIREVNGDSITVDFNHPLAGRTVHFDIEVLEIDPALEE
>Mature_148_residues
SKSVQSNSAVLVHFTLKLDDGSTAESTRSNGKPALFRLGDTSLSEGLEQQLLGLKEGEKKAFSLEPDAAFGVPSPDLIQY
FSRREFIDAGEPEIGAIMLFTAMDGSEMPGVIREVNGDSITVDFNHPLAGRTVHFDIEVLEIDPALEE

Specific function: PPIases accelerate the folding of proteins. Substrate specificity carried out with 'Suc-Ala-Xaa-Pro-Phe-4-nitroanilide', where Xaa is the amino acid tested, was found to be Phe > Leu >> Ile > Lys = Ala > Trp > His >> Gln [H]

COG id: COG1047

COG function: function code O; FKBP-type peptidyl-prolyl cis-trans isomerases 2

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase FKBP-type domain [H]

Homologues:

Organism=Escherichia coli, GI1786211, Length=148, Percent_Identity=91.8918918918919, Blast_Score=279, Evalue=5e-77,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001179 [H]

Pfam domain/function: PF00254 FKBP_C [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 16155; Mature: 16024

Theoretical pI: Translated: 4.17; Mature: 4.17

Prosite motif: PS50059 FKBP_PPIASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKSVQSNSAVLVHFTLKLDDGSTAESTRSNGKPALFRLGDTSLSEGLEQQLLGLKEGEK
CCCCCCCCCEEEEEEEEEECCCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHCCCCCCCC
KAFSLEPDAAFGVPSPDLIQYFSRREFIDAGEPEIGAIMLFTAMDGSEMPGVIREVNGDS
EEEEECCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCEEEEEEECCCCCCCCEEEECCCCE
ITVDFNHPLAGRTVHFDIEVLEIDPALEE
EEEEECCCCCCCEEEEEEEEEEECCCCCC
>Mature Secondary Structure 
SKSVQSNSAVLVHFTLKLDDGSTAESTRSNGKPALFRLGDTSLSEGLEQQLLGLKEGEK
CCCCCCCCEEEEEEEEEECCCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHCCCCCCCC
KAFSLEPDAAFGVPSPDLIQYFSRREFIDAGEPEIGAIMLFTAMDGSEMPGVIREVNGDS
EEEEECCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCEEEEEEECCCCCCCCEEEECCCCE
ITVDFNHPLAGRTVHFDIEVLEIDPALEE
EEEEECCCCCCCEEEEEEEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]