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The map label for this gene is wecC [H]

Identifier: 238892391

GI number: 238892391

Start: 152679

End: 153941

Strand: Direct

Name: wecC [H]

Synonym: KP1_0149

Alternate gene names: 238892391

Gene position: 152679-153941 (Clockwise)

Preceding gene: 238892390

Following gene: 238892392

Centisome position: 2.91

GC content: 59.7

Gene sequence:

>1263_bases
ATGAGTTTTTCTACCATTTCAGTGATTGGCCTTGGCTATATCGGGCTGCCAACCGCTGCCGCGTTCGCCTCCCGGCAGAA
GCGGGTGGTCGGCGTTGATGTTAATCAACATGCCGTGGAGACCATTAACCGTGGAGAGATTCATATCGTGGAGCCGGATC
TGGCGAGCGTGGTGAAGACCGCGGTCGAGCAGGGGTATTTAAGCGCCACCACCACCTCGGTGGAGGCGGATGCTTACCTG
ATTGCCGTGCCGACGCCGTTTAAAGATCGCCACGAGCCGGATATGGTGTTTGTCGAGTCGGCCGCCAAATCCATTGCGCC
GACGTTAAAGAAAGGGTCGCTGGTGATCCTCGAGTCCACTTCGCCGGTCGGGTCGACCGAACAGATGGCCGAGTGGCTGG
CGGAGATGCGCCCGGATCTTAGCTTCCCCCAGCAGGTGGGTGAAGCGGCGGACGTGAATATCGCCTACTGCCCGGAGCGG
GTATTGCCCGGTCAGGTGATGGTCGAGCTGATTAAAAACGACCGTGTTATCGGCGGCATGTCGCCGGTCTGCTCCGCTCG
CGCCAGCGAGCTGTATAAAATCTTCCTTGAAGGCGAATGCGTGGTGACCAACTCGCGCACCGCCGAGATGTGCAAGCTGA
CGGAAAACAGCTTCCGCGACGTCAACATCGCTTTTGCCAACGAGCTGTCGCTGATTTGCGCCGACCAGGGGATTAACGTC
TGGGAGCTGATCCGCCTGGCGAACCGCCATCCGCGCGTCAATATCCTGCAGCCGGGCCCGGGTGTTGGCGGCCACTGTAT
CGCCGTCGACCCATGGTTTATCGTGGCGCAAAACCCGCAGCAGGCGCGTCTGATCCGCACCGCTCGCGAGGTCAACGACC
ACAAGCCGGAATGGGTTATCGAACAGGTGAAAGCGCAGGTGGCGGACTGCCTGAATGCCACCAACAAGCGGGCCAGCGAA
CTGACGATCGCCTGTTTTGGCCTCGCTTTTAAACCGAATATTGACGACCTGCGCGAAAGTCCGGCGATGGAAATTGCCGC
GCAGATTGCCCGCTGGCACAGCGGCACGACCCAGGTGGTTGAGCCCAACATTCACGCGCTGCCGAAGAAACTCGATGGAC
TGTGTACGCTGGCGACCCTTGAGGCGGCGCTGGCCAGCGCCGATGTGCTGGTGATGTTGGTCGATCATAACCAATTTAAA
GCCGTTAGCGGCGATAGCGTCACCCAGGCGTTTATCGTCGACACCAAAGGAGTGTGGCGGTGA

Upstream 100 bases:

>100_bases
ATGCTGCATACCAGGCGATGAGCCGTGCGCATAATCCCTATGGCGATGGCGAAGCATGTCGTCGCATTTTGTCTGCACTT
AAAAATAATCAGGTAACGCT

Downstream 100 bases:

>100_bases
GAACCATTCTGGTCACCGGCGGCGCGGGCTTCATTGGTTCGGCGGTAGTGCGGGAGATTATCCAGCACACCGCCGATCGC
GTGGTGGTGGTGGATAAACT

Product: UDP-N-acetyl-D-mannosamine dehydrogenase

Products: UDP-N-acetyl-D-mannosaminuronic-acid; NADH; Proton [C]

Alternate protein names: UDP-ManNAc 6-dehydrogenase [H]

Number of amino acids: Translated: 420; Mature: 419

Protein sequence:

>420_residues
MSFSTISVIGLGYIGLPTAAAFASRQKRVVGVDVNQHAVETINRGEIHIVEPDLASVVKTAVEQGYLSATTTSVEADAYL
IAVPTPFKDRHEPDMVFVESAAKSIAPTLKKGSLVILESTSPVGSTEQMAEWLAEMRPDLSFPQQVGEAADVNIAYCPER
VLPGQVMVELIKNDRVIGGMSPVCSARASELYKIFLEGECVVTNSRTAEMCKLTENSFRDVNIAFANELSLICADQGINV
WELIRLANRHPRVNILQPGPGVGGHCIAVDPWFIVAQNPQQARLIRTAREVNDHKPEWVIEQVKAQVADCLNATNKRASE
LTIACFGLAFKPNIDDLRESPAMEIAAQIARWHSGTTQVVEPNIHALPKKLDGLCTLATLEAALASADVLVMLVDHNQFK
AVSGDSVTQAFIVDTKGVWR

Sequences:

>Translated_420_residues
MSFSTISVIGLGYIGLPTAAAFASRQKRVVGVDVNQHAVETINRGEIHIVEPDLASVVKTAVEQGYLSATTTSVEADAYL
IAVPTPFKDRHEPDMVFVESAAKSIAPTLKKGSLVILESTSPVGSTEQMAEWLAEMRPDLSFPQQVGEAADVNIAYCPER
VLPGQVMVELIKNDRVIGGMSPVCSARASELYKIFLEGECVVTNSRTAEMCKLTENSFRDVNIAFANELSLICADQGINV
WELIRLANRHPRVNILQPGPGVGGHCIAVDPWFIVAQNPQQARLIRTAREVNDHKPEWVIEQVKAQVADCLNATNKRASE
LTIACFGLAFKPNIDDLRESPAMEIAAQIARWHSGTTQVVEPNIHALPKKLDGLCTLATLEAALASADVLVMLVDHNQFK
AVSGDSVTQAFIVDTKGVWR
>Mature_419_residues
SFSTISVIGLGYIGLPTAAAFASRQKRVVGVDVNQHAVETINRGEIHIVEPDLASVVKTAVEQGYLSATTTSVEADAYLI
AVPTPFKDRHEPDMVFVESAAKSIAPTLKKGSLVILESTSPVGSTEQMAEWLAEMRPDLSFPQQVGEAADVNIAYCPERV
LPGQVMVELIKNDRVIGGMSPVCSARASELYKIFLEGECVVTNSRTAEMCKLTENSFRDVNIAFANELSLICADQGINVW
ELIRLANRHPRVNILQPGPGVGGHCIAVDPWFIVAQNPQQARLIRTAREVNDHKPEWVIEQVKAQVADCLNATNKRASEL
TIACFGLAFKPNIDDLRESPAMEIAAQIARWHSGTTQVVEPNIHALPKKLDGLCTLATLEAALASADVLVMLVDHNQFKA
VSGDSVTQAFIVDTKGVWR

Specific function: Catalyzes the four-electron oxidation of UDP-N-acetyl-D- mannosamine (UDP-ManNAc), reducing NAD(+) and releasing UDP-N- acetylmannosaminuronic acid (UDP-ManNAcA) [H]

COG id: COG0677

COG function: function code M; UDP-N-acetyl-D-mannosaminuronate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4507813, Length=455, Percent_Identity=26.1538461538462, Blast_Score=97, Evalue=3e-20,
Organism=Homo sapiens, GI296040438, Length=357, Percent_Identity=24.6498599439776, Blast_Score=67, Evalue=3e-11,
Organism=Escherichia coli, GI48994968, Length=420, Percent_Identity=88.3333333333333, Blast_Score=775, Evalue=0.0,
Organism=Escherichia coli, GI1788340, Length=286, Percent_Identity=24.4755244755245, Blast_Score=66, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17560350, Length=432, Percent_Identity=27.0833333333333, Blast_Score=111, Evalue=9e-25,
Organism=Drosophila melanogaster, GI17136908, Length=364, Percent_Identity=27.7472527472527, Blast_Score=103, Evalue=3e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR017476
- InterPro:   IPR014027
- InterPro:   IPR014026
- InterPro:   IPR014028
- InterPro:   IPR001732 [H]

Pfam domain/function: PF00984 UDPG_MGDP_dh; PF03720 UDPG_MGDP_dh_C; PF03721 UDPG_MGDP_dh_N [H]

EC number: 1.1.1.- [C]

Molecular weight: Translated: 45632; Mature: 45501

Theoretical pI: Translated: 5.16; Mature: 5.16

Prosite motif: PS00678 WD_REPEATS_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSFSTISVIGLGYIGLPTAAAFASRQKRVVGVDVNQHAVETINRGEIHIVEPDLASVVKT
CCCCEEEEEEECCCCCHHHHHHHHCCCEEEEECCCHHHHHHCCCCEEEEECCCHHHHHHH
AVEQGYLSATTTSVEADAYLIAVPTPFKDRHEPDMVFVESAAKSIAPTLKKGSLVILEST
HHHCCCCEEEEEEEECCEEEEEECCCCCCCCCCCEEEEHHHHHHHCCHHCCCCEEEEECC
SPVGSTEQMAEWLAEMRPDLSFPQQVGEAADVNIAYCPERVLPGQVMVELIKNDRVIGGM
CCCCCHHHHHHHHHHHCCCCCCHHHHCCCCCCEEEECCCCCCCHHHHHHHHHCCCEECCC
SPVCSARASELYKIFLEGECVVTNSRTAEMCKLTENSFRDVNIAFANELSLICADQGINV
CHHHHHHHHHHEEEEECCEEEEECCCHHHHHHHHCCCCCEEEEEEECCEEEEEECCCCCH
WELIRLANRHPRVNILQPGPGVGGHCIAVDPWFIVAQNPQQARLIRTAREVNDHKPEWVI
HHHHHHHCCCCCEEEECCCCCCCCEEEEECCEEEEECCCHHHHHHHHHHHHCCCCHHHHH
EQVKAQVADCLNATNKRASELTIACFGLAFKPNIDDLRESPAMEIAAQIARWHSGTTQVV
HHHHHHHHHHHHHCCCCHHEEEEEEEEEEECCCHHHHHCCHHHHHHHHHHHHCCCCCEEE
EPNIHALPKKLDGLCTLATLEAALASADVLVMLVDHNQFKAVSGDSVTQAFIVDTKGVWR
CCCHHHHHHHHCCHHHHHHHHHHHCCCCEEEEEEECCCEEEECCCCCEEEEEEECCCCCC
>Mature Secondary Structure 
SFSTISVIGLGYIGLPTAAAFASRQKRVVGVDVNQHAVETINRGEIHIVEPDLASVVKT
CCCEEEEEEECCCCCHHHHHHHHCCCEEEEECCCHHHHHHCCCCEEEEECCCHHHHHHH
AVEQGYLSATTTSVEADAYLIAVPTPFKDRHEPDMVFVESAAKSIAPTLKKGSLVILEST
HHHCCCCEEEEEEEECCEEEEEECCCCCCCCCCCEEEEHHHHHHHCCHHCCCCEEEEECC
SPVGSTEQMAEWLAEMRPDLSFPQQVGEAADVNIAYCPERVLPGQVMVELIKNDRVIGGM
CCCCCHHHHHHHHHHHCCCCCCHHHHCCCCCCEEEECCCCCCCHHHHHHHHHCCCEECCC
SPVCSARASELYKIFLEGECVVTNSRTAEMCKLTENSFRDVNIAFANELSLICADQGINV
CHHHHHHHHHHEEEEECCEEEEECCCHHHHHHHHCCCCCEEEEEEECCEEEEEECCCCCH
WELIRLANRHPRVNILQPGPGVGGHCIAVDPWFIVAQNPQQARLIRTAREVNDHKPEWVI
HHHHHHHCCCCCEEEECCCCCCCCEEEEECCEEEEECCCHHHHHHHHHHHHCCCCHHHHH
EQVKAQVADCLNATNKRASELTIACFGLAFKPNIDDLRESPAMEIAAQIARWHSGTTQVV
HHHHHHHHHHHHHCCCCHHEEEEEEEEEEECCCHHHHHCCHHHHHHHHHHHHCCCCCEEE
EPNIHALPKKLDGLCTLATLEAALASADVLVMLVDHNQFKAVSGDSVTQAFIVDTKGVWR
CCCHHHHHHHHCCHHHHHHHHHHHCCCCEEEEEEECCCEEEECCCCCEEEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: UDP-N-acetyl-D-mannosamine; NAD [C]

Specific reaction: UDP-N-acetyl-D-mannosamine + NAD = UDP-N-acetyl-D-mannosaminuronic-acid + NADH + Proton [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]