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The map label for this gene is wecB [H]

Identifier: 238892390

GI number: 238892390

Start: 151552

End: 152682

Strand: Direct

Name: wecB [H]

Synonym: KP1_0148

Alternate gene names: 238892390

Gene position: 151552-152682 (Clockwise)

Preceding gene: 238892389

Following gene: 238892391

Centisome position: 2.89

GC content: 57.65

Gene sequence:

>1131_bases
GTGAAAGTACTAACTGTATTTGGCACGAGGCCGGAAGCCATCAAGATGGCGCCTCTGGTCCATGCGCTGGCAAAGGATCC
TCATTTTGAGGCGAAAGTATGCGTGACCGCGCAGCATCGGGAGATGCTCGATCAGGTGTTGAAACTTTTCTCTATTGTCC
CGGACTACGATCTCAACATCATGAAGCCGGGGCAGGGGCTGACCGAGATCACCTGTCGCATCCTTGAAGGGCTGAAGCCG
GTGCTGGAGTCGTTTAAACCCGACGTGGTGCTGGTACATGGCGATACCACCACCACCATGGCGGCGAGCCTGGCGGCGTT
TTATCAGCGGATACCGGTGGGCCACGTAGAGGCCGGCCTGCGCACCGGCGATTTAAGTTCGCCGTGGCCGGAAGAAGGCA
ACCGTACGTTGACCGGCCATCTGGCGACATACCATTTCGCCCCCACGGAAACCTCGCGGCAGAACCTGCTACGGGAAAAT
ATTGCCGACAGTCGCATCACGGTCACCGGGAATACGGTCATTGACGCCCTGTTCTGGGTGCGGGATCGGGTGCTGGGTGA
TGAAGCGCTACGGGAGACCCTGCTGCAGCGCTATCCTTTCATCAGCCACGGTAAAAAGATGATTCTGGTTACCGGCCACC
GGCGGGAAAGCTTTGGGCTCGGTTTTGAACAGATCTGCCAGGCGCTGGCCGAGATAGCCCATACCCACCCTGAGGTGCAG
ATTGTCTATCCGGTTCACCTGAATCCTAATGTCAGCGAGCCGGTGAATCGTATTCTTGGTCATATTGACAATGTGATGTT
GATTGAACCGCAGGATTACCTGCCGTTCGTCTGGCTGATGGATCGCGCCTGGCTGATCCTGACCGATTCCGGCGGCATTC
AGGAAGAGGCCCCCTCGCTGGGTAAGCCGGTGCTGGTCATGCGCGATATGACCGAACGTCCGGAAGCGGTGGCCGCCGGC
ACCGTGTGTCTGGTGGGCACCGACAGCCAGCGCATCGTCGCGGAAGTGACGCGACTGCTGGAGGATGATGCTGCATACCA
GGCGATGAGCCGTGCGCATAATCCCTATGGCGATGGCGAAGCATGTCGTCGCATTTTGTCTGCACTTAAAAATAATCAGG
TAACGCTATGA

Upstream 100 bases:

>100_bases
TCATCGGCGCAGGCGTGGCGTTATCGCGTCGTCGTGTCCTGTGATTGCGGCCTGTGGTGAAGGGCAGATGACCTTCATCG
CCTAATCGAAGAGAATCGAT

Downstream 100 bases:

>100_bases
GTTTTTCTACCATTTCAGTGATTGGCCTTGGCTATATCGGGCTGCCAACCGCTGCCGCGTTCGCCTCCCGGCAGAAGCGG
GTGGTCGGCGTTGATGTTAA

Product: UDP-N-acetylglucosamine 2-epimerase

Products: NA

Alternate protein names: UDP-GlcNAc-2-epimerase [H]

Number of amino acids: Translated: 376; Mature: 376

Protein sequence:

>376_residues
MKVLTVFGTRPEAIKMAPLVHALAKDPHFEAKVCVTAQHREMLDQVLKLFSIVPDYDLNIMKPGQGLTEITCRILEGLKP
VLESFKPDVVLVHGDTTTTMAASLAAFYQRIPVGHVEAGLRTGDLSSPWPEEGNRTLTGHLATYHFAPTETSRQNLLREN
IADSRITVTGNTVIDALFWVRDRVLGDEALRETLLQRYPFISHGKKMILVTGHRRESFGLGFEQICQALAEIAHTHPEVQ
IVYPVHLNPNVSEPVNRILGHIDNVMLIEPQDYLPFVWLMDRAWLILTDSGGIQEEAPSLGKPVLVMRDMTERPEAVAAG
TVCLVGTDSQRIVAEVTRLLEDDAAYQAMSRAHNPYGDGEACRRILSALKNNQVTL

Sequences:

>Translated_376_residues
MKVLTVFGTRPEAIKMAPLVHALAKDPHFEAKVCVTAQHREMLDQVLKLFSIVPDYDLNIMKPGQGLTEITCRILEGLKP
VLESFKPDVVLVHGDTTTTMAASLAAFYQRIPVGHVEAGLRTGDLSSPWPEEGNRTLTGHLATYHFAPTETSRQNLLREN
IADSRITVTGNTVIDALFWVRDRVLGDEALRETLLQRYPFISHGKKMILVTGHRRESFGLGFEQICQALAEIAHTHPEVQ
IVYPVHLNPNVSEPVNRILGHIDNVMLIEPQDYLPFVWLMDRAWLILTDSGGIQEEAPSLGKPVLVMRDMTERPEAVAAG
TVCLVGTDSQRIVAEVTRLLEDDAAYQAMSRAHNPYGDGEACRRILSALKNNQVTL
>Mature_376_residues
MKVLTVFGTRPEAIKMAPLVHALAKDPHFEAKVCVTAQHREMLDQVLKLFSIVPDYDLNIMKPGQGLTEITCRILEGLKP
VLESFKPDVVLVHGDTTTTMAASLAAFYQRIPVGHVEAGLRTGDLSSPWPEEGNRTLTGHLATYHFAPTETSRQNLLREN
IADSRITVTGNTVIDALFWVRDRVLGDEALRETLLQRYPFISHGKKMILVTGHRRESFGLGFEQICQALAEIAHTHPEVQ
IVYPVHLNPNVSEPVNRILGHIDNVMLIEPQDYLPFVWLMDRAWLILTDSGGIQEEAPSLGKPVLVMRDMTERPEAVAAG
TVCLVGTDSQRIVAEVTRLLEDDAAYQAMSRAHNPYGDGEACRRILSALKNNQVTL

Specific function: Catalyzes the reversible epimerization at C-2 of UDP-N- acetylglucosamine (UDP-GlcNAc) and thereby provides bacteria with UDP-N-acetylmannosamine (UDP-ManNAc), the activated donor of ManNAc residues [H]

COG id: COG0381

COG function: function code M; UDP-N-acetylglucosamine 2-epimerase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UDP-N-acetylglucosamine 2-epimerase family [H]

Homologues:

Organism=Escherichia coli, GI48994967, Length=376, Percent_Identity=84.0425531914894, Blast_Score=644, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003331 [H]

Pfam domain/function: PF02350 Epimerase_2 [H]

EC number: =5.1.3.14 [H]

Molecular weight: Translated: 41821; Mature: 41821

Theoretical pI: Translated: 6.15; Mature: 6.15

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVLTVFGTRPEAIKMAPLVHALAKDPHFEAKVCVTAQHREMLDQVLKLFSIVPDYDLNI
CEEEEEECCCCCHHHHHHHHHHHHCCCCCCEEEEEEHHHHHHHHHHHHHHHHCCCCCCEE
MKPGQGLTEITCRILEGLKPVLESFKPDVVLVHGDTTTTMAASLAAFYQRIPVGHVEAGL
ECCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHCCCCHHHCCC
RTGDLSSPWPEEGNRTLTGHLATYHFAPTETSRQNLLRENIADSRITVTGNTVIDALFWV
CCCCCCCCCCCCCCEEEEEEEEEEEECCCCHHHHHHHHHHCCCCEEEEECHHHHHHHHHH
RDRVLGDEALRETLLQRYPFISHGKKMILVTGHRRESFGLGFEQICQALAEIAHTHPEVQ
HHHHHCHHHHHHHHHHHCCHHHCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHCCCCEE
IVYPVHLNPNVSEPVNRILGHIDNVMLIEPQDYLPFVWLMDRAWLILTDSGGIQEEAPSL
EEEEEECCCCCHHHHHHHHHHCCCEEEECCCCCCCHHEEECCCEEEEECCCCCCCCCCCC
GKPVLVMRDMTERPEAVAAGTVCLVGTDSQRIVAEVTRLLEDDAAYQAMSRAHNPYGDGE
CCCEEEECCCCCCCCHHECCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHH
ACRRILSALKNNQVTL
HHHHHHHHHHCCCCCC
>Mature Secondary Structure
MKVLTVFGTRPEAIKMAPLVHALAKDPHFEAKVCVTAQHREMLDQVLKLFSIVPDYDLNI
CEEEEEECCCCCHHHHHHHHHHHHCCCCCCEEEEEEHHHHHHHHHHHHHHHHCCCCCCEE
MKPGQGLTEITCRILEGLKPVLESFKPDVVLVHGDTTTTMAASLAAFYQRIPVGHVEAGL
ECCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHCCCCHHHCCC
RTGDLSSPWPEEGNRTLTGHLATYHFAPTETSRQNLLRENIADSRITVTGNTVIDALFWV
CCCCCCCCCCCCCCEEEEEEEEEEEECCCCHHHHHHHHHHCCCCEEEEECHHHHHHHHHH
RDRVLGDEALRETLLQRYPFISHGKKMILVTGHRRESFGLGFEQICQALAEIAHTHPEVQ
HHHHHCHHHHHHHHHHHCCHHHCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHCCCCEE
IVYPVHLNPNVSEPVNRILGHIDNVMLIEPQDYLPFVWLMDRAWLILTDSGGIQEEAPSL
EEEEEECCCCCHHHHHHHHHHCCCEEEECCCCCCCHHEEECCCEEEEECCCCCCCCCCCC
GKPVLVMRDMTERPEAVAAGTVCLVGTDSQRIVAEVTRLLEDDAAYQAMSRAHNPYGDGE
CCCEEEECCCCCCCCHHECCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHH
ACRRILSALKNNQVTL
HHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11677608; 12644504 [H]