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The map label for this gene is rmlB [H]

Identifier: 238892392

GI number: 238892392

Start: 153938

End: 155005

Strand: Direct

Name: rmlB [H]

Synonym: KP1_0150

Alternate gene names: 238892392

Gene position: 153938-155005 (Clockwise)

Preceding gene: 238892391

Following gene: 238892393

Centisome position: 2.93

GC content: 59.36

Gene sequence:

>1068_bases
GTGAGAACCATTCTGGTCACCGGCGGCGCGGGCTTCATTGGTTCGGCGGTAGTGCGGGAGATTATCCAGCACACCGCCGA
TCGCGTGGTGGTGGTGGATAAACTGACCTACGCCGGCAATTTAATGTCGCTGGCGCCGGTGGCGCAGGATGCGCGTTTCG
CCTTTGAACAGGTGGATATCTGCGACCGCGCCGAGCTGGATCGCATTTTTCGTCAGCATCAACCGGATACGGTGATGCAC
CTGGCGGCGGAAAGCCATGTCGATCGTTCGATTGACGGCCCGGCGGCGTTTATCGAGACTAATATCGTGGGCACCTATAC
GCTGCTGGAGGCGGCCCGTAGCTGGTGGAATACCCTGGCTACGGCGCAAAAATCGGCGTTTCGCTTCCATCACATCTCCA
CCGATGAAGTGTATGGCGATCTGCATGGCAGCGATGATTTCTTTACCGAGACCACGCCCTATGCGCCAAGCAGCCCCTAT
TCGGCTTCGAAAGCCAGCAGCGACCACCTGGTGCGCGCCTGGCTGCGAACCTATGGCCTGCCGACGCTTATCACCAACTG
CTCAAATAACTACGGCCCGTATCACTTTCCCGAGAAGCTGATCCCGCTGACGATCCTTAACGCGCTGGCGGGCAAGCCGC
TGCCGGTGTATGGCAATGGACAACAGATCCGCGACTGGCTGTACGTGGAAGATCACGCCAGAGCGCTGTATCTGGTGGCG
ACCTGCGGCGAACCGGGCGAAACTTACAATATCGGCGGTCATAACGAACGGAAAAATATCGAGGTGGTGGAAACCATTTG
TCAGCTGCTGGAAGAGCTGGCGCCGGATAAGCCGCAGGGCGTGGCGCACTATCGCGATCTGATCGCCTTCGTTGCCGATC
GTCCGGGCCACGATCTGCGCTATGCCATTGATGCCTCGAAGATTGCCCGCGAGCTGGGCTGGACGCCGGCAGAGACTTTC
ACCTCCGGTATGCGTAAGACCGTGGCGTGGTATCTGGCGAACGAGGCCTGGTGGCGTCGGGTTCAGGACGGAAGCTATCA
GGGCGAGCGTCTTGGGCTGCAAAGCTAA

Upstream 100 bases:

>100_bases
CCGATGTGCTGGTGATGTTGGTCGATCATAACCAATTTAAAGCCGTTAGCGGCGATAGCGTCACCCAGGCGTTTATCGTC
GACACCAAAGGAGTGTGGCG

Downstream 100 bases:

>100_bases
TCATCTCTGGGGGGAATGATGAAAGGTATTATTCTGGCGGGCGGTTCCGGAACGCGGCTACATCCCATCACCCGCGGCGT
ATCGAAGCAGCTGTTGCCGA

Product: dTDP-glucose 4,6-dehydratase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 355; Mature: 355

Protein sequence:

>355_residues
MRTILVTGGAGFIGSAVVREIIQHTADRVVVVDKLTYAGNLMSLAPVAQDARFAFEQVDICDRAELDRIFRQHQPDTVMH
LAAESHVDRSIDGPAAFIETNIVGTYTLLEAARSWWNTLATAQKSAFRFHHISTDEVYGDLHGSDDFFTETTPYAPSSPY
SASKASSDHLVRAWLRTYGLPTLITNCSNNYGPYHFPEKLIPLTILNALAGKPLPVYGNGQQIRDWLYVEDHARALYLVA
TCGEPGETYNIGGHNERKNIEVVETICQLLEELAPDKPQGVAHYRDLIAFVADRPGHDLRYAIDASKIARELGWTPAETF
TSGMRKTVAWYLANEAWWRRVQDGSYQGERLGLQS

Sequences:

>Translated_355_residues
MRTILVTGGAGFIGSAVVREIIQHTADRVVVVDKLTYAGNLMSLAPVAQDARFAFEQVDICDRAELDRIFRQHQPDTVMH
LAAESHVDRSIDGPAAFIETNIVGTYTLLEAARSWWNTLATAQKSAFRFHHISTDEVYGDLHGSDDFFTETTPYAPSSPY
SASKASSDHLVRAWLRTYGLPTLITNCSNNYGPYHFPEKLIPLTILNALAGKPLPVYGNGQQIRDWLYVEDHARALYLVA
TCGEPGETYNIGGHNERKNIEVVETICQLLEELAPDKPQGVAHYRDLIAFVADRPGHDLRYAIDASKIARELGWTPAETF
TSGMRKTVAWYLANEAWWRRVQDGSYQGERLGLQS
>Mature_355_residues
MRTILVTGGAGFIGSAVVREIIQHTADRVVVVDKLTYAGNLMSLAPVAQDARFAFEQVDICDRAELDRIFRQHQPDTVMH
LAAESHVDRSIDGPAAFIETNIVGTYTLLEAARSWWNTLATAQKSAFRFHHISTDEVYGDLHGSDDFFTETTPYAPSSPY
SASKASSDHLVRAWLRTYGLPTLITNCSNNYGPYHFPEKLIPLTILNALAGKPLPVYGNGQQIRDWLYVEDHARALYLVA
TCGEPGETYNIGGHNERKNIEVVETICQLLEELAPDKPQGVAHYRDLIAFVADRPGHDLRYAIDASKIARELGWTPAETF
TSGMRKTVAWYLANEAWWRRVQDGSYQGERLGLQS

Specific function: Catalyzes the dehydration of dTDP-D-glucose to form dTDP-6-deoxy-D-xylo-4-hexulose via a three-step process involving oxidation, dehydration and reduction [H]

COG id: COG1088

COG function: function code M; dTDP-D-glucose 4,6-dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sugar epimerase family. dTDP-glucose dehydratase subfamily [H]

Homologues:

Organism=Homo sapiens, GI7657641, Length=345, Percent_Identity=33.9130434782609, Blast_Score=216, Evalue=2e-56,
Organism=Homo sapiens, GI42516563, Length=337, Percent_Identity=25.5192878338279, Blast_Score=98, Evalue=1e-20,
Organism=Homo sapiens, GI4504031, Length=285, Percent_Identity=25.2631578947368, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI56237023, Length=346, Percent_Identity=27.1676300578035, Blast_Score=70, Evalue=3e-12,
Organism=Homo sapiens, GI56118217, Length=346, Percent_Identity=27.1676300578035, Blast_Score=70, Evalue=3e-12,
Organism=Homo sapiens, GI189083684, Length=346, Percent_Identity=27.1676300578035, Blast_Score=70, Evalue=3e-12,
Organism=Escherichia coli, GI48994969, Length=354, Percent_Identity=87.2881355932203, Blast_Score=654, Evalue=0.0,
Organism=Escherichia coli, GI1788353, Length=352, Percent_Identity=71.3068181818182, Blast_Score=513, Evalue=1e-147,
Organism=Escherichia coli, GI1786974, Length=352, Percent_Identity=27.2727272727273, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1788366, Length=253, Percent_Identity=28.0632411067194, Blast_Score=82, Evalue=7e-17,
Organism=Caenorhabditis elegans, GI17568069, Length=348, Percent_Identity=34.4827586206897, Blast_Score=196, Evalue=2e-50,
Organism=Caenorhabditis elegans, GI115532424, Length=337, Percent_Identity=33.8278931750742, Blast_Score=174, Evalue=9e-44,
Organism=Caenorhabditis elegans, GI71982035, Length=350, Percent_Identity=26, Blast_Score=88, Evalue=8e-18,
Organism=Caenorhabditis elegans, GI71982038, Length=352, Percent_Identity=25.8522727272727, Blast_Score=87, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17539532, Length=342, Percent_Identity=24.5614035087719, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI133901786, Length=294, Percent_Identity=24.4897959183673, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI133901788, Length=294, Percent_Identity=24.4897959183673, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17539422, Length=294, Percent_Identity=24.4897959183673, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI133901790, Length=294, Percent_Identity=24.4897959183673, Blast_Score=70, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17539424, Length=294, Percent_Identity=24.4897959183673, Blast_Score=70, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17507723, Length=300, Percent_Identity=25, Blast_Score=68, Evalue=7e-12,
Organism=Saccharomyces cerevisiae, GI6319493, Length=341, Percent_Identity=26.3929618768328, Blast_Score=90, Evalue=6e-19,
Organism=Drosophila melanogaster, GI21356223, Length=351, Percent_Identity=25.3561253561254, Blast_Score=89, Evalue=5e-18,
Organism=Drosophila melanogaster, GI19923002, Length=284, Percent_Identity=28.5211267605634, Blast_Score=86, Evalue=3e-17,
Organism=Drosophila melanogaster, GI24158427, Length=339, Percent_Identity=24.7787610619469, Blast_Score=78, Evalue=8e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005888
- InterPro:   IPR001509
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01370 Epimerase [H]

EC number: =4.2.1.46 [H]

Molecular weight: Translated: 39641; Mature: 39641

Theoretical pI: Translated: 5.89; Mature: 5.89

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRTILVTGGAGFIGSAVVREIIQHTADRVVVVDKLTYAGNLMSLAPVAQDARFAFEQVDI
CCEEEEECCCCHHHHHHHHHHHHHCCCCEEEEECHHHCCCHHHHHHHHHHHHHHHHHHCH
CDRAELDRIFRQHQPDTVMHLAAESHVDRSIDGPAAFIETNIVGTYTLLEAARSWWNTLA
HHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCHHEEECCCHHHHHHHHHHHHHHHHHH
TAQKSAFRFHHISTDEVYGDLHGSDDFFTETTPYAPSSPYSASKASSDHLVRAWLRTYGL
HHHHHHHHEECCCHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCC
PTLITNCSNNYGPYHFPEKLIPLTILNALAGKPLPVYGNGQQIRDWLYVEDHARALYLVA
HHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCCEECCCCHHHHHEEEEECCCCEEEEEE
TCGEPGETYNIGGHNERKNIEVVETICQLLEELAPDKPQGVAHYRDLIAFVADRPGHDLR
ECCCCCCEEECCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCEE
YAIDASKIARELGWTPAETFTSGMRKTVAWYLANEAWWRRVQDGSYQGERLGLQS
EEECHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
>Mature Secondary Structure
MRTILVTGGAGFIGSAVVREIIQHTADRVVVVDKLTYAGNLMSLAPVAQDARFAFEQVDI
CCEEEEECCCCHHHHHHHHHHHHHCCCCEEEEECHHHCCCHHHHHHHHHHHHHHHHHHCH
CDRAELDRIFRQHQPDTVMHLAAESHVDRSIDGPAAFIETNIVGTYTLLEAARSWWNTLA
HHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCHHEEECCCHHHHHHHHHHHHHHHHHH
TAQKSAFRFHHISTDEVYGDLHGSDDFFTETTPYAPSSPYSASKASSDHLVRAWLRTYGL
HHHHHHHHEECCCHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCC
PTLITNCSNNYGPYHFPEKLIPLTILNALAGKPLPVYGNGQQIRDWLYVEDHARALYLVA
HHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCCEECCCCHHHHHEEEEECCCCEEEEEE
TCGEPGETYNIGGHNERKNIEVVETICQLLEELAPDKPQGVAHYRDLIAFVADRPGHDLR
ECCCCCCEEECCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCEE
YAIDASKIARELGWTPAETFTSGMRKTVAWYLANEAWWRRVQDGSYQGERLGLQS
EEECHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1379743; 9278503; 7559340 [H]