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The map label for this gene is pcm [H]

Identifier: 339905964

GI number: 339905964

Start: 1585436

End: 1586302

Strand: Direct

Name: pcm [H]

Synonym: NA

Alternate gene names: 339905964

Gene position: 1585436-1586302 (Clockwise)

Preceding gene: 238027060

Following gene: 238027062

Centisome position: 40.58

GC content: 72.32

Gene sequence:

>867_bases
ATGAGCGGCGAGCGCGCCAAGCGGTTCCCGCTTGCGCTCGAGGATCTCAAACGCGCGCCGCGCAAGGCCGCCGCCCGCAC
CACCGAGCGCCATCCGACTTCGCCCGCGCGGCCGACGCTCGGCGCCTCGGTCGCGGGCTCGCCGGCGCGGCCGGCCGGGC
TCGCGCGCGCGGCCGCGCACGGCCCCGCCGGCGCCGCGGGTCCGGCGGGCAAACCCGCGCTCGCGCTGACGTCGGAACGG
GTCCGCGAGCGCATGGTCGAACGTCTGCGCGCCAATGGGGTGACCGATACGCGCGTGCTCGGCGCGATAGCGGCCGTGCC
GCGCCACCTGTTCGTGGATCCGGGCCTCGCCGCCCAGGCCTACGAGGACGCGGCGCTGCCGATCGGCCATCAGCAGACCA
TTTCGAAACCGTCGGTGGTGGCCCGCATGATCGAGCTCGCGCTGGCGGGCCGCTCGCCCGAGCGCGTGCTCGAGATCGGC
ACCGGCTGTGGCTATCAGGCGGCCGTGCTGAGCCATCTCGCGCGGGATGTTTATTCGATCGAGCGTGTCAAGCCATTGTT
CGAGCGCGCGAAACGCAACCTCCGGCCGTTGCGCGTTCCGAACATCCGGCTGCATTACGGCGACGGCCGCCTCGGCCTGC
CGTCGGCCGCGCCGTTCGATGCGATCGTGATCGCCGCGGCGGGGCTCGACGTGCCGCAGGCGCTTGTCGAACAACTGGCC
GTGGGCGGGCGGCTCGTCGCGCCGGTAGGCGCGCAGAGCGGCGACTCGCAGGTGCTGACGCTCGTCGAGCGGGTCGGGCC
GACGCAATGGCGGGAGTCCCGGCTTGATCGCGTTTTCTTTGTCCCCTTAAAATCCGGAGTGATTTGA

Upstream 100 bases:
NA

Downstream 100 bases:
NA

Product: Protein-L-isoaspartate carboxylmethyltransferase

Products: NA

Alternate protein names: L-isoaspartyl protein carboxyl methyltransferase; Protein L-isoaspartyl methyltransferase; Protein-beta-aspartate methyltransferase; PIMT [H]

Number of amino acids: Translated: 288; Mature: 287

Protein sequence:
NA

Sequences:

>Translated_288_residues
MSGERAKRFPLALEDLKRAPRKAAARTTERHPTSPARPTLGASVAGSPARPAGLARAAAHGPAGAAGPAGKPALALTSER
VRERMVERLRANGVTDTRVLGAIAAVPRHLFVDPGLAAQAYEDAALPIGHQQTISKPSVVARMIELALAGRSPERVLEIG
TGCGYQAAVLSHLARDVYSIERVKPLFERAKRNLRPLRVPNIRLHYGDGRLGLPSAAPFDAIVIAAAGLDVPQALVEQLA
VGGRLVAPVGAQSGDSQVLTLVERVGPTQWRESRLDRVFFVPLKSGVI
>Mature_287_residues
SGERAKRFPLALEDLKRAPRKAAARTTERHPTSPARPTLGASVAGSPARPAGLARAAAHGPAGAAGPAGKPALALTSERV
RERMVERLRANGVTDTRVLGAIAAVPRHLFVDPGLAAQAYEDAALPIGHQQTISKPSVVARMIELALAGRSPERVLEIGT
GCGYQAAVLSHLARDVYSIERVKPLFERAKRNLRPLRVPNIRLHYGDGRLGLPSAAPFDAIVIAAAGLDVPQALVEQLAV
GGRLVAPVGAQSGDSQVLTLVERVGPTQWRESRLDRVFFVPLKSGVI

Specific function: Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. L- isoaspartyl/D-aspartyl protein methyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI226530908, Length=212, Percent_Identity=31.6037735849057, Blast_Score=90, Evalue=2e-18,
Organism=Escherichia coli, GI1789100, Length=211, Percent_Identity=46.4454976303318, Blast_Score=163, Evalue=1e-41,
Organism=Caenorhabditis elegans, GI71983477, Length=223, Percent_Identity=31.390134529148, Blast_Score=84, Evalue=7e-17,
Organism=Caenorhabditis elegans, GI193207222, Length=219, Percent_Identity=30.5936073059361, Blast_Score=77, Evalue=9e-15,
Organism=Drosophila melanogaster, GI17981723, Length=177, Percent_Identity=35.0282485875706, Blast_Score=85, Evalue=5e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000682 [H]

Pfam domain/function: PF01135 PCMT [H]

EC number: =2.1.1.77 [H]

Molecular weight: Translated: 30457; Mature: 30325

Theoretical pI: Translated: 11.45; Mature: 11.45

Prosite motif: PS01279 PCMT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
1.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSGERAKRFPLALEDLKRAPRKAAARTTERHPTSPARPTLGASVAGSPARPAGLARAAAH
CCCCCCHHCCCHHHHHHHCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHC
GPAGAAGPAGKPALALTSERVRERMVERLRANGVTDTRVLGAIAAVPRHLFVDPGLAAQA
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCHHHH
YEDAALPIGHQQTISKPSVVARMIELALAGRSPERVLEIGTGCGYQAAVLSHLARDVYSI
HHCCCCCCCCHHHCCCHHHHHHHHHHHHCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHH
ERVKPLFERAKRNLRPLRVPNIRLHYGDGRLGLPSAAPFDAIVIAAAGLDVPQALVEQLA
HHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHH
VGGRLVAPVGAQSGDSQVLTLVERVGPTQWRESRLDRVFFVPLKSGVI
HCCEEEECCCCCCCCHHHHHHHHHCCCCHHHHHHCCEEEEEECCCCCC
>Mature Secondary Structure 
SGERAKRFPLALEDLKRAPRKAAARTTERHPTSPARPTLGASVAGSPARPAGLARAAAH
CCCCCHHCCCHHHHHHHCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHC
GPAGAAGPAGKPALALTSERVRERMVERLRANGVTDTRVLGAIAAVPRHLFVDPGLAAQA
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCHHHH
YEDAALPIGHQQTISKPSVVARMIELALAGRSPERVLEIGTGCGYQAAVLSHLARDVYSI
HHCCCCCCCCHHHCCCHHHHHHHHHHHHCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHH
ERVKPLFERAKRNLRPLRVPNIRLHYGDGRLGLPSAAPFDAIVIAAAGLDVPQALVEQLA
HHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHH
VGGRLVAPVGAQSGDSQVLTLVERVGPTQWRESRLDRVFFVPLKSGVI
HCCEEEECCCCCCCCHHHHHHHHHCCCCHHHHHHCCEEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA