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The map label for this gene is gyaR [H]

Identifier: 238028950

GI number: 238028950

Start: 3882516

End: 3883532

Strand: Direct

Name: gyaR [H]

Synonym: bglu_1g34150

Alternate gene names: 238028950

Gene position: 3882516-3883532 (Clockwise)

Preceding gene: 238028948

Following gene: 238028956

Centisome position: 99.39

GC content: 65.19

Gene sequence:

>1017_bases
ATGAAAATAGCCATCCTCGACGACTATCAGGACGCCGTCCGCAAGCTCAACTGTTTCGAGCTGCTCGCCGATCACGAAGT
CAAGGTCTTCAACAACACGGTGCGCGGGCTTGGCCAGCTCGCCAGCCGGCTCACCGAAGTCGAAGCGCTGGTCCTGATCC
GCGAACGCACTCACATCACCTCTCAACTGCTCGCAAAGCTACCGCATCTGCGCATGATCAGCCAGACCGGCAAGGTTTCG
AGCCATATCGACATGGACGCCTGCACCGAGCGCGGCATCGCCGTGCTCGAAGGCACCGGCTCGCCCGTCGCGCCCGCCGA
GCTGACCTGGGCGCTGATCATGGCCGCCCAGCGCAGGATTCCGCAGTATGTCGCCAATCTGAAGCAGGGCGCCTGGCAGC
AATCGGGCCTGAAGACCTCGGCGATGCCGCCGAACTTCGGCCTCGGCCAGGTGCTGCGCGGCCAGACGCTCGGCATCTGG
GGCTACGGCAAGATCGGCCAGTTGCTGGCCGGCTACGGCAAGGCGTTCGGCATGAACGTGATGATCTGGGGCCGCGAGCC
GTCGCTCGAACGCGCGCGCAGCGACGGCTATCTGGCCGCCGAGAGCCGCGAGGCGTTCTTCGAGCAGGCCGACATCCTGA
CGCTGCAACTGCGCCTGAACGACGACACGCGCGGCATCGTCAAGCAGGACGACCTGATGCGGATGAAGCCGACCTCGCTG
TTCGTGAACACGAGCCGCGCCGAGTTGCTGGAGGAGAGCGCGCTCGTCAACGCACTGGCCAACAACCGCCCCGGCATGGT
CGCCATCGACGTGTTCGAGAGCGAGCCGATCCTGCAGGGCTACAGCCTGCTGCGCATGGAGAACGTGATCTGCACGCCGC
ACATCGGCTATGTCGAGCGCGAGAGCTACGAGCTGTATTTCGGCGCCGCGTTCCGCAACATCCTCGCCTTCGACAGCGGC
GACACGACGAGCGTCGCGAATCCGGAAGCGCTGACGGGCGGACGCAATCGGCGCTAG

Upstream 100 bases:

>100_bases
CCTGCCGGGGCGGCGGCATAAGATCATGACGGCCCGCCGCTCGGGCCGCCGGGTCGCGCGCCCGGCGCATCCGTTTTTCC
GTGCCGCTCTCGAATACTTC

Downstream 100 bases:

>100_bases
GCGCCGAATTCACGCGGTAACGGCCGCCCCCGGCGGCGGCGCGTGCGGCGCCTGGGCCGAGATCGCCGCCACGAAGCGTT
CGCCGTCGCGGCGCCCCAGA

Product: Glyoxylate reductase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 338; Mature: 338

Protein sequence:

>338_residues
MKIAILDDYQDAVRKLNCFELLADHEVKVFNNTVRGLGQLASRLTEVEALVLIRERTHITSQLLAKLPHLRMISQTGKVS
SHIDMDACTERGIAVLEGTGSPVAPAELTWALIMAAQRRIPQYVANLKQGAWQQSGLKTSAMPPNFGLGQVLRGQTLGIW
GYGKIGQLLAGYGKAFGMNVMIWGREPSLERARSDGYLAAESREAFFEQADILTLQLRLNDDTRGIVKQDDLMRMKPTSL
FVNTSRAELLEESALVNALANNRPGMVAIDVFESEPILQGYSLLRMENVICTPHIGYVERESYELYFGAAFRNILAFDSG
DTTSVANPEALTGGRNRR

Sequences:

>Translated_338_residues
MKIAILDDYQDAVRKLNCFELLADHEVKVFNNTVRGLGQLASRLTEVEALVLIRERTHITSQLLAKLPHLRMISQTGKVS
SHIDMDACTERGIAVLEGTGSPVAPAELTWALIMAAQRRIPQYVANLKQGAWQQSGLKTSAMPPNFGLGQVLRGQTLGIW
GYGKIGQLLAGYGKAFGMNVMIWGREPSLERARSDGYLAAESREAFFEQADILTLQLRLNDDTRGIVKQDDLMRMKPTSL
FVNTSRAELLEESALVNALANNRPGMVAIDVFESEPILQGYSLLRMENVICTPHIGYVERESYELYFGAAFRNILAFDSG
DTTSVANPEALTGGRNRR
>Mature_338_residues
MKIAILDDYQDAVRKLNCFELLADHEVKVFNNTVRGLGQLASRLTEVEALVLIRERTHITSQLLAKLPHLRMISQTGKVS
SHIDMDACTERGIAVLEGTGSPVAPAELTWALIMAAQRRIPQYVANLKQGAWQQSGLKTSAMPPNFGLGQVLRGQTLGIW
GYGKIGQLLAGYGKAFGMNVMIWGREPSLERARSDGYLAAESREAFFEQADILTLQLRLNDDTRGIVKQDDLMRMKPTSL
FVNTSRAELLEESALVNALANNRPGMVAIDVFESEPILQGYSLLRMENVICTPHIGYVERESYELYFGAAFRNILAFDSG
DTTSVANPEALTGGRNRR

Specific function: Unknown

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GyaR subfamily [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=336, Percent_Identity=27.9761904761905, Blast_Score=123, Evalue=3e-28,
Organism=Homo sapiens, GI6912396, Length=266, Percent_Identity=29.6992481203008, Blast_Score=107, Evalue=1e-23,
Organism=Homo sapiens, GI145580578, Length=258, Percent_Identity=31.7829457364341, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI4557499, Length=258, Percent_Identity=31.7829457364341, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI4557497, Length=255, Percent_Identity=31.3725490196078, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI61743967, Length=255, Percent_Identity=31.3725490196078, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI145580575, Length=258, Percent_Identity=32.1705426356589, Blast_Score=96, Evalue=3e-20,
Organism=Escherichia coli, GI87082289, Length=297, Percent_Identity=29.2929292929293, Blast_Score=111, Evalue=7e-26,
Organism=Escherichia coli, GI1789279, Length=293, Percent_Identity=29.3515358361775, Blast_Score=108, Evalue=7e-25,
Organism=Escherichia coli, GI1787645, Length=258, Percent_Identity=24.8062015503876, Blast_Score=77, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17532191, Length=329, Percent_Identity=27.355623100304, Blast_Score=111, Evalue=6e-25,
Organism=Caenorhabditis elegans, GI25147481, Length=252, Percent_Identity=28.968253968254, Blast_Score=88, Evalue=7e-18,
Organism=Saccharomyces cerevisiae, GI6320925, Length=273, Percent_Identity=27.1062271062271, Blast_Score=92, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6322116, Length=273, Percent_Identity=25.2747252747253, Blast_Score=83, Evalue=6e-17,
Organism=Saccharomyces cerevisiae, GI6324055, Length=227, Percent_Identity=28.1938325991189, Blast_Score=82, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6324964, Length=254, Percent_Identity=23.2283464566929, Blast_Score=67, Evalue=3e-12,
Organism=Drosophila melanogaster, GI28574286, Length=253, Percent_Identity=28.0632411067194, Blast_Score=107, Evalue=1e-23,
Organism=Drosophila melanogaster, GI24646446, Length=249, Percent_Identity=31.7269076305221, Blast_Score=105, Evalue=4e-23,
Organism=Drosophila melanogaster, GI24646448, Length=249, Percent_Identity=31.7269076305221, Blast_Score=105, Evalue=4e-23,
Organism=Drosophila melanogaster, GI24646452, Length=249, Percent_Identity=31.7269076305221, Blast_Score=105, Evalue=4e-23,
Organism=Drosophila melanogaster, GI24646450, Length=249, Percent_Identity=31.7269076305221, Blast_Score=105, Evalue=4e-23,
Organism=Drosophila melanogaster, GI62472511, Length=252, Percent_Identity=31.7460317460317, Blast_Score=104, Evalue=9e-23,
Organism=Drosophila melanogaster, GI19921140, Length=296, Percent_Identity=26.6891891891892, Blast_Score=99, Evalue=5e-21,
Organism=Drosophila melanogaster, GI24585514, Length=250, Percent_Identity=25.6, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI28574282, Length=250, Percent_Identity=25.6, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI45551003, Length=250, Percent_Identity=25.6, Blast_Score=93, Evalue=2e-19,
Organism=Drosophila melanogaster, GI45552429, Length=250, Percent_Identity=25.6, Blast_Score=93, Evalue=2e-19,
Organism=Drosophila melanogaster, GI28574284, Length=250, Percent_Identity=25.6, Blast_Score=93, Evalue=2e-19,
Organism=Drosophila melanogaster, GI28571528, Length=265, Percent_Identity=27.1698113207547, Blast_Score=93, Evalue=3e-19,
Organism=Drosophila melanogaster, GI24585516, Length=231, Percent_Identity=26.4069264069264, Blast_Score=80, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C [H]

EC number: =1.1.1.26 [H]

Molecular weight: Translated: 37416; Mature: 37416

Theoretical pI: Translated: 6.68; Mature: 6.68

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIAILDDYQDAVRKLNCFELLADHEVKVFNNTVRGLGQLASRLTEVEALVLIRERTHIT
CEEEEECCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SQLLAKLPHLRMISQTGKVSSHIDMDACTERGIAVLEGTGSPVAPAELTWALIMAAQRRI
HHHHHHCCCHHHHHHCCCCCCCCCHHHHHHCCEEEEECCCCCCCCHHHHHHHHHHHHHHH
PQYVANLKQGAWQQSGLKTSAMPPNFGLGQVLRGQTLGIWGYGKIGQLLAGYGKAFGMNV
HHHHHHHHHCCHHHCCCCCCCCCCCCCHHHHHCCCEEEEECCCHHHHHHHHHHHHHCCEE
MIWGREPSLERARSDGYLAAESREAFFEQADILTLQLRLNDDTRGIVKQDDLMRMKPTSL
EEECCCCCHHHHCCCCEEEECHHHHHHHCCCEEEEEEEECCCCCCCCCCCCCCEECCCEE
FVNTSRAELLEESALVNALANNRPGMVAIDVFESEPILQGYSLLRMENVICTPHIGYVER
EEECHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCHHHHHHHHHHCCEEECCCCCCEEC
ESYELYFGAAFRNILAFDSGDTTSVANPEALTGGRNRR
CCEEEEEEHHHHHHHEECCCCCCCCCCCHHHCCCCCCC
>Mature Secondary Structure
MKIAILDDYQDAVRKLNCFELLADHEVKVFNNTVRGLGQLASRLTEVEALVLIRERTHIT
CEEEEECCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SQLLAKLPHLRMISQTGKVSSHIDMDACTERGIAVLEGTGSPVAPAELTWALIMAAQRRI
HHHHHHCCCHHHHHHCCCCCCCCCHHHHHHCCEEEEECCCCCCCCHHHHHHHHHHHHHHH
PQYVANLKQGAWQQSGLKTSAMPPNFGLGQVLRGQTLGIWGYGKIGQLLAGYGKAFGMNV
HHHHHHHHHCCHHHCCCCCCCCCCCCCHHHHHCCCEEEEECCCHHHHHHHHHHHHHCCEE
MIWGREPSLERARSDGYLAAESREAFFEQADILTLQLRLNDDTRGIVKQDDLMRMKPTSL
EEECCCCCHHHHCCCCEEEECHHHHHHHCCCEEEEEEEECCCCCCCCCCCCCCEECCCEE
FVNTSRAELLEESALVNALANNRPGMVAIDVFESEPILQGYSLLRMENVICTPHIGYVER
EEECHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCHHHHHHHHHHCCEEECCCCCCEEC
ESYELYFGAAFRNILAFDSGDTTSVANPEALTGGRNRR
CCEEEEEEHHHHHHHEECCCCCCCCCCCHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10382966 [H]