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The map label for this gene is bioF [H]

Identifier: 238028780

GI number: 238028780

Start: 3684988

End: 3686190

Strand: Direct

Name: bioF [H]

Synonym: bglu_1g32440

Alternate gene names: 238028780

Gene position: 3684988-3686190 (Clockwise)

Preceding gene: 238028779

Following gene: 238028781

Centisome position: 94.33

GC content: 75.23

Gene sequence:

>1203_bases
ATGAGCCCGCCGCCGAACCTGCTGGCCGCGCTCGAACGCGGCCTGGCCGAGATCGACGCCCAGGGCCTGCGCCGCGTGCG
CCGCACCGCCGACACCGCGTGCGGCGCGCACATGACGGTGGACGGCCGCGAGATCGTCGGCTTCGCCAGCAACGACTACC
TGGGCCTCGCCGCGCATCCGGCGCTCGTCGAGGCGTTCGCCGAGGGCGCGCGGCGCTACGGCTCCGGCAGCGGCGGCTCG
CACCTGCTGGGCGGCCATTCGCGCGCGCACGCCGCGCTCGAGGACGCGCTCGCCGAGTTCGCCGGCGGCTTCAGCCGCGC
GCCGCGCGCGCTCTACTTCAGCACCGGCTACATGGCGAACCTCGCCGCGCTGAGCGCCCTGGTGGGGCGCGGTGCGGCGA
TCTTCTCCGATTCGCTGAACCACGCCTCGCTGATCGACGGCGCGCGGCTCTCGCGCGCCGAGATCCACGTCTATCCGCAC
GGCGACATGGACGCGCTGTCGGTGCAGCTGGCCGCCTCCGACGCCACCGTCAAGCTGATCGTCTCCGACACCGTGTTCAG
CATGGACGGCACCATCGCGCCGCTGGCACGGCTCGTCACGCTGGCCGAGGCGCATGGCGCCTGGCTGGTGGTGGACGACG
CGCACGGCTTCGGCGTGCTCGGCCCGCAGGGGCGCGGCGCGCTGGCCGAGTACGCGCTGCGCTCCGAGCAGCTGATCTAC
GTGGGCACGCTCGGCAAGGCCGCCGGCGTGGCCGGCGCGTTCGTGATCGCGCACGAGACCGTGATCGAGTGGATGATCCA
GCGCGCGCGCAGCTACATCTTCACCACCGCCGCGCCGCCCTCGGTCGCGCACGCCGTGTCGGCCAGCCTGGCCGTGATCG
GCGGCGCCGAGGGCGACGCGCGGCGCGCCCACCTGGCCGCGCTGATCGAGCGCACGCGCGCGATCCTGCGCGGCACGCGC
TGGCAGCCGATCGATTCGGCCACCGCCGTACAGCCGCTCGTGATCGGCGAGAACGACGCCACCCTGGCCGCGATGCGCGC
GCTCGACGCGCACGGCCTGTGGGTGCCCGCGATCCGGCCGCCCACCGTGCCGGCCGGCACCTCGCGGCTGCGCATCTCGC
TGTCCGCCGCGCATTCGTTCGACGATCTGGCGCGGCTCGACGCGGCGCTCGCCGCCGCCGGCGCCGCGGAGGCCGCCGCA
TGA

Upstream 100 bases:

>100_bases
TCTACCTGATGCCGCCCTACGTGCTCGACGACGACGAGATCGACTGGCTCGCCGCGCGCACGCGCGAGACGCTCGACGCC
ACGCTGGCCGAGGTGCGCGC

Downstream 100 bases:

>100_bases
GCGCGCCGACGCCACCCCGCGCCGGCACCGGCGCCCGCGCGCTATCGTGCTTCGTGACCGGCACCGACACCGAGATCGGC
AAGACCTTCGTGTCCGCCGC

Product: 8-amino-7-oxononanoate synthase

Products: NA

Alternate protein names: AONS; 7-keto-8-amino-pelargonic acid synthase; 7-KAP synthase; KAPA synthase; 8-amino-7-ketopelargonate synthase; L-alanine--pimeloyl-CoA ligase [H]

Number of amino acids: Translated: 400; Mature: 399

Protein sequence:

>400_residues
MSPPPNLLAALERGLAEIDAQGLRRVRRTADTACGAHMTVDGREIVGFASNDYLGLAAHPALVEAFAEGARRYGSGSGGS
HLLGGHSRAHAALEDALAEFAGGFSRAPRALYFSTGYMANLAALSALVGRGAAIFSDSLNHASLIDGARLSRAEIHVYPH
GDMDALSVQLAASDATVKLIVSDTVFSMDGTIAPLARLVTLAEAHGAWLVVDDAHGFGVLGPQGRGALAEYALRSEQLIY
VGTLGKAAGVAGAFVIAHETVIEWMIQRARSYIFTTAAPPSVAHAVSASLAVIGGAEGDARRAHLAALIERTRAILRGTR
WQPIDSATAVQPLVIGENDATLAAMRALDAHGLWVPAIRPPTVPAGTSRLRISLSAAHSFDDLARLDAALAAAGAAEAAA

Sequences:

>Translated_400_residues
MSPPPNLLAALERGLAEIDAQGLRRVRRTADTACGAHMTVDGREIVGFASNDYLGLAAHPALVEAFAEGARRYGSGSGGS
HLLGGHSRAHAALEDALAEFAGGFSRAPRALYFSTGYMANLAALSALVGRGAAIFSDSLNHASLIDGARLSRAEIHVYPH
GDMDALSVQLAASDATVKLIVSDTVFSMDGTIAPLARLVTLAEAHGAWLVVDDAHGFGVLGPQGRGALAEYALRSEQLIY
VGTLGKAAGVAGAFVIAHETVIEWMIQRARSYIFTTAAPPSVAHAVSASLAVIGGAEGDARRAHLAALIERTRAILRGTR
WQPIDSATAVQPLVIGENDATLAAMRALDAHGLWVPAIRPPTVPAGTSRLRISLSAAHSFDDLARLDAALAAAGAAEAAA
>Mature_399_residues
SPPPNLLAALERGLAEIDAQGLRRVRRTADTACGAHMTVDGREIVGFASNDYLGLAAHPALVEAFAEGARRYGSGSGGSH
LLGGHSRAHAALEDALAEFAGGFSRAPRALYFSTGYMANLAALSALVGRGAAIFSDSLNHASLIDGARLSRAEIHVYPHG
DMDALSVQLAASDATVKLIVSDTVFSMDGTIAPLARLVTLAEAHGAWLVVDDAHGFGVLGPQGRGALAEYALRSEQLIYV
GTLGKAAGVAGAFVIAHETVIEWMIQRARSYIFTTAAPPSVAHAVSASLAVIGGAEGDARRAHLAALIERTRAILRGTRW
QPIDSATAVQPLVIGENDATLAAMRALDAHGLWVPAIRPPTVPAGTSRLRISLSAAHSFDDLARLDAALAAAGAAEAAA

Specific function: Catalyzes the decarboxylative condensation of pimeloyl- CoA and L-alanine to produce 8-amino-7-oxononanoate (AON), coenzyme A, and carbon dioxide [H]

COG id: COG0156

COG function: function code H; 7-keto-8-aminopelargonate synthetase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. BioF subfamily [H]

Homologues:

Organism=Homo sapiens, GI7657118, Length=393, Percent_Identity=32.5699745547074, Blast_Score=197, Evalue=1e-50,
Organism=Homo sapiens, GI284448556, Length=366, Percent_Identity=32.5136612021858, Blast_Score=190, Evalue=2e-48,
Organism=Homo sapiens, GI83977442, Length=347, Percent_Identity=34.5821325648415, Blast_Score=185, Evalue=8e-47,
Organism=Homo sapiens, GI83977440, Length=347, Percent_Identity=34.5821325648415, Blast_Score=184, Evalue=9e-47,
Organism=Homo sapiens, GI83977444, Length=347, Percent_Identity=34.5821325648415, Blast_Score=184, Evalue=9e-47,
Organism=Homo sapiens, GI4502025, Length=344, Percent_Identity=31.6860465116279, Blast_Score=170, Evalue=3e-42,
Organism=Homo sapiens, GI40316939, Length=344, Percent_Identity=31.6860465116279, Blast_Score=170, Evalue=3e-42,
Organism=Homo sapiens, GI4758668, Length=366, Percent_Identity=30.0546448087432, Blast_Score=150, Evalue=2e-36,
Organism=Homo sapiens, GI119220554, Length=377, Percent_Identity=26.790450928382, Blast_Score=142, Evalue=8e-34,
Organism=Homo sapiens, GI5454084, Length=258, Percent_Identity=28.2945736434109, Blast_Score=109, Evalue=5e-24,
Organism=Escherichia coli, GI1786993, Length=360, Percent_Identity=44.4444444444444, Blast_Score=279, Evalue=2e-76,
Organism=Escherichia coli, GI1790046, Length=372, Percent_Identity=35.2150537634409, Blast_Score=201, Evalue=8e-53,
Organism=Caenorhabditis elegans, GI71994529, Length=393, Percent_Identity=32.0610687022901, Blast_Score=182, Evalue=4e-46,
Organism=Caenorhabditis elegans, GI32566772, Length=385, Percent_Identity=28.051948051948, Blast_Score=138, Evalue=4e-33,
Organism=Caenorhabditis elegans, GI17560914, Length=365, Percent_Identity=26.5753424657534, Blast_Score=119, Evalue=4e-27,
Organism=Caenorhabditis elegans, GI17560912, Length=365, Percent_Identity=26.5753424657534, Blast_Score=118, Evalue=5e-27,
Organism=Caenorhabditis elegans, GI71982617, Length=278, Percent_Identity=23.021582733813, Blast_Score=91, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI71982625, Length=278, Percent_Identity=23.021582733813, Blast_Score=91, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6320438, Length=405, Percent_Identity=29.1358024691358, Blast_Score=172, Evalue=1e-43,
Organism=Saccharomyces cerevisiae, GI6320267, Length=376, Percent_Identity=27.6595744680851, Blast_Score=125, Evalue=1e-29,
Organism=Saccharomyces cerevisiae, GI6323954, Length=263, Percent_Identity=27.3764258555133, Blast_Score=95, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24662918, Length=386, Percent_Identity=34.4559585492228, Blast_Score=199, Evalue=3e-51,
Organism=Drosophila melanogaster, GI17137420, Length=348, Percent_Identity=31.0344827586207, Blast_Score=173, Evalue=2e-43,
Organism=Drosophila melanogaster, GI17136286, Length=386, Percent_Identity=26.6839378238342, Blast_Score=114, Evalue=1e-25,
Organism=Drosophila melanogaster, GI24653280, Length=325, Percent_Identity=25.2307692307692, Blast_Score=110, Evalue=1e-24,
Organism=Drosophila melanogaster, GI24653276, Length=325, Percent_Identity=25.2307692307692, Blast_Score=110, Evalue=1e-24,
Organism=Drosophila melanogaster, GI24653278, Length=325, Percent_Identity=25.2307692307692, Blast_Score=110, Evalue=1e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022834
- InterPro:   IPR004839
- InterPro:   IPR004723
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.3.1.47 [H]

Molecular weight: Translated: 41315; Mature: 41184

Theoretical pI: Translated: 6.68; Mature: 6.68

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSPPPNLLAALERGLAEIDAQGLRRVRRTADTACGAHMTVDGREIVGFASNDYLGLAAHP
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCEEEEECCCCCEEEECCH
ALVEAFAEGARRYGSGSGGSHLLGGHSRAHAALEDALAEFAGGFSRAPRALYFSTGYMAN
HHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCEEEEECCHHHH
LAALSALVGRGAAIFSDSLNHASLIDGARLSRAEIHVYPHGDMDALSVQLAASDATVKLI
HHHHHHHHHCCHHEECCCCCCHHHHCCCCCCCEEEEEECCCCCCEEEEEEEECCCEEEEE
VSDTVFSMDGTIAPLARLVTLAEAHGAWLVVDDAHGFGVLGPQGRGALAEYALRSEQLIY
EECEEEECCCCHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCHHHHHHHCCCCEEE
VGTLGKAAGVAGAFVIAHETVIEWMIQRARSYIFTTAAPPSVAHAVSASLAVIGGAEGDA
EECCCCHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCHHHHHHHHCEEEEECCCCCH
RRAHLAALIERTRAILRGTRWQPIDSATAVQPLVIGENDATLAAMRALDAHGLWVPAIRP
HHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEECCCCHHHHHHHHHCCCCEEECCCCC
PTVPAGTSRLRISLSAAHSFDDLARLDAALAAAGAAEAAA
CCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHCCCHHCCC
>Mature Secondary Structure 
SPPPNLLAALERGLAEIDAQGLRRVRRTADTACGAHMTVDGREIVGFASNDYLGLAAHP
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCEEEEECCCCCEEEECCH
ALVEAFAEGARRYGSGSGGSHLLGGHSRAHAALEDALAEFAGGFSRAPRALYFSTGYMAN
HHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCEEEEECCHHHH
LAALSALVGRGAAIFSDSLNHASLIDGARLSRAEIHVYPHGDMDALSVQLAASDATVKLI
HHHHHHHHHCCHHEECCCCCCHHHHCCCCCCCEEEEEECCCCCCEEEEEEEECCCEEEEE
VSDTVFSMDGTIAPLARLVTLAEAHGAWLVVDDAHGFGVLGPQGRGALAEYALRSEQLIY
EECEEEECCCCHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCHHHHHHHCCCCEEE
VGTLGKAAGVAGAFVIAHETVIEWMIQRARSYIFTTAAPPSVAHAVSASLAVIGGAEGDA
EECCCCHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCHHHHHHHHCEEEEECCCCCH
RRAHLAALIERTRAILRGTRWQPIDSATAVQPLVIGENDATLAAMRALDAHGLWVPAIRP
HHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEECCCCHHHHHHHHHCCCCEEECCCCC
PTVPAGTSRLRISLSAAHSFDDLARLDAALAAAGAAEAAA
CCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHCCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA