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The map label for this gene is bioA [H]

Identifier: 238028779

GI number: 238028779

Start: 3683648

End: 3684991

Strand: Direct

Name: bioA [H]

Synonym: bglu_1g32430

Alternate gene names: 238028779

Gene position: 3683648-3684991 (Clockwise)

Preceding gene: 238028778

Following gene: 238028780

Centisome position: 94.3

GC content: 72.99

Gene sequence:

>1344_bases
TTGAGCACACAACCCGACGACTGGGTTGCGCGCAGCCTGCGCGCAGTCTGGCATCCCTGTACGCAGATGAAGCACCACGA
GCGCCTGCCGCTCGTGCCCGTGGCGCGCGGCGCCGGCCCCTGGCTCTACGACCGCTCGGGCGCGCGCTACCTCGACGCGA
TCAGCTCGTGGTGGGTCAACCTGTTCGGCCATGCGAACCCGCGCATCAACGCCGCGCTGAAGACGCAGCTCGACACGCTC
GAGCACGCGATGCTGGCCGGCTGCACGCACGAGAGCGCGATCGAGCTGGCCGAGCGCCTGGCTGCGCTCACGCAGCACAC
GCTCGGCCACGCGTTCTTCGCCTCGGACGGCGCCTCGGCCGTCGAGATCGCGCTGAAGATGAGCTTCCACGCCTGGCGCA
ACGGCGGGCGCGCCGACAAGCGCGAGTTCGCCTGCGTGGCCAACGGCTATCACGGCGAGACCGTCGGCGCGCTCGGCGTG
ACCGACGTGGCGCTGTTCAAGGACGCCTACGATCCGCTGATCCGCCACGCCCATGTGGTGGCCTCGCCCGACGCGCGGCA
GGCCGCGCCCGGCGAGGGCGCGGCCGAGGTGGCCGCGCGCGCGCTGGCCGACGTCGAGCGGCTGTTCGCCGAACGCGCCG
GCGCGATCGCCGCGCTGATCGTCGAGCCGCTCGTGCAGTGCGCGGCCGGCATGGCGATGCACGACCCGTCGTACCTGAGC
GGGCTGCGCGCGCTGTGCGACCGCTACGAGGTCCACCTGATCGCCGACGAGATCGCCGTGGGCTGCGGGCGCACCGGCAC
CTTCTTCGCCTGCGAGCAGGCCAGCGTGTGGCCCGACTTCCTGTGCCTGTCGAAGGGCATCAGCGGCGGCTACCTGCCGC
TGTCGCTGGTGCTCTCGCGCGACGCGATCTACGCGGCCTTCTACGACGACGACACCACGCGCGGCTTCCTGCACTCGCAC
TCGTACACCGGCAACCCGCTGGCCTGCCGCGCCGCGCTCGCCACGCTCGACCTGTTCGCCGCCGACGACGTGCTGGCCGC
CAACGCGCGCAAGTCGGCGCGGCTGCGCGAGGCGCTCGCCCCGCTCGGCGCGCGCGACGAGGTGCGCCACCTGCGCGAGC
GCGGCACCATCTTCGCGTTCGACGTGGCGCTCGAGCCCGCGGCCGCGCGCGGCTTCTCGCGGCGCTTCTTCGAGCAGGGC
CTGCAGCGCGAGCTGCTGCTGCGCCCGATCGGCACCACCGTCTACCTGATGCCGCCCTACGTGCTCGACGACGACGAGAT
CGACTGGCTCGCCGCGCGCACGCGCGAGACGCTCGACGCCACGCTGGCCGAGGTGCGCGCATGA

Upstream 100 bases:

>100_bases
GCATCCGCTGCCGTTGCCGCCGCGTCCCGCCCGCGCGGACCGTTTCGTTTTCGTCCGGCCCGCCCGGCCCCGCCGCGCCG
CGTCCCGTTCCGGAGCTGTT

Downstream 100 bases:

>100_bases
GCCCGCCGCCGAACCTGCTGGCCGCGCTCGAACGCGGCCTGGCCGAGATCGACGCCCAGGGCCTGCGCCGCGTGCGCCGC
ACCGCCGACACCGCGTGCGG

Product: adenosylmethionine--8-amino-7-oxononanoate transaminase

Products: NA

Alternate protein names: 7,8-diamino-pelargonic acid aminotransferase; DAPA AT; DAPA aminotransferase; Diaminopelargonic acid synthase [H]

Number of amino acids: Translated: 447; Mature: 446

Protein sequence:

>447_residues
MSTQPDDWVARSLRAVWHPCTQMKHHERLPLVPVARGAGPWLYDRSGARYLDAISSWWVNLFGHANPRINAALKTQLDTL
EHAMLAGCTHESAIELAERLAALTQHTLGHAFFASDGASAVEIALKMSFHAWRNGGRADKREFACVANGYHGETVGALGV
TDVALFKDAYDPLIRHAHVVASPDARQAAPGEGAAEVAARALADVERLFAERAGAIAALIVEPLVQCAAGMAMHDPSYLS
GLRALCDRYEVHLIADEIAVGCGRTGTFFACEQASVWPDFLCLSKGISGGYLPLSLVLSRDAIYAAFYDDDTTRGFLHSH
SYTGNPLACRAALATLDLFAADDVLAANARKSARLREALAPLGARDEVRHLRERGTIFAFDVALEPAAARGFSRRFFEQG
LQRELLLRPIGTTVYLMPPYVLDDDEIDWLAARTRETLDATLAEVRA

Sequences:

>Translated_447_residues
MSTQPDDWVARSLRAVWHPCTQMKHHERLPLVPVARGAGPWLYDRSGARYLDAISSWWVNLFGHANPRINAALKTQLDTL
EHAMLAGCTHESAIELAERLAALTQHTLGHAFFASDGASAVEIALKMSFHAWRNGGRADKREFACVANGYHGETVGALGV
TDVALFKDAYDPLIRHAHVVASPDARQAAPGEGAAEVAARALADVERLFAERAGAIAALIVEPLVQCAAGMAMHDPSYLS
GLRALCDRYEVHLIADEIAVGCGRTGTFFACEQASVWPDFLCLSKGISGGYLPLSLVLSRDAIYAAFYDDDTTRGFLHSH
SYTGNPLACRAALATLDLFAADDVLAANARKSARLREALAPLGARDEVRHLRERGTIFAFDVALEPAAARGFSRRFFEQG
LQRELLLRPIGTTVYLMPPYVLDDDEIDWLAARTRETLDATLAEVRA
>Mature_446_residues
STQPDDWVARSLRAVWHPCTQMKHHERLPLVPVARGAGPWLYDRSGARYLDAISSWWVNLFGHANPRINAALKTQLDTLE
HAMLAGCTHESAIELAERLAALTQHTLGHAFFASDGASAVEIALKMSFHAWRNGGRADKREFACVANGYHGETVGALGVT
DVALFKDAYDPLIRHAHVVASPDARQAAPGEGAAEVAARALADVERLFAERAGAIAALIVEPLVQCAAGMAMHDPSYLSG
LRALCDRYEVHLIADEIAVGCGRTGTFFACEQASVWPDFLCLSKGISGGYLPLSLVLSRDAIYAAFYDDDTTRGFLHSHS
YTGNPLACRAALATLDLFAADDVLAANARKSARLREALAPLGARDEVRHLRERGTIFAFDVALEPAAARGFSRRFFEQGL
QRELLLRPIGTTVYLMPPYVLDDDEIDWLAARTRETLDATLAEVRA

Specific function: Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor [H]

COG id: COG0161

COG function: function code H; Adenosylmethionine-8-amino-7-oxononanoate aminotransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=413, Percent_Identity=31.2348668280872, Blast_Score=143, Evalue=3e-34,
Organism=Homo sapiens, GI284507298, Length=314, Percent_Identity=30.8917197452229, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI37574042, Length=423, Percent_Identity=24.113475177305, Blast_Score=105, Evalue=9e-23,
Organism=Homo sapiens, GI226442705, Length=423, Percent_Identity=24.113475177305, Blast_Score=100, Evalue=4e-21,
Organism=Homo sapiens, GI226442709, Length=392, Percent_Identity=23.9795918367347, Blast_Score=90, Evalue=4e-18,
Organism=Homo sapiens, GI24119277, Length=320, Percent_Identity=24.375, Blast_Score=85, Evalue=2e-16,
Organism=Escherichia coli, GI1786991, Length=442, Percent_Identity=38.2352941176471, Blast_Score=261, Evalue=9e-71,
Organism=Escherichia coli, GI145693181, Length=411, Percent_Identity=29.1970802919708, Blast_Score=172, Evalue=3e-44,
Organism=Escherichia coli, GI1789759, Length=400, Percent_Identity=28.25, Blast_Score=135, Evalue=4e-33,
Organism=Escherichia coli, GI1789016, Length=349, Percent_Identity=30.945558739255, Blast_Score=135, Evalue=7e-33,
Organism=Escherichia coli, GI1788044, Length=349, Percent_Identity=29.7994269340974, Blast_Score=120, Evalue=3e-28,
Organism=Escherichia coli, GI1787560, Length=433, Percent_Identity=29.0993071593533, Blast_Score=109, Evalue=4e-25,
Organism=Caenorhabditis elegans, GI25144271, Length=424, Percent_Identity=26.1792452830189, Blast_Score=122, Evalue=3e-28,
Organism=Caenorhabditis elegans, GI25144274, Length=246, Percent_Identity=30.0813008130081, Blast_Score=106, Evalue=3e-23,
Organism=Caenorhabditis elegans, GI32564660, Length=429, Percent_Identity=25.8741258741259, Blast_Score=104, Evalue=9e-23,
Organism=Caenorhabditis elegans, GI71992977, Length=375, Percent_Identity=23.2, Blast_Score=79, Evalue=4e-15,
Organism=Saccharomyces cerevisiae, GI6324386, Length=468, Percent_Identity=28.2051282051282, Blast_Score=201, Evalue=3e-52,
Organism=Saccharomyces cerevisiae, GI6324432, Length=419, Percent_Identity=26.2529832935561, Blast_Score=127, Evalue=3e-30,
Organism=Saccharomyces cerevisiae, GI6323470, Length=439, Percent_Identity=26.879271070615, Blast_Score=114, Evalue=3e-26,
Organism=Drosophila melanogaster, GI21357415, Length=420, Percent_Identity=27.8571428571429, Blast_Score=122, Evalue=7e-28,
Organism=Drosophila melanogaster, GI21356575, Length=310, Percent_Identity=24.8387096774194, Blast_Score=97, Evalue=3e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005814
- InterPro:   IPR005815
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.62 [H]

Molecular weight: Translated: 48687; Mature: 48555

Theoretical pI: Translated: 6.26; Mature: 6.26

Prosite motif: PS00436 PEROXIDASE_2 ; PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTQPDDWVARSLRAVWHPCTQMKHHERLPLVPVARGAGPWLYDRSGARYLDAISSWWVN
CCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCCCEECCCCCHHHHHHHHHHHH
LFGHANPRINAALKTQLDTLEHAMLAGCTHESAIELAERLAALTQHTLGHAFFASDGASA
HHCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHEECCCCCHH
VEIALKMSFHAWRNGGRADKREFACVANGYHGETVGALGVTDVALFKDAYDPLIRHAHVV
HHHHHHHHHHHHCCCCCCCCHHEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHEE
ASPDARQAAPGEGAAEVAARALADVERLFAERAGAIAALIVEPLVQCAAGMAMHDPSYLS
ECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHH
GLRALCDRYEVHLIADEIAVGCGRTGTFFACEQASVWPDFLCLSKGISGGYLPLSLVLSR
HHHHHHHHHHEEEEHHHHHHCCCCCCCEEEECCCCCCHHHHHHHCCCCCCCHHHHHHEEC
DAIYAAFYDDDTTRGFLHSHSYTGNPLACRAALATLDLFAADDVLAANARKSARLREALA
CEEEEEEECCCCCCCHHCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHCCHHHHHHHHHHC
PLGARDEVRHLRERGTIFAFDVALEPAAARGFSRRFFEQGLQRELLLRPIGTTVYLMPPY
CCCCHHHHHHHHHCCCEEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCE
VLDDDEIDWLAARTRETLDATLAEVRA
EECCCCCHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
STQPDDWVARSLRAVWHPCTQMKHHERLPLVPVARGAGPWLYDRSGARYLDAISSWWVN
CCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCCCEECCCCCHHHHHHHHHHHH
LFGHANPRINAALKTQLDTLEHAMLAGCTHESAIELAERLAALTQHTLGHAFFASDGASA
HHCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHEECCCCCHH
VEIALKMSFHAWRNGGRADKREFACVANGYHGETVGALGVTDVALFKDAYDPLIRHAHVV
HHHHHHHHHHHHCCCCCCCCHHEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHEE
ASPDARQAAPGEGAAEVAARALADVERLFAERAGAIAALIVEPLVQCAAGMAMHDPSYLS
ECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHH
GLRALCDRYEVHLIADEIAVGCGRTGTFFACEQASVWPDFLCLSKGISGGYLPLSLVLSR
HHHHHHHHHHEEEEHHHHHHCCCCCCCEEEECCCCCCHHHHHHHCCCCCCCHHHHHHEEC
DAIYAAFYDDDTTRGFLHSHSYTGNPLACRAALATLDLFAADDVLAANARKSARLREALA
CEEEEEEECCCCCCCHHCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHCCHHHHHHHHHHC
PLGARDEVRHLRERGTIFAFDVALEPAAARGFSRRFFEQGLQRELLLRPIGTTVYLMPPY
CCCCHHHHHHHHHCCCEEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCE
VLDDDEIDWLAARTRETLDATLAEVRA
EECCCCCHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2110099 [H]