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The map label for this gene is kynA [H]

Identifier: 238028476

GI number: 238028476

Start: 3327648

End: 3328553

Strand: Direct

Name: kynA [H]

Synonym: bglu_1g29400

Alternate gene names: 238028476

Gene position: 3327648-3328553 (Clockwise)

Preceding gene: 238028475

Following gene: 238028478

Centisome position: 85.18

GC content: 69.09

Gene sequence:

>906_bases
ATGAGTTCCCATCAACCGCAAGCGGGCGCGCCCGACGCCGCGCGCTGCCCGTTCTCGGGCGCCCCGGCCGCCGCACCGGA
CGGCCCCGAGGGCTGGCACGACGCGCAGCTCGACTTCTCGAAGTCGATGAGCTACGGCGATTACCTCTCGCTCGGCCCGA
TCCTCACGGCCCAGCATCCGCTCTCGCCCGATCACAACGAGATGCTGTTCATCATCCAGCATCAGACCAGCGAACTCTGG
ATGAAGCTCGCGCTCTACGAGCTGCGCGCCGCGCTCGCCTCGATCGGCAGCGACGCGCTGCCGCCCGCCTTCAAGATGCT
CGCGCGCGTCTCGCGCATCCTCGAGCAGCTGGTGCAGGCCTGGAACGTGCTGGCCACCATGACGCCGTCCGAGTACTCGG
CGATGCGGCCCTACCTGGGCGCGTCGTCGGGCTTCCAGTCGTACCAGTACCGGCAGCTCGAGTTCCTGCTCGGCAACAAG
AACGCGCAGATGCTCAAGCCGCACGCGCACCGGCCCGAGATCCTGGCCGAAGTGGAGGCCACGCTCGACGCGCCGTCGCT
GTACGACGAGGTGGTGCGCCTGCTCGCGCGGCGCGGCTTCCCGATCGCGGCCGAGCGGCTCGCGCGCGACTGGCGCGCGC
CGACCACGCACGACGTGTCGGTCGAGGCGGCCTGGCTCGCCGTCTACCGAGAGCCGTCGGCGCACTGGGATCTGTACGAG
ATGGCCGAGGAACTGGTCGATCTCGAGGATGCGTTTCGCCAGTGGCGCTTCCGCCACGTCACGACGGTCGAGCGCATCAT
CGGCTTCAAGCAGGGCACGGGCGGCACCAACGGCGCGCCCTACCTGCGCAAGATGCTCGACGTGGTGCTGTTTCCGGAAC
TCTGGCACGTGCGCACGACGCTGTGA

Upstream 100 bases:

>100_bases
GCCCGAATTCGCCGCGCGAACCGCCGTGACCTGAGCCGCGGCGCCGCATCGCCCGCCGAGCCGACCCGTTGCAACGAAAC
CAGCCGGAGAGTCCCCCATC

Downstream 100 bases:

>100_bases
GTGACAGCCGCGGCCCACGCGCCGGCCGCGGCTCGCTTTCCCTCTGCTTTCCTTGCCGCGCCGGCACGTCTCGCGCGGCG
CGGCTCAGCGCCGCCGTGCC

Product: Tryptophan 2,3-dioxygenase

Products: NA

Alternate protein names: TDO; Tryptamin 2,3-dioxygenase; Tryptophan oxygenase; TO; TRPO; Tryptophan pyrrolase; Tryptophanase [H]

Number of amino acids: Translated: 301; Mature: 300

Protein sequence:

>301_residues
MSSHQPQAGAPDAARCPFSGAPAAAPDGPEGWHDAQLDFSKSMSYGDYLSLGPILTAQHPLSPDHNEMLFIIQHQTSELW
MKLALYELRAALASIGSDALPPAFKMLARVSRILEQLVQAWNVLATMTPSEYSAMRPYLGASSGFQSYQYRQLEFLLGNK
NAQMLKPHAHRPEILAEVEATLDAPSLYDEVVRLLARRGFPIAAERLARDWRAPTTHDVSVEAAWLAVYREPSAHWDLYE
MAEELVDLEDAFRQWRFRHVTTVERIIGFKQGTGGTNGAPYLRKMLDVVLFPELWHVRTTL

Sequences:

>Translated_301_residues
MSSHQPQAGAPDAARCPFSGAPAAAPDGPEGWHDAQLDFSKSMSYGDYLSLGPILTAQHPLSPDHNEMLFIIQHQTSELW
MKLALYELRAALASIGSDALPPAFKMLARVSRILEQLVQAWNVLATMTPSEYSAMRPYLGASSGFQSYQYRQLEFLLGNK
NAQMLKPHAHRPEILAEVEATLDAPSLYDEVVRLLARRGFPIAAERLARDWRAPTTHDVSVEAAWLAVYREPSAHWDLYE
MAEELVDLEDAFRQWRFRHVTTVERIIGFKQGTGGTNGAPYLRKMLDVVLFPELWHVRTTL
>Mature_300_residues
SSHQPQAGAPDAARCPFSGAPAAAPDGPEGWHDAQLDFSKSMSYGDYLSLGPILTAQHPLSPDHNEMLFIIQHQTSELWM
KLALYELRAALASIGSDALPPAFKMLARVSRILEQLVQAWNVLATMTPSEYSAMRPYLGASSGFQSYQYRQLEFLLGNKN
AQMLKPHAHRPEILAEVEATLDAPSLYDEVVRLLARRGFPIAAERLARDWRAPTTHDVSVEAAWLAVYREPSAHWDLYEM
AEELVDLEDAFRQWRFRHVTTVERIIGFKQGTGGTNGAPYLRKMLDVVLFPELWHVRTTL

Specific function: Catalyzes the oxidative cleavage of the L-tryptophan (L- Trp) pyrrole ring [H]

COG id: COG3483

COG function: function code E; Tryptophan 2,3-dioxygenase (vermilion)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the tryptophan 2,3-dioxygenase family [H]

Homologues:

Organism=Homo sapiens, GI5032165, Length=163, Percent_Identity=34.3558282208589, Blast_Score=82, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI17552370, Length=369, Percent_Identity=25.4742547425474, Blast_Score=102, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI32564651, Length=175, Percent_Identity=31.4285714285714, Blast_Score=79, Evalue=4e-15,
Organism=Drosophila melanogaster, GI17530891, Length=360, Percent_Identity=27.7777777777778, Blast_Score=111, Evalue=5e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017485
- InterPro:   IPR004981 [H]

Pfam domain/function: PF03301 Trp_dioxygenase [H]

EC number: =1.13.11.11 [H]

Molecular weight: Translated: 33828; Mature: 33697

Theoretical pI: Translated: 6.13; Mature: 6.13

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSHQPQAGAPDAARCPFSGAPAAAPDGPEGWHDAQLDFSKSMSYGDYLSLGPILTAQHP
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCHHCCCCCCCCCC
LSPDHNEMLFIIQHQTSELWMKLALYELRAALASIGSDALPPAFKMLARVSRILEQLVQA
CCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHH
WNVLATMTPSEYSAMRPYLGASSGFQSYQYRQLEFLLGNKNAQMLKPHAHRPEILAEVEA
HHHHHHCCCHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCCCCHHCCCCCCCCHHHHHHHH
TLDAPSLYDEVVRLLARRGFPIAAERLARDWRAPTTHDVSVEAAWLAVYREPSAHWDLYE
HCCCHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCHHHEEHEEECCCCCCCCHHH
MAEELVDLEDAFRQWRFRHVTTVERIIGFKQGTGGTNGAPYLRKMLDVVLFPELWHVRTT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHC
L
C
>Mature Secondary Structure 
SSHQPQAGAPDAARCPFSGAPAAAPDGPEGWHDAQLDFSKSMSYGDYLSLGPILTAQHP
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCHHCCCCCCCCCC
LSPDHNEMLFIIQHQTSELWMKLALYELRAALASIGSDALPPAFKMLARVSRILEQLVQA
CCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHH
WNVLATMTPSEYSAMRPYLGASSGFQSYQYRQLEFLLGNKNAQMLKPHAHRPEILAEVEA
HHHHHHCCCHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCCCCHHCCCCCCCCHHHHHHHH
TLDAPSLYDEVVRLLARRGFPIAAERLARDWRAPTTHDVSVEAAWLAVYREPSAHWDLYE
HCCCHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCHHHEEHEEECCCCCCCCHHH
MAEELVDLEDAFRQWRFRHVTTVERIIGFKQGTGGTNGAPYLRKMLDVVLFPELWHVRTT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHC
L
C

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA