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The map label for this gene is kynU [H]

Identifier: 238028475

GI number: 238028475

Start: 3326331

End: 3327581

Strand: Direct

Name: kynU [H]

Synonym: bglu_1g29390

Alternate gene names: 238028475

Gene position: 3326331-3327581 (Clockwise)

Preceding gene: 238028474

Following gene: 238028476

Centisome position: 85.15

GC content: 71.46

Gene sequence:

>1251_bases
ATGAACTCACGTGAAGACGCACTCGCGCTCGATCGCGACGACCCCCTCGCCGCCCTGCGCGGCCGCTTCCTGCTGCCCGA
CGACACGATCTACCTCGACGGCAACTCGCTCGGCGCGCGGCCGGCCGCTGCAGCCGCGCGCGCGCAGGCCGTGATCGCCG
ACGAATGGGGCCGCGACCTGATCCGCAGCTGGAACACCGCGGGCTGGTTCGCACTGCCGCGCCGCCTCGGCGACCGCCTC
GCCCCGCTGATCGGCGCGGCGAGCGGCGAGGTGACGATCACCGACACGATCTCGGTGAACCTGTTCAAGCTGCTCTCGGC
GATGCTGCGCGAGCAGGCCAAGCGCGCGCCCGAACGCCGCGTGATCGTCTCCGAGCGCTCGAACTTCCCGACCGATCTCT
ACATCGCGCAGGGCCTCATCGCCCAGCTCGATCGCGGCTACACGCTGCGCCTCGTCGACGATCCGGCCGAACTCGAAGCG
GCGATCGACGCGCAGACGGCCGTGGCCATGATCACGCACGTGAACTACCGCACCGGCTACCTGCACGACATGCCGGCCGT
CACGCGCCACGCGCAGCAGGCCGGCGCGCTGATGCTGTGGGATCTCGCGCATTCGGCCGGCGCGGTGCCGGTCGACCTGA
ACGGCGCCGGCGCGGACGGCGCGGTCGGCTGCACCTACAAGTACCTGAACGGCGGCCCCGGCTCGCCGGCCTTCGTCTGG
GTGCCGCAGCGCCACCTCGCGCAGTTCGAGCAGCCGCTCTCGGGATGGTGGGGCCACCGCGCGCCGTTCGCGATGGAGCC
CGGCTTCGCGCCCGACGCCGGCATCGCGCGCTTCCAGTGCGGCACTCAGCCGATCGTCTCGATGGCGATGGTGGAGTGCG
GGCTCGACATCTTCCACGAGACCGACATGCAAACGATCCGCCGCAAGTCGCTCGCGCTCTCCGATGCCTTCATCGCGCTC
GTCGAGCGCCGCTGCGCCGGGCTCGACCTGACGCTCGTCACGCCGCGCGAGCATGCGCGACGCGGCTCGCAGGTCAGCTT
CGAGCACCCGCACGGCTACGAGGTGATGCGCGCGCTGATCGCGCGCGGCGTGATCGGCGACTACCGCGAGCCGCGCATCC
TGCGCTTCGGCTTCACGCCGCTCTACACGCGCTACGCGGATGTCTGGGACGCCGTGGAGGTGCTGCGCGAGATCCTCGAG
ACCCGGGCCTGGCAGGCGCCCGAATTCGCCGCGCGAACCGCCGTGACCTGA

Upstream 100 bases:

>100_bases
CGGCTCGGGCCGCAGATCGCCCCCGCTCCCGGTCATCCGCCTGCCGGCCGCGGCCGCCGGCCTGAATCAGGATTGGTTCT
TTCCTCACCCGGATTTCGCC

Downstream 100 bases:

>100_bases
GCCGCGGCGCCGCATCGCCCGCCGAGCCGACCCGTTGCAACGAAACCAGCCGGAGAGTCCCCCATCATGAGTTCCCATCA
ACCGCAAGCGGGCGCGCCCG

Product: Kynureninase

Products: NA

Alternate protein names: L-kynurenine hydrolase [H]

Number of amino acids: Translated: 416; Mature: 416

Protein sequence:

>416_residues
MNSREDALALDRDDPLAALRGRFLLPDDTIYLDGNSLGARPAAAAARAQAVIADEWGRDLIRSWNTAGWFALPRRLGDRL
APLIGAASGEVTITDTISVNLFKLLSAMLREQAKRAPERRVIVSERSNFPTDLYIAQGLIAQLDRGYTLRLVDDPAELEA
AIDAQTAVAMITHVNYRTGYLHDMPAVTRHAQQAGALMLWDLAHSAGAVPVDLNGAGADGAVGCTYKYLNGGPGSPAFVW
VPQRHLAQFEQPLSGWWGHRAPFAMEPGFAPDAGIARFQCGTQPIVSMAMVECGLDIFHETDMQTIRRKSLALSDAFIAL
VERRCAGLDLTLVTPREHARRGSQVSFEHPHGYEVMRALIARGVIGDYREPRILRFGFTPLYTRYADVWDAVEVLREILE
TRAWQAPEFAARTAVT

Sequences:

>Translated_416_residues
MNSREDALALDRDDPLAALRGRFLLPDDTIYLDGNSLGARPAAAAARAQAVIADEWGRDLIRSWNTAGWFALPRRLGDRL
APLIGAASGEVTITDTISVNLFKLLSAMLREQAKRAPERRVIVSERSNFPTDLYIAQGLIAQLDRGYTLRLVDDPAELEA
AIDAQTAVAMITHVNYRTGYLHDMPAVTRHAQQAGALMLWDLAHSAGAVPVDLNGAGADGAVGCTYKYLNGGPGSPAFVW
VPQRHLAQFEQPLSGWWGHRAPFAMEPGFAPDAGIARFQCGTQPIVSMAMVECGLDIFHETDMQTIRRKSLALSDAFIAL
VERRCAGLDLTLVTPREHARRGSQVSFEHPHGYEVMRALIARGVIGDYREPRILRFGFTPLYTRYADVWDAVEVLREILE
TRAWQAPEFAARTAVT
>Mature_416_residues
MNSREDALALDRDDPLAALRGRFLLPDDTIYLDGNSLGARPAAAAARAQAVIADEWGRDLIRSWNTAGWFALPRRLGDRL
APLIGAASGEVTITDTISVNLFKLLSAMLREQAKRAPERRVIVSERSNFPTDLYIAQGLIAQLDRGYTLRLVDDPAELEA
AIDAQTAVAMITHVNYRTGYLHDMPAVTRHAQQAGALMLWDLAHSAGAVPVDLNGAGADGAVGCTYKYLNGGPGSPAFVW
VPQRHLAQFEQPLSGWWGHRAPFAMEPGFAPDAGIARFQCGTQPIVSMAMVECGLDIFHETDMQTIRRKSLALSDAFIAL
VERRCAGLDLTLVTPREHARRGSQVSFEHPHGYEVMRALIARGVIGDYREPRILRFGFTPLYTRYADVWDAVEVLREILE
TRAWQAPEFAARTAVT

Specific function: Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively [H]

COG id: COG3844

COG function: function code E; Kynureninase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the kynureninase family [H]

Homologues:

Organism=Homo sapiens, GI4504937, Length=439, Percent_Identity=26.879271070615, Blast_Score=157, Evalue=2e-38,
Organism=Homo sapiens, GI74101437, Length=271, Percent_Identity=26.9372693726937, Blast_Score=92, Evalue=7e-19,
Organism=Caenorhabditis elegans, GI17550466, Length=406, Percent_Identity=27.8325123152709, Blast_Score=154, Evalue=8e-38,
Organism=Saccharomyces cerevisiae, GI6323261, Length=456, Percent_Identity=29.3859649122807, Blast_Score=152, Evalue=7e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000192
- InterPro:   IPR010111
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00266 Aminotran_5 [H]

EC number: =3.7.1.3 [H]

Molecular weight: Translated: 45786; Mature: 45786

Theoretical pI: Translated: 6.36; Mature: 6.36

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNSREDALALDRDDPLAALRGRFLLPDDTIYLDGNSLGARPAAAAARAQAVIADEWGRDL
CCCCCCCEEECCCCCHHHHCCCEECCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHH
IRSWNTAGWFALPRRLGDRLAPLIGAASGEVTITDTISVNLFKLLSAMLREQAKRAPERR
HHCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEEECHHHHHHHHHHHHHHHHHCCCCCE
VIVSERSNFPTDLYIAQGLIAQLDRGYTLRLVDDPAELEAAIDAQTAVAMITHVNYRTGY
EEEECCCCCCHHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHHHHHHCCCCCCC
LHDMPAVTRHAQQAGALMLWDLAHSAGAVPVDLNGAGADGAVGCTYKYLNGGPGSPAFVW
CCCCHHHHHHHHHCCCEEEEEHHHCCCCCEEECCCCCCCCCCEEEEEECCCCCCCCEEEE
VPQRHLAQFEQPLSGWWGHRAPFAMEPGFAPDAGIARFQCGTQPIVSMAMVECGLDIFHE
CCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEECCCHHHHHHHHHHHCHHHHHH
TDMQTIRRKSLALSDAFIALVERRCAGLDLTLVTPREHARRGSQVSFEHPHGYEVMRALI
HHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCHHHHCCCCCCCCCCCCCHHHHHHHH
ARGVIGDYREPRILRFGFTPLYTRYADVWDAVEVLREILETRAWQAPEFAARTAVT
HHHHHCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHCCCC
>Mature Secondary Structure
MNSREDALALDRDDPLAALRGRFLLPDDTIYLDGNSLGARPAAAAARAQAVIADEWGRDL
CCCCCCCEEECCCCCHHHHCCCEECCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHH
IRSWNTAGWFALPRRLGDRLAPLIGAASGEVTITDTISVNLFKLLSAMLREQAKRAPERR
HHCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEEECHHHHHHHHHHHHHHHHHCCCCCE
VIVSERSNFPTDLYIAQGLIAQLDRGYTLRLVDDPAELEAAIDAQTAVAMITHVNYRTGY
EEEECCCCCCHHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHHHHHHCCCCCCC
LHDMPAVTRHAQQAGALMLWDLAHSAGAVPVDLNGAGADGAVGCTYKYLNGGPGSPAFVW
CCCCHHHHHHHHHCCCEEEEEHHHCCCCCEEECCCCCCCCCCEEEEEECCCCCCCCEEEE
VPQRHLAQFEQPLSGWWGHRAPFAMEPGFAPDAGIARFQCGTQPIVSMAMVECGLDIFHE
CCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEECCCHHHHHHHHHHHCHHHHHH
TDMQTIRRKSLALSDAFIALVERRCAGLDLTLVTPREHARRGSQVSFEHPHGYEVMRALI
HHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCHHHHCCCCCCCCCCCCCHHHHHHHH
ARGVIGDYREPRILRFGFTPLYTRYADVWDAVEVLREILETRAWQAPEFAARTAVT
HHHHHCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA