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The map label for this gene is xdhB [H]

Identifier: 238026365

GI number: 238026365

Start: 754033

End: 755613

Strand: Direct

Name: xdhB [H]

Synonym: bglu_1g06990

Alternate gene names: 238026365

Gene position: 754033-755613 (Clockwise)

Preceding gene: 238026363

Following gene: 238026366

Centisome position: 19.3

GC content: 74.13

Gene sequence:

>1581_bases
ATGAGCCAACCGATCCGTTTCCATTTTCGCCAGGCAATCCGCGAAGTCGGCGGTGCCGCCACCACCCGCACCGTCCTGCA
GTACCTGCGCGAGGACGCCGCCTGCACCGGCACCAAGGAAGGCTGCGCCGAGGGCGACTGCGGGGCCTGCACGGTGGTGG
TCGGCGAGCTGAACGACGCCGGCCGCGTCGAGTTCAAGGCCGTCAACGCCTGCATCCAGTTCCTGCCCACGCTCGACGGC
CGCGCGCTCTACACCGTGGAGGACCTGCGCCAGCCCGACGGCTCGCTGCACCCCGTGCAGCAGGCGATGGTCGATTGCCA
CGGCTCGCAGTGCGGGTTTTGCACGCCGGGCTTCGTGATGTCGATGTGGGCGCTCTACGAGCGGCACGGCGGCGCGCACG
CGGCCGGCCCGTGCGATTCGGCTGCGCCGGCGGGCTCGCCCTGCGCGCGGGCCGCTGCGCCGTCGCGCGCCGAGATCGCC
GACGCGCTGACCGGCAACCTGTGCCGCTGCACCGGCTACCGGCCGATCGTCGACGCGGCCGAGCGGATGTTCGCGATGGC
GCCGCCCGCGGCGCCCGTCGATACCGCCGCGCTGGCCCGCACGCTCACCGCGCTGCGCCGCGACGACACGTTCCACTACG
AGCACGCCGGCCGCCGCTTCGACGCGCCGCGCAGCATCGAGGCGCTGGCCGCGCTGCGCGCCGCCAAGCCCGAGGCACGG
CTGCTGGCCGGCAGCACCGACGTGGGGCTGTGGGTCACCAAGCAGCTGCGCGAGCTCGGCGACCTGATCTACCTGGGCCA
GGTGGCCGAGCTGCGCCGCATCGACGAGCGCGACGGCTGGCTCGAGATCGGCGCGGGCGTGTCGGTCGAGCGCGCCTATG
CGGCGCTCGCCGCGCACTACCCCGAGCTGACCGAGATGTGGAAGCGCTTCGCCTCGCTGCCGATCCGCAACGCCGGCACG
CTCGGCGGCAACGTCGCGAACGGCTCGCCGATCGGCGATTCGATGCCGGGCCTGATCGCGCTCGGCGCGCGCGTGGTGCT
GCGCGGCCCCGAGGCGGCCCGCGAGCTGCCGCTCGAGGATCTCTACCTCGCGTACCAGAAGAAGGACATGGCCGCCGACG
AGTTCGTCGCCGCGCTGCGCGTGCCGCTGCGTACCGGCGCGCGCGCGAACCTGCGGTTTCGGACCTACAAGCTGTCGAAG
CGCTTCGACTCGGACATCTCGGCGGTCTGCGCCGCGTTCGCGTTCATCGCCGACGGCGAGGCGATCCGCACGCCGCGCGT
GGCGTTCGGCGGCATGGCGGCCACCCCGAAGCGCGCCGCGCAGGCGGAGGCGGCGCTGGCCGACGCGCGCTGGCACGAGG
TCACCGTGCAGGCCGCGATGCAGGCGGTCGAGCGCGATTTCGCGCCGCTCAGCGACATGCGCGCGACGAGCGGCTACCGG
CTCGACGCCGCGCGCAACCTGCTGTACCGCTTCTGGCTGGAGACCCGTGCGCACGCGCCGCTCGGGCCCGAGGCGCTGAA
CGTGCGCTGCGTGAGCGCCGAGGCGGCGGGGGCCGCCGGGCCCGCCGTCGCCGACCTTTGA

Upstream 100 bases:

>100_bases
GCGATGATAGCTTGCGACCTATTGACTCAGACCACGGCGCGAATGCCGGGCAACGGCCGCCGCGCCTGCGCCTCGCCGCG
TGCCCCGACCCACGATACCC

Downstream 100 bases:

>100_bases
CCGAACCGGAACACGAAAGACCCGCGCCATGAACCAGCAAGCCGAACCGTTCCTGAATGACCTCGATTTCCGGCAGGTGC
ACGTCTCGCGTCCGCACGAA

Product: FAD-binding molybdopterin dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 526; Mature: 525

Protein sequence:

>526_residues
MSQPIRFHFRQAIREVGGAATTRTVLQYLREDAACTGTKEGCAEGDCGACTVVVGELNDAGRVEFKAVNACIQFLPTLDG
RALYTVEDLRQPDGSLHPVQQAMVDCHGSQCGFCTPGFVMSMWALYERHGGAHAAGPCDSAAPAGSPCARAAAPSRAEIA
DALTGNLCRCTGYRPIVDAAERMFAMAPPAAPVDTAALARTLTALRRDDTFHYEHAGRRFDAPRSIEALAALRAAKPEAR
LLAGSTDVGLWVTKQLRELGDLIYLGQVAELRRIDERDGWLEIGAGVSVERAYAALAAHYPELTEMWKRFASLPIRNAGT
LGGNVANGSPIGDSMPGLIALGARVVLRGPEAARELPLEDLYLAYQKKDMAADEFVAALRVPLRTGARANLRFRTYKLSK
RFDSDISAVCAAFAFIADGEAIRTPRVAFGGMAATPKRAAQAEAALADARWHEVTVQAAMQAVERDFAPLSDMRATSGYR
LDAARNLLYRFWLETRAHAPLGPEALNVRCVSAEAAGAAGPAVADL

Sequences:

>Translated_526_residues
MSQPIRFHFRQAIREVGGAATTRTVLQYLREDAACTGTKEGCAEGDCGACTVVVGELNDAGRVEFKAVNACIQFLPTLDG
RALYTVEDLRQPDGSLHPVQQAMVDCHGSQCGFCTPGFVMSMWALYERHGGAHAAGPCDSAAPAGSPCARAAAPSRAEIA
DALTGNLCRCTGYRPIVDAAERMFAMAPPAAPVDTAALARTLTALRRDDTFHYEHAGRRFDAPRSIEALAALRAAKPEAR
LLAGSTDVGLWVTKQLRELGDLIYLGQVAELRRIDERDGWLEIGAGVSVERAYAALAAHYPELTEMWKRFASLPIRNAGT
LGGNVANGSPIGDSMPGLIALGARVVLRGPEAARELPLEDLYLAYQKKDMAADEFVAALRVPLRTGARANLRFRTYKLSK
RFDSDISAVCAAFAFIADGEAIRTPRVAFGGMAATPKRAAQAEAALADARWHEVTVQAAMQAVERDFAPLSDMRATSGYR
LDAARNLLYRFWLETRAHAPLGPEALNVRCVSAEAAGAAGPAVADL
>Mature_525_residues
SQPIRFHFRQAIREVGGAATTRTVLQYLREDAACTGTKEGCAEGDCGACTVVVGELNDAGRVEFKAVNACIQFLPTLDGR
ALYTVEDLRQPDGSLHPVQQAMVDCHGSQCGFCTPGFVMSMWALYERHGGAHAAGPCDSAAPAGSPCARAAAPSRAEIAD
ALTGNLCRCTGYRPIVDAAERMFAMAPPAAPVDTAALARTLTALRRDDTFHYEHAGRRFDAPRSIEALAALRAAKPEARL
LAGSTDVGLWVTKQLRELGDLIYLGQVAELRRIDERDGWLEIGAGVSVERAYAALAAHYPELTEMWKRFASLPIRNAGTL
GGNVANGSPIGDSMPGLIALGARVVLRGPEAARELPLEDLYLAYQKKDMAADEFVAALRVPLRTGARANLRFRTYKLSKR
FDSDISAVCAAFAFIADGEAIRTPRVAFGGMAATPKRAAQAEAALADARWHEVTVQAAMQAVERDFAPLSDMRATSGYRL
DAARNLLYRFWLETRAHAPLGPEALNVRCVSAEAAGAAGPAVADL

Specific function: Presumed to be a dehydrogenase, but possibly an oxidase. Participates in limited purine salvage (requires aspartate) but does not support aerobic growth on purines as the sole carbon source (purine catabolism) [H]

COG id: COG4630

COG function: function code F; Xanthine dehydrogenase, iron-sulfur cluster and FAD-binding subunit A

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FAD-binding PCMH-type domain [H]

Homologues:

Organism=Homo sapiens, GI91823271, Length=544, Percent_Identity=25.7352941176471, Blast_Score=146, Evalue=5e-35,
Organism=Homo sapiens, GI71773480, Length=496, Percent_Identity=24.3951612903226, Blast_Score=136, Evalue=6e-32,
Organism=Escherichia coli, GI1789231, Length=267, Percent_Identity=29.2134831460674, Blast_Score=100, Evalue=4e-22,
Organism=Escherichia coli, GI1786480, Length=163, Percent_Identity=35.5828220858896, Blast_Score=88, Evalue=1e-18,
Organism=Escherichia coli, GI1789232, Length=159, Percent_Identity=33.3333333333333, Blast_Score=78, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17540638, Length=157, Percent_Identity=40.1273885350318, Blast_Score=122, Evalue=4e-28,
Organism=Caenorhabditis elegans, GI17539860, Length=360, Percent_Identity=27.5, Blast_Score=114, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI32566215, Length=157, Percent_Identity=39.4904458598726, Blast_Score=111, Evalue=9e-25,
Organism=Drosophila melanogaster, GI17737937, Length=494, Percent_Identity=30.7692307692308, Blast_Score=191, Evalue=1e-48,
Organism=Drosophila melanogaster, GI24647199, Length=515, Percent_Identity=28.1553398058252, Blast_Score=160, Evalue=2e-39,
Organism=Drosophila melanogaster, GI24647201, Length=515, Percent_Identity=26.4077669902913, Blast_Score=154, Evalue=2e-37,
Organism=Drosophila melanogaster, GI24647197, Length=504, Percent_Identity=27.3809523809524, Blast_Score=150, Evalue=2e-36,
Organism=Drosophila melanogaster, GI24647193, Length=519, Percent_Identity=26.9749518304432, Blast_Score=141, Evalue=1e-33,
Organism=Drosophila melanogaster, GI24647195, Length=324, Percent_Identity=30.2469135802469, Blast_Score=141, Evalue=1e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005107
- InterPro:   IPR016169
- InterPro:   IPR016166
- InterPro:   IPR016167
- InterPro:   IPR002346 [H]

Pfam domain/function: PF03450 CO_deh_flav_C; PF00941 FAD_binding_5 [H]

EC number: =1.17.1.4 [H]

Molecular weight: Translated: 56315; Mature: 56183

Theoretical pI: Translated: 7.00; Mature: 7.00

Prosite motif: PS00197 2FE2S_FER_1 ; PS51085 2FE2S_FER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.7 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQPIRFHFRQAIREVGGAATTRTVLQYLREDAACTGTKEGCAEGDCGACTVVVGELNDA
CCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEEECCCCC
GRVEFKAVNACIQFLPTLDGRALYTVEDLRQPDGSLHPVQQAMVDCHGSQCGFCTPGFVM
CCCHHHHHHHHHHHHCCCCCCEEEEHHHHHCCCCCCCHHHHHHHHHCCCCCCCCCHHHHH
SMWALYERHGGAHAAGPCDSAAPAGSPCARAAAPSRAEIADALTGNLCRCTGYRPIVDAA
HHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHCCCCHHHHHHHHHCCCEEECCCCHHHHHH
ERMFAMAPPAAPVDTAALARTLTALRRDDTFHYEHAGRRFDAPRSIEALAALRAAKPEAR
HHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHCCCCCCCCHHHHHHHHHHHCCCCHH
LLAGSTDVGLWVTKQLRELGDLIYLGQVAELRRIDERDGWLEIGAGVSVERAYAALAAHY
EEECCCCCHHHHHHHHHHHHHEEHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHCC
PELTEMWKRFASLPIRNAGTLGGNVANGSPIGDSMPGLIALGARVVLRGPEAARELPLED
HHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHCCEEEEECCHHHHHCCHHH
LYLAYQKKDMAADEFVAALRVPLRTGARANLRFRTYKLSKRFDSDISAVCAAFAFIADGE
HHHHHHHHCCCHHHHHHHHHHHHHCCCCCCEEEEEEEHHHHHCCHHHHHHHHHHHHCCCC
AIRTPRVAFGGMAATPKRAAQAEAALADARWHEVTVQAAMQAVERDFAPLSDMRATSGYR
HHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCC
LDAARNLLYRFWLETRAHAPLGPEALNVRCVSAEAAGAAGPAVADL
HHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCCCCCCHHCCC
>Mature Secondary Structure 
SQPIRFHFRQAIREVGGAATTRTVLQYLREDAACTGTKEGCAEGDCGACTVVVGELNDA
CCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEEECCCCC
GRVEFKAVNACIQFLPTLDGRALYTVEDLRQPDGSLHPVQQAMVDCHGSQCGFCTPGFVM
CCCHHHHHHHHHHHHCCCCCCEEEEHHHHHCCCCCCCHHHHHHHHHCCCCCCCCCHHHHH
SMWALYERHGGAHAAGPCDSAAPAGSPCARAAAPSRAEIADALTGNLCRCTGYRPIVDAA
HHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHCCCCHHHHHHHHHCCCEEECCCCHHHHHH
ERMFAMAPPAAPVDTAALARTLTALRRDDTFHYEHAGRRFDAPRSIEALAALRAAKPEAR
HHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHCCCCCCCCHHHHHHHHHHHCCCCHH
LLAGSTDVGLWVTKQLRELGDLIYLGQVAELRRIDERDGWLEIGAGVSVERAYAALAAHY
EEECCCCCHHHHHHHHHHHHHEEHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHCC
PELTEMWKRFASLPIRNAGTLGGNVANGSPIGDSMPGLIALGARVVLRGPEAARELPLED
HHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHCCEEEEECCHHHHHCCHHH
LYLAYQKKDMAADEFVAALRVPLRTGARANLRFRTYKLSKRFDSDISAVCAAFAFIADGE
HHHHHHHHCCCHHHHHHHHHHHHHCCCCCCEEEEEEEHHHHHCCHHHHHHHHHHHHCCCC
AIRTPRVAFGGMAATPKRAAQAEAALADARWHEVTVQAAMQAVERDFAPLSDMRATSGYR
HHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCC
LDAARNLLYRFWLETRAHAPLGPEALNVRCVSAEAAGAAGPAVADL
HHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCCCCCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]