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The map label for this gene is mutL [H]

Identifier: 238026311

GI number: 238026311

Start: 687112

End: 689223

Strand: Reverse

Name: mutL [H]

Synonym: bglu_1g06450

Alternate gene names: 238026311

Gene position: 689223-687112 (Counterclockwise)

Preceding gene: 238026313

Following gene: 238026310

Centisome position: 17.64

GC content: 73.44

Gene sequence:

>2112_bases
ATGTCCGAATTTACCGATTCCACCGATTCCACCGGTGCCGACGCCGCCGCGAGCGCCGCCGTCCCCGCGGCCGGCCCGCG
CCCGCTGCGCGCGATCCAGCCGCTGCCCGACCAGTTGATCAGCCAGATCGCGGCCGGCGAGGTGGTCGAGCGCCCGGCAT
CCGTCGTCAAGGAGTTGCTCGAGAACGCGCTCGACGCGGGCGCCACCACGCTGCGCATCGCACTCGACGAGGGCGGCGTC
AAGCGCATCTCGATCACCGACGACGGCTGCGGCATCCCCGCCGACGAGCTGCCGCTCGCGCTGATGCGCCACGCCACCAG
CAAGATCCGCTCGCTCGTCGAGCTCGAGTCGGTAGCCACGCTCGGCTTTCGCGGCGAGGCGCTGGCCTCGATCGCCTCGG
TCTCCGAGCTGGCGATCACGAGCCGCACCGAGCAGGCGCCGCACGCCACGCGCATCGACGCCGACACCGGCGCGCTGTCG
CCCGCGGCCGGCACGCGCGGCACCACCATCGAGGTGCGCGAGCTGTACTTCAACACGCCTGCGCGCCGCAAGTTCCTGAA
GAGCGAGCAGACCGAATTCGGCCACTGCCTCGAGATGATCCGCCGCGTGGCGCTGGCACGCCCCGACGTGGCGATCTCGG
TGCTGCACAACGGCCGGGCCGTCGAGCACTGGAACGCGAGCGAGCCGGCCGTGCGCGTCGCGAAGATCCTCGGCGAGGGC
TTCGCCACCGCGCACCTGCCGCTCGACGAGCAGGCCGGGCCGCTCGCCGTGTACGGCTGCGCGGGCCTGCCCACCGCGAG
CCGCGGCCGCGCCGACCAGCAATACTTCTTCGTCAACGGCCGCTTCGTGCGCGACAAGCTGCTCACGCACGCGGTGCGCG
CCGCCTACGAGGACGTGCTGCACGGCGACCGCTACCCGTCCTACGTGCTGTTTCTCGACCTGCCGCCCGAGGCCGTCGAC
GTGAACGTCCATCCGTCGAAGATCGAGGTGCGGTTTCGCGATTCACGCTCGATCCACCAGTACGTGTTCCACGCGGTGCA
GCGCGCGCTCGCGCGGCACGCGGGGGCCTCGCCCGGGACCACGGCGGGCGGCCACGCCGCGCATCTGGCACCGGCCGGCG
AGAGCGCCGCGCCAGAACGTGCCCCGGCCGGGTCCGCCGGCCAAGCCGGCGACCACGCGGCACGCGCCGACGGCGTGAGC
GGCTCCGGCTTGGCCGATGGCGCCGGCAGCGCGACGTCCTCGGGCCCGGCGGGCGGCTTCGGCCGCGCCTCGGGCGGCTT
CGGCTCGGCCGCCGGCAGCAGCAGCAGCGGTGGATTCGGTGGCGGCGGTGCGGCGCGCTCGGGCGCGGGCAACACCTGGA
CGCGCCATTCACGCATGACGCAGGGCACGCTGCCGGTCGCGCAGCCGCTGGCGCTCTACGACGCGTCGCCCGGGCGCAAG
GCAGCCGGCGGCGAAGCGACCGGCACGGCCGAGCCGGCGCCGTTCGGCGCCACACCCGGCACGCTGCCGGCCGACGCCGG
GCACGACGCGCAGCCGCTCGGCTTCGCGCTCGGCCAGGTCCACGGCATCTACGTGCTCGCGCAGAACGCGCAGGGCCTCG
TGATCGTCGACATGCACGCCGCGCACGAACGCATCCTCTACGAGCAGTTCAAGACCGCGCTCGCGAACCGCGCGATCGCG
GTGCAGTCGCTGCTGCTGCCGGTGACGATGGCGGCCACGCCGGTCGAGATCGGTACCGCCGAGGAGGAACGCGAGACGCT
CGACGCGCTCGGCTTCGACCTGGCCACGCTCTCGCCCACCACCCTCGCGATCCGCGCGGTGCCCGCACTGCTGCGCGATG
CCGACCTGCCGACGCTGGCGCGAGCGGTGCTGGCCGACCTGCACGAATTCGGCGGCTCGCGCGTGCTGACCGAGCGCCAG
CACGAACTGCTCGGCACGCTGGCCTGCCATCATGCGGTGCGTGCCAACCGGCGCCTGACGCTCGACGAGATGAACGCGCT
GCTGCGCCAGATGGAGGCCACCGAGCGCGCCGACCAGTGCAACCACGGCCGGCCGACCTGGTACCAGCTCACGCTCGGCG
ATCTCGACCGCCTGTTCATGCGCGGCCAATGA

Upstream 100 bases:

>100_bases
TGATACCGAAGGAAGCCCGGGCGCCCGTGGATGCACTTGAAAAAAATTGTGTCCGCGCCCGGCGCCGGTGCCGGCTCGGC
GGCGTCGTTATAATTCCCGC

Downstream 100 bases:

>100_bases
GCGGCGCACCCGAATCGCCCCGCGTCACCGTCGCCTGCCTGCTCGGCCCCACCGCCTCGGGCAAGACCGCCGCGGCGCTG
GCGCTGGCCGAGCGGCGGCC

Product: DNA mismatch repair protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 703; Mature: 702

Protein sequence:

>703_residues
MSEFTDSTDSTGADAAASAAVPAAGPRPLRAIQPLPDQLISQIAAGEVVERPASVVKELLENALDAGATTLRIALDEGGV
KRISITDDGCGIPADELPLALMRHATSKIRSLVELESVATLGFRGEALASIASVSELAITSRTEQAPHATRIDADTGALS
PAAGTRGTTIEVRELYFNTPARRKFLKSEQTEFGHCLEMIRRVALARPDVAISVLHNGRAVEHWNASEPAVRVAKILGEG
FATAHLPLDEQAGPLAVYGCAGLPTASRGRADQQYFFVNGRFVRDKLLTHAVRAAYEDVLHGDRYPSYVLFLDLPPEAVD
VNVHPSKIEVRFRDSRSIHQYVFHAVQRALARHAGASPGTTAGGHAAHLAPAGESAAPERAPAGSAGQAGDHAARADGVS
GSGLADGAGSATSSGPAGGFGRASGGFGSAAGSSSSGGFGGGGAARSGAGNTWTRHSRMTQGTLPVAQPLALYDASPGRK
AAGGEATGTAEPAPFGATPGTLPADAGHDAQPLGFALGQVHGIYVLAQNAQGLVIVDMHAAHERILYEQFKTALANRAIA
VQSLLLPVTMAATPVEIGTAEEERETLDALGFDLATLSPTTLAIRAVPALLRDADLPTLARAVLADLHEFGGSRVLTERQ
HELLGTLACHHAVRANRRLTLDEMNALLRQMEATERADQCNHGRPTWYQLTLGDLDRLFMRGQ

Sequences:

>Translated_703_residues
MSEFTDSTDSTGADAAASAAVPAAGPRPLRAIQPLPDQLISQIAAGEVVERPASVVKELLENALDAGATTLRIALDEGGV
KRISITDDGCGIPADELPLALMRHATSKIRSLVELESVATLGFRGEALASIASVSELAITSRTEQAPHATRIDADTGALS
PAAGTRGTTIEVRELYFNTPARRKFLKSEQTEFGHCLEMIRRVALARPDVAISVLHNGRAVEHWNASEPAVRVAKILGEG
FATAHLPLDEQAGPLAVYGCAGLPTASRGRADQQYFFVNGRFVRDKLLTHAVRAAYEDVLHGDRYPSYVLFLDLPPEAVD
VNVHPSKIEVRFRDSRSIHQYVFHAVQRALARHAGASPGTTAGGHAAHLAPAGESAAPERAPAGSAGQAGDHAARADGVS
GSGLADGAGSATSSGPAGGFGRASGGFGSAAGSSSSGGFGGGGAARSGAGNTWTRHSRMTQGTLPVAQPLALYDASPGRK
AAGGEATGTAEPAPFGATPGTLPADAGHDAQPLGFALGQVHGIYVLAQNAQGLVIVDMHAAHERILYEQFKTALANRAIA
VQSLLLPVTMAATPVEIGTAEEERETLDALGFDLATLSPTTLAIRAVPALLRDADLPTLARAVLADLHEFGGSRVLTERQ
HELLGTLACHHAVRANRRLTLDEMNALLRQMEATERADQCNHGRPTWYQLTLGDLDRLFMRGQ
>Mature_702_residues
SEFTDSTDSTGADAAASAAVPAAGPRPLRAIQPLPDQLISQIAAGEVVERPASVVKELLENALDAGATTLRIALDEGGVK
RISITDDGCGIPADELPLALMRHATSKIRSLVELESVATLGFRGEALASIASVSELAITSRTEQAPHATRIDADTGALSP
AAGTRGTTIEVRELYFNTPARRKFLKSEQTEFGHCLEMIRRVALARPDVAISVLHNGRAVEHWNASEPAVRVAKILGEGF
ATAHLPLDEQAGPLAVYGCAGLPTASRGRADQQYFFVNGRFVRDKLLTHAVRAAYEDVLHGDRYPSYVLFLDLPPEAVDV
NVHPSKIEVRFRDSRSIHQYVFHAVQRALARHAGASPGTTAGGHAAHLAPAGESAAPERAPAGSAGQAGDHAARADGVSG
SGLADGAGSATSSGPAGGFGRASGGFGSAAGSSSSGGFGGGGAARSGAGNTWTRHSRMTQGTLPVAQPLALYDASPGRKA
AGGEATGTAEPAPFGATPGTLPADAGHDAQPLGFALGQVHGIYVLAQNAQGLVIVDMHAAHERILYEQFKTALANRAIAV
QSLLLPVTMAATPVEIGTAEEERETLDALGFDLATLSPTTLAIRAVPALLRDADLPTLARAVLADLHEFGGSRVLTERQH
ELLGTLACHHAVRANRRLTLDEMNALLRQMEATERADQCNHGRPTWYQLTLGDLDRLFMRGQ

Specific function: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a "molecular matchmaker", a protein that promotes the formation of a stable complex between two or more DNA-bindi

COG id: COG0323

COG function: function code L; DNA mismatch repair enzyme (predicted ATPase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DNA mismatch repair mutL/hexB family [H]

Homologues:

Organism=Homo sapiens, GI4557757, Length=330, Percent_Identity=34.8484848484849, Blast_Score=189, Evalue=1e-47,
Organism=Homo sapiens, GI189458898, Length=351, Percent_Identity=28.7749287749288, Blast_Score=149, Evalue=1e-35,
Organism=Homo sapiens, GI4505911, Length=463, Percent_Identity=25.4859611231102, Blast_Score=149, Evalue=1e-35,
Organism=Homo sapiens, GI189458896, Length=453, Percent_Identity=26.4900662251656, Blast_Score=142, Evalue=2e-33,
Organism=Homo sapiens, GI310128478, Length=345, Percent_Identity=26.6666666666667, Blast_Score=141, Evalue=2e-33,
Organism=Homo sapiens, GI4505913, Length=345, Percent_Identity=26.6666666666667, Blast_Score=141, Evalue=2e-33,
Organism=Homo sapiens, GI310128480, Length=300, Percent_Identity=24.3333333333333, Blast_Score=100, Evalue=5e-21,
Organism=Homo sapiens, GI263191589, Length=235, Percent_Identity=31.063829787234, Blast_Score=97, Evalue=4e-20,
Organism=Homo sapiens, GI91992160, Length=268, Percent_Identity=26.1194029850746, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI91992162, Length=268, Percent_Identity=25.7462686567164, Blast_Score=72, Evalue=1e-12,
Organism=Escherichia coli, GI1790612, Length=331, Percent_Identity=51.3595166163142, Blast_Score=317, Evalue=1e-87,
Organism=Caenorhabditis elegans, GI71991825, Length=320, Percent_Identity=33.75, Blast_Score=158, Evalue=9e-39,
Organism=Caenorhabditis elegans, GI17562796, Length=364, Percent_Identity=25.8241758241758, Blast_Score=135, Evalue=7e-32,
Organism=Saccharomyces cerevisiae, GI6323819, Length=364, Percent_Identity=31.043956043956, Blast_Score=179, Evalue=1e-45,
Organism=Saccharomyces cerevisiae, GI6324247, Length=468, Percent_Identity=23.0769230769231, Blast_Score=126, Evalue=1e-29,
Organism=Saccharomyces cerevisiae, GI6325093, Length=697, Percent_Identity=20.2295552367288, Blast_Score=88, Evalue=4e-18,
Organism=Saccharomyces cerevisiae, GI6323063, Length=366, Percent_Identity=22.9508196721311, Blast_Score=71, Evalue=5e-13,
Organism=Drosophila melanogaster, GI17136968, Length=320, Percent_Identity=33.4375, Blast_Score=170, Evalue=3e-42,
Organism=Drosophila melanogaster, GI17136970, Length=348, Percent_Identity=27.0114942528736, Blast_Score=106, Evalue=4e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR002099
- InterPro:   IPR013507
- InterPro:   IPR014762
- InterPro:   IPR020667
- InterPro:   IPR014763
- InterPro:   IPR014790
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF01119 DNA_mis_repair; PF02518 HATPase_c; PF08676 MutL_C [H]

EC number: NA

Molecular weight: Translated: 73450; Mature: 73319

Theoretical pI: Translated: 6.41; Mature: 6.41

Prosite motif: PS00058 DNA_MISMATCH_REPAIR_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEFTDSTDSTGADAAASAAVPAAGPRPLRAIQPLPDQLISQIAAGEVVERPASVVKELL
CCCCCCCCCCCCCCHHHHCCCCCCCCCCCHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
ENALDAGATTLRIALDEGGVKRISITDDGCGIPADELPLALMRHATSKIRSLVELESVAT
HHHHCCCCEEEEEEECCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
LGFRGEALASIASVSELAITSRTEQAPHATRIDADTGALSPAAGTRGTTIEVRELYFNTP
CCCCHHHHHHHHHHHHHHHHCCCCCCCCCEEECCCCCCCCCCCCCCCCEEEEHHHHHCCH
ARRKFLKSEQTEFGHCLEMIRRVALARPDVAISVLHNGRAVEHWNASEPAVRVAKILGEG
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCEEECCCCCCHHHHHHHHHHCC
FATAHLPLDEQAGPLAVYGCAGLPTASRGRADQQYFFVNGRFVRDKLLTHAVRAAYEDVL
CCEEECCCCCCCCCEEEEECCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHH
HGDRYPSYVLFLDLPPEAVDVNVHPSKIEVRFRDSRSIHQYVFHAVQRALARHAGASPGT
CCCCCCCEEEEEECCCCEEEEEECCCEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCC
TAGGHAAHLAPAGESAAPERAPAGSAGQAGDHAARADGVSGSGLADGAGSATSSGPAGGF
CCCCCCEEECCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCCCCCCCCCCCCCCCCCCC
GRASGGFGSAAGSSSSGGFGGGGAARSGAGNTWTRHSRMTQGTLPVAQPLALYDASPGRK
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCCCCCCCHHEECCCCCCC
AAGGEATGTAEPAPFGATPGTLPADAGHDAQPLGFALGQVHGIYVLAQNAQGLVIVDMHA
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCEEEEEEECCCCEEEEECHH
AHERILYEQFKTALANRAIAVQSLLLPVTMAATPVEIGTAEEERETLDALGFDLATLSPT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCHHHCCCH
TLAIRAVPALLRDADLPTLARAVLADLHEFGGSRVLTERQHELLGTLACHHAVRANRRLT
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCC
LDEMNALLRQMEATERADQCNHGRPTWYQLTLGDLDRLFMRGQ
HHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEHHHHHHHHHCCC
>Mature Secondary Structure 
SEFTDSTDSTGADAAASAAVPAAGPRPLRAIQPLPDQLISQIAAGEVVERPASVVKELL
CCCCCCCCCCCCCHHHHCCCCCCCCCCCHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
ENALDAGATTLRIALDEGGVKRISITDDGCGIPADELPLALMRHATSKIRSLVELESVAT
HHHHCCCCEEEEEEECCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
LGFRGEALASIASVSELAITSRTEQAPHATRIDADTGALSPAAGTRGTTIEVRELYFNTP
CCCCHHHHHHHHHHHHHHHHCCCCCCCCCEEECCCCCCCCCCCCCCCCEEEEHHHHHCCH
ARRKFLKSEQTEFGHCLEMIRRVALARPDVAISVLHNGRAVEHWNASEPAVRVAKILGEG
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCEEECCCCCCHHHHHHHHHHCC
FATAHLPLDEQAGPLAVYGCAGLPTASRGRADQQYFFVNGRFVRDKLLTHAVRAAYEDVL
CCEEECCCCCCCCCEEEEECCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHH
HGDRYPSYVLFLDLPPEAVDVNVHPSKIEVRFRDSRSIHQYVFHAVQRALARHAGASPGT
CCCCCCCEEEEEECCCCEEEEEECCCEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCC
TAGGHAAHLAPAGESAAPERAPAGSAGQAGDHAARADGVSGSGLADGAGSATSSGPAGGF
CCCCCCEEECCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCCCCCCCCCCCCCCCCCCC
GRASGGFGSAAGSSSSGGFGGGGAARSGAGNTWTRHSRMTQGTLPVAQPLALYDASPGRK
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCCCCCCCHHEECCCCCCC
AAGGEATGTAEPAPFGATPGTLPADAGHDAQPLGFALGQVHGIYVLAQNAQGLVIVDMHA
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCEEEEEEECCCCEEEEECHH
AHERILYEQFKTALANRAIAVQSLLLPVTMAATPVEIGTAEEERETLDALGFDLATLSPT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCHHHCCCH
TLAIRAVPALLRDADLPTLARAVLADLHEFGGSRVLTERQHELLGTLACHHAVRANRRLT
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCC
LDEMNALLRQMEATERADQCNHGRPTWYQLTLGDLDRLFMRGQ
HHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12910271 [H]