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The map label for this gene is mscS [H]

Identifier: 238026313

GI number: 238026313

Start: 690168

End: 690983

Strand: Reverse

Name: mscS [H]

Synonym: bglu_1g06470

Alternate gene names: 238026313

Gene position: 690983-690168 (Counterclockwise)

Preceding gene: 238026314

Following gene: 238026311

Centisome position: 17.69

GC content: 68.26

Gene sequence:

>816_bases
ATGGTGGAACTCGCTACCGCCCAACAATTCCTGATGACCCGTGGCCTCGATTTCGGCCTCAAGGTGCTCGCCGCGATCGC
GCTATGGATCGTCGGCCGCTGGCTGATCCGCCTTTCCACGCGGCTGCTCGGCCGGCTCGTGCAGCGCAGCGGGCGCGTCG
ACACCACGCTCGCCTACTACCTGTCGTCGGTGGTCAGCGTGCTGCTGACCATCGTGCTGATCCTCGCGATCCTGCAGGTG
TTCGGCGTGCAGACCACCTCGTTCGCGGCACTGCTGGCCGGCATCGGCCTCGCGGTCGGCACCGCCTGGGGCGGCCTGCT
CGCGCACTTCGCGGCCGGCGTGTTCCTGCAGGTGCTGCGCCCGTTCAAGGTCGGCGACTCGATCTCGGCGGCCGGCGTGA
CCGGCACCGTCAAGGAACTCGGGCTGTTCAGCACCACGCTGCTGACCAGCGACAACGTCGTGACCATCGTCGGCAATAAC
AAGATCTTCTCCGACAACATCGCCAACTACAGCGCAACGCCGCATCGCCGCGTGGACCTGACCGCGAAGATCGCCCACGG
CGTCGACGCGGCCGAGGCGATCGCGAAGCTGAAGGCGGCCGTGGCGGCGATCCCGAACGTGCTGCCGACGCCCGCGCCCG
ACGTCGGCATCCTGCAGTTCACGCCGGAAGGCCCGCTGCTGTTCGTGCGCCCCTGCACGCCGCCCGCCAGCTACTGGCAG
GTCTATTGCGACGCGCAGCACGCGATCCTCGACACCTTCCGTCAGGCCGGCTATCCGACGCCGGAGACGCCGACCATCCA
ACGCTCGGCCGGATAA

Upstream 100 bases:

>100_bases
GGCCTGGCATCGCGGGCCACGATTGCCGGCGCGCGACCGGGCGGTTATAACTGCGCGGCCGGACGCATGTCGCGTCCCGC
CTTCCCGATTCGGAGACCCC

Downstream 100 bases:

>100_bases
GGCGCGAACCGCGCCGCGGCGGCACGGGCCTCAGCCGCGCCCGCGCGGCGTATTCGGGCCGCCCCGCGACGGGCGGGTCC
GACCGCGCAGCAGCTTCCAG

Product: mechanosensitive ion channel MscS

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 271; Mature: 271

Protein sequence:

>271_residues
MVELATAQQFLMTRGLDFGLKVLAAIALWIVGRWLIRLSTRLLGRLVQRSGRVDTTLAYYLSSVVSVLLTIVLILAILQV
FGVQTTSFAALLAGIGLAVGTAWGGLLAHFAAGVFLQVLRPFKVGDSISAAGVTGTVKELGLFSTTLLTSDNVVTIVGNN
KIFSDNIANYSATPHRRVDLTAKIAHGVDAAEAIAKLKAAVAAIPNVLPTPAPDVGILQFTPEGPLLFVRPCTPPASYWQ
VYCDAQHAILDTFRQAGYPTPETPTIQRSAG

Sequences:

>Translated_271_residues
MVELATAQQFLMTRGLDFGLKVLAAIALWIVGRWLIRLSTRLLGRLVQRSGRVDTTLAYYLSSVVSVLLTIVLILAILQV
FGVQTTSFAALLAGIGLAVGTAWGGLLAHFAAGVFLQVLRPFKVGDSISAAGVTGTVKELGLFSTTLLTSDNVVTIVGNN
KIFSDNIANYSATPHRRVDLTAKIAHGVDAAEAIAKLKAAVAAIPNVLPTPAPDVGILQFTPEGPLLFVRPCTPPASYWQ
VYCDAQHAILDTFRQAGYPTPETPTIQRSAG
>Mature_271_residues
MVELATAQQFLMTRGLDFGLKVLAAIALWIVGRWLIRLSTRLLGRLVQRSGRVDTTLAYYLSSVVSVLLTIVLILAILQV
FGVQTTSFAALLAGIGLAVGTAWGGLLAHFAAGVFLQVLRPFKVGDSISAAGVTGTVKELGLFSTTLLTSDNVVTIVGNN
KIFSDNIANYSATPHRRVDLTAKIAHGVDAAEAIAKLKAAVAAIPNVLPTPAPDVGILQFTPEGPLLFVRPCTPPASYWQ
VYCDAQHAILDTFRQAGYPTPETPTIQRSAG

Specific function: Mechanosensitive channel that participates in the regulation of osmotic pressure changes within the cell. Forms an ion channel of 1.0 nanosiemens conductance with a slight preference for anions. The channel is sensitive to voltage [H]

COG id: COG0668

COG function: function code M; Small-conductance mechanosensitive channel

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mscS (TC 1.A.23) family [H]

Homologues:

Organism=Escherichia coli, GI1789291, Length=249, Percent_Identity=32.1285140562249, Blast_Score=120, Evalue=1e-28,
Organism=Escherichia coli, GI1787591, Length=210, Percent_Identity=28.5714285714286, Blast_Score=65, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010920
- InterPro:   IPR011066
- InterPro:   IPR006685
- InterPro:   IPR006686
- InterPro:   IPR011014
- InterPro:   IPR008910 [H]

Pfam domain/function: PF00924 MS_channel; PF05552 TM_helix [H]

EC number: NA

Molecular weight: Translated: 28766; Mature: 28766

Theoretical pI: Translated: 9.69; Mature: 9.69

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVELATAQQFLMTRGLDFGLKVLAAIALWIVGRWLIRLSTRLLGRLVQRSGRVDTTLAYY
CCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
LSSVVSVLLTIVLILAILQVFGVQTTSFAALLAGIGLAVGTAWGGLLAHFAAGVFLQVLR
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
PFKVGDSISAAGVTGTVKELGLFSTTLLTSDNVVTIVGNNKIFSDNIANYSATPHRRVDL
HHCCCCCCCCCCCCHHHHHHHHHHHHEECCCCEEEEEECCEEECCCCCCCCCCCCCEEEH
TAKIAHGVDAAEAIAKLKAAVAAIPNVLPTPAPDVGILQFTPEGPLLFVRPCTPPASYWQ
HHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEECCCCCEEEEECCCCCHHHHE
VYCDAQHAILDTFRQAGYPTPETPTIQRSAG
EHHCHHHHHHHHHHHCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MVELATAQQFLMTRGLDFGLKVLAAIALWIVGRWLIRLSTRLLGRLVQRSGRVDTTLAYY
CCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
LSSVVSVLLTIVLILAILQVFGVQTTSFAALLAGIGLAVGTAWGGLLAHFAAGVFLQVLR
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
PFKVGDSISAAGVTGTVKELGLFSTTLLTSDNVVTIVGNNKIFSDNIANYSATPHRRVDL
HHCCCCCCCCCCCCHHHHHHHHHHHHEECCCCEEEEEECCEEECCCCCCCCCCCCCEEEH
TAKIAHGVDAAEAIAKLKAAVAAIPNVLPTPAPDVGILQFTPEGPLLFVRPCTPPASYWQ
HHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEECCCCCEEEEECCCCCHHHHE
VYCDAQHAILDTFRQAGYPTPETPTIQRSAG
EHHCHHHHHHHHHHHCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 12542086 [H]