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The map label for this gene is edd [H]

Identifier: 238026221

GI number: 238026221

Start: 581948

End: 583813

Strand: Direct

Name: edd [H]

Synonym: bglu_1g05520

Alternate gene names: 238026221

Gene position: 581948-583813 (Clockwise)

Preceding gene: 238026219

Following gene: 238026222

Centisome position: 14.9

GC content: 70.74

Gene sequence:

>1866_bases
ATGGCCTCGCCGCATCCCACTCTCGTGAACGTGACCGAGCGCGTGATCGCGCGCAGCCGTCCGACCCGCACCGCCTATCT
CGACCGCATCGCCGCCGCGCAGGGACGCTTTCCGGCGCGCGGCGCGCTGTCGTGCGCGAACCTCGCGCACGGCTTCGCCG
GCCTCGAAGGCAACGACAAGTTCGTGATCAAGGCGATCCGCGAGCCGAATATCGGCATCGTCTCGTCGTACAACGAGATG
CTGTCGGCGCACGCGCCCTACGTCTCGTATCCCGACATCATCAAGGCAGCCGCGCGCGAGAACGGCGGCGTGGCGCAATT
CGCGGGCGGCGTGCCGGCGATGTGCGACGGCGTCACGCAGGGCAACCCGGGCATGGAGCTGTCGCTGTTCTCGCGCGAGA
CGATCGCGATGAGCACGGCGATCGCGCTGACCCACAACATGTTCGACGCGGCGCTCTGCCTCGGCATCTGCGACAAGATC
GTGCCGGGCCTGCTGATCGGCGCGCTGCAGTTCGGCCACCTGCCGACCATCTTCGTGCCGGCCGGCCCGATGACGAGCGG
CCTGTCGAACGACGACAAGGCGAAGATCCGCCAGCAGTTCGCGACCGGCCAGGTGGGCCGCGACGCGCTGCTCGAGGCCG
AATCGGCCGCCTATCACGGCCAGGGCACCTGCACGTTCTACGGCACCGCCAACAGCAACCAGATGCTGATGGAGGTGATG
GGCCTGCATCTGCCGGGCTCGGCGTTCGTGCACCCGCACACGCCGTTGCGCGACGCGCTGACGGCCGCCGCGGCGCGCCG
CGTGCTCGATCTGACCGTCGAGCGCGGCAGCTACACGCCGATCGGGCACGTGGTGGACGAGAAGGCCGTGATCAACGGCA
TCGTCGCGCTGCTCGCCACGGGCGGCTCGACCAACCACACCATGCACCTGGTCGCGATCGCGCGTGCCGCCGGCATCCTG
ATCGACTGGGACGACTTCGACGCGCTGTCGGCGATCGTGCCGCTGCTCGCGAAGATCTACCCGAACGGCAAGGCCGACGT
GAACCACTTCCACGCGGCGGGCGGCGTGGCGTTCCTGGTGCGCAACCTGCTGGAAGGCGGTCTGCTGCACGAGGACGTGA
CGACGGTGGCGGGCCGCGGCCTGTCGCACTATACGCACGAGCCGAAGCTCATCGACGGCAGGCTCGAATGGGTGCCGGGC
GTGGCCGAGAGCCAGGATCCGAAGGTGCTGCGGCCGCTCGCCGAGCCGTTCGCGCCGGACGGCGGCCTGCGCCTGATGCA
GGGGCGTCTCGGCCGCGGCGTGATCAAGATCTCGGCGGTCGCGCCCGAGCACCGCAAGGTGGTCGCGCCGGCCATCGTGT
TCGATTCCCAGGAGGCCGTGCAGGCCGCCTTCGACGCGGGCGAGCTCAAGCGCGACTTCGTCGCCGTGGTGCGGTTCCAG
GGCGCGCGCGCCAACGGCATGCCGGAGCTGCACCGTTTGACGCCGCTGCTCGGCGTGCTGCAGGATCAGGGTTTCCATGT
CGCGCTGGTTACCGACGGCCGCATGTCGGGCGCCTCGGGCAAGGTTCCGGCGGTGATCCACGTCTCGCCGGAGGCGCTGC
TCGACGGGCCGCTCGCCAAGGTGCGCAGCGGCGACACCATCGTGATCGACGCGCAGGCCGGCGTGCTCGACGTCGAGATC
GACGCGGGCGAATGGGCCGCGCGCGAGCTGGCGCGCCCCACGCATCAGGCCGACAACGAGGTCGGCTTCGGCCGCGAGCT
GTTCGGCGTGTTCCGCGCCGCGGCGATGCCGGCCGAGGCGGGCGCCTCGGTGTTCGGTGCGCTGGTCGGCGAGACCGCGC
AGGCCGGCGCGAGCGTCACGCACTGA

Upstream 100 bases:

>100_bases
TGTAGTTTTTCTACTAGACTTTGGCGCGTTTGGTCGGCAAGCCGGCCAGCCCCACGATTCCAGCCGCCGGCACCGCCCGG
CATCAGAGGAGCCGCCCAGC

Downstream 100 bases:

>100_bases
GCCGCATGGCATGGAACCGAATCGGGCCGGTCGCGCCACGGCGAATCCGCCGCGGCCCGGCCCACGCATCGAATCATAGG
AGAAGCAGCAGATGAAGACG

Product: phosphogluconate dehydratase

Products: NA

Alternate protein names: 6-phosphogluconate dehydratase [H]

Number of amino acids: Translated: 621; Mature: 620

Protein sequence:

>621_residues
MASPHPTLVNVTERVIARSRPTRTAYLDRIAAAQGRFPARGALSCANLAHGFAGLEGNDKFVIKAIREPNIGIVSSYNEM
LSAHAPYVSYPDIIKAAARENGGVAQFAGGVPAMCDGVTQGNPGMELSLFSRETIAMSTAIALTHNMFDAALCLGICDKI
VPGLLIGALQFGHLPTIFVPAGPMTSGLSNDDKAKIRQQFATGQVGRDALLEAESAAYHGQGTCTFYGTANSNQMLMEVM
GLHLPGSAFVHPHTPLRDALTAAAARRVLDLTVERGSYTPIGHVVDEKAVINGIVALLATGGSTNHTMHLVAIARAAGIL
IDWDDFDALSAIVPLLAKIYPNGKADVNHFHAAGGVAFLVRNLLEGGLLHEDVTTVAGRGLSHYTHEPKLIDGRLEWVPG
VAESQDPKVLRPLAEPFAPDGGLRLMQGRLGRGVIKISAVAPEHRKVVAPAIVFDSQEAVQAAFDAGELKRDFVAVVRFQ
GARANGMPELHRLTPLLGVLQDQGFHVALVTDGRMSGASGKVPAVIHVSPEALLDGPLAKVRSGDTIVIDAQAGVLDVEI
DAGEWAARELARPTHQADNEVGFGRELFGVFRAAAMPAEAGASVFGALVGETAQAGASVTH

Sequences:

>Translated_621_residues
MASPHPTLVNVTERVIARSRPTRTAYLDRIAAAQGRFPARGALSCANLAHGFAGLEGNDKFVIKAIREPNIGIVSSYNEM
LSAHAPYVSYPDIIKAAARENGGVAQFAGGVPAMCDGVTQGNPGMELSLFSRETIAMSTAIALTHNMFDAALCLGICDKI
VPGLLIGALQFGHLPTIFVPAGPMTSGLSNDDKAKIRQQFATGQVGRDALLEAESAAYHGQGTCTFYGTANSNQMLMEVM
GLHLPGSAFVHPHTPLRDALTAAAARRVLDLTVERGSYTPIGHVVDEKAVINGIVALLATGGSTNHTMHLVAIARAAGIL
IDWDDFDALSAIVPLLAKIYPNGKADVNHFHAAGGVAFLVRNLLEGGLLHEDVTTVAGRGLSHYTHEPKLIDGRLEWVPG
VAESQDPKVLRPLAEPFAPDGGLRLMQGRLGRGVIKISAVAPEHRKVVAPAIVFDSQEAVQAAFDAGELKRDFVAVVRFQ
GARANGMPELHRLTPLLGVLQDQGFHVALVTDGRMSGASGKVPAVIHVSPEALLDGPLAKVRSGDTIVIDAQAGVLDVEI
DAGEWAARELARPTHQADNEVGFGRELFGVFRAAAMPAEAGASVFGALVGETAQAGASVTH
>Mature_620_residues
ASPHPTLVNVTERVIARSRPTRTAYLDRIAAAQGRFPARGALSCANLAHGFAGLEGNDKFVIKAIREPNIGIVSSYNEML
SAHAPYVSYPDIIKAAARENGGVAQFAGGVPAMCDGVTQGNPGMELSLFSRETIAMSTAIALTHNMFDAALCLGICDKIV
PGLLIGALQFGHLPTIFVPAGPMTSGLSNDDKAKIRQQFATGQVGRDALLEAESAAYHGQGTCTFYGTANSNQMLMEVMG
LHLPGSAFVHPHTPLRDALTAAAARRVLDLTVERGSYTPIGHVVDEKAVINGIVALLATGGSTNHTMHLVAIARAAGILI
DWDDFDALSAIVPLLAKIYPNGKADVNHFHAAGGVAFLVRNLLEGGLLHEDVTTVAGRGLSHYTHEPKLIDGRLEWVPGV
AESQDPKVLRPLAEPFAPDGGLRLMQGRLGRGVIKISAVAPEHRKVVAPAIVFDSQEAVQAAFDAGELKRDFVAVVRFQG
ARANGMPELHRLTPLLGVLQDQGFHVALVTDGRMSGASGKVPAVIHVSPEALLDGPLAKVRSGDTIVIDAQAGVLDVEID
AGEWAARELARPTHQADNEVGFGRELFGVFRAAAMPAEAGASVFGALVGETAQAGASVTH

Specific function: KEY ENZYME IN THE ENTNER-DOUDOROFF PATHWAY. [C]

COG id: COG0129

COG function: function code EG; Dihydroxyacid dehydratase/phosphogluconate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ilvD/edd family [H]

Homologues:

Organism=Escherichia coli, GI1788157, Length=601, Percent_Identity=60.2329450915141, Blast_Score=723, Evalue=0.0,
Organism=Escherichia coli, GI48994964, Length=543, Percent_Identity=30.0184162062615, Blast_Score=193, Evalue=3e-50,
Organism=Escherichia coli, GI2367371, Length=529, Percent_Identity=30.4347826086957, Blast_Score=158, Evalue=1e-39,
Organism=Escherichia coli, GI1786464, Length=532, Percent_Identity=30.8270676691729, Blast_Score=137, Evalue=2e-33,
Organism=Saccharomyces cerevisiae, GI6322476, Length=527, Percent_Identity=28.842504743833, Blast_Score=185, Evalue=2e-47,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004786
- InterPro:   IPR015928
- InterPro:   IPR000581
- InterPro:   IPR020558 [H]

Pfam domain/function: PF00920 ILVD_EDD [H]

EC number: =4.2.1.12 [H]

Molecular weight: Translated: 65265; Mature: 65134

Theoretical pI: Translated: 6.55; Mature: 6.55

Prosite motif: PS00886 ILVD_EDD_1 ; PS00887 ILVD_EDD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MASPHPTLVNVTERVIARSRPTRTAYLDRIAAAQGRFPARGALSCANLAHGFAGLEGNDK
CCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCCCCE
FVIKAIREPNIGIVSSYNEMLSAHAPYVSYPDIIKAAARENGGVAQFAGGVPAMCDGVTQ
EEEEEECCCCCCEECCHHHHHHHCCCCCCCHHHHHHHHHCCCCEEECCCCCCHHHCCCCC
GNPGMELSLFSRETIAMSTAIALTHNMFDAALCLGICDKIVPGLLIGALQFGHLPTIFVP
CCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEE
AGPMTSGLSNDDKAKIRQQFATGQVGRDALLEAESAAYHGQGTCTFYGTANSNQMLMEVM
CCCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCEEEEEECCCCCHHHHHHH
GLHLPGSAFVHPHTPLRDALTAAAARRVLDLTVERGSYTPIGHVVDEKAVINGIVALLAT
CCCCCCCCEECCCCCHHHHHHHHHHHHHHHEEECCCCCCCHHHHHHHHHHHHHHHHHHCC
GGSTNHTMHLVAIARAAGILIDWDDFDALSAIVPLLAKIYPNGKADVNHFHAAGGVAFLV
CCCCCCEEEEEEEHHHCCEEEECCCHHHHHHHHHHHHHHCCCCCCCCCHHHHCCHHHHHH
RNLLEGGLLHEDVTTVAGRGLSHYTHEPKLIDGRLEWVPGVAESQDPKVLRPLAEPFAPD
HHHHCCCCCHHHHHHHHCCCCHHCCCCCCEECCCHHCCCCCCCCCCCHHHHHHHHHCCCC
GGLRLMQGRLGRGVIKISAVAPEHRKVVAPAIVFDSQEAVQAAFDAGELKRDFVAVVRFQ
CCHHHHHCCCCCCEEEEEEECCCCCEEEEHEEEECCHHHHHHHHHHHHHHHHHHHHHEEC
GARANGMPELHRLTPLLGVLQDQGFHVALVTDGRMSGASGKVPAVIHVSPEALLDGPLAK
CCCCCCCCHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCEEEEECHHHHHCCCHHH
VRSGDTIVIDAQAGVLDVEIDAGEWAARELARPTHQADNEVGFGRELFGVFRAAAMPAEA
HCCCCEEEEECCCCEEEEEECCCHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHCCCHHH
GASVFGALVGETAQAGASVTH
HHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
ASPHPTLVNVTERVIARSRPTRTAYLDRIAAAQGRFPARGALSCANLAHGFAGLEGNDK
CCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCCCCE
FVIKAIREPNIGIVSSYNEMLSAHAPYVSYPDIIKAAARENGGVAQFAGGVPAMCDGVTQ
EEEEEECCCCCCEECCHHHHHHHCCCCCCCHHHHHHHHHCCCCEEECCCCCCHHHCCCCC
GNPGMELSLFSRETIAMSTAIALTHNMFDAALCLGICDKIVPGLLIGALQFGHLPTIFVP
CCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEE
AGPMTSGLSNDDKAKIRQQFATGQVGRDALLEAESAAYHGQGTCTFYGTANSNQMLMEVM
CCCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCEEEEEECCCCCHHHHHHH
GLHLPGSAFVHPHTPLRDALTAAAARRVLDLTVERGSYTPIGHVVDEKAVINGIVALLAT
CCCCCCCCEECCCCCHHHHHHHHHHHHHHHEEECCCCCCCHHHHHHHHHHHHHHHHHHCC
GGSTNHTMHLVAIARAAGILIDWDDFDALSAIVPLLAKIYPNGKADVNHFHAAGGVAFLV
CCCCCCEEEEEEEHHHCCEEEECCCHHHHHHHHHHHHHHCCCCCCCCCHHHHCCHHHHHH
RNLLEGGLLHEDVTTVAGRGLSHYTHEPKLIDGRLEWVPGVAESQDPKVLRPLAEPFAPD
HHHHCCCCCHHHHHHHHCCCCHHCCCCCCEECCCHHCCCCCCCCCCCHHHHHHHHHCCCC
GGLRLMQGRLGRGVIKISAVAPEHRKVVAPAIVFDSQEAVQAAFDAGELKRDFVAVVRFQ
CCHHHHHCCCCCCEEEEEEECCCCCEEEEHEEEECCHHHHHHHHHHHHHHHHHHHHHEEC
GARANGMPELHRLTPLLGVLQDQGFHVALVTDGRMSGASGKVPAVIHVSPEALLDGPLAK
CCCCCCCCHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCEEEEECHHHHHCCCHHH
VRSGDTIVIDAQAGVLDVEIDAGEWAARELARPTHQADNEVGFGRELFGVFRAAAMPAEA
HCCCCEEEEECCCCEEEEEECCCHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHCCCHHH
GASVFGALVGETAQAGASVTH
HHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8045900; 10984043 [H]