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The map label for this gene is hisG [H]

Identifier: 238026004

GI number: 238026004

Start: 349768

End: 350424

Strand: Direct

Name: hisG [H]

Synonym: bglu_1g03300

Alternate gene names: 238026004

Gene position: 349768-350424 (Clockwise)

Preceding gene: 238026003

Following gene: 238026005

Centisome position: 8.95

GC content: 68.49

Gene sequence:

>657_bases
ATGACCGCACCGCTGACCCTCGCGCTGTCGAAAGGGCGTATCTTCGAGGAAACCGTGCCGCTGCTCGCGGCCGCCGGCAT
CGAGGTGGCGGGGGACCCCGAATCGTCGCGCAAGCTGATCCTGCCGACCAACGACCCGAACGTGCGCGTGATCATCGTGC
GCGCCACCGACGTGCCGACCTACGTCGAGTACGGCGCGGCCGATTTCGGCGTGGCCGGCAAGGACGTGCTGATCGAGCAC
GGCGGCGGCGGGCTCTACCAGCCGATCGACCTGAGCATCGCGCGCTGCCGGATGTCGGTGGCGGTGCAGGCGGGCTTCGA
CTACGCTAATGCGGTGCGCCAGGGCGCGCGGCTGCGGGTGGCGACGAAGTACGTGTCCACTGCACGGGAGCACTTCGCGG
CCAAGGGCGTCCACGTCGACCTGATCAAGCTGTACGGCTCGATGGAGCTCGCTCCGCTGGTCGGGCTGGCCGACGCGATC
GTCGATCTGGTCAGCTCGGGCGGCACGCTGCGGGCGAACAATCTGGTCGAGGTCGAGGAGATCATGCCGATCTCCTCGCG
CCTCGTCGTGAACCAGGCCGCGCTGAAACTGAAGCGCGCCGCGCTGAAGCCGATCCTCGACGCGTTCGAACGCGCGTCGA
AGCAGAGCGGGAGCTGA

Upstream 100 bases:

>100_bases
TCATCGACCGCATCTACCATCTCGATCGCGGCTATGATCGGATGGAGACCAAGCTGAACGCAGTTGGCGCCGACGTGCGC
CGCATCACCGGGAGTGCCGC

Downstream 100 bases:

>100_bases
GCGCTCCCGGCACCGGCGCATTACCGGAACGAACAGCATCATGCCCATCAAGATTCGCAAACTCGATTCGCGCAGCGAGG
GCTTCGGCGCCGCGCTGCGC

Product: ATP phosphoribosyltransferase catalytic subunit

Products: NA

Alternate protein names: ATP-PRT; ATP-PRTase [H]

Number of amino acids: Translated: 218; Mature: 217

Protein sequence:

>218_residues
MTAPLTLALSKGRIFEETVPLLAAAGIEVAGDPESSRKLILPTNDPNVRVIIVRATDVPTYVEYGAADFGVAGKDVLIEH
GGGGLYQPIDLSIARCRMSVAVQAGFDYANAVRQGARLRVATKYVSTAREHFAAKGVHVDLIKLYGSMELAPLVGLADAI
VDLVSSGGTLRANNLVEVEEIMPISSRLVVNQAALKLKRAALKPILDAFERASKQSGS

Sequences:

>Translated_218_residues
MTAPLTLALSKGRIFEETVPLLAAAGIEVAGDPESSRKLILPTNDPNVRVIIVRATDVPTYVEYGAADFGVAGKDVLIEH
GGGGLYQPIDLSIARCRMSVAVQAGFDYANAVRQGARLRVATKYVSTAREHFAAKGVHVDLIKLYGSMELAPLVGLADAI
VDLVSSGGTLRANNLVEVEEIMPISSRLVVNQAALKLKRAALKPILDAFERASKQSGS
>Mature_217_residues
TAPLTLALSKGRIFEETVPLLAAAGIEVAGDPESSRKLILPTNDPNVRVIIVRATDVPTYVEYGAADFGVAGKDVLIEHG
GGGLYQPIDLSIARCRMSVAVQAGFDYANAVRQGARLRVATKYVSTAREHFAAKGVHVDLIKLYGSMELAPLVGLADAIV
DLVSSGGTLRANNLVEVEEIMPISSRLVVNQAALKLKRAALKPILDAFERASKQSGS

Specific function: Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic

COG id: COG0040

COG function: function code E; ATP phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP phosphoribosyltransferase family. Short subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788330, Length=186, Percent_Identity=34.4086021505376, Blast_Score=86, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6320896, Length=185, Percent_Identity=30.2702702702703, Blast_Score=74, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001348
- InterPro:   IPR013820
- InterPro:   IPR018198 [H]

Pfam domain/function: PF01634 HisG [H]

EC number: =2.4.2.17 [H]

Molecular weight: Translated: 23108; Mature: 22977

Theoretical pI: Translated: 8.43; Mature: 8.43

Prosite motif: PS01316 ATP_P_PHORIBOSYLTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAPLTLALSKGRIFEETVPLLAAAGIEVAGDPESSRKLILPTNDPNVRVIIVRATDVPT
CCCCEEEEECCCCHHHHHHHHHHHCCCEEECCCCCCCEEEEECCCCCEEEEEEEECCCCH
YVEYGAADFGVAGKDVLIEHGGGGLYQPIDLSIARCRMSVAVQAGFDYANAVRQGARLRV
HHHCCCCCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHEECCCCHHHHHHCCCEEEH
ATKYVSTAREHFAAKGVHVDLIKLYGSMELAPLVGLADAIVDLVSSGGTLRANNLVEVEE
HHHHHHHHHHHHHHCCCEEEEHHHHCCCCHHHHHHHHHHHHHHHHCCCEEECCCEEEHHH
IMPISSRLVVNQAALKLKRAALKPILDAFERASKQSGS
HCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
TAPLTLALSKGRIFEETVPLLAAAGIEVAGDPESSRKLILPTNDPNVRVIIVRATDVPT
CCCEEEEECCCCHHHHHHHHHHHCCCEEECCCCCCCEEEEECCCCCEEEEEEEECCCCH
YVEYGAADFGVAGKDVLIEHGGGGLYQPIDLSIARCRMSVAVQAGFDYANAVRQGARLRV
HHHCCCCCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHEECCCCHHHHHHCCCEEEH
ATKYVSTAREHFAAKGVHVDLIKLYGSMELAPLVGLADAIVDLVSSGGTLRANNLVEVEE
HHHHHHHHHHHHHHCCCEEEEHHHHCCCCHHHHHHHHHHHHHHHHCCCEEECCCEEEHHH
IMPISSRLVVNQAALKLKRAALKPILDAFERASKQSGS
HCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA