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The map label for this gene is hisD [H]

Identifier: 238026005

GI number: 238026005

Start: 350465

End: 351790

Strand: Direct

Name: hisD [H]

Synonym: bglu_1g03310

Alternate gene names: 238026005

Gene position: 350465-351790 (Clockwise)

Preceding gene: 238026004

Following gene: 238026006

Centisome position: 8.97

GC content: 70.66

Gene sequence:

>1326_bases
ATGCCCATCAAGATTCGCAAACTCGATTCGCGCAGCGAGGGCTTCGGCGCCGCGCTGCGCGCGGTGCTCGCCTTCGAGGC
GAGCGAGGACGAGGCGATCGAGCGCTCGGTCGCGGGGATTCTCGCCGACGTGAAGGTGCGCGGCGACGCGGCCGTGCTCG
ACTACACGAACCGCTTCGACCGGCTCGGCGCGCCCAGCGTGGCCGCGCTGGAGCTGCGCCAGGACGCGCTCGAGGCCGCG
CTCGAGACGCTCGAGCCGAAGCGCCGCGCGGCGCTCGAGGCGGCCGCCGCGCGGGTGCGCGGCTATCACGAGAAACAGAA
GCTCGAATGCGGCAGCCATAGCTGGCAGTACACCGAGTCCGACGGCACGGTGCTGGGCCAGAAGGTGCTGCCGCTCGATC
GCGTCGGCCTGTACGTGCCGGGCGGCAAGGCCGCCTATCCGTCGTCGGTGCTGATGAACGCGATTCCGGCCCGGGTGGCC
GGGGTCGGCGAGATCGTGATGGTGGTGCCCACGCCCGACGGCGTGAAGAACGACCTCGTGCTCGCGGCCGCCTATCTCGG
CGGCGTCGATCGCGTGTTCACCATCGGCGGGGCGCAGGCGGTGGCCGCGCTCGCCTACGGCACCGAGACGGTGCCGGCCG
TCGACAAGATCTGCGGCCCCGGCAACGCCTACGTGGCCTCGGCCAAGCGCCGCGTGTTCGGCACCGTGGGCATCGACATG
ATCGCCGGGCCGTCCGAGATCCTCGTGCTCTGCGACGGCACCACCGATCCGCACTGGGTCGCGATGGACCTGTTCTCGCA
GGCCGAGCACGACGAACTGGCGCAGTCGATCCTGCTGTGCCCGGACGCGGGCTTCATCGAGCGCGTCGAGAAGGCGATCG
ACGAGCTGCTGCCGGCCATGCCGCGCGAGGCCGTGATCCGCGCCTCGCTGGAAGGGCGCGGCGCGCTGATCACGGTGCGC
GACATGGCCGAGGCCTGCAAGATCGCCAACGAGATCGCGCCCGAGCACCTCGAGATCTCGGCGCTCGAGCCGCAGCAATG
GGGCAAGCTGATTCGCCATGCCGGCGCGATCTTCCTCGGCCGCTACACGAGCGAGAGCCTCGGCGACTACTGCGCCGGGC
CGAACCACGTGCTGCCGACCTCGCGCACGGCGCGCTTCTCGTCGCCGCTGGGCGTCTACGACTTCATCAAGCGCTCGAGC
CTGATCGAGGTCAGCGCCGACGGCGCGCACACGCTCGGCGAGATCGCCTCGGAGCTGGCTTACGGCGAGGGGCTGCAGGC
GCACGCGAAAAGCGCCGAATACCGGATGCGCAACCACGGCAACTGA

Upstream 100 bases:

>100_bases
GCCGCGCTGAAGCCGATCCTCGACGCGTTCGAACGCGCGTCGAAGCAGAGCGGGAGCTGAGCGCTCCCGGCACCGGCGCA
TTACCGGAACGAACAGCATC

Downstream 100 bases:

>100_bases
GCCGGCGCGGCGGCGCGGGCAAGCGGCAGCCAAGCACCACATGGCCAGCGCGACGGAGCCGGCCGCGGCCGGGCCGGCGG
CATCGAGACCCGCGGCCCGG

Product: bifunctional histidinal dehydrogenase/ histidinol dehydrogenase

Products: NA

Alternate protein names: HDH [H]

Number of amino acids: Translated: 441; Mature: 440

Protein sequence:

>441_residues
MPIKIRKLDSRSEGFGAALRAVLAFEASEDEAIERSVAGILADVKVRGDAAVLDYTNRFDRLGAPSVAALELRQDALEAA
LETLEPKRRAALEAAAARVRGYHEKQKLECGSHSWQYTESDGTVLGQKVLPLDRVGLYVPGGKAAYPSSVLMNAIPARVA
GVGEIVMVVPTPDGVKNDLVLAAAYLGGVDRVFTIGGAQAVAALAYGTETVPAVDKICGPGNAYVASAKRRVFGTVGIDM
IAGPSEILVLCDGTTDPHWVAMDLFSQAEHDELAQSILLCPDAGFIERVEKAIDELLPAMPREAVIRASLEGRGALITVR
DMAEACKIANEIAPEHLEISALEPQQWGKLIRHAGAIFLGRYTSESLGDYCAGPNHVLPTSRTARFSSPLGVYDFIKRSS
LIEVSADGAHTLGEIASELAYGEGLQAHAKSAEYRMRNHGN

Sequences:

>Translated_441_residues
MPIKIRKLDSRSEGFGAALRAVLAFEASEDEAIERSVAGILADVKVRGDAAVLDYTNRFDRLGAPSVAALELRQDALEAA
LETLEPKRRAALEAAAARVRGYHEKQKLECGSHSWQYTESDGTVLGQKVLPLDRVGLYVPGGKAAYPSSVLMNAIPARVA
GVGEIVMVVPTPDGVKNDLVLAAAYLGGVDRVFTIGGAQAVAALAYGTETVPAVDKICGPGNAYVASAKRRVFGTVGIDM
IAGPSEILVLCDGTTDPHWVAMDLFSQAEHDELAQSILLCPDAGFIERVEKAIDELLPAMPREAVIRASLEGRGALITVR
DMAEACKIANEIAPEHLEISALEPQQWGKLIRHAGAIFLGRYTSESLGDYCAGPNHVLPTSRTARFSSPLGVYDFIKRSS
LIEVSADGAHTLGEIASELAYGEGLQAHAKSAEYRMRNHGN
>Mature_440_residues
PIKIRKLDSRSEGFGAALRAVLAFEASEDEAIERSVAGILADVKVRGDAAVLDYTNRFDRLGAPSVAALELRQDALEAAL
ETLEPKRRAALEAAAARVRGYHEKQKLECGSHSWQYTESDGTVLGQKVLPLDRVGLYVPGGKAAYPSSVLMNAIPARVAG
VGEIVMVVPTPDGVKNDLVLAAAYLGGVDRVFTIGGAQAVAALAYGTETVPAVDKICGPGNAYVASAKRRVFGTVGIDMI
AGPSEILVLCDGTTDPHWVAMDLFSQAEHDELAQSILLCPDAGFIERVEKAIDELLPAMPREAVIRASLEGRGALITVRD
MAEACKIANEIAPEHLEISALEPQQWGKLIRHAGAIFLGRYTSESLGDYCAGPNHVLPTSRTARFSSPLGVYDFIKRSSL
IEVSADGAHTLGEIASELAYGEGLQAHAKSAEYRMRNHGN

Specific function: Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine [H]

COG id: COG0141

COG function: function code E; Histidinol dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histidinol dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1788331, Length=413, Percent_Identity=41.6464891041162, Blast_Score=286, Evalue=2e-78,
Organism=Saccharomyces cerevisiae, GI6319819, Length=414, Percent_Identity=35.5072463768116, Blast_Score=230, Evalue=3e-61,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016161
- InterPro:   IPR022695
- InterPro:   IPR001692
- InterPro:   IPR012131 [H]

Pfam domain/function: PF00815 Histidinol_dh [H]

EC number: =1.1.1.23 [H]

Molecular weight: Translated: 47011; Mature: 46880

Theoretical pI: Translated: 5.22; Mature: 5.22

Prosite motif: PS00611 HISOL_DEHYDROGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPIKIRKLDSRSEGFGAALRAVLAFEASEDEAIERSVAGILADVKVRGDAAVLDYTNRFD
CCEEEEECCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHEEECCCEEEEEHHHHHH
RLGAPSVAALELRQDALEAALETLEPKRRAALEAAAARVRGYHEKQKLECGSHSWQYTES
HCCCCCHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHCCHHHHHHCCCCCCCEEECC
DGTVLGQKVLPLDRVGLYVPGGKAAYPSSVLMNAIPARVAGVGEIVMVVPTPDGVKNDLV
CCCEECCCCCCHHHCCEEECCCCCCCCHHHHHHHHHHHHCCCCCEEEEEECCCCCCCHHH
LAAAYLGGVDRVFTIGGAQAVAALAYGTETVPAVDKICGPGNAYVASAKRRVFGTVGIDM
HHHHHHCCCCCEEEECCHHHHHHHHHCCCCCHHHHHHCCCCCHHHHHHHHHHHEECCHHE
IAGPSEILVLCDGTTDPHWVAMDLFSQAEHDELAQSILLCPDAGFIERVEKAIDELLPAM
ECCCCEEEEEECCCCCCCCHHHHHHHCCCHHHHHHHHEECCCCHHHHHHHHHHHHHHHCC
PREAVIRASLEGRGALITVRDMAEACKIANEIAPEHLEISALEPQQWGKLIRHAGAIFLG
CHHHHHHHCCCCCCCEEEHHHHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHCCCEEEE
RYTSESLGDYCAGPNHVLPTSRTARFSSPLGVYDFIKRSSLIEVSADGAHTLGEIASELA
CCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHCCCEEEEECCCCHHHHHHHHHHH
YGEGLQAHAKSAEYRMRNHGN
HCCCHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
PIKIRKLDSRSEGFGAALRAVLAFEASEDEAIERSVAGILADVKVRGDAAVLDYTNRFD
CEEEEECCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHEEECCCEEEEEHHHHHH
RLGAPSVAALELRQDALEAALETLEPKRRAALEAAAARVRGYHEKQKLECGSHSWQYTES
HCCCCCHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHCCHHHHHHCCCCCCCEEECC
DGTVLGQKVLPLDRVGLYVPGGKAAYPSSVLMNAIPARVAGVGEIVMVVPTPDGVKNDLV
CCCEECCCCCCHHHCCEEECCCCCCCCHHHHHHHHHHHHCCCCCEEEEEECCCCCCCHHH
LAAAYLGGVDRVFTIGGAQAVAALAYGTETVPAVDKICGPGNAYVASAKRRVFGTVGIDM
HHHHHHCCCCCEEEECCHHHHHHHHHCCCCCHHHHHHCCCCCHHHHHHHHHHHEECCHHE
IAGPSEILVLCDGTTDPHWVAMDLFSQAEHDELAQSILLCPDAGFIERVEKAIDELLPAM
ECCCCEEEEEECCCCCCCCHHHHHHHCCCHHHHHHHHEECCCCHHHHHHHHHHHHHHHCC
PREAVIRASLEGRGALITVRDMAEACKIANEIAPEHLEISALEPQQWGKLIRHAGAIFLG
CHHHHHHHCCCCCCCEEEHHHHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHCCCEEEE
RYTSESLGDYCAGPNHVLPTSRTARFSSPLGVYDFIKRSSLIEVSADGAHTLGEIASELA
CCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHCCCEEEEECCCCHHHHHHHHHHH
YGEGLQAHAKSAEYRMRNHGN
HCCCHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA