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The map label for this gene is shc [H]

Identifier: 238025575

GI number: 238025575

Start: 2817548

End: 2819878

Strand: Reverse

Name: shc [H]

Synonym: bglu_2g22720

Alternate gene names: 238025575

Gene position: 2819878-2817548 (Counterclockwise)

Preceding gene: 238025576

Following gene: 238025574

Centisome position: 99.74

GC content: 72.8

Gene sequence:

>2331_bases
ATGAACGATCTCACCAATTCGAGCGCGCCGGGCGCGAGGCCAGACGACGCGACGCCGTCCGCTGCCGGACCCACGCCCGC
AGAGGCGGCGGGCGGCGCCGTCGCACCGTCGCGCGCCGTGCAGCCCGCCGATACCCAAACGGCAGCGACCGGCGCCGCCG
GTGCGGCCGCGGCGGTTGGCGCGACGCCCGCCGAACTCGCCGCCACTGCGCCGGCATCGTCCGGCACGCCGGCCGGCGCC
TCTGCCGCACCGGCACCATCCGGCACGCCGTCGGTCGACGCGCCCGCCGAGCTCGCCTCCGCCGCACCGGCTCCGTCCGG
CGCCACGCCTGCCGCCACTGCCACCGCAGCCACCGCGCCGGCGCCGGCCCGCGCGGCATCGATCGATGCCCCCGCCCTCG
CCGCCGCCGATCTCGATGCGGCCATCACGCGCGCCACCGACGCGCTGCTCGCCGCCCAGCAAGCCGACGGCCACTGGATC
TACGAGCTGGAGGCCGATTCGACGATTCCCGCCGAATACGTGCTGCTGGTCCATTACCTCGGCGAGACGCCCAACCTCGA
GCTCGAACGCAAGATCGCGCGCTACCTGCGCCGCGTGCAGCTGCCCGGCGGCGGCTGGCCGCTGTTCACCGACGGCGCGC
CCGACGTCAGCGCGAGCGTGAAGGCCTACTTCGCGCTGAAGATGATCGGCGACGACGCGAACGCCGAGCACATGGTGCGC
GCCCGCAATGCGATCCACGCGATGGGCGGCGCCGAGATGTCGAACGTGTTTACGCGCATCCAGCTCGCGCTGTTCGGCGT
GGTGCCGTGGTTCGCGGTGCCGATGATGCCGGTCGAGATCATGCTGCTGCCGCAGTGGTTCCCGTTCCACCTTTCGAAGG
TGTCGTACTGGGCGCGCACCGTGACCGTGCCGCTGCTGGTGCTCAGCGCGAAGCGCCCGCTCGCCAGGAATCCGCGCGGC
GTGCGGGTCGACGAGCTGTTCGTCGCCCCGCCCGTGAACGCCGGCCTGCTGCCGCGCGCGGGACACCAGAGCCCGGCCTG
GTTCGCCTGCTTTCGCCTGCTCGACGGCCTGCTGCGCCTGACCGACGGGCTGTTCCCGCGCTACACGCGCGAGCGCGCGA
TCCGCCAGGCCTTGCAGTTCGTCGACGAGCGCCTGAACGGCGAGGACGGCCTCGGCGCGATCTATCCGGCGATGGCGAAC
TCGGTGATGATGTACGCCGCGCTCGGCTATCCCGAGGATCATCCGAACCGCGCGACCGCGCGCCGCGCGATCGAGAAGCT
GCTGGTGATCCATGACGACGAGGCCTATTGCCAGCCGTGCCTGTCGCCCGTCTGGGACACCTCGCTCGCGGCCCACGCCC
TGCTCGAGACCGGCGAGCCGCGCGCCGAAGCCGCCGCGATCCGCGGCCTGGACTGGCTGCGCCCGCTGCAGATCCTCGAC
GTGCGCGGCGACTGGATCTCGCGCCGCCCCGACGTGCGGCCCGGCGGCTGGGCGTTCCAGTACGCGAACCCGCACTACCC
CGACGTCGACGATACGGCCGTGGTCACGCTCGCGATGGATCGCGTGGCCAAGCTCGCGCAGACCGATGCCTACCGCGACG
CGATCGCGCGTGCGCGCGAGTGGGTGGTGGGCATGCAGAGCAGCGACGGCGGCTGGGGCGCGTTCGAGCCCGAGAACACC
CACCAGTACCTGAACAGCATCCCGTTCTCCGATCACGGCGCGCTGCTCGATCCGCCCACCGCCGACGTGTCGGGCCGCTG
CCTGTCGATGCTCGCGCAGCTCGGCGAGACTGCCGCCAACAGCGCGCCCGCCCGCCGCGCGCTCGACTACCTGCTGGCCG
AGCAGGGGGCCGACGGCAGCTGGTACGGCCGCTGGGGCATGAACTACATCTACGGCACCTGGAGCGCGCTCGGCGCGCTG
AACGCGGCCGGCCTGCCGTTCGACGATCCGCGCGTGAAGCGCGCCGCGCAGTGGCTGCTGTCGATCCAGAACCCGGACGG
CGGCTGGGGCGAGGACGGCGACAGCTACAAGCTCGACTATCGCGGCTACGAGCGCGCCGCCAGCACCGCGTCGCAGACGG
CCTGGGCGCTGCTCGGCCTGATGGCGGCCGGCGAGGTCGAGCATCCCGCCGTGGCGCGCGGCATCGCCTGGCTCGCGGCC
CAACAGCGCGAGCACGGCCTCTGGGACGAGGCGCGCTTCACCGCCACGGGTTTCCCGCGCGTGTTCTATCTGCGCTACCA
CGGCTATCGCAAGTTCTTCCCGCTGTGGGCGCTCGCGCGCTACCGCAATCTGCGACGCACCGGCACCCGGCGCGTGACGG
TGGGCATGTAG

Upstream 100 bases:

>100_bases
CCGCCGTGCGCGGGCACCGGGTCCGCCGCCCTGCCCGCGTCGATCGACGGGGCGTGCCGCCGAGCGGTACCGCACGCGCC
GCATGACAAGAGAGGGACCG

Downstream 100 bases:

>100_bases
ATGCGGGTGGCCACCTCCACCCCGCGCGCGCCCGTGATCGCCGTCAGCGGCATGGCGTTCGAGGCGAGGATCGCGGCCGG
CGACGGTGTCGAAACCGTGT

Product: Squalene-hopene cyclase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 776; Mature: 776

Protein sequence:

>776_residues
MNDLTNSSAPGARPDDATPSAAGPTPAEAAGGAVAPSRAVQPADTQTAATGAAGAAAAVGATPAELAATAPASSGTPAGA
SAAPAPSGTPSVDAPAELASAAPAPSGATPAATATAATAPAPARAASIDAPALAAADLDAAITRATDALLAAQQADGHWI
YELEADSTIPAEYVLLVHYLGETPNLELERKIARYLRRVQLPGGGWPLFTDGAPDVSASVKAYFALKMIGDDANAEHMVR
ARNAIHAMGGAEMSNVFTRIQLALFGVVPWFAVPMMPVEIMLLPQWFPFHLSKVSYWARTVTVPLLVLSAKRPLARNPRG
VRVDELFVAPPVNAGLLPRAGHQSPAWFACFRLLDGLLRLTDGLFPRYTRERAIRQALQFVDERLNGEDGLGAIYPAMAN
SVMMYAALGYPEDHPNRATARRAIEKLLVIHDDEAYCQPCLSPVWDTSLAAHALLETGEPRAEAAAIRGLDWLRPLQILD
VRGDWISRRPDVRPGGWAFQYANPHYPDVDDTAVVTLAMDRVAKLAQTDAYRDAIARAREWVVGMQSSDGGWGAFEPENT
HQYLNSIPFSDHGALLDPPTADVSGRCLSMLAQLGETAANSAPARRALDYLLAEQGADGSWYGRWGMNYIYGTWSALGAL
NAAGLPFDDPRVKRAAQWLLSIQNPDGGWGEDGDSYKLDYRGYERAASTASQTAWALLGLMAAGEVEHPAVARGIAWLAA
QQREHGLWDEARFTATGFPRVFYLRYHGYRKFFPLWALARYRNLRRTGTRRVTVGM

Sequences:

>Translated_776_residues
MNDLTNSSAPGARPDDATPSAAGPTPAEAAGGAVAPSRAVQPADTQTAATGAAGAAAAVGATPAELAATAPASSGTPAGA
SAAPAPSGTPSVDAPAELASAAPAPSGATPAATATAATAPAPARAASIDAPALAAADLDAAITRATDALLAAQQADGHWI
YELEADSTIPAEYVLLVHYLGETPNLELERKIARYLRRVQLPGGGWPLFTDGAPDVSASVKAYFALKMIGDDANAEHMVR
ARNAIHAMGGAEMSNVFTRIQLALFGVVPWFAVPMMPVEIMLLPQWFPFHLSKVSYWARTVTVPLLVLSAKRPLARNPRG
VRVDELFVAPPVNAGLLPRAGHQSPAWFACFRLLDGLLRLTDGLFPRYTRERAIRQALQFVDERLNGEDGLGAIYPAMAN
SVMMYAALGYPEDHPNRATARRAIEKLLVIHDDEAYCQPCLSPVWDTSLAAHALLETGEPRAEAAAIRGLDWLRPLQILD
VRGDWISRRPDVRPGGWAFQYANPHYPDVDDTAVVTLAMDRVAKLAQTDAYRDAIARAREWVVGMQSSDGGWGAFEPENT
HQYLNSIPFSDHGALLDPPTADVSGRCLSMLAQLGETAANSAPARRALDYLLAEQGADGSWYGRWGMNYIYGTWSALGAL
NAAGLPFDDPRVKRAAQWLLSIQNPDGGWGEDGDSYKLDYRGYERAASTASQTAWALLGLMAAGEVEHPAVARGIAWLAA
QQREHGLWDEARFTATGFPRVFYLRYHGYRKFFPLWALARYRNLRRTGTRRVTVGM
>Mature_776_residues
MNDLTNSSAPGARPDDATPSAAGPTPAEAAGGAVAPSRAVQPADTQTAATGAAGAAAAVGATPAELAATAPASSGTPAGA
SAAPAPSGTPSVDAPAELASAAPAPSGATPAATATAATAPAPARAASIDAPALAAADLDAAITRATDALLAAQQADGHWI
YELEADSTIPAEYVLLVHYLGETPNLELERKIARYLRRVQLPGGGWPLFTDGAPDVSASVKAYFALKMIGDDANAEHMVR
ARNAIHAMGGAEMSNVFTRIQLALFGVVPWFAVPMMPVEIMLLPQWFPFHLSKVSYWARTVTVPLLVLSAKRPLARNPRG
VRVDELFVAPPVNAGLLPRAGHQSPAWFACFRLLDGLLRLTDGLFPRYTRERAIRQALQFVDERLNGEDGLGAIYPAMAN
SVMMYAALGYPEDHPNRATARRAIEKLLVIHDDEAYCQPCLSPVWDTSLAAHALLETGEPRAEAAAIRGLDWLRPLQILD
VRGDWISRRPDVRPGGWAFQYANPHYPDVDDTAVVTLAMDRVAKLAQTDAYRDAIARAREWVVGMQSSDGGWGAFEPENT
HQYLNSIPFSDHGALLDPPTADVSGRCLSMLAQLGETAANSAPARRALDYLLAEQGADGSWYGRWGMNYIYGTWSALGAL
NAAGLPFDDPRVKRAAQWLLSIQNPDGGWGEDGDSYKLDYRGYERAASTASQTAWALLGLMAAGEVEHPAVARGIAWLAA
QQREHGLWDEARFTATGFPRVFYLRYHGYRKFFPLWALARYRNLRRTGTRRVTVGM

Specific function: Catalyzes the cyclization of squalene into hopene [H]

COG id: COG1657

COG function: function code I; Squalene cyclase

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 3 PFTB repeats [H]

Homologues:

Organism=Homo sapiens, GI47933395, Length=648, Percent_Identity=27.1604938271605, Blast_Score=199, Evalue=7e-51,
Organism=Homo sapiens, GI47933397, Length=648, Percent_Identity=27.1604938271605, Blast_Score=199, Evalue=7e-51,
Organism=Homo sapiens, GI224177558, Length=648, Percent_Identity=27.1604938271605, Blast_Score=199, Evalue=9e-51,
Organism=Homo sapiens, GI224177556, Length=648, Percent_Identity=25.9259259259259, Blast_Score=176, Evalue=6e-44,
Organism=Saccharomyces cerevisiae, GI6321863, Length=166, Percent_Identity=34.3373493975904, Blast_Score=92, Evalue=4e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006400
- InterPro:   IPR001330
- InterPro:   IPR018333
- InterPro:   IPR002365
- InterPro:   IPR008930 [H]

Pfam domain/function: PF00432 Prenyltrans [H]

EC number: =5.4.99.17 [H]

Molecular weight: Translated: 83081; Mature: 83081

Theoretical pI: Translated: 6.02; Mature: 6.02

Prosite motif: PS01074 TERPENE_SYNTHASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNDLTNSSAPGARPDDATPSAAGPTPAEAAGGAVAPSRAVQPADTQTAATGAAGAAAAVG
CCCCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCCCCCCCCCCCHHHCCCCCHHHHCC
ATPAELAATAPASSGTPAGASAAPAPSGTPSVDAPAELASAAPAPSGATPAATATAATAP
CCHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCCCCCCCCCCHHCCCCC
APARAASIDAPALAAADLDAAITRATDALLAAQQADGHWIYELEADSTIPAEYVLLVHYL
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHHHH
GETPNLELERKIARYLRRVQLPGGGWPLFTDGAPDVSASVKAYFALKMIGDDANAEHMVR
CCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHEEEEEEEEECCCCCHHHHHH
ARNAIHAMGGAEMSNVFTRIQLALFGVVPWFAVPMMPVEIMLLPQWFPFHLSKVSYWART
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHH
VTVPLLVLSAKRPLARNPRGVRVDELFVAPPVNAGLLPRAGHQSPAWFACFRLLDGLLRL
HHHHHHHHHCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
TDGLFPRYTRERAIRQALQFVDERLNGEDGLGAIYPAMANSVMMYAALGYPEDHPNRATA
HHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHEEHCCCCCCCCCCHHHH
RRAIEKLLVIHDDEAYCQPCLSPVWDTSLAAHALLETGEPRAEAAAIRGLDWLRPLQILD
HHHHHHHHEEECCHHHHHHHCCHHHHHHHHHHHHHHCCCCHHHHHHHHCCHHHCCEEEEE
VRGDWISRRPDVRPGGWAFQYANPHYPDVDDTAVVTLAMDRVAKLAQTDAYRDAIARARE
CCCCHHCCCCCCCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
WVVGMQSSDGGWGAFEPENTHQYLNSIPFSDHGALLDPPTADVSGRCLSMLAQLGETAAN
HHEEECCCCCCCCCCCCCHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCC
SAPARRALDYLLAEQGADGSWYGRWGMNYIYGTWSALGALNAAGLPFDDPRVKRAAQWLL
CCHHHHHHHHHHHHCCCCCCEEECCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHH
SIQNPDGGWGEDGDSYKLDYRGYERAASTASQTAWALLGLMAAGEVEHPAVARGIAWLAA
EECCCCCCCCCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
QQREHGLWDEARFTATGFPRVFYLRYHGYRKFFPLWALARYRNLRRTGTRRVTVGM
HHHHCCCCCCCCEEECCCCEEEEEEECCCHHHHHHHHHHHHHHHHHCCCCEEEECC
>Mature Secondary Structure
MNDLTNSSAPGARPDDATPSAAGPTPAEAAGGAVAPSRAVQPADTQTAATGAAGAAAAVG
CCCCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCCCCCCCCCCCHHHCCCCCHHHHCC
ATPAELAATAPASSGTPAGASAAPAPSGTPSVDAPAELASAAPAPSGATPAATATAATAP
CCHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCCCCCCCCCCHHCCCCC
APARAASIDAPALAAADLDAAITRATDALLAAQQADGHWIYELEADSTIPAEYVLLVHYL
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHHHH
GETPNLELERKIARYLRRVQLPGGGWPLFTDGAPDVSASVKAYFALKMIGDDANAEHMVR
CCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHEEEEEEEEECCCCCHHHHHH
ARNAIHAMGGAEMSNVFTRIQLALFGVVPWFAVPMMPVEIMLLPQWFPFHLSKVSYWART
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHH
VTVPLLVLSAKRPLARNPRGVRVDELFVAPPVNAGLLPRAGHQSPAWFACFRLLDGLLRL
HHHHHHHHHCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
TDGLFPRYTRERAIRQALQFVDERLNGEDGLGAIYPAMANSVMMYAALGYPEDHPNRATA
HHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHEEHCCCCCCCCCCHHHH
RRAIEKLLVIHDDEAYCQPCLSPVWDTSLAAHALLETGEPRAEAAAIRGLDWLRPLQILD
HHHHHHHHEEECCHHHHHHHCCHHHHHHHHHHHHHHCCCCHHHHHHHHCCHHHCCEEEEE
VRGDWISRRPDVRPGGWAFQYANPHYPDVDDTAVVTLAMDRVAKLAQTDAYRDAIARARE
CCCCHHCCCCCCCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
WVVGMQSSDGGWGAFEPENTHQYLNSIPFSDHGALLDPPTADVSGRCLSMLAQLGETAAN
HHEEECCCCCCCCCCCCCHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCC
SAPARRALDYLLAEQGADGSWYGRWGMNYIYGTWSALGALNAAGLPFDDPRVKRAAQWLL
CCHHHHHHHHHHHHCCCCCCEEECCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHH
SIQNPDGGWGEDGDSYKLDYRGYERAASTASQTAWALLGLMAAGEVEHPAVARGIAWLAA
EECCCCCCCCCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
QQREHGLWDEARFTATGFPRVFYLRYHGYRKFFPLWALARYRNLRRTGTRRVTVGM
HHHHCCCCCCCCEEECCCCEEEEEEECCCHHHHHHHHHHHHHHHHHCCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12597275 [H]