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The map label for this gene is iorA [H]

Identifier: 238023784

GI number: 238023784

Start: 378545

End: 379000

Strand: Direct

Name: iorA [H]

Synonym: bglu_2g03190

Alternate gene names: 238023784

Gene position: 378545-379000 (Clockwise)

Preceding gene: 238023781

Following gene: 238023785

Centisome position: 13.39

GC content: 70.18

Gene sequence:

>456_bases
ATGACCACGTTGAACATCAATGGCGTGACGCACAGCGTCGACGCGCCCGACGACATGCCTCTCCTCTGGGTGCTGCGCGA
CCTCGTCGGTCTGACCGGCACGAAGTTCGGCTGCGGCATCGCCCAGTGCGGCGCCTGCACCGTCCACCTGGACGGCGAGG
CCGCGCGCTCGTGCGTGCTGCCGGTGGCCGCCGTGGCCGGCCGCCGGATCACGACCATCGAGGCGGTCGGTATGACGCCG
GTGGGCGCGAAGGTCCAGCAGGCATGGCGCAAGCTCGACGTGGTGCAGTGCGGCTACTGCCAGTCGGGGCAGGTGATGGC
GGCCGCTTCGCTGCTGGCCTCGAACCCGCACCCGAGCGACGCCGACATCGATGCGGCGATGGCGGGCAACATCTGCCGCT
GCGGCACCTACAACCGGATTCGCGCAGCCATCAAGCTGGCCGCGCAGGAGGCCTGA

Upstream 100 bases:

>100_bases
GGCCAAGCAAGGCGTCGATCTCGCGCCCTTCGCCGTCGATCCGCTCCAAGCCTTGCCGCGACACGCTCCAACCCTTCCCC
CACCAAACCGGGAGCTTCCG

Downstream 100 bases:

>100_bases
CCATGTCCTCGGGAATCATCGAAGCGAGCCGCGCCGCGCGCGCGGCCGGCGGCGACGCGACGGGCATCTCGCGGCGCCAT
TTCCTGCAGGCCGGCTTCAC

Product: isoquinoline 1-oxidoreductase subunit alpha

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 151; Mature: 150

Protein sequence:

>151_residues
MTTLNINGVTHSVDAPDDMPLLWVLRDLVGLTGTKFGCGIAQCGACTVHLDGEAARSCVLPVAAVAGRRITTIEAVGMTP
VGAKVQQAWRKLDVVQCGYCQSGQVMAAASLLASNPHPSDADIDAAMAGNICRCGTYNRIRAAIKLAAQEA

Sequences:

>Translated_151_residues
MTTLNINGVTHSVDAPDDMPLLWVLRDLVGLTGTKFGCGIAQCGACTVHLDGEAARSCVLPVAAVAGRRITTIEAVGMTP
VGAKVQQAWRKLDVVQCGYCQSGQVMAAASLLASNPHPSDADIDAAMAGNICRCGTYNRIRAAIKLAAQEA
>Mature_150_residues
TTLNINGVTHSVDAPDDMPLLWVLRDLVGLTGTKFGCGIAQCGACTVHLDGEAARSCVLPVAAVAGRRITTIEAVGMTPV
GAKVQQAWRKLDVVQCGYCQSGQVMAAASLLASNPHPSDADIDAAMAGNICRCGTYNRIRAAIKLAAQEA

Specific function: Specific towards N-containing N-heterocyclic substrates, including isoquinoline, isoquinolin-5-ol, phthalazine and quinazoline [H]

COG id: COG2080

COG function: function code C; Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 2Fe-2S ferredoxin-type domain [H]

Homologues:

Organism=Homo sapiens, GI91823271, Length=147, Percent_Identity=35.3741496598639, Blast_Score=69, Evalue=1e-12,
Organism=Homo sapiens, GI71773480, Length=107, Percent_Identity=32.7102803738318, Blast_Score=69, Evalue=2e-12,
Organism=Escherichia coli, GI1786480, Length=163, Percent_Identity=38.6503067484663, Blast_Score=101, Evalue=2e-23,
Organism=Escherichia coli, GI1789232, Length=138, Percent_Identity=39.1304347826087, Blast_Score=90, Evalue=8e-20,
Organism=Caenorhabditis elegans, GI17540638, Length=140, Percent_Identity=40.7142857142857, Blast_Score=105, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI17539860, Length=152, Percent_Identity=34.2105263157895, Blast_Score=91, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI32566215, Length=159, Percent_Identity=32.0754716981132, Blast_Score=89, Evalue=8e-19,
Organism=Drosophila melanogaster, GI17737937, Length=157, Percent_Identity=36.3057324840764, Blast_Score=89, Evalue=8e-19,
Organism=Drosophila melanogaster, GI24647193, Length=157, Percent_Identity=35.6687898089172, Blast_Score=86, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24647199, Length=153, Percent_Identity=34.640522875817, Blast_Score=77, Evalue=4e-15,
Organism=Drosophila melanogaster, GI24647201, Length=153, Percent_Identity=33.3333333333333, Blast_Score=74, Evalue=5e-14,
Organism=Drosophila melanogaster, GI24647197, Length=157, Percent_Identity=31.8471337579618, Blast_Score=69, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24647195, Length=157, Percent_Identity=31.8471337579618, Blast_Score=69, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002888
- InterPro:   IPR006058
- InterPro:   IPR012675
- InterPro:   IPR001041 [H]

Pfam domain/function: PF00111 Fer2; PF01799 Fer2_2 [H]

EC number: =1.3.99.16 [H]

Molecular weight: Translated: 15681; Mature: 15550

Theoretical pI: Translated: 7.24; Mature: 7.24

Prosite motif: PS00197 2FE2S_FER_1 ; PS51085 2FE2S_FER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

5.3 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
8.6 %Cys+Met (Translated Protein)
5.3 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
8.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTLNINGVTHSVDAPDDMPLLWVLRDLVGLTGTKFGCGIAQCGACTVHLDGEAARSCVL
CEEEECCCEEECCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEECCHHHHHHHH
PVAAVAGRRITTIEAVGMTPVGAKVQQAWRKLDVVQCGYCQSGQVMAAASLLASNPHPSD
HHHHHCCCEEEEEEECCCCCCCHHHHHHHHHHCCEECCCCCCCCHHHHHHHHHCCCCCCC
ADIDAAMAGNICRCGTYNRIRAAIKLAAQEA
CCCHHHHCCCEEECCCHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TTLNINGVTHSVDAPDDMPLLWVLRDLVGLTGTKFGCGIAQCGACTVHLDGEAARSCVL
EEEECCCEEECCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEECCHHHHHHHH
PVAAVAGRRITTIEAVGMTPVGAKVQQAWRKLDVVQCGYCQSGQVMAAASLLASNPHPSD
HHHHHCCCEEEEEEECCCCCCCHHHHHHHHHHCCEECCCCCCCCHHHHHHHHHCCCCCCC
ADIDAAMAGNICRCGTYNRIRAAIKLAAQEA
CCCHHHHCCCEEECCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7782304; 8157655 [H]