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The map label for this gene is emrY [H]

Identifier: 238023532

GI number: 238023532

Start: 35894

End: 37474

Strand: Direct

Name: emrY [H]

Synonym: bglu_2g00330

Alternate gene names: 238023532

Gene position: 35894-37474 (Clockwise)

Preceding gene: 238023531

Following gene: 238023533

Centisome position: 1.27

GC content: 68.44

Gene sequence:

>1581_bases
GTGAGCCGGGCCGCCGCCGGATCGGGCGCCTGGCGCCCGGCGGCCAACCCCTGGCTGATCGCCGTGGTGGTCACGCTCGC
CGCGTTCATGGAAGTGCTCGACACGACCATCGTCAACGTCGCGCTGCCGCATATCGCCGGCACCATGTCGGCGAGCTACG
ACGAGGCTACCTGGACGCTCACCTCGTATCTGGTCGCCAACGGCATCGTGCTGCCGATCTCGGGCTTCCTCGGCCGGCTG
CTCGGCCGCAAGCGCTATTTCGTGATCTGCATCGCCGCGTTCACGGTCTGCTCGTTCCTGTGCGGGATCGCCACCAACCT
CGGCCAGCTGATCGTGTTCCGCATCCTGCAGGGGCTGTTCGGCGGCGGCCTGCAGCCGAACCAGCAGTCGATCATCCTCG
ACACCTTTCCGCCCGAGCAGCGCAACCGCGCGTTCTCGATCTCGGCGATCGCGATCGTGGTGGCGCCGGTGCTCGGCCCG
ACGCTCGGCGGCTGGATCACCGACACCTTCTCGTGGCGCTGGGTGTTCCTGCTCAACGTGCCGGTGGGCATCCTCACCGT
GCTGGCGGTGACGCAGCTGGTGGAGGACCCGCCGTGGCGGCGCGACGGCGAGCGCGGCATCCGCATCGACTACATCGGCA
TCGGCCTGATCGCGCTCGGCCTCGGCTGCCTGCAGGTGATGCTCGACCGCGGCGAGGACGAAGACTGGTTCGGCTCGAAC
TTCATCCGCCTGTTCGCCGTGCTGACGGTGCTGGGGCTCACCGGCGCGGTGCTCTGGCTGCGCTACGCGAAGAAGCCGGT
GGTGGATCTGGCCTGCCTGCGCGACCGCAATTTCGCGCTCGGCTGCCTGACCATCGCCTGCTTCGCGGCGGTGCTCTACG
GCAGCGCCGTGATCGTGCCGCAGCTCGCGCAGCAGCAGCTCGGCTACACCGCCACGCTGGCCGGGCTCGTGCTGTCGCCG
GGCGCGATCCTGATCACGCTGGAGATCCCGATCGTGAGCCGCCTGATGCCGGTGGTGCAGACGCGCTACCTGGTGGGCGT
CGGCTTCGTGCTGCTGACCCTCTCGCTCGTCTATTCGCGCACGCTGGTGCCCGACATCGACTACCGGCACCTGATGATGA
TCCGCTGCGCGCAGTCGCTGGCGATCGGCTTCCTGTTCGTGCCGATCACCACGCTCGCCTACCTGACCATCCCGCAGCGG
CTCAACGACGACGCCTCGGCGCTGTTCACGATGTTCCGCAACGTGGCCGGCTCGATCGGCATCTCGGTGTCCACGGCGCT
GATCCGCGAGCGCACCCAGGCGCAGATGGCGCATCTGTCCGGCCACATGTCGCCGTTCTCGCAGAACTTCCAGGACGCGC
TGCAGCGCAACGCGCAGTCGATCACCGCGCTCTCGGGCGCGCCGCCCGCGGCCGCGCTGCAGACCGCGAACGGCCGGCTC
TACGAGACCTTCGTCTCGCAGGCCACGATCCTCGCCTATCTCGACGTGTTCGCGATCCTGGCGGTGTTCTGCGCGATCTG
CATCCCGTTGACGTTCATGTTCTCGCCGGTGAAGGCGGCGCAGGGCGGAGGAGGACATTGA

Upstream 100 bases:

>100_bases
GCCGCCCCGCCATGGCCCACTTCGCGGCACCGCCGCCTGGGAGCGAACCGATGTCCGTGCCGTTGCCGTTGTCGCCCGCG
CCGCGCGCGGGCCGCCGCCC

Downstream 100 bases:

>100_bases
GATGAAGCATCAGGCACCGCAGGGCCCGCGGGCTTTCCGGGCACGCACGCGCGCACGCGCACTCGCCTGGCCGGCCGCGC
TGGCCGGCTGTCTGGCGCTG

Product: EmrB/QacA subfamily drug resistance transporter

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 526; Mature: 525

Protein sequence:

>526_residues
MSRAAAGSGAWRPAANPWLIAVVVTLAAFMEVLDTTIVNVALPHIAGTMSASYDEATWTLTSYLVANGIVLPISGFLGRL
LGRKRYFVICIAAFTVCSFLCGIATNLGQLIVFRILQGLFGGGLQPNQQSIILDTFPPEQRNRAFSISAIAIVVAPVLGP
TLGGWITDTFSWRWVFLLNVPVGILTVLAVTQLVEDPPWRRDGERGIRIDYIGIGLIALGLGCLQVMLDRGEDEDWFGSN
FIRLFAVLTVLGLTGAVLWLRYAKKPVVDLACLRDRNFALGCLTIACFAAVLYGSAVIVPQLAQQQLGYTATLAGLVLSP
GAILITLEIPIVSRLMPVVQTRYLVGVGFVLLTLSLVYSRTLVPDIDYRHLMMIRCAQSLAIGFLFVPITTLAYLTIPQR
LNDDASALFTMFRNVAGSIGISVSTALIRERTQAQMAHLSGHMSPFSQNFQDALQRNAQSITALSGAPPAAALQTANGRL
YETFVSQATILAYLDVFAILAVFCAICIPLTFMFSPVKAAQGGGGH

Sequences:

>Translated_526_residues
MSRAAAGSGAWRPAANPWLIAVVVTLAAFMEVLDTTIVNVALPHIAGTMSASYDEATWTLTSYLVANGIVLPISGFLGRL
LGRKRYFVICIAAFTVCSFLCGIATNLGQLIVFRILQGLFGGGLQPNQQSIILDTFPPEQRNRAFSISAIAIVVAPVLGP
TLGGWITDTFSWRWVFLLNVPVGILTVLAVTQLVEDPPWRRDGERGIRIDYIGIGLIALGLGCLQVMLDRGEDEDWFGSN
FIRLFAVLTVLGLTGAVLWLRYAKKPVVDLACLRDRNFALGCLTIACFAAVLYGSAVIVPQLAQQQLGYTATLAGLVLSP
GAILITLEIPIVSRLMPVVQTRYLVGVGFVLLTLSLVYSRTLVPDIDYRHLMMIRCAQSLAIGFLFVPITTLAYLTIPQR
LNDDASALFTMFRNVAGSIGISVSTALIRERTQAQMAHLSGHMSPFSQNFQDALQRNAQSITALSGAPPAAALQTANGRL
YETFVSQATILAYLDVFAILAVFCAICIPLTFMFSPVKAAQGGGGH
>Mature_525_residues
SRAAAGSGAWRPAANPWLIAVVVTLAAFMEVLDTTIVNVALPHIAGTMSASYDEATWTLTSYLVANGIVLPISGFLGRLL
GRKRYFVICIAAFTVCSFLCGIATNLGQLIVFRILQGLFGGGLQPNQQSIILDTFPPEQRNRAFSISAIAIVVAPVLGPT
LGGWITDTFSWRWVFLLNVPVGILTVLAVTQLVEDPPWRRDGERGIRIDYIGIGLIALGLGCLQVMLDRGEDEDWFGSNF
IRLFAVLTVLGLTGAVLWLRYAKKPVVDLACLRDRNFALGCLTIACFAAVLYGSAVIVPQLAQQQLGYTATLAGLVLSPG
AILITLEIPIVSRLMPVVQTRYLVGVGFVLLTLSLVYSRTLVPDIDYRHLMMIRCAQSLAIGFLFVPITTLAYLTIPQRL
NDDASALFTMFRNVAGSIGISVSTALIRERTQAQMAHLSGHMSPFSQNFQDALQRNAQSITALSGAPPAAALQTANGRLY
ETFVSQATILAYLDVFAILAVFCAICIPLTFMFSPVKAAQGGGGH

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. EmrB family [H]

Homologues:

Organism=Escherichia coli, GI1788710, Length=508, Percent_Identity=33.4645669291339, Blast_Score=310, Evalue=1e-85,
Organism=Escherichia coli, GI1789042, Length=480, Percent_Identity=34.375, Blast_Score=308, Evalue=8e-85,
Organism=Escherichia coli, GI1790195, Length=427, Percent_Identity=27.4004683840749, Blast_Score=139, Evalue=4e-34,
Organism=Escherichia coli, GI1788392, Length=413, Percent_Identity=28.0871670702179, Blast_Score=112, Evalue=4e-26,
Organism=Escherichia coli, GI87081983, Length=342, Percent_Identity=29.2397660818713, Blast_Score=109, Evalue=4e-25,
Organism=Saccharomyces cerevisiae, GI6322958, Length=187, Percent_Identity=28.8770053475936, Blast_Score=77, Evalue=6e-15,
Organism=Saccharomyces cerevisiae, GI6325455, Length=171, Percent_Identity=27.4853801169591, Blast_Score=73, Evalue=9e-14,
Organism=Saccharomyces cerevisiae, GI6321663, Length=150, Percent_Identity=29.3333333333333, Blast_Score=72, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6323735, Length=195, Percent_Identity=29.2307692307692, Blast_Score=64, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004638
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 56689; Mature: 56558

Theoretical pI: Translated: 8.40; Mature: 8.40

Prosite motif: PS00092 N6_MTASE ; PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRAAAGSGAWRPAANPWLIAVVVTLAAFMEVLDTTIVNVALPHIAGTMSASYDEATWTL
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHH
TSYLVANGIVLPISGFLGRLLGRKRYFVICIAAFTVCSFLCGIATNLGQLIVFRILQGLF
HHHHHHCCCEEEHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GGGLQPNQQSIILDTFPPEQRNRAFSISAIAIVVAPVLGPTLGGWITDTFSWRWVFLLNV
CCCCCCCCCEEEEECCCCHHCCCEEEHHHHHHHHHHHHCCCCCCHHCCCCCEEEEEEECC
PVGILTVLAVTQLVEDPPWRRDGERGIRIDYIGIGLIALGLGCLQVMLDRGEDEDWFGSN
CHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHCCCCCCCCCHH
FIRLFAVLTVLGLTGAVLWLRYAKKPVVDLACLRDRNFALGCLTIACFAAVLYGSAVIVP
HHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHCCHHHHH
QLAQQQLGYTATLAGLVLSPGAILITLEIPIVSRLMPVVQTRYLVGVGFVLLTLSLVYSR
HHHHHHCCHHHHHHHHHHCCCEEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TLVPDIDYRHLMMIRCAQSLAIGFLFVPITTLAYLTIPQRLNDDASALFTMFRNVAGSIG
HCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCC
ISVSTALIRERTQAQMAHLSGHMSPFSQNFQDALQRNAQSITALSGAPPAAALQTANGRL
HHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCHHHHHHCCCCCCHHHHCCCCCHH
YETFVSQATILAYLDVFAILAVFCAICIPLTFMFSPVKAAQGGGGH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCCCC
>Mature Secondary Structure 
SRAAAGSGAWRPAANPWLIAVVVTLAAFMEVLDTTIVNVALPHIAGTMSASYDEATWTL
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHH
TSYLVANGIVLPISGFLGRLLGRKRYFVICIAAFTVCSFLCGIATNLGQLIVFRILQGLF
HHHHHHCCCEEEHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GGGLQPNQQSIILDTFPPEQRNRAFSISAIAIVVAPVLGPTLGGWITDTFSWRWVFLLNV
CCCCCCCCCEEEEECCCCHHCCCEEEHHHHHHHHHHHHCCCCCCHHCCCCCEEEEEEECC
PVGILTVLAVTQLVEDPPWRRDGERGIRIDYIGIGLIALGLGCLQVMLDRGEDEDWFGSN
CHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHCCCCCCCCCHH
FIRLFAVLTVLGLTGAVLWLRYAKKPVVDLACLRDRNFALGCLTIACFAAVLYGSAVIVP
HHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHCCHHHHH
QLAQQQLGYTATLAGLVLSPGAILITLEIPIVSRLMPVVQTRYLVGVGFVLLTLSLVYSR
HHHHHHCCHHHHHHHHHHCCCEEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TLVPDIDYRHLMMIRCAQSLAIGFLFVPITTLAYLTIPQRLNDDASALFTMFRNVAGSIG
HCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCC
ISVSTALIRERTQAQMAHLSGHMSPFSQNFQDALQRNAQSITALSGAPPAAALQTANGRL
HHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCHHHHHHCCCCCCHHHHCCCCCHH
YETFVSQATILAYLDVFAILAVFCAICIPLTFMFSPVKAAQGGGGH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9205837; 9278503 [H]