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The map label for this gene is purP [H]

Identifier: 237813347

GI number: 237813347

Start: 3024910

End: 3026358

Strand: Direct

Name: purP [H]

Synonym: GBP346_A3116

Alternate gene names: 237813347

Gene position: 3024910-3026358 (Clockwise)

Preceding gene: 237813346

Following gene: 237813348

Centisome position: 73.8

GC content: 67.15

Gene sequence:

>1449_bases
ATGCGGCGGCGCGCGAAGCGCGCGCGTTGCGACGCGTTGCGCTCGACACGAGACACTGAGGAGAGCTTAACGATGGACCT
CTATCAAGGCACCGCCGCGCCCGCGAAGCGCTCGGCGCTCGAGCGCCACTTCGGCATCCGCGAGTCCGGCTCGCGGCTGC
GCACCGAGATCGTCGCCGGCGTGACGACATTCCTCACCGCGATGTACATCATCGTCGTGAATCCCGGCATCCTGTCGCAG
GCGGGCGTGCCGTTCGCAGCCGCGCTCACGGCGACCGTGATCGTCAGCTTCCTCGGCAGTTGCGCGATGGGCCTGTACGC
GCGCAATCCGGTGCTCGTCGCGCCGGGCATGGGAATGAACGCGCTCTTCACGTTCGTGATGGTCCACGGCGGCAAGATGC
CGTGGCAAACCGCGCTCGGCTGCGTGTTCTGGGCAGGCGTGCTGTTCGCGACACTCGCCGCGTTCAATGCGCGCAAGCTC
GTCGTCGACGCGATTCCGGCGAACCTGCGGCATGCGGTGTCGTGCGGCATCGGCCTGTTCATCAGCCTGATCGGGCTCGT
GAACGCGAAGTTCATCGTCGGCGATCCGGTGACGATCGTTCACGCGACGTCGCTCAACCCTGTGATCGTCACGTTTCTCG
CCGGCCTCGCGGTCACGACCGTGCTCGTCGTGCGCCGCGTGACGGGCGCGCTGATGCTCGGCATCGTCGCGACGACGCTG
CTCGCGATCCCGATCGGCCGCGTGTGGGGCGACGGCAGCGCGTACTGGCCCGCCGCGATCGCGACGAAGACGCTCGTCAA
CTGGAACGGCCTCGTTGCCGCGCCGGATTTCTCCGCGCTCGGCCAGCTCGATCTGCTCGGCTCGCTGAAGGTCGCGTACT
GGCCGTTCATCTTCGTGATGCTGTTCACCGCGTTCTTCGACGCGCTCTCGACGTTCATGGCGATCTCGGAGGCGGGCAAC
CTGCGCGACCGCGACGGCAATCCGCGCAACATCCGCCAATCGATGATCGTCGACGCGTTCTCGGCCGTCGTGTCCGCGCC
GCTCGGCACGAGCCCCGCGAACGCGTACATCGAATCGGCGGCCGGCATCTCGGCGGGCGGCCGCACGGGGCTCGTCGCGG
TGGTCGCGGGCTTGTGCTTCGTGCCGTTCCTGTTCCTGTCGCCGCTGCTCTCGCTCGTGCCGGCGATCGCGACGGCGCCC
GCGCTCGTGCTCGTCGGCGTATTCATGATGGAATCGATCACGAAGATCGAATGGCACCGCTTCGACGAGGCGATCCCCGC
GTTTCTCGCGATGATCCTGATACCGCTCACATACTCGATCACCGAAGGCATCGCATACGGCTTTCTCGCGTTCGTCGTGC
TCAAGCTCTTCACCGGCCGCCGCGGCGACGTGAAGCCCGCGATGTGGGTGGTCGCCGCGCTGTCGCTGCTGCTCGTCGCA
CAACTCTGA

Upstream 100 bases:

>100_bases
GAAGCGTCGTTCGTGAGCGCCGACGAACGCGCGGCGCTGATCGCGAAGCTCGACGCGCACTGGCACGCGGCCTGACGGCC
GCGCAACGCGCGCGCCCCGC

Downstream 100 bases:

>100_bases
TTTCAATCGATACGGATTCCCCACGATGACTCAAACCGCTTTCCGCGCCCGCCTGCTGAGGTTCGACGGCGACCCCGCGC
AATCGGACGATGCGCTCGCG

Product: xanthine/uracil permease family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 482; Mature: 482

Protein sequence:

>482_residues
MRRRAKRARCDALRSTRDTEESLTMDLYQGTAAPAKRSALERHFGIRESGSRLRTEIVAGVTTFLTAMYIIVVNPGILSQ
AGVPFAAALTATVIVSFLGSCAMGLYARNPVLVAPGMGMNALFTFVMVHGGKMPWQTALGCVFWAGVLFATLAAFNARKL
VVDAIPANLRHAVSCGIGLFISLIGLVNAKFIVGDPVTIVHATSLNPVIVTFLAGLAVTTVLVVRRVTGALMLGIVATTL
LAIPIGRVWGDGSAYWPAAIATKTLVNWNGLVAAPDFSALGQLDLLGSLKVAYWPFIFVMLFTAFFDALSTFMAISEAGN
LRDRDGNPRNIRQSMIVDAFSAVVSAPLGTSPANAYIESAAGISAGGRTGLVAVVAGLCFVPFLFLSPLLSLVPAIATAP
ALVLVGVFMMESITKIEWHRFDEAIPAFLAMILIPLTYSITEGIAYGFLAFVVLKLFTGRRGDVKPAMWVVAALSLLLVA
QL

Sequences:

>Translated_482_residues
MRRRAKRARCDALRSTRDTEESLTMDLYQGTAAPAKRSALERHFGIRESGSRLRTEIVAGVTTFLTAMYIIVVNPGILSQ
AGVPFAAALTATVIVSFLGSCAMGLYARNPVLVAPGMGMNALFTFVMVHGGKMPWQTALGCVFWAGVLFATLAAFNARKL
VVDAIPANLRHAVSCGIGLFISLIGLVNAKFIVGDPVTIVHATSLNPVIVTFLAGLAVTTVLVVRRVTGALMLGIVATTL
LAIPIGRVWGDGSAYWPAAIATKTLVNWNGLVAAPDFSALGQLDLLGSLKVAYWPFIFVMLFTAFFDALSTFMAISEAGN
LRDRDGNPRNIRQSMIVDAFSAVVSAPLGTSPANAYIESAAGISAGGRTGLVAVVAGLCFVPFLFLSPLLSLVPAIATAP
ALVLVGVFMMESITKIEWHRFDEAIPAFLAMILIPLTYSITEGIAYGFLAFVVLKLFTGRRGDVKPAMWVVAALSLLLVA
QL
>Mature_482_residues
MRRRAKRARCDALRSTRDTEESLTMDLYQGTAAPAKRSALERHFGIRESGSRLRTEIVAGVTTFLTAMYIIVVNPGILSQ
AGVPFAAALTATVIVSFLGSCAMGLYARNPVLVAPGMGMNALFTFVMVHGGKMPWQTALGCVFWAGVLFATLAAFNARKL
VVDAIPANLRHAVSCGIGLFISLIGLVNAKFIVGDPVTIVHATSLNPVIVTFLAGLAVTTVLVVRRVTGALMLGIVATTL
LAIPIGRVWGDGSAYWPAAIATKTLVNWNGLVAAPDFSALGQLDLLGSLKVAYWPFIFVMLFTAFFDALSTFMAISEAGN
LRDRDGNPRNIRQSMIVDAFSAVVSAPLGTSPANAYIESAAGISAGGRTGLVAVVAGLCFVPFLFLSPLLSLVPAIATAP
ALVLVGVFMMESITKIEWHRFDEAIPAFLAMILIPLTYSITEGIAYGFLAFVVLKLFTGRRGDVKPAMWVVAALSLLLVA
QL

Specific function: High-affinity uptake of adenine [H]

COG id: COG2252

COG function: function code R; Permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xanthine/uracil permease family. AzgA purine transporter (TC 2.A.1.40) subfamily [H]

Homologues:

Organism=Escherichia coli, GI1790150, Length=453, Percent_Identity=39.514348785872, Blast_Score=313, Evalue=1e-86,
Organism=Escherichia coli, GI87082309, Length=441, Percent_Identity=38.3219954648526, Blast_Score=293, Evalue=2e-80,
Organism=Escherichia coli, GI1790499, Length=436, Percent_Identity=36.9266055045872, Blast_Score=243, Evalue=2e-65,
Organism=Escherichia coli, GI48994909, Length=443, Percent_Identity=36.568848758465, Blast_Score=238, Evalue=8e-64,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006043 [H]

Pfam domain/function: PF00860 Xan_ur_permease [H]

EC number: NA

Molecular weight: Translated: 51156; Mature: 51156

Theoretical pI: Translated: 10.03; Mature: 10.03

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRRRAKRARCDALRSTRDTEESLTMDLYQGTAAPAKRSALERHFGIRESGSRLRTEIVAG
CCCHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHH
VTTFLTAMYIIVVNPGILSQAGVPFAAALTATVIVSFLGSCAMGLYARNPVLVAPGMGMN
HHHHHHHHHHHHCCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCHH
ALFTFVMVHGGKMPWQTALGCVFWAGVLFATLAAFNARKLVVDAIPANLRHAVSCGIGLF
HHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCHHHHHHHHHHHHHH
ISLIGLVNAKFIVGDPVTIVHATSLNPVIVTFLAGLAVTTVLVVRRVTGALMLGIVATTL
HHHHHHHCCCEEECCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LAIPIGRVWGDGSAYWPAAIATKTLVNWNGLVAAPDFSALGQLDLLGSLKVAYWPFIFVM
HHHHHHHHCCCCCCCCHHHHHHHHHCCCCCEEECCCHHHHCCHHHHHHHHHHHHHHHHHH
LFTAFFDALSTFMAISEAGNLRDRDGNPRNIRQSMIVDAFSAVVSAPLGTSPANAYIESA
HHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHH
AGISAGGRTGLVAVVAGLCFVPFLFLSPLLSLVPAIATAPALVLVGVFMMESITKIEWHR
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FDEAIPAFLAMILIPLTYSITEGIAYGFLAFVVLKLFTGRRGDVKPAMWVVAALSLLLVA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHH
QL
CC
>Mature Secondary Structure
MRRRAKRARCDALRSTRDTEESLTMDLYQGTAAPAKRSALERHFGIRESGSRLRTEIVAG
CCCHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHH
VTTFLTAMYIIVVNPGILSQAGVPFAAALTATVIVSFLGSCAMGLYARNPVLVAPGMGMN
HHHHHHHHHHHHCCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCHH
ALFTFVMVHGGKMPWQTALGCVFWAGVLFATLAAFNARKLVVDAIPANLRHAVSCGIGLF
HHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCHHHHHHHHHHHHHH
ISLIGLVNAKFIVGDPVTIVHATSLNPVIVTFLAGLAVTTVLVVRRVTGALMLGIVATTL
HHHHHHHCCCEEECCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LAIPIGRVWGDGSAYWPAAIATKTLVNWNGLVAAPDFSALGQLDLLGSLKVAYWPFIFVM
HHHHHHHHCCCCCCCCHHHHHHHHHCCCCCEEECCCHHHHCCHHHHHHHHHHHHHHHHHH
LFTAFFDALSTFMAISEAGNLRDRDGNPRNIRQSMIVDAFSAVVSAPLGTSPANAYIESA
HHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHH
AGISAGGRTGLVAVVAGLCFVPFLFLSPLLSLVPAIATAPALVLVGVFMMESITKIEWHR
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FDEAIPAFLAMILIPLTYSITEGIAYGFLAFVVLKLFTGRRGDVKPAMWVVAALSLLLVA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHH
QL
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7686882; 9278503 [H]