Click here to switch to the map view.

The map label for this gene is guaD [H]

Identifier: 237813348

GI number: 237813348

Start: 3026384

End: 3027694

Strand: Direct

Name: guaD [H]

Synonym: GBP346_A3117

Alternate gene names: 237813348

Gene position: 3026384-3027694 (Clockwise)

Preceding gene: 237813347

Following gene: 237813349

Centisome position: 73.84

GC content: 70.71

Gene sequence:

>1311_bases
ATGACTCAAACCGCTTTCCGCGCCCGCCTGCTGAGGTTCGACGGCGACCCCGCGCAATCGGACGATGCGCTCGCGTACGA
CGAGGACGGCCTGCTGATCGTCGAGAACGGGCGCGTCGTCGCGGCGGGCGCCCATGCGGCGCTCGCCGCGCGCCTCGCGC
CCGGCGCGACGCTCGTCGAGATGCGCGACAAGCTGATCGCGCCCGGCTTCATCGACACGCACGTGCACTATCCGCAGACC
GAAATGATCGCCTCGCCGGCGCCGGGCCTGTTGCCGTGGCTCGACCGCTACACGTTCCCGACCGAGCGGCGCTTCGCCGA
TCCCGCGCATGCGCGCGACGTCGCCGAGTTCTTCCTCGATACGCTGCTCGCGTGCGGCACGACGACGGCGCTCGTCTACT
GCACGGTGCACAAGCAGTCGGCCGACGCGCTGTTCGGCGCGAGCGAGGCGCGCGGCTTGCGGATGATCGCGGGCAAGGTG
CTGATGGACCGCCACTGCCCCGAGTTCCTGCGCGACACCGCGCAATCGGGCTACGACGACAGCGCCGAGCTGATCGCCCG
CTGGCACGGCCACGGCCGGCAGTCGTACGCGCTCACGCCGCGCTTCGCGCCGACATCGACGCACGCACAGCTCGAAGCGT
GCGGCGCGCTCGCCCGGCTTCATCCGGACGTGTTCATCCAGAGCCACGTCGCGGAGAATCTCGACGAGCTCCGCTGGGCG
GCCGAGCTGTTTCCCGAGCGGCGCAGCTATCTCGATGTCTACGATCACTACGGGCTGCTGCGCCGTCGCGCCGTGTACGG
CCACTGCATCCATCTCGACGACGACGACCGCCGGCGCTTCGCCGAAACGGGCGCGATCGCCGCGCACTGCCCGACGTCGA
ACCTGTTCCTCGGCAGCGGCCTGTTCGATTTCGAGCGCGCGAACGCGCGGCACATGGCCGTCACGCTCGCGACCGACGTC
GGCGGCGGCACATCGTTCTCGATGCTCCAAACGATGAACGAAGCGCACAAGATCGCGCGGATGACGGGCCATCACCTGAG
CGCGACGCGCATGTTCTGGCTCGCGACGGCAGGCGCCGCGCACGCGCTCGATCTCGCGGACACGATCGGCACGCTCGCGC
CGCACGCGGAAGCCGACTTCGTCGTGCTCGATCCTGCCGCGACGCCGCTGCTCGCGCGCCGCACCGCGCGCGCGGAATCG
CTCGAGGAGCTGCTGTTCGCGCTCGCGCTGCTCGGCGACGATCGCGCGGTCTATCGCACGTATGCCGCCGGCCGCTGCGT
GCACCGGCGCGACATCGCCGACGCGGGCTGA

Upstream 100 bases:

>100_bases
GGCCGCCGCGGCGACGTGAAGCCCGCGATGTGGGTGGTCGCCGCGCTGTCGCTGCTGCTCGTCGCACAACTCTGATTTCA
ATCGATACGGATTCCCCACG

Downstream 100 bases:

>100_bases
GCGCGCGAACGCGGCCGGGGCCGGGCCGCCAGGACGGCGGGCCGCGCGGCGCGCGCCGCCGCCGCGCGATCTCGCGGCGG
TTGTCAGCCTCGGCGGCCTC

Product: guanine deaminase

Products: NA

Alternate protein names: Guanase; Guanine aminase; Guanine aminohydrolase; GAH [H]

Number of amino acids: Translated: 436; Mature: 435

Protein sequence:

>436_residues
MTQTAFRARLLRFDGDPAQSDDALAYDEDGLLIVENGRVVAAGAHAALAARLAPGATLVEMRDKLIAPGFIDTHVHYPQT
EMIASPAPGLLPWLDRYTFPTERRFADPAHARDVAEFFLDTLLACGTTTALVYCTVHKQSADALFGASEARGLRMIAGKV
LMDRHCPEFLRDTAQSGYDDSAELIARWHGHGRQSYALTPRFAPTSTHAQLEACGALARLHPDVFIQSHVAENLDELRWA
AELFPERRSYLDVYDHYGLLRRRAVYGHCIHLDDDDRRRFAETGAIAAHCPTSNLFLGSGLFDFERANARHMAVTLATDV
GGGTSFSMLQTMNEAHKIARMTGHHLSATRMFWLATAGAAHALDLADTIGTLAPHAEADFVVLDPAATPLLARRTARAES
LEELLFALALLGDDRAVYRTYAAGRCVHRRDIADAG

Sequences:

>Translated_436_residues
MTQTAFRARLLRFDGDPAQSDDALAYDEDGLLIVENGRVVAAGAHAALAARLAPGATLVEMRDKLIAPGFIDTHVHYPQT
EMIASPAPGLLPWLDRYTFPTERRFADPAHARDVAEFFLDTLLACGTTTALVYCTVHKQSADALFGASEARGLRMIAGKV
LMDRHCPEFLRDTAQSGYDDSAELIARWHGHGRQSYALTPRFAPTSTHAQLEACGALARLHPDVFIQSHVAENLDELRWA
AELFPERRSYLDVYDHYGLLRRRAVYGHCIHLDDDDRRRFAETGAIAAHCPTSNLFLGSGLFDFERANARHMAVTLATDV
GGGTSFSMLQTMNEAHKIARMTGHHLSATRMFWLATAGAAHALDLADTIGTLAPHAEADFVVLDPAATPLLARRTARAES
LEELLFALALLGDDRAVYRTYAAGRCVHRRDIADAG
>Mature_435_residues
TQTAFRARLLRFDGDPAQSDDALAYDEDGLLIVENGRVVAAGAHAALAARLAPGATLVEMRDKLIAPGFIDTHVHYPQTE
MIASPAPGLLPWLDRYTFPTERRFADPAHARDVAEFFLDTLLACGTTTALVYCTVHKQSADALFGASEARGLRMIAGKVL
MDRHCPEFLRDTAQSGYDDSAELIARWHGHGRQSYALTPRFAPTSTHAQLEACGALARLHPDVFIQSHVAENLDELRWAA
ELFPERRSYLDVYDHYGLLRRRAVYGHCIHLDDDDRRRFAETGAIAAHCPTSNLFLGSGLFDFERANARHMAVTLATDVG
GGTSFSMLQTMNEAHKIARMTGHHLSATRMFWLATAGAAHALDLADTIGTLAPHAEADFVVLDPAATPLLARRTARAESL
EELLFALALLGDDRAVYRTYAAGRCVHRRDIADAG

Specific function: Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia [H]

COG id: COG0402

COG function: function code FR; Cytosine deaminase and related metal-dependent hydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATZ/TRZ family [H]

Homologues:

Organism=Homo sapiens, GI4758426, Length=378, Percent_Identity=31.4814814814815, Blast_Score=187, Evalue=2e-47,
Organism=Escherichia coli, GI1789249, Length=416, Percent_Identity=48.0769230769231, Blast_Score=429, Evalue=1e-121,
Organism=Saccharomyces cerevisiae, GI6319963, Length=409, Percent_Identity=30.8068459657702, Blast_Score=189, Evalue=8e-49,
Organism=Drosophila melanogaster, GI24643849, Length=431, Percent_Identity=31.554524361949, Blast_Score=196, Evalue=4e-50,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR014311
- InterPro:   IPR011059 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: =3.5.4.3 [H]

Molecular weight: Translated: 47814; Mature: 47682

Theoretical pI: Translated: 6.36; Mature: 6.36

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQTAFRARLLRFDGDPAQSDDALAYDEDGLLIVENGRVVAAGAHAALAARLAPGATLVE
CCCHHHHHHHHHCCCCCCCCCCCEEECCCCEEEEECCEEEEECCHHHHHHHHCCCCHHHH
MRDKLIAPGFIDTHVHYPQTEMIASPAPGLLPWLDRYTFPTERRFADPAHARDVAEFFLD
HHHHHCCCCCEECCCCCCCHHHHCCCCCCHHHHHHHCCCCCHHCCCCCHHHHHHHHHHHH
TLLACGTTTALVYCTVHKQSADALFGASEARGLRMIAGKVLMDRHCPEFLRDTAQSGYDD
HHHHCCCCEEEEEEEEECCCCHHHHCCHHCCCHHHHHHHHHHHHCCHHHHHHHHHCCCCC
SAELIARWHGHGRQSYALTPRFAPTSTHAQLEACGALARLHPDVFIQSHVAENLDELRWA
HHHHHHHHHCCCCCCEEECCCCCCCCCHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHH
AELFPERRSYLDVYDHYGLLRRRAVYGHCIHLDDDDRRRFAETGAIAAHCPTSNLFLGSG
HHHHHHHHHHHHHHHHHHHHHHHHHHCEEEECCCHHHHHHHHCCCEEEECCCCCEEEECC
LFDFERANARHMAVTLATDVGGGTSFSMLQTMNEAHKIARMTGHHLSATRMFWLATAGAA
CCHHHHCCCCEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHEEEEEECCCH
HALDLADTIGTLAPHAEADFVVLDPAATPLLARRTARAESLEELLFALALLGDDRAVYRT
HHHHHHHHHHHCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
YAAGRCVHRRDIADAG
HHHCCHHHHHCCCCCC
>Mature Secondary Structure 
TQTAFRARLLRFDGDPAQSDDALAYDEDGLLIVENGRVVAAGAHAALAARLAPGATLVE
CCHHHHHHHHHCCCCCCCCCCCEEECCCCEEEEECCEEEEECCHHHHHHHHCCCCHHHH
MRDKLIAPGFIDTHVHYPQTEMIASPAPGLLPWLDRYTFPTERRFADPAHARDVAEFFLD
HHHHHCCCCCEECCCCCCCHHHHCCCCCCHHHHHHHCCCCCHHCCCCCHHHHHHHHHHHH
TLLACGTTTALVYCTVHKQSADALFGASEARGLRMIAGKVLMDRHCPEFLRDTAQSGYDD
HHHHCCCCEEEEEEEEECCCCHHHHCCHHCCCHHHHHHHHHHHHCCHHHHHHHHHCCCCC
SAELIARWHGHGRQSYALTPRFAPTSTHAQLEACGALARLHPDVFIQSHVAENLDELRWA
HHHHHHHHHCCCCCCEEECCCCCCCCCHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHH
AELFPERRSYLDVYDHYGLLRRRAVYGHCIHLDDDDRRRFAETGAIAAHCPTSNLFLGSG
HHHHHHHHHHHHHHHHHHHHHHHHHHCEEEECCCHHHHHHHHCCCEEEECCCCCEEEECC
LFDFERANARHMAVTLATDVGGGTSFSMLQTMNEAHKIARMTGHHLSATRMFWLATAGAA
CCHHHHCCCCEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHEEEEEECCCH
HALDLADTIGTLAPHAEADFVVLDPAATPLLARRTARAESLEELLFALALLGDDRAVYRT
HHHHHHHHHHHCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
YAAGRCVHRRDIADAG
HHHCCHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9278503; 10913105 [H]