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The map label for this gene is norM

Identifier: 237813238

GI number: 237813238

Start: 2922341

End: 2923747

Strand: Direct

Name: norM

Synonym: GBP346_A3005

Alternate gene names: 237813238

Gene position: 2922341-2923747 (Clockwise)

Preceding gene: 237813237

Following gene: 237813240

Centisome position: 71.3

GC content: 71.5

Gene sequence:

>1407_bases
ATGTCGCCTACCGGTTTCACGCGCGCGGCCGCCGCGCCGCCTCCCACGCTGTCCCGCCACGCCGCCGATACGGCGCGCCT
CGCCGCGCCGCTCGCGATCGCGCAACTGTCGCAAATGGCGATGAGCGTCACCGACACCGTGCTGCTCGGCTCGCTCGGCC
CCGACGCGCTCGCGGCAGGCGGCCTCGGCGCGAATCTGTTCTTCGTCGTCGTGACGCTGCTACAAGGCGTGCTGACGTCG
GTCAGCGTGAGCGTCGCGCACGCGCGCGGCGCCATGGCCGAGGATCGCGTGCCGCATATCTACTGGACGGGCTTCGCGCT
GTCGCTGTTGCTCGCGGTTCCGGCGTTCGCGCTGCTGTCGTTCGCGCAGCCGCTGTTGCTCGCGTTCGGCGAACCGGCGG
CGCTCGCGCGCAACGTCGGCGAATACGCGGCCGTGCTGCGCTTCGCCGCGCCCGGCAGCCTGATCGGCGTCGGGCTGATG
CGCTCGTTCTTGCCCGCGATCGGCGCGGCGAAGCGGCTGCTGTGGGTGTCGCTCGCGGGCGTCGGCGTCAACGCGTTTCT
CAACTACGGGCTGATCCACGGTGCATTCGGGCTGCCCCGGCTCGGCTTCCTCGGCTCCGCGACGGCCACGACGATCACGA
TCTGGCTCACCGCGATCACGCTCGTCGCGCTGCTGCACGGACGCTCGACGTTCAGGCACTTCGTCGCCGCCACGCGGCCG
CGGCTGCCGCTGATGGGCGAGCTGTTCGGCATCGGCTGGCCGGTCGCGATCACGTATGGCGTCGAGTCGACGCTCTTTCT
CGCGACGGGGCTCACCGTCGGCGTGCTCGGCGAATCTTCGCTCGCCGCGCACCAGATCGCGCTGAACGTCGCGTCGGTCG
CGTTCATGGTGCCGCTCGCGATCGGCCAGGCGGCGAACGTGCGCGTCGGCTACTGGGCCGGCGCGGGTGCGCCCGTGGCC
GCACGCCATGCGGGTTTCGTCGCGCTCGGGCTCGGCGTCGCGTTCATGTCGCTGTCGGGGCTCGTGCTGATCGTCGCGCC
GCACGCGATCGTCGGTCTTTATCTGAAGCTCGACGATCCCGCGAACGCGCGGACGGTCGTGCTCGCGACGTCGCTGCTCG
GCATCGCCGCGGTGTTCCAGATCGTCGACGGGATGCAGACGGTCGGCTCCGGCTGCCTGCGCGGCCTGAAGGACACGCGC
GTGCCGATGCTCGCCGCGACGCTCGGCTACTGGGGCATCGGCTTCCCGACCGGCTACTGGTTCGCGTTCCACGCGGGCCT
CGGCGCGCGCGGCTTGTGGTGGGGACTCGCGGCCGGCCTCGCGAGCGTCGCGATGCTGATGACGTGGCGATTCCATCGCA
AGAGCGCGGCGCTCGGCGTGCGAGCGGATGCTCGAGGGCAGGCTTAG

Upstream 100 bases:

>100_bases
ATCGGCGAGTCTCGTCGACAGCGCTCCGGGAAACTCGTAAGCTGATCGTTTCCAAAAAACAAGCAAAGCGCGGGCGGGGC
CGCTCGTGCGAACGCGTCCC

Downstream 100 bases:

>100_bases
GCTTTTGGGCTTTTTTAGCGGATAGCGGTTAGCCGTTAGCCGTTAGCCGTTAGCCGTTAGCCGTTAGCCGTTAGCCGTTA
GCCGTTAGCCGTTAGCCGTT

Product: multidrug resistance protein NorM (Multidrug-efflux transporter)

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: Multidrug-efflux transporter

Number of amino acids: Translated: 468; Mature: 467

Protein sequence:

>468_residues
MSPTGFTRAAAAPPPTLSRHAADTARLAAPLAIAQLSQMAMSVTDTVLLGSLGPDALAAGGLGANLFFVVVTLLQGVLTS
VSVSVAHARGAMAEDRVPHIYWTGFALSLLLAVPAFALLSFAQPLLLAFGEPAALARNVGEYAAVLRFAAPGSLIGVGLM
RSFLPAIGAAKRLLWVSLAGVGVNAFLNYGLIHGAFGLPRLGFLGSATATTITIWLTAITLVALLHGRSTFRHFVAATRP
RLPLMGELFGIGWPVAITYGVESTLFLATGLTVGVLGESSLAAHQIALNVASVAFMVPLAIGQAANVRVGYWAGAGAPVA
ARHAGFVALGLGVAFMSLSGLVLIVAPHAIVGLYLKLDDPANARTVVLATSLLGIAAVFQIVDGMQTVGSGCLRGLKDTR
VPMLAATLGYWGIGFPTGYWFAFHAGLGARGLWWGLAAGLASVAMLMTWRFHRKSAALGVRADARGQA

Sequences:

>Translated_468_residues
MSPTGFTRAAAAPPPTLSRHAADTARLAAPLAIAQLSQMAMSVTDTVLLGSLGPDALAAGGLGANLFFVVVTLLQGVLTS
VSVSVAHARGAMAEDRVPHIYWTGFALSLLLAVPAFALLSFAQPLLLAFGEPAALARNVGEYAAVLRFAAPGSLIGVGLM
RSFLPAIGAAKRLLWVSLAGVGVNAFLNYGLIHGAFGLPRLGFLGSATATTITIWLTAITLVALLHGRSTFRHFVAATRP
RLPLMGELFGIGWPVAITYGVESTLFLATGLTVGVLGESSLAAHQIALNVASVAFMVPLAIGQAANVRVGYWAGAGAPVA
ARHAGFVALGLGVAFMSLSGLVLIVAPHAIVGLYLKLDDPANARTVVLATSLLGIAAVFQIVDGMQTVGSGCLRGLKDTR
VPMLAATLGYWGIGFPTGYWFAFHAGLGARGLWWGLAAGLASVAMLMTWRFHRKSAALGVRADARGQA
>Mature_467_residues
SPTGFTRAAAAPPPTLSRHAADTARLAAPLAIAQLSQMAMSVTDTVLLGSLGPDALAAGGLGANLFFVVVTLLQGVLTSV
SVSVAHARGAMAEDRVPHIYWTGFALSLLLAVPAFALLSFAQPLLLAFGEPAALARNVGEYAAVLRFAAPGSLIGVGLMR
SFLPAIGAAKRLLWVSLAGVGVNAFLNYGLIHGAFGLPRLGFLGSATATTITIWLTAITLVALLHGRSTFRHFVAATRPR
LPLMGELFGIGWPVAITYGVESTLFLATGLTVGVLGESSLAAHQIALNVASVAFMVPLAIGQAANVRVGYWAGAGAPVAA
RHAGFVALGLGVAFMSLSGLVLIVAPHAIVGLYLKLDDPANARTVVLATSLLGIAAVFQIVDGMQTVGSGCLRGLKDTRV
PMLAATLGYWGIGFPTGYWFAFHAGLGARGLWWGLAAGLASVAMLMTWRFHRKSAALGVRADARGQA

Specific function: Multidrug efflux pump

COG id: COG0534

COG function: function code V; Na+-driven multidrug efflux pump

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family

Homologues:

Organism=Homo sapiens, GI22907060, Length=425, Percent_Identity=27.5294117647059, Blast_Score=89, Evalue=9e-18,
Organism=Homo sapiens, GI153792564, Length=418, Percent_Identity=23.6842105263158, Blast_Score=68, Evalue=2e-11,
Organism=Escherichia coli, GI48994890, Length=435, Percent_Identity=31.9540229885057, Blast_Score=174, Evalue=9e-45,
Organism=Escherichia coli, GI226510954, Length=449, Percent_Identity=26.0579064587973, Blast_Score=85, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6320545, Length=430, Percent_Identity=23.0232558139535, Blast_Score=69, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NORM_BURMA (Q62LW6)

Other databases:

- EMBL:   CP000010
- RefSeq:   YP_102302.1
- ProteinModelPortal:   Q62LW6
- GeneID:   3088315
- GenomeReviews:   CP000010_GR
- KEGG:   bma:BMA0502
- TIGR:   BMA0502
- HOGENOM:   HBG479615
- OMA:   MMGELIG
- PhylomeDB:   Q62LW6
- ProtClustDB:   CLSK930984
- BioCyc:   BMAL243160:BMA_0502-MONOMER
- InterPro:   IPR002528
- PANTHER:   PTHR11206
- TIGRFAMs:   TIGR00797

Pfam domain/function: PF01554 MatE

EC number: NA

Molecular weight: Translated: 48189; Mature: 48058

Theoretical pI: Translated: 11.13; Mature: 11.13

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x18bb3e84)-; HASH(0x1c160164)-; HASH(0x1c16d6d4)-; HASH(0x1bc12174)-; HASH(0x1a9cb6e8)-; HASH(0x1c18fdf8)-; HASH(0x1bef04c0)-; HASH(0x1bb8ca20)-; HASH(0x1ba9382c)-; HASH(0x1c1233a4)-; HASH(0x1c0f6e88)-;

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSPTGFTRAAAAPPPTLSRHAADTARLAAPLAIAQLSQMAMSVTDTVLLGSLGPDALAAG
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHCC
GLGANLFFVVVTLLQGVLTSVSVSVAHARGAMAEDRVPHIYWTGFALSLLLAVPAFALLS
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHH
FAQPLLLAFGEPAALARNVGEYAAVLRFAAPGSLIGVGLMRSFLPAIGAAKRLLWVSLAG
HHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VGVNAFLNYGLIHGAFGLPRLGFLGSATATTITIWLTAITLVALLHGRSTFRHFVAATRP
CCHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHCCC
RLPLMGELFGIGWPVAITYGVESTLFLATGLTVGVLGESSLAAHQIALNVASVAFMVPLA
CCCHHHHHHCCCCCEEEEECCCHHHHHHCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHH
IGQAANVRVGYWAGAGAPVAARHAGFVALGLGVAFMSLSGLVLIVAPHAIVGLYLKLDDP
CCCCCCEEEEEECCCCCCHHHHHCCHHHHHHHHHHHHHCCEEEEEECHHHEEEEEEECCC
ANARTVVLATSLLGIAAVFQIVDGMQTVGSGCLRGLKDTRVPMLAATLGYWGIGFPTGYW
CCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCHHH
FAFHAGLGARGLWWGLAAGLASVAMLMTWRFHRKSAALGVRADARGQA
HHEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCH
>Mature Secondary Structure 
SPTGFTRAAAAPPPTLSRHAADTARLAAPLAIAQLSQMAMSVTDTVLLGSLGPDALAAG
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHCC
GLGANLFFVVVTLLQGVLTSVSVSVAHARGAMAEDRVPHIYWTGFALSLLLAVPAFALLS
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHH
FAQPLLLAFGEPAALARNVGEYAAVLRFAAPGSLIGVGLMRSFLPAIGAAKRLLWVSLAG
HHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VGVNAFLNYGLIHGAFGLPRLGFLGSATATTITIWLTAITLVALLHGRSTFRHFVAATRP
CCHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHCCC
RLPLMGELFGIGWPVAITYGVESTLFLATGLTVGVLGESSLAAHQIALNVASVAFMVPLA
CCCHHHHHHCCCCCEEEEECCCHHHHHHCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHH
IGQAANVRVGYWAGAGAPVAARHAGFVALGLGVAFMSLSGLVLIVAPHAIVGLYLKLDDP
CCCCCCEEEEEECCCCCCHHHHHCCHHHHHHHHHHHHHCCEEEEEECHHHEEEEEEECCC
ANARTVVLATSLLGIAAVFQIVDGMQTVGSGCLRGLKDTRVPMLAATLGYWGIGFPTGYW
CCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCHHH
FAFHAGLGARGLWWGLAAGLASVAMLMTWRFHRKSAALGVRADARGQA
HHEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA