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The map label for this gene is fumC [H]

Identifier: 237813240

GI number: 237813240

Start: 2924377

End: 2925771

Strand: Direct

Name: fumC [H]

Synonym: GBP346_A3007

Alternate gene names: 237813240

Gene position: 2924377-2925771 (Clockwise)

Preceding gene: 237813238

Following gene: 237813243

Centisome position: 71.35

GC content: 67.24

Gene sequence:

>1395_bases
ATGAGCGAAGCAGTACGGATGGAACGCGACACGTTCGGCGAAATCGCCGTGCCGGCCGCCCGGCTATGGGGCGCGCAGAC
GCAGCGCTCGCTGCAGAACTTCAAGATCTCGACCGAGAAGCAGTCGCCCGAACTGATCCACGCGCTCGCGCTGATCAAGC
GCGCGGCCGCCGCCGTCAATCTCGAGCTCGGCGTGCTCGCGCAGGACAAGGCGAACGCGATCGTCGCCGCCGCCGACGAG
ATCATCGCCGGCCGTCACGCCGACGAATTCCCGCTCGCCGTCTGGCAAACGGGTTCGGGCACGCAGACCAACATGAACCT
CAACGAGGTGATCGCGAACCGCGCGAGCGAGCTGCTCGGCGGCGAGCGCGGCGAAAGCCGCGCCGTGCATCCAAACGATG
ACGTCAATCGCGGCCAGTCGTCGAACGACGTGTTCCCGACCGCAATGCACATCGCCGCCGCGCGTGCGATCGTCGACCAT
CTGCTGCCCGCGCTGCGCACGCTGCGCGCGACACTCGACGCGAAGGCCGCCGCGTTCGCCGACATCGTGAAGATCGGCCG
CACGCACCTGCAGGACGCGACGCCGCTCACGCTCGGCCAGGAATTCTCCGGCTACGTCGCGCAGCTCGATCAGGGCATCC
GTCACGTCGAGGCGGCGCTGCCTCATCTGTACGAGCTCGCGCAAGGCGGCACCGCGGTCGGCACGGGCCTGAACGCGCAT
CCGAAGTTCGCGGCGGGCGTTGCGGCCGAGATCGGCCGGCTCACCGGCCTGCCGTTCGTCAGCGCACCGAACAAATTCGA
AGTGATGGCCGCTGCCGACGCGCTCGTGTTCGCGCACGGCGCGCTGAAGACGGTCGCCGCGAGCCTGATGAAGATCGCGA
ACGACATCCGCTGGCTCGCGAGCGGGCCGCGCTGCGGGCTCGGCGAGCTGTCGATTCCGGAAAACGAGCCGGGCAGCTCG
ATCATGCCGGGCAAGGTCAATCCGACGCAATCCGAAGCGGTGACGATGCTGTGCTGCCAGGTGTTCGGCAATGACGTCGC
GGTGAACTTCGGCGGCGCGAGCGGCAATTTCGAGCTGAACGTGTTTCGGCCGATGATCGCGCACAACGTGCTGCAATCGG
TGCGGCTGCTCGCGGACGGCGCACAGGGCTTCAACGATCATTGCGCGGTCGGCATCGAGCCGAATCGCGCGCGCATCGAC
GCGCTGCTGAACGAATCGCTGATGCTCGTGACGGCGCTCAATCCGCACATCGGCTACGACAAGGCCGCGCAGATCGCGAA
GAAGGCGCACAAGGAGGGCACCACGCTCAAAGCCGCCGCGCTTGCGCTCGGTTACGTGACCGATGCGCAGTTCGACGAAT
GGGTGCGGCCGGAGCATATGGTCGGCAACCGCTGA

Upstream 100 bases:

>100_bases
TGCTTGCCCATCAGTGGATGCCGTCGCGAGAACGGCTCCGTCCCCGCATGCGCATCGCGCCGCGCCCGCGCGGCGTCCCC
CGTCATCTGAAGGAGCAATC

Downstream 100 bases:

>100_bases
CGCCGACGCGGCGCACGAGCGACGCGGCCGGCCTCTCTTACGCGCGCCGAAGCGCCGAAGCGCCGAAGCCCCGGAGCACG
TCGGCGCGCCCCGGTGAACG

Product: fumarate hydratase

Products: NA

Alternate protein names: Fumarase C [H]

Number of amino acids: Translated: 464; Mature: 463

Protein sequence:

>464_residues
MSEAVRMERDTFGEIAVPAARLWGAQTQRSLQNFKISTEKQSPELIHALALIKRAAAAVNLELGVLAQDKANAIVAAADE
IIAGRHADEFPLAVWQTGSGTQTNMNLNEVIANRASELLGGERGESRAVHPNDDVNRGQSSNDVFPTAMHIAAARAIVDH
LLPALRTLRATLDAKAAAFADIVKIGRTHLQDATPLTLGQEFSGYVAQLDQGIRHVEAALPHLYELAQGGTAVGTGLNAH
PKFAAGVAAEIGRLTGLPFVSAPNKFEVMAAADALVFAHGALKTVAASLMKIANDIRWLASGPRCGLGELSIPENEPGSS
IMPGKVNPTQSEAVTMLCCQVFGNDVAVNFGGASGNFELNVFRPMIAHNVLQSVRLLADGAQGFNDHCAVGIEPNRARID
ALLNESLMLVTALNPHIGYDKAAQIAKKAHKEGTTLKAAALALGYVTDAQFDEWVRPEHMVGNR

Sequences:

>Translated_464_residues
MSEAVRMERDTFGEIAVPAARLWGAQTQRSLQNFKISTEKQSPELIHALALIKRAAAAVNLELGVLAQDKANAIVAAADE
IIAGRHADEFPLAVWQTGSGTQTNMNLNEVIANRASELLGGERGESRAVHPNDDVNRGQSSNDVFPTAMHIAAARAIVDH
LLPALRTLRATLDAKAAAFADIVKIGRTHLQDATPLTLGQEFSGYVAQLDQGIRHVEAALPHLYELAQGGTAVGTGLNAH
PKFAAGVAAEIGRLTGLPFVSAPNKFEVMAAADALVFAHGALKTVAASLMKIANDIRWLASGPRCGLGELSIPENEPGSS
IMPGKVNPTQSEAVTMLCCQVFGNDVAVNFGGASGNFELNVFRPMIAHNVLQSVRLLADGAQGFNDHCAVGIEPNRARID
ALLNESLMLVTALNPHIGYDKAAQIAKKAHKEGTTLKAAALALGYVTDAQFDEWVRPEHMVGNR
>Mature_463_residues
SEAVRMERDTFGEIAVPAARLWGAQTQRSLQNFKISTEKQSPELIHALALIKRAAAAVNLELGVLAQDKANAIVAAADEI
IAGRHADEFPLAVWQTGSGTQTNMNLNEVIANRASELLGGERGESRAVHPNDDVNRGQSSNDVFPTAMHIAAARAIVDHL
LPALRTLRATLDAKAAAFADIVKIGRTHLQDATPLTLGQEFSGYVAQLDQGIRHVEAALPHLYELAQGGTAVGTGLNAHP
KFAAGVAAEIGRLTGLPFVSAPNKFEVMAAADALVFAHGALKTVAASLMKIANDIRWLASGPRCGLGELSIPENEPGSSI
MPGKVNPTQSEAVTMLCCQVFGNDVAVNFGGASGNFELNVFRPMIAHNVLQSVRLLADGAQGFNDHCAVGIEPNRARIDA
LLNESLMLVTALNPHIGYDKAAQIAKKAHKEGTTLKAAALALGYVTDAQFDEWVRPEHMVGNR

Specific function: Tricarboxylic acid cycle [C]

COG id: COG0114

COG function: function code C; Fumarase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II fumarase/aspartase family. Fumarase subfamily [H]

Homologues:

Organism=Homo sapiens, GI19743875, Length=463, Percent_Identity=63.2829373650108, Blast_Score=582, Evalue=1e-166,
Organism=Homo sapiens, GI266458395, Length=66, Percent_Identity=48.4848484848485, Blast_Score=69, Evalue=9e-12,
Organism=Escherichia coli, GI1787896, Length=459, Percent_Identity=74.2919389978213, Blast_Score=704, Evalue=0.0,
Organism=Escherichia coli, GI87082375, Length=464, Percent_Identity=38.7931034482759, Blast_Score=347, Evalue=1e-96,
Organism=Caenorhabditis elegans, GI17553882, Length=462, Percent_Identity=63.8528138528139, Blast_Score=602, Evalue=1e-172,
Organism=Caenorhabditis elegans, GI32565146, Length=326, Percent_Identity=67.1779141104295, Blast_Score=454, Evalue=1e-128,
Organism=Saccharomyces cerevisiae, GI6324993, Length=466, Percent_Identity=59.2274678111588, Blast_Score=561, Evalue=1e-161,
Organism=Drosophila melanogaster, GI24640179, Length=466, Percent_Identity=61.1587982832618, Blast_Score=589, Evalue=1e-168,
Organism=Drosophila melanogaster, GI24640177, Length=466, Percent_Identity=61.1587982832618, Blast_Score=588, Evalue=1e-168,
Organism=Drosophila melanogaster, GI78710009, Length=461, Percent_Identity=59.6529284164859, Blast_Score=568, Evalue=1e-162,
Organism=Drosophila melanogaster, GI24662684, Length=462, Percent_Identity=59.95670995671, Blast_Score=563, Evalue=1e-160,
Organism=Drosophila melanogaster, GI24583245, Length=461, Percent_Identity=52.9284164859002, Blast_Score=491, Evalue=1e-139,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005677
- InterPro:   IPR018951
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761 [H]

Pfam domain/function: PF10415 FumaraseC_C; PF00206 Lyase_1 [H]

EC number: =4.2.1.2 [H]

Molecular weight: Translated: 49231; Mature: 49099

Theoretical pI: Translated: 6.46; Mature: 6.46

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEAVRMERDTFGEIAVPAARLWGAQTQRSLQNFKISTEKQSPELIHALALIKRAAAAVN
CCCCHHCCHHCCCCHHCCHHHHHCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHC
LELGVLAQDKANAIVAAADEIIAGRHADEFPLAVWQTGSGTQTNMNLNEVIANRASELLG
EEEEEEECCCCCEEEEEHHHHHHCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHC
GERGESRAVHPNDDVNRGQSSNDVFPTAMHIAAARAIVDHLLPALRTLRATLDAKAAAFA
CCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DIVKIGRTHLQDATPLTLGQEFSGYVAQLDQGIRHVEAALPHLYELAQGGTAVGTGLNAH
HHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCCCC
PKFAAGVAAEIGRLTGLPFVSAPNKFEVMAAADALVFAHGALKTVAASLMKIANDIRWLA
CCHHHHHHHHHHHHCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SGPRCGLGELSIPENEPGSSIMPGKVNPTQSEAVTMLCCQVFGNDVAVNFGGASGNFELN
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEECCCCCCEEEE
VFRPMIAHNVLQSVRLLADGAQGFNDHCAVGIEPNRARIDALLNESLMLVTALNPHIGYD
HHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCHHHHHHHHCCCEEEEEECCCCCCCH
KAAQIAKKAHKEGTTLKAAALALGYVTDAQFDEWVRPEHMVGNR
HHHHHHHHHHHCCCHHHHHHHHHHHHCCCCHHHHCCCCHHCCCC
>Mature Secondary Structure 
SEAVRMERDTFGEIAVPAARLWGAQTQRSLQNFKISTEKQSPELIHALALIKRAAAAVN
CCCHHCCHHCCCCHHCCHHHHHCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHC
LELGVLAQDKANAIVAAADEIIAGRHADEFPLAVWQTGSGTQTNMNLNEVIANRASELLG
EEEEEEECCCCCEEEEEHHHHHHCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHC
GERGESRAVHPNDDVNRGQSSNDVFPTAMHIAAARAIVDHLLPALRTLRATLDAKAAAFA
CCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DIVKIGRTHLQDATPLTLGQEFSGYVAQLDQGIRHVEAALPHLYELAQGGTAVGTGLNAH
HHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCCCC
PKFAAGVAAEIGRLTGLPFVSAPNKFEVMAAADALVFAHGALKTVAASLMKIANDIRWLA
CCHHHHHHHHHHHHCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SGPRCGLGELSIPENEPGSSIMPGKVNPTQSEAVTMLCCQVFGNDVAVNFGGASGNFELN
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEECCCCCCEEEE
VFRPMIAHNVLQSVRLLADGAQGFNDHCAVGIEPNRARIDALLNESLMLVTALNPHIGYD
HHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCHHHHHHHHCCCEEEEEECCCCCCCH
KAAQIAKKAHKEGTTLKAAALALGYVTDAQFDEWVRPEHMVGNR
HHHHHHHHHHHCCCHHHHHHHHHHHHCCCCHHHHCCCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11823852 [H]