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The map label for this gene is hutC [H]

Identifier: 237813083

GI number: 237813083

Start: 2780405

End: 2781100

Strand: Reverse

Name: hutC [H]

Synonym: GBP346_A2845

Alternate gene names: 237813083

Gene position: 2781100-2780405 (Counterclockwise)

Preceding gene: 237813084

Following gene: 237813082

Centisome position: 67.86

GC content: 66.95

Gene sequence:

>696_bases
ATGAGCACGCCCGCCTATCAGGAAATCAAGGATTTCATCCTTGCGCGCATTCACGCCGGCGAATGGGCGGAGGGCGATCA
GGTGCCGTCCGAGAACGAGCTCGCGCGCGAGTTCAAGGTCGCGCGGATGACCGTCAACCGCGCGCTGCGCGAGCTGACGG
CCGAGCAGGTGCTCACGCGCATCCAGGGGGCGGGTACGTTCGTCGCGCGGCCGAAGTACGAATCGACGCTCGTCGCGATC
CGCAGCATCTCCGACGAAGTCGCTGCGCGCGGCCACCGGCATCACGCGCGCGTGCTCGACCTCGTCACGATGAAGGCCGA
CGAAGCGCTCGCCGACGAGATGCAGGTGCCGCCTCACACGAGGCTCTTCCGCTCGGTGATGCTGCACTACGAGAACGACG
AGCCGGTGCAGCTCGAGGAGCGCTGGGTGAATCCGGCCGTCGCCGCCGATTACGCGGATCAGGATTTCTCGGCGATCACG
CCGAACCAGTACCTGATGCGCGTCGCGCCGCTGCAGCGCGTCGAATACCGGATCGAGGCGGCGATGCCCGATCGCGCGAT
GCGCGAGGCGCTCGAGATGGCCGATACCGAACCGTGCCTCGTGCTGCATCGGCGCACGTGGTCGCAGGGCGTCGTCGCAT
CGGTCGTGAACCTCTGGCATCCGGGCAGCCGCTATCGCTTCACCGGCCATTTCTGA

Upstream 100 bases:

>100_bases
CACTACTTCGCGCCCGACATCGCGGTGGTCGCGCGGCGCGTGCGCGAGCGCGCGTTCGCGACGCTGAGCCCGCTGTCGTT
CGAATCGGAACAATAAGACG

Downstream 100 bases:

>100_bases
ACGCTTGACGAATCTTCACATTCCTTTCCGGGAGCAGTTGCGATGAACCACCCGAAACATATCGATCCGCGCCTCGATCC
GACCCGCGTGATCCGCGCGC

Product: histidine utilization repressor

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 231; Mature: 230

Protein sequence:

>231_residues
MSTPAYQEIKDFILARIHAGEWAEGDQVPSENELAREFKVARMTVNRALRELTAEQVLTRIQGAGTFVARPKYESTLVAI
RSISDEVAARGHRHHARVLDLVTMKADEALADEMQVPPHTRLFRSVMLHYENDEPVQLEERWVNPAVAADYADQDFSAIT
PNQYLMRVAPLQRVEYRIEAAMPDRAMREALEMADTEPCLVLHRRTWSQGVVASVVNLWHPGSRYRFTGHF

Sequences:

>Translated_231_residues
MSTPAYQEIKDFILARIHAGEWAEGDQVPSENELAREFKVARMTVNRALRELTAEQVLTRIQGAGTFVARPKYESTLVAI
RSISDEVAARGHRHHARVLDLVTMKADEALADEMQVPPHTRLFRSVMLHYENDEPVQLEERWVNPAVAADYADQDFSAIT
PNQYLMRVAPLQRVEYRIEAAMPDRAMREALEMADTEPCLVLHRRTWSQGVVASVVNLWHPGSRYRFTGHF
>Mature_230_residues
STPAYQEIKDFILARIHAGEWAEGDQVPSENELAREFKVARMTVNRALRELTAEQVLTRIQGAGTFVARPKYESTLVAIR
SISDEVAARGHRHHARVLDLVTMKADEALADEMQVPPHTRLFRSVMLHYENDEPVQLEERWVNPAVAADYADQDFSAITP
NQYLMRVAPLQRVEYRIEAAMPDRAMREALEMADTEPCLVLHRRTWSQGVVASVVNLWHPGSRYRFTGHF

Specific function: Repressor which binds to the hutP region in the histidine utilization (hut) operon. It blocks the expression of all the hut genes in the absence of inducer [H]

COG id: COG2188

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH gntR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1786950, Length=201, Percent_Identity=30.3482587064677, Blast_Score=102, Evalue=3e-23,
Organism=Escherichia coli, GI87082252, Length=138, Percent_Identity=28.2608695652174, Blast_Score=83, Evalue=1e-17,
Organism=Escherichia coli, GI1788418, Length=210, Percent_Identity=26.6666666666667, Blast_Score=75, Evalue=4e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010248
- InterPro:   IPR000524
- InterPro:   IPR011663
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00392 GntR; PF07702 UTRA [H]

EC number: NA

Molecular weight: Translated: 26408; Mature: 26277

Theoretical pI: Translated: 6.24; Mature: 6.24

Prosite motif: PS50949 HTH_GNTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTPAYQEIKDFILARIHAGEWAEGDQVPSENELAREFKVARMTVNRALRELTAEQVLTR
CCCCHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IQGAGTFVARPKYESTLVAIRSISDEVAARGHRHHARVLDLVTMKADEALADEMQVPPHT
HHCCCCEEECCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHH
RLFRSVMLHYENDEPVQLEERWVNPAVAADYADQDFSAITPNQYLMRVAPLQRVEYRIEA
HHHHHHHHHCCCCCCCCHHHHHCCCHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
AMPDRAMREALEMADTEPCLVLHRRTWSQGVVASVVNLWHPGSRYRFTGHF
CCCHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHCCCCCCCEEECCC
>Mature Secondary Structure 
STPAYQEIKDFILARIHAGEWAEGDQVPSENELAREFKVARMTVNRALRELTAEQVLTR
CCCHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IQGAGTFVARPKYESTLVAIRSISDEVAARGHRHHARVLDLVTMKADEALADEMQVPPHT
HHCCCCEEECCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHH
RLFRSVMLHYENDEPVQLEERWVNPAVAADYADQDFSAITPNQYLMRVAPLQRVEYRIEA
HHHHHHHHHCCCCCCCCHHHHHCCCHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
AMPDRAMREALEMADTEPCLVLHRRTWSQGVVASVVNLWHPGSRYRFTGHF
CCCHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHCCCCCCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]