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The map label for this gene is hutH [H]

Identifier: 237813084

GI number: 237813084

Start: 2781105

End: 2782628

Strand: Reverse

Name: hutH [H]

Synonym: GBP346_A2846

Alternate gene names: 237813084

Gene position: 2782628-2781105 (Counterclockwise)

Preceding gene: 237813086

Following gene: 237813083

Centisome position: 67.89

GC content: 70.73

Gene sequence:

>1524_bases
ATGATCACGCTGACCCCAGGCCGTCTGACTCTCCCGCAACTGCGCCGGATCGCCCGCGAGAACGTGCAGATCGCGCTCGA
TCCCGCGAGCTTCGCCGCGATCGACCGGGGCGCGCAGGCCGTCGCCGACATCGCCGCGAAGGGCGAGCCGGCGTACGGCA
TCAACACGGGCTTCGGGCGCCTCGCGAGCACGCACATTCCGCACGACCAGCTCGAGCTGCTGCAGAAGAACCTCGTGCTG
TCGCACGCGGTGGGCGTCGGCGAGCCGATGGCGCGCCCCGTCGTGCGCCTGTTGATGGCGCTCAAGCTCTCGAGCCTCGG
CCGCGGCCACTCGGGCATTCGTCGCGTCGTGATGGACGCGCTCGTCACGCTGTTCAACGCGGACGTGCTGCCGCTCATTC
CGGTCAAGGGCTCGGTGGGCGCGTCGGGCGACCTTGCGCCGCTCGCGCACATGTCGGCCGTGCTGCTCGGCATCGGCGAC
GTGTTCATCCGCGGCGAGCGCGCGAGCGCGGCCGAAGGGCTGCGTGTCGCGGGCCTCGCGCCGCTCACGCTCGAAGCGAA
GGAGGGCCTCGCGCTGCTGAACGGCACGCAGGCGTCGACCGCGCTCGCGCTCGACAACCTGTTCGCGATCGAGGACCTGT
ACCGCACGGCGCTCGTGTCGGGCGCGCTGTCGGTCGACGCGGCGGCGGGCTCGGTGAAGCCGTTCGACGCGCGCATCCAC
GAGCTGCGCGGCCATCGCGGCCAGATCGACGCGGCCGCCGCGTACCGGTCGCTGCTCGACGGCTCGGCGATCAACGTGTC
GCACCGCGATTGCGACAAGGTGCAGGACCCGTACAGCCTGCGCTGCCAGCCGCAGGTGATGGGCGCGTGTCTCGACCAGA
TCCGCCACGCGGCCGGCGTGCTGCTCATCGAGGCGAACGCGGTGTCGGACAACCCGCTGATCTTCCCGGACACGGGCGAG
GTGCTGTCGGGCGGCAATTTCCACGCGGAGCCCGTCGCGTTCGCGGCCGACAATCTCGCGATCGCCGCGGCCGAGATCGG
CGCGCTCGCCGAGCGCCGCATCGCGCTGTTGATCGACGCGACGCTCTCCGGCCTGCCGCCTTTCCTCGTGAAGGACGGCG
GCGTGAACTCGGGCTTCATGATCGCGCACGTGACGGCCGCCGCGCTCGCGTCGGAAAACAAGACGCTCGCGCATCCGGCG
TCGGTCGATTCGCTGCCGACGTCGGCGAACCAGGAAGACCACGTGTCGATGGCGACGTTCGCCGCGCGCAAGCTCGCGGA
CATCGCGGAGAACGTCGCGAACATCCTTGCGATCGAGCTGCTCGCCGCGGCGCAAGGCGTCGACCTGCGCGCGCCGCACG
CAACGAGCCCGGCGCTGCAGCACGCGATGAAGACGATTCGCGCGGACGTCGCGCACTACGATCTCGACCACTACTTCGCG
CCCGACATCGCGGTGGTCGCGCGGCGCGTGCGCGAGCGCGCGTTCGCGACGCTGAGCCCGCTGTCGTTCGAATCGGAACA
ATAA

Upstream 100 bases:

>100_bases
GGGAAACTCCTAGCCCCGATTTTTGAAAAACAAGTTGTCTATACAACATCGAATCACTACACTCGTTTCATTCCGAAACT
TGTATAGACAGGACCCCTTC

Downstream 100 bases:

>100_bases
GACGATGAGCACGCCCGCCTATCAGGAAATCAAGGATTTCATCCTTGCGCGCATTCACGCCGGCGAATGGGCGGAGGGCG
ATCAGGTGCCGTCCGAGAAC

Product: histidine ammonia-lyase

Products: NA

Alternate protein names: Histidase [H]

Number of amino acids: Translated: 507; Mature: 507

Protein sequence:

>507_residues
MITLTPGRLTLPQLRRIARENVQIALDPASFAAIDRGAQAVADIAAKGEPAYGINTGFGRLASTHIPHDQLELLQKNLVL
SHAVGVGEPMARPVVRLLMALKLSSLGRGHSGIRRVVMDALVTLFNADVLPLIPVKGSVGASGDLAPLAHMSAVLLGIGD
VFIRGERASAAEGLRVAGLAPLTLEAKEGLALLNGTQASTALALDNLFAIEDLYRTALVSGALSVDAAAGSVKPFDARIH
ELRGHRGQIDAAAAYRSLLDGSAINVSHRDCDKVQDPYSLRCQPQVMGACLDQIRHAAGVLLIEANAVSDNPLIFPDTGE
VLSGGNFHAEPVAFAADNLAIAAAEIGALAERRIALLIDATLSGLPPFLVKDGGVNSGFMIAHVTAAALASENKTLAHPA
SVDSLPTSANQEDHVSMATFAARKLADIAENVANILAIELLAAAQGVDLRAPHATSPALQHAMKTIRADVAHYDLDHYFA
PDIAVVARRVRERAFATLSPLSFESEQ

Sequences:

>Translated_507_residues
MITLTPGRLTLPQLRRIARENVQIALDPASFAAIDRGAQAVADIAAKGEPAYGINTGFGRLASTHIPHDQLELLQKNLVL
SHAVGVGEPMARPVVRLLMALKLSSLGRGHSGIRRVVMDALVTLFNADVLPLIPVKGSVGASGDLAPLAHMSAVLLGIGD
VFIRGERASAAEGLRVAGLAPLTLEAKEGLALLNGTQASTALALDNLFAIEDLYRTALVSGALSVDAAAGSVKPFDARIH
ELRGHRGQIDAAAAYRSLLDGSAINVSHRDCDKVQDPYSLRCQPQVMGACLDQIRHAAGVLLIEANAVSDNPLIFPDTGE
VLSGGNFHAEPVAFAADNLAIAAAEIGALAERRIALLIDATLSGLPPFLVKDGGVNSGFMIAHVTAAALASENKTLAHPA
SVDSLPTSANQEDHVSMATFAARKLADIAENVANILAIELLAAAQGVDLRAPHATSPALQHAMKTIRADVAHYDLDHYFA
PDIAVVARRVRERAFATLSPLSFESEQ
>Mature_507_residues
MITLTPGRLTLPQLRRIARENVQIALDPASFAAIDRGAQAVADIAAKGEPAYGINTGFGRLASTHIPHDQLELLQKNLVL
SHAVGVGEPMARPVVRLLMALKLSSLGRGHSGIRRVVMDALVTLFNADVLPLIPVKGSVGASGDLAPLAHMSAVLLGIGD
VFIRGERASAAEGLRVAGLAPLTLEAKEGLALLNGTQASTALALDNLFAIEDLYRTALVSGALSVDAAAGSVKPFDARIH
ELRGHRGQIDAAAAYRSLLDGSAINVSHRDCDKVQDPYSLRCQPQVMGACLDQIRHAAGVLLIEANAVSDNPLIFPDTGE
VLSGGNFHAEPVAFAADNLAIAAAEIGALAERRIALLIDATLSGLPPFLVKDGGVNSGFMIAHVTAAALASENKTLAHPA
SVDSLPTSANQEDHVSMATFAARKLADIAENVANILAIELLAAAQGVDLRAPHATSPALQHAMKTIRADVAHYDLDHYFA
PDIAVVARRVRERAFATLSPLSFESEQ

Specific function: Unknown

COG id: COG2986

COG function: function code E; Histidine ammonia-lyase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PAL/histidase family [H]

Homologues:

Organism=Homo sapiens, GI4504333, Length=497, Percent_Identity=45.271629778672, Blast_Score=417, Evalue=1e-116,
Organism=Caenorhabditis elegans, GI17567831, Length=492, Percent_Identity=43.4959349593496, Blast_Score=369, Evalue=1e-102,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005921
- InterPro:   IPR008948
- InterPro:   IPR001106
- InterPro:   IPR022313 [H]

Pfam domain/function: PF00221 PAL [H]

EC number: =4.3.1.3 [H]

Molecular weight: Translated: 53111; Mature: 53111

Theoretical pI: Translated: 6.27; Mature: 6.27

Prosite motif: PS00488 PAL_HISTIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MITLTPGRLTLPQLRRIARENVQIALDPASFAAIDRGAQAVADIAAKGEPAYGINTGFGR
CEEECCCCCCHHHHHHHHHCCCEEEECCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHH
LASTHIPHDQLELLQKNLVLSHAVGVGEPMARPVVRLLMALKLSSLGRGHSGIRRVVMDA
HHHCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
LVTLFNADVLPLIPVKGSVGASGDLAPLAHMSAVLLGIGDVFIRGERASAAEGLRVAGLA
HHHHHCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHCHHEEECCCCCHHCCCEEECCC
PLTLEAKEGLALLNGTQASTALALDNLFAIEDLYRTALVSGALSVDAAAGSVKPFDARIH
CEEEECCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEECCCCCCCCHHHHHHH
ELRGHRGQIDAAAAYRSLLDGSAINVSHRDCDKVQDPYSLRCQPQVMGACLDQIRHAAGV
HHCCCCCCCHHHHHHHHHHCCCEEECCCCCHHHCCCCCCCCCCHHHHHHHHHHHHHHHCE
LLIEANAVSDNPLIFPDTGEVLSGGNFHAEPVAFAADNLAIAAAEIGALAERRIALLIDA
EEEEECCCCCCCEEECCCCCCCCCCCCCCCCCEEECCCCEEHHHHHHHHHHHHEEEEEEC
TLSGLPPFLVKDGGVNSGFMIAHVTAAALASENKTLAHPASVDSLPTSANQEDHVSMATF
HHCCCCCCEEECCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHH
AARKLADIAENVANILAIELLAAAQGVDLRAPHATSPALQHAMKTIRADVAHYDLDHYFA
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCHHHCC
PDIAVVARRVRERAFATLSPLSFESEQ
CCHHHHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MITLTPGRLTLPQLRRIARENVQIALDPASFAAIDRGAQAVADIAAKGEPAYGINTGFGR
CEEECCCCCCHHHHHHHHHCCCEEEECCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHH
LASTHIPHDQLELLQKNLVLSHAVGVGEPMARPVVRLLMALKLSSLGRGHSGIRRVVMDA
HHHCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
LVTLFNADVLPLIPVKGSVGASGDLAPLAHMSAVLLGIGDVFIRGERASAAEGLRVAGLA
HHHHHCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHCHHEEECCCCCHHCCCEEECCC
PLTLEAKEGLALLNGTQASTALALDNLFAIEDLYRTALVSGALSVDAAAGSVKPFDARIH
CEEEECCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEECCCCCCCCHHHHHHH
ELRGHRGQIDAAAAYRSLLDGSAINVSHRDCDKVQDPYSLRCQPQVMGACLDQIRHAAGV
HHCCCCCCCHHHHHHHHHHCCCEEECCCCCHHHCCCCCCCCCCHHHHHHHHHHHHHHHCE
LLIEANAVSDNPLIFPDTGEVLSGGNFHAEPVAFAADNLAIAAAEIGALAERRIALLIDA
EEEEECCCCCCCEEECCCCCCCCCCCCCCCCCEEECCCCEEHHHHHHHHHHHHEEEEEEC
TLSGLPPFLVKDGGVNSGFMIAHVTAAALASENKTLAHPASVDSLPTSANQEDHVSMATF
HHCCCCCCEEECCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHH
AARKLADIAENVANILAIELLAAAQGVDLRAPHATSPALQHAMKTIRADVAHYDLDHYFA
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCHHHCC
PDIAVVARRVRERAFATLSPLSFESEQ
CCHHHHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA