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The map label for this gene is hutU_2 [H]

Identifier: 237813082

GI number: 237813082

Start: 2778674

End: 2780362

Strand: Reverse

Name: hutU_2 [H]

Synonym: GBP346_A2844

Alternate gene names: 237813082

Gene position: 2780362-2778674 (Counterclockwise)

Preceding gene: 237813083

Following gene: 237813081

Centisome position: 67.84

GC content: 67.73

Gene sequence:

>1689_bases
ATGAACCACCCGAAACATATCGATCCGCGCCTCGATCCGACCCGCGTGATCCGCGCGCCGCGCGGCGGCGAGAAGACCTG
CAAGAACTGGCTCGCCGAGGCGGCGTACCGGATGATCCAGAACAATCTGGACCCCGAAGTGGCCGAGCATCCGCACGCGC
TCGTCGTCTACGGCGGCATCGGCCGCGCGGCGCGCAACTGGGATTGCTTCGATCAGATCCTCGCGTCGCTGAAGGATCTG
AACGACGACGAGACGCTGCTCGTGCAGTCGGGCAAGCCGGTGGGCGTGTTCCGCACGCACGAGAACGCGCCGCGCGTGCT
GATCGCGAACTCGAACCTTGTGCCGCACTGGGCGACGTGGGACCACTTCAACGAGCTCGACCGCAAGGGCCTGATGATGT
ACGGCCAGATGACGGCGGGCAGCTGGATCTACATCGGCAGCCAGGGGATCGTGCAGGGCACCTACGAGACCTTCTTCGCG
GTCGCGAACCAGCACTTCAACGGCGATCCGTCTGGCCGCTGGATCCTGACGGGCGGCCTGGGCGGGATGGGCGGCGCGCA
GCCGCTTGCCGCGACGATGGCGGGCTTCTCGATGATCGCGGTCGAGTGCGACGAATCGCGGATCGATTTCCGCCTGAAGA
CGCGCTATGTCGACAGGAAGGCGACGACTCTCGACGAAGCGCTCGGCATGATCGAAGAGGCGAAGCGCACGGGCAAGCCC
GTATCGGTGGGCCTGCTCGGCAACGCGGCCGACGTGTTCACCGAGCTCGTCGAGCGCGGCATCACGCCGGACTGCGTGAC
CGACCAGACGAGCGCGCACGATCCGATCAACGGCTACCTGCCGCAGGGCTGGAGCGTCGCGCAGTGGCGCGACGCGCAGA
AGGTCGATCCGCGAAGCATCGTGCAGGTCGCCAAGCAATCGATGGCCGTGCAGGTGCGCGCGATGCTCACGCTGCAGGCG
CGCGGCGCGGCGACGCTCGACTACGGCAACAACATCCGCCAGATGGCGCTGGAGATGGGCGTCGAGAATGCGTTCGACTT
TCCGGGCTTCGTGCCCGCCTATATCCGGCCGCTCTTCTGCGAGGGCAAGGGCCCGTTCCGTTGGGTCGCGCTGTCGGGCG
ATCCGGAGGACATCTACAAGACCGACCGGAAGGTGAAGGAGCTGATCCCCGACGATGCGCACCTGCACAACTGGCTCGAC
ATGGCGCGCGAGCGCATCGCGTTCCAGGGGCTGCCCGCGCGGATCTGCTGGGTCGGCGTGAACGATCGCTATCGTCTCGG
CCAGGCGTTCAACGAGATGGTGAAGACGGGCGAGCTGAAGGCGCCGATCGTGATCGGGCGCGACCACCTCGACACCGGCT
CGGTCGCGAGCCCGAATCGCGAGACCGAAGCGATGAAGGACGGCTCGGACGCGGTCAGCGATTGGCCGCTGCTCAACGCG
CTGCTGAACACGGCGGGCGGCGCGTCGTGGGTGTCGCTGCATCACGGCGGCGGCGTCGGCATGGGCTTCTCGCAGCATGC
GGGCGTCGTGATCGTCGCCGACGGCACCGATGCCGCGCACGCGCGCCTCGGCCGCGTGCTGTTCAACGATCCGGCCACGG
GCGTGATGCGTCACGCGGACGCCGGCTATGAGCTCGCGCAGCGCACCGCGAACGAAGCGGGCCTGAAGCTGCCGATGCTC
GGGCGCTGA

Upstream 100 bases:

>100_bases
ATCGGTCGTGAACCTCTGGCATCCGGGCAGCCGCTATCGCTTCACCGGCCATTTCTGAACGCTTGACGAATCTTCACATT
CCTTTCCGGGAGCAGTTGCG

Downstream 100 bases:

>100_bases
TGCGGGCCGCGTCGTCCACGATGCAGGCGAGCTTGATTCGCGCGGATGCGCTCGTCGCGTCGCCGTGGAAGAATGGCGGC
GGCGTGACGCGCGAGATCGC

Product: urocanate hydratase

Products: NA

Alternate protein names: Urocanase; Imidazolonepropionate hydrolase [H]

Number of amino acids: Translated: 562; Mature: 562

Protein sequence:

>562_residues
MNHPKHIDPRLDPTRVIRAPRGGEKTCKNWLAEAAYRMIQNNLDPEVAEHPHALVVYGGIGRAARNWDCFDQILASLKDL
NDDETLLVQSGKPVGVFRTHENAPRVLIANSNLVPHWATWDHFNELDRKGLMMYGQMTAGSWIYIGSQGIVQGTYETFFA
VANQHFNGDPSGRWILTGGLGGMGGAQPLAATMAGFSMIAVECDESRIDFRLKTRYVDRKATTLDEALGMIEEAKRTGKP
VSVGLLGNAADVFTELVERGITPDCVTDQTSAHDPINGYLPQGWSVAQWRDAQKVDPRSIVQVAKQSMAVQVRAMLTLQA
RGAATLDYGNNIRQMALEMGVENAFDFPGFVPAYIRPLFCEGKGPFRWVALSGDPEDIYKTDRKVKELIPDDAHLHNWLD
MARERIAFQGLPARICWVGVNDRYRLGQAFNEMVKTGELKAPIVIGRDHLDTGSVASPNRETEAMKDGSDAVSDWPLLNA
LLNTAGGASWVSLHHGGGVGMGFSQHAGVVIVADGTDAAHARLGRVLFNDPATGVMRHADAGYELAQRTANEAGLKLPML
GR

Sequences:

>Translated_562_residues
MNHPKHIDPRLDPTRVIRAPRGGEKTCKNWLAEAAYRMIQNNLDPEVAEHPHALVVYGGIGRAARNWDCFDQILASLKDL
NDDETLLVQSGKPVGVFRTHENAPRVLIANSNLVPHWATWDHFNELDRKGLMMYGQMTAGSWIYIGSQGIVQGTYETFFA
VANQHFNGDPSGRWILTGGLGGMGGAQPLAATMAGFSMIAVECDESRIDFRLKTRYVDRKATTLDEALGMIEEAKRTGKP
VSVGLLGNAADVFTELVERGITPDCVTDQTSAHDPINGYLPQGWSVAQWRDAQKVDPRSIVQVAKQSMAVQVRAMLTLQA
RGAATLDYGNNIRQMALEMGVENAFDFPGFVPAYIRPLFCEGKGPFRWVALSGDPEDIYKTDRKVKELIPDDAHLHNWLD
MARERIAFQGLPARICWVGVNDRYRLGQAFNEMVKTGELKAPIVIGRDHLDTGSVASPNRETEAMKDGSDAVSDWPLLNA
LLNTAGGASWVSLHHGGGVGMGFSQHAGVVIVADGTDAAHARLGRVLFNDPATGVMRHADAGYELAQRTANEAGLKLPML
GR
>Mature_562_residues
MNHPKHIDPRLDPTRVIRAPRGGEKTCKNWLAEAAYRMIQNNLDPEVAEHPHALVVYGGIGRAARNWDCFDQILASLKDL
NDDETLLVQSGKPVGVFRTHENAPRVLIANSNLVPHWATWDHFNELDRKGLMMYGQMTAGSWIYIGSQGIVQGTYETFFA
VANQHFNGDPSGRWILTGGLGGMGGAQPLAATMAGFSMIAVECDESRIDFRLKTRYVDRKATTLDEALGMIEEAKRTGKP
VSVGLLGNAADVFTELVERGITPDCVTDQTSAHDPINGYLPQGWSVAQWRDAQKVDPRSIVQVAKQSMAVQVRAMLTLQA
RGAATLDYGNNIRQMALEMGVENAFDFPGFVPAYIRPLFCEGKGPFRWVALSGDPEDIYKTDRKVKELIPDDAHLHNWLD
MARERIAFQGLPARICWVGVNDRYRLGQAFNEMVKTGELKAPIVIGRDHLDTGSVASPNRETEAMKDGSDAVSDWPLLNA
LLNTAGGASWVSLHHGGGVGMGFSQHAGVVIVADGTDAAHARLGRVLFNDPATGVMRHADAGYELAQRTANEAGLKLPML
GR

Specific function: Unknown

COG id: COG2987

COG function: function code E; Urocanate hydratase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the urocanase family [H]

Homologues:

Organism=Homo sapiens, GI21389467, Length=576, Percent_Identity=33.6805555555556, Blast_Score=301, Evalue=1e-81,
Organism=Homo sapiens, GI260306182, Length=636, Percent_Identity=30.8176100628931, Blast_Score=271, Evalue=8e-73,
Organism=Caenorhabditis elegans, GI71997891, Length=571, Percent_Identity=33.9754816112084, Blast_Score=307, Evalue=9e-84,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000193 [H]

Pfam domain/function: PF01175 Urocanase [H]

EC number: =4.2.1.49 [H]

Molecular weight: Translated: 61529; Mature: 61529

Theoretical pI: Translated: 6.46; Mature: 6.46

Prosite motif: PS01233 UROCANASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNHPKHIDPRLDPTRVIRAPRGGEKTCKNWLAEAAYRMIQNNLDPEVAEHPHALVVYGGI
CCCCCCCCCCCCHHHEEECCCCCHHHHHHHHHHHHHHHHHCCCCCHHHCCCCEEEEECCC
GRAARNWDCFDQILASLKDLNDDETLLVQSGKPVGVFRTHENAPRVLIANSNLVPHWATW
CCCCCCCHHHHHHHHHHHCCCCCCEEEEECCCCEEEEEECCCCCEEEEECCCCCCCCCCH
DHFNELDRKGLMMYGQMTAGSWIYIGSQGIVQGTYETFFAVANQHFNGDPSGRWILTGGL
HHHHHHCCCCEEEEEEECCCCEEEECCCCCCCHHHHHHHHHHHCCCCCCCCCCEEEECCC
GGMGGAQPLAATMAGFSMIAVECDESRIDFRLKTRYVDRKATTLDEALGMIEEAKRTGKP
CCCCCCCHHHHHHCCCEEEEEEECCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHCCCC
VSVGLLGNAADVFTELVERGITPDCVTDQTSAHDPINGYLPQGWSVAQWRDAQKVDPRSI
EEEEECCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHCCCCCCCCHHHH
VQVAKQSMAVQVRAMLTLQARGAATLDYGNNIRQMALEMGVENAFDFPGFVPAYIRPLFC
HHHHHHHHHHEEEEEEEEECCCCEEECCCCHHHHHHHHHCCCCCCCCCCCCHHHHCEEEE
EGKGPFRWVALSGDPEDIYKTDRKVKELIPDDAHLHNWLDMARERIAFQGLPARICWVGV
CCCCCEEEEEECCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEEC
NDRYRLGQAFNEMVKTGELKAPIVIGRDHLDTGSVASPNRETEAMKDGSDAVSDWPLLNA
CCCHHHHHHHHHHHHCCCCCCCEEECCCCCCCCCCCCCCCHHHHHCCCCCHHHHHHHHHH
LLNTAGGASWVSLHHGGGVGMGFSQHAGVVIVADGTDAAHARLGRVLFNDPATGVMRHAD
HHHCCCCCEEEEEECCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHCCCCCHHHHHHCC
AGYELAQRTANEAGLKLPMLGR
CCHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MNHPKHIDPRLDPTRVIRAPRGGEKTCKNWLAEAAYRMIQNNLDPEVAEHPHALVVYGGI
CCCCCCCCCCCCHHHEEECCCCCHHHHHHHHHHHHHHHHHCCCCCHHHCCCCEEEEECCC
GRAARNWDCFDQILASLKDLNDDETLLVQSGKPVGVFRTHENAPRVLIANSNLVPHWATW
CCCCCCCHHHHHHHHHHHCCCCCCEEEEECCCCEEEEEECCCCCEEEEECCCCCCCCCCH
DHFNELDRKGLMMYGQMTAGSWIYIGSQGIVQGTYETFFAVANQHFNGDPSGRWILTGGL
HHHHHHCCCCEEEEEEECCCCEEEECCCCCCCHHHHHHHHHHHCCCCCCCCCCEEEECCC
GGMGGAQPLAATMAGFSMIAVECDESRIDFRLKTRYVDRKATTLDEALGMIEEAKRTGKP
CCCCCCCHHHHHHCCCEEEEEEECCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHCCCC
VSVGLLGNAADVFTELVERGITPDCVTDQTSAHDPINGYLPQGWSVAQWRDAQKVDPRSI
EEEEECCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHCCCCCCCCHHHH
VQVAKQSMAVQVRAMLTLQARGAATLDYGNNIRQMALEMGVENAFDFPGFVPAYIRPLFC
HHHHHHHHHHEEEEEEEEECCCCEEECCCCHHHHHHHHHCCCCCCCCCCCCHHHHCEEEE
EGKGPFRWVALSGDPEDIYKTDRKVKELIPDDAHLHNWLDMARERIAFQGLPARICWVGV
CCCCCEEEEEECCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEEC
NDRYRLGQAFNEMVKTGELKAPIVIGRDHLDTGSVASPNRETEAMKDGSDAVSDWPLLNA
CCCHHHHHHHHHHHHCCCCCCCEEECCCCCCCCCCCCCCCHHHHHCCCCCHHHHHHHHHH
LLNTAGGASWVSLHHGGGVGMGFSQHAGVVIVADGTDAAHARLGRVLFNDPATGVMRHAD
HHHCCCCCEEEEEECCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHCCCCCHHHHHHCC
AGYELAQRTANEAGLKLPMLGR
CCHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 14500782 [H]