Click here to switch to the map view.

The map label for this gene is panC

Identifier: 229918729

GI number: 229918729

Start: 2974834

End: 2975664

Strand: Direct

Name: panC

Synonym: EAT1b_3016

Alternate gene names: 229918729

Gene position: 2974834-2975664 (Clockwise)

Preceding gene: 229918728

Following gene: 229918730

Centisome position: 99.16

GC content: 49.22

Gene sequence:

>831_bases
ATGAGAATTGTATCGACCGTCGAAGAATTACGTAGTGCTTTACCAATGGATCAAACGATTGGGTTCGTGCCGACGATGGG
ATATTTGCATGAAGGACATATGAGCCTCGTTGAAAACGCGCGACGGGAAAATGACGTCGTCGTCATGAGTATTTTTGTCA
ATCCGACACAGTTCGGACCGAATGAAGATCTCGACCGTTATCCCCGTGACTTTGAACGGGATGAGAAGTTGGCACGTGAA
GCGGGAGTCGATGTCCTGTTCTATCCGACGACGGAGACGATGTATCCCCTTGATATGGCCCGCGTGACCGTTCGTCACGG
GGCGGACGTATTATGTGGGGCGAGTCGTCCCGGCCATTTTGATGGTGTGTTGACAATCGTCTCGAAATTATTTAACCTTG
TTCAACCGACACGCGCTTATTTCGGTCTAAAGGATGCCCAACAAGTGGCATTGATTGAAGGATATGTCCGAGATTATTTC
GTACCGGTAGAGATTCGACGCTGCCCGATTATTCGTGAGGAGACAGGACTAGCCAAATCTTCTCGAAACGTCTACTTGTC
AGATATCGAAACGGTAGAGGCGAGTCGGATCTTCAGCGCATTGACGATGGCGCGAGAGGCACTCGATGCAGGTCAACAAG
TTGATGAAGTAAAACGACAGCTGATTGAACGTTTGGACGAGATTCCGAACAGTCAAATCGATTACGTCGAGCTTGTCGAT
TATCCGACGCTCGGTGCCGTCTCGAGCGACTCGACTGAACTCTTGTTAGCAGTGGCCATTCAGTTTGAACGGGCCCGATT
GATTGATAATGTGATTTGGAAGAAGGGATGA

Upstream 100 bases:

>100_bases
GCTCTTATGTCGAAGAGACGAAGAACGGTCACTTCCCACAAGAACGTCATACGTTCACAATGGATGAGTCGTTGCTCGAC
TCGTTGTATGGAGGAAAATG

Downstream 100 bases:

>100_bases
ATCCAATGATTCGTACATTTATGCACGCAAAGCTTCATAAAGCAACAGTGACAGAAGCAAACTTACACTACGTCGGTTCG
ATTACAATCGATGAGGATTT

Product: pantoate--beta-alanine ligase

Products: NA

Alternate protein names: PS; Pantoate--beta-alanine ligase; Pantoate-activating enzyme

Number of amino acids: Translated: 276; Mature: 276

Protein sequence:

>276_residues
MRIVSTVEELRSALPMDQTIGFVPTMGYLHEGHMSLVENARRENDVVVMSIFVNPTQFGPNEDLDRYPRDFERDEKLARE
AGVDVLFYPTTETMYPLDMARVTVRHGADVLCGASRPGHFDGVLTIVSKLFNLVQPTRAYFGLKDAQQVALIEGYVRDYF
VPVEIRRCPIIREETGLAKSSRNVYLSDIETVEASRIFSALTMAREALDAGQQVDEVKRQLIERLDEIPNSQIDYVELVD
YPTLGAVSSDSTELLLAVAIQFERARLIDNVIWKKG

Sequences:

>Translated_276_residues
MRIVSTVEELRSALPMDQTIGFVPTMGYLHEGHMSLVENARRENDVVVMSIFVNPTQFGPNEDLDRYPRDFERDEKLARE
AGVDVLFYPTTETMYPLDMARVTVRHGADVLCGASRPGHFDGVLTIVSKLFNLVQPTRAYFGLKDAQQVALIEGYVRDYF
VPVEIRRCPIIREETGLAKSSRNVYLSDIETVEASRIFSALTMAREALDAGQQVDEVKRQLIERLDEIPNSQIDYVELVD
YPTLGAVSSDSTELLLAVAIQFERARLIDNVIWKKG
>Mature_276_residues
MRIVSTVEELRSALPMDQTIGFVPTMGYLHEGHMSLVENARRENDVVVMSIFVNPTQFGPNEDLDRYPRDFERDEKLARE
AGVDVLFYPTTETMYPLDMARVTVRHGADVLCGASRPGHFDGVLTIVSKLFNLVQPTRAYFGLKDAQQVALIEGYVRDYF
VPVEIRRCPIIREETGLAKSSRNVYLSDIETVEASRIFSALTMAREALDAGQQVDEVKRQLIERLDEIPNSQIDYVELVD
YPTLGAVSSDSTELLLAVAIQFERARLIDNVIWKKG

Specific function: Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate

COG id: COG0414

COG function: function code H; Panthothenate synthetase

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pantothenate synthetase family

Homologues:

Organism=Escherichia coli, GI1786325, Length=278, Percent_Identity=43.5251798561151, Blast_Score=183, Evalue=1e-47,
Organism=Saccharomyces cerevisiae, GI6322046, Length=309, Percent_Identity=37.5404530744337, Blast_Score=177, Evalue=2e-45,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PANC_EXISA (C4L6Q1)

Other databases:

- EMBL:   CP001615
- RefSeq:   YP_002887375.1
- GeneID:   7868620
- GenomeReviews:   CP001615_GR
- KEGG:   eat:EAT1b_3016
- OMA:   ASSKENH
- ProtClustDB:   PRK00380
- GO:   GO:0005737
- HAMAP:   MF_00158
- InterPro:   IPR004821
- InterPro:   IPR003721
- InterPro:   IPR014729
- Gene3D:   G3DSA:3.40.50.620
- PANTHER:   PTHR21299:SF1
- TIGRFAMs:   TIGR00125
- TIGRFAMs:   TIGR00018

Pfam domain/function: PF02569 Pantoate_ligase

EC number: =6.3.2.1

Molecular weight: Translated: 31205; Mature: 31205

Theoretical pI: Translated: 4.59; Mature: 4.59

Prosite motif: NA

Important sites: ACT_SITE 33-33 BINDING 57-57 BINDING 57-57 BINDING 148-148 BINDING 171-171

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRIVSTVEELRSALPMDQTIGFVPTMGYLHEGHMSLVENARRENDVVVMSIFVNPTQFGP
CCHHHHHHHHHHHCCCHHHCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCCC
NEDLDRYPRDFERDEKLAREAGVDVLFYPTTETMYPLDMARVTVRHGADVLCGASRPGHF
CCCHHHCCCCHHHHHHHHHHHCCCEEEECCCCCCCCHHHHHHHHHCCCCEEECCCCCCCH
DGVLTIVSKLFNLVQPTRAYFGLKDAQQVALIEGYVRDYFVPVEIRRCPIIREETGLAKS
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHEEEEEEHHCCCCEECCCCCCCC
SRNVYLSDIETVEASRIFSALTMAREALDAGQQVDEVKRQLIERLDEIPNSQIDYVELVD
CCCEEEHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEC
YPTLGAVSSDSTELLLAVAIQFERARLIDNVIWKKG
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MRIVSTVEELRSALPMDQTIGFVPTMGYLHEGHMSLVENARRENDVVVMSIFVNPTQFGP
CCHHHHHHHHHHHCCCHHHCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCCC
NEDLDRYPRDFERDEKLAREAGVDVLFYPTTETMYPLDMARVTVRHGADVLCGASRPGHF
CCCHHHCCCCHHHHHHHHHHHCCCEEEECCCCCCCCHHHHHHHHHCCCCEEECCCCCCCH
DGVLTIVSKLFNLVQPTRAYFGLKDAQQVALIEGYVRDYFVPVEIRRCPIIREETGLAKS
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHEEEEEEHHCCCCEECCCCCCCC
SRNVYLSDIETVEASRIFSALTMAREALDAGQQVDEVKRQLIERLDEIPNSQIDYVELVD
CCCEEEHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEC
YPTLGAVSSDSTELLLAVAIQFERARLIDNVIWKKG
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA