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The map label for this gene is fmt [H]

Identifier: 229918580

GI number: 229918580

Start: 2832889

End: 2834289

Strand: Direct

Name: fmt [H]

Synonym: EAT1b_2867

Alternate gene names: 229918580

Gene position: 2832889-2834289 (Clockwise)

Preceding gene: 229918579

Following gene: 229918581

Centisome position: 94.43

GC content: 51.11

Gene sequence:

>1401_bases
ATGTATAAAGTAGTAGAAGTACCAAATGACATTTTGCGCGTAACGTGCGAACCGGTGACGAAGTTTGATAAAAAATTGCG
TCAGACTGTCGACCGATTGTTTGATACGATGTATGAGTATGACGGAGTCGGTGTCGCGGCACCGCAAGTCAATTTGAACC
AGCGGCTCGCGGTCGTCCATACCGATGATGAGACGGGACCGCTCGTCTTGATCAACCCGGAAATCATTGAAACATCTGGT
CGAGAAGTTGGGCTAGAGGGATGTTTGAGCATCCCAGGCGAATTCGGATTCGTGGAACGACACGAGTCGATCGTCGTCAA
AAATCAAGATGTGAAAGGGCGGACGCATACAATTCAAGCGAGCGGCTTTTTCGCTCGTGCGATCCAACATGAGATGGATC
ATTTGGATGGCGTCTTGTTCACGGACAAGCTCGCCGTCCCGAACCCTGGAAAAGACAAACGCATCGTCTTCATGGGGACG
CCGACGTTTGCCGTATCGGTACTTGAGCGACTGCTTGAAGAAGGATACAATGTCGTAGGTGTCGTATCGCAACCGGATAA
ACCGGTCGGGCGAAAACGTGAACTTAAGCCGACTCCAGTAAAAGAATGTGCGCTTCGTCACGGCATTCCCGTGTTGCAGC
CTGAAAAAGTGCGCACAGACTATGCAGACATTTTAGAGCTGAAGCCTGATTTGATTGTGACAGCTGCGTACGGACAAATC
GTGCCGACCGCCTTACTAGAAGCCCCGCCTCACGGAGCCATCAACGTACATGCCTCGCTCCTTCCGAAATATCGTGGAGG
TGCCCCGATTCATCAAGCCATCCTTGATGGGGAGTCGGAGACAGGTGTGACGATCATGTACATGGTCGACAAGTTAGATG
CAGGTGACATGATTGCCAATACCATCGTACCTATCGAAGAGACGGATACAGTCGGATCTTTATTTGATAAACTGGCTGTA
GCAGGAAGCGATCTTCTCATCCGTACGCTTCCCGCCTTCTTAGAAGGGTGGATTGAGGCTGTGCCTCAAGACGAGCGTGA
CGTGACGTTTGCCCCGAACATCAGCCGTGAGCGTGAACAAATCGATTGGACAATGAACGGCGAGTCCATTTACAACCATA
TTCGAGGAATGAACCCATTCCCGACGGCCTATTCAACGCTTGACGGTGAACGTGTGAAATTGTTCATGGGAGAAAAAACG
ACAGGTTCGGGACAGCCGGGAGAAGTCGTTCGTCTGGAAGAAGACGGATTTGTCGTGGCGACAGGGAACGACGTCGCCAT
CAAAGTGACCGATTTGCAACCTGCAGGTAAGAAACGGATGGATGGTGCAACCTTCATGCGTGGTGCCGGACAAAAGCTAC
GGATTGGCGACCGATTAGGAGGAACACATGAACGTACGTGA

Upstream 100 bases:

>100_bases
TGGCACGATTACAGCAAGCGAGAGCCAAAGCAATCAGCAAGAAAGAATATCAAATGAGTATCGATGTGAACCCATACGTA
TTCATGTGAGGTGGAGAGAC

Downstream 100 bases:

>100_bases
AGCAGCGCTTGATACGCTGATGAAAATTGAACAAGGTGGCGCATATTCGACGATTGCCGTCAATGATACATTGAAACAAA
AAAAAGTTGCCCCAAAAGAT

Product: methionyl-tRNA formyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 466; Mature: 466

Protein sequence:

>466_residues
MYKVVEVPNDILRVTCEPVTKFDKKLRQTVDRLFDTMYEYDGVGVAAPQVNLNQRLAVVHTDDETGPLVLINPEIIETSG
REVGLEGCLSIPGEFGFVERHESIVVKNQDVKGRTHTIQASGFFARAIQHEMDHLDGVLFTDKLAVPNPGKDKRIVFMGT
PTFAVSVLERLLEEGYNVVGVVSQPDKPVGRKRELKPTPVKECALRHGIPVLQPEKVRTDYADILELKPDLIVTAAYGQI
VPTALLEAPPHGAINVHASLLPKYRGGAPIHQAILDGESETGVTIMYMVDKLDAGDMIANTIVPIEETDTVGSLFDKLAV
AGSDLLIRTLPAFLEGWIEAVPQDERDVTFAPNISREREQIDWTMNGESIYNHIRGMNPFPTAYSTLDGERVKLFMGEKT
TGSGQPGEVVRLEEDGFVVATGNDVAIKVTDLQPAGKKRMDGATFMRGAGQKLRIGDRLGGTHERT

Sequences:

>Translated_466_residues
MYKVVEVPNDILRVTCEPVTKFDKKLRQTVDRLFDTMYEYDGVGVAAPQVNLNQRLAVVHTDDETGPLVLINPEIIETSG
REVGLEGCLSIPGEFGFVERHESIVVKNQDVKGRTHTIQASGFFARAIQHEMDHLDGVLFTDKLAVPNPGKDKRIVFMGT
PTFAVSVLERLLEEGYNVVGVVSQPDKPVGRKRELKPTPVKECALRHGIPVLQPEKVRTDYADILELKPDLIVTAAYGQI
VPTALLEAPPHGAINVHASLLPKYRGGAPIHQAILDGESETGVTIMYMVDKLDAGDMIANTIVPIEETDTVGSLFDKLAV
AGSDLLIRTLPAFLEGWIEAVPQDERDVTFAPNISREREQIDWTMNGESIYNHIRGMNPFPTAYSTLDGERVKLFMGEKT
TGSGQPGEVVRLEEDGFVVATGNDVAIKVTDLQPAGKKRMDGATFMRGAGQKLRIGDRLGGTHERT
>Mature_466_residues
MYKVVEVPNDILRVTCEPVTKFDKKLRQTVDRLFDTMYEYDGVGVAAPQVNLNQRLAVVHTDDETGPLVLINPEIIETSG
REVGLEGCLSIPGEFGFVERHESIVVKNQDVKGRTHTIQASGFFARAIQHEMDHLDGVLFTDKLAVPNPGKDKRIVFMGT
PTFAVSVLERLLEEGYNVVGVVSQPDKPVGRKRELKPTPVKECALRHGIPVLQPEKVRTDYADILELKPDLIVTAAYGQI
VPTALLEAPPHGAINVHASLLPKYRGGAPIHQAILDGESETGVTIMYMVDKLDAGDMIANTIVPIEETDTVGSLFDKLAV
AGSDLLIRTLPAFLEGWIEAVPQDERDVTFAPNISREREQIDWTMNGESIYNHIRGMNPFPTAYSTLDGERVKLFMGEKT
TGSGQPGEVVRLEEDGFVVATGNDVAIKVTDLQPAGKKRMDGATFMRGAGQKLRIGDRLGGTHERT

Specific function: Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by:(I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-

COG id: COG0223

COG function: function code J; Methionyl-tRNA formyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the fmt family [H]

Homologues:

Organism=Homo sapiens, GI238814322, Length=313, Percent_Identity=25.8785942492013, Blast_Score=120, Evalue=3e-27,
Organism=Homo sapiens, GI21614513, Length=321, Percent_Identity=26.1682242990654, Blast_Score=119, Evalue=5e-27,
Organism=Homo sapiens, GI164663775, Length=316, Percent_Identity=28.4810126582279, Blast_Score=94, Evalue=4e-19,
Organism=Homo sapiens, GI11641243, Length=162, Percent_Identity=31.4814814814815, Blast_Score=75, Evalue=9e-14,
Organism=Escherichia coli, GI1789683, Length=310, Percent_Identity=41.9354838709677, Blast_Score=243, Evalue=2e-65,
Organism=Escherichia coli, GI1788589, Length=299, Percent_Identity=30.7692307692308, Blast_Score=130, Evalue=2e-31,
Organism=Escherichia coli, GI1789682, Length=157, Percent_Identity=41.4012738853503, Blast_Score=120, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI133930964, Length=327, Percent_Identity=27.82874617737, Blast_Score=119, Evalue=5e-27,
Organism=Saccharomyces cerevisiae, GI6319458, Length=298, Percent_Identity=25.503355704698, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI45550868, Length=307, Percent_Identity=28.9902280130293, Blast_Score=124, Evalue=1e-28,
Organism=Drosophila melanogaster, GI28571984, Length=231, Percent_Identity=31.6017316017316, Blast_Score=118, Evalue=1e-26,
Organism=Drosophila melanogaster, GI24585660, Length=275, Percent_Identity=28, Blast_Score=90, Evalue=4e-18,
Organism=Drosophila melanogaster, GI24645726, Length=138, Percent_Identity=30.4347826086957, Blast_Score=69, Evalue=7e-12,
Organism=Drosophila melanogaster, GI24645728, Length=160, Percent_Identity=29.375, Blast_Score=69, Evalue=9e-12,

Paralogues:

None

Copy number: 400 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005794
- InterPro:   IPR005793
- InterPro:   IPR002376
- InterPro:   IPR011034
- InterPro:   IPR001555
- InterPro:   IPR015518 [H]

Pfam domain/function: PF02911 Formyl_trans_C; PF00551 Formyl_trans_N [H]

EC number: =2.1.2.9 [H]

Molecular weight: Translated: 51183; Mature: 51183

Theoretical pI: Translated: 5.01; Mature: 5.01

Prosite motif: PS00373 GART

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYKVVEVPNDILRVTCEPVTKFDKKLRQTVDRLFDTMYEYDGVGVAAPQVNLNQRLAVVH
CCEEEECCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCCCEEEEEE
TDDETGPLVLINPEIIETSGREVGLEGCLSIPGEFGFVERHESIVVKNQDVKGRTHTIQA
ECCCCCCEEEECCHHEECCCCEECCHHHCCCCCCCCEEECCCEEEEECCCCCCCEEEEEE
SGFFARAIQHEMDHLDGVLFTDKLAVPNPGKDKRIVFMGTPTFAVSVLERLLEEGYNVVG
CCHHHHHHHHHHHHHCCEEEECCCCCCCCCCCCEEEEEECCHHHHHHHHHHHHCCCCEEE
VVSQPDKPVGRKRELKPTPVKECALRHGIPVLQPEKVRTDYADILELKPDLIVTAAYGQI
EECCCCCCCCCCCCCCCCCHHHHHHHCCCCCCCCHHHHCCHHHHHHCCCCEEEEECCCHH
VPTALLEAPPHGAINVHASLLPKYRGGAPIHQAILDGESETGVTIMYMVDKLDAGDMIAN
HHHHHHCCCCCCEEEEEHHHCCCCCCCCCHHHHHHCCCCCCCEEEEEEEECCCCCCHHHH
TIVPIEETDTVGSLFDKLAVAGSDLLIRTLPAFLEGWIEAVPQDERDVTFAPNISREREQ
CEECCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCCCHHH
IDWTMNGESIYNHIRGMNPFPTAYSTLDGERVKLFMGEKTTGSGQPGEVVRLEEDGFVVA
EEEEECHHHHHHHHCCCCCCCCHHHCCCCCEEEEEECCCCCCCCCCCCEEEEECCCEEEE
TGNDVAIKVTDLQPAGKKRMDGATFMRGAGQKLRIGDRLGGTHERT
ECCCEEEEEECCCCCCCCCCCCHHHHHCCCCEEEECCCCCCCCCCC
>Mature Secondary Structure
MYKVVEVPNDILRVTCEPVTKFDKKLRQTVDRLFDTMYEYDGVGVAAPQVNLNQRLAVVH
CCEEEECCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCCCEEEEEE
TDDETGPLVLINPEIIETSGREVGLEGCLSIPGEFGFVERHESIVVKNQDVKGRTHTIQA
ECCCCCCEEEECCHHEECCCCEECCHHHCCCCCCCCEEECCCEEEEECCCCCCCEEEEEE
SGFFARAIQHEMDHLDGVLFTDKLAVPNPGKDKRIVFMGTPTFAVSVLERLLEEGYNVVG
CCHHHHHHHHHHHHHCCEEEECCCCCCCCCCCCEEEEEECCHHHHHHHHHHHHCCCCEEE
VVSQPDKPVGRKRELKPTPVKECALRHGIPVLQPEKVRTDYADILELKPDLIVTAAYGQI
EECCCCCCCCCCCCCCCCCHHHHHHHCCCCCCCCHHHHCCHHHHHHCCCCEEEEECCCHH
VPTALLEAPPHGAINVHASLLPKYRGGAPIHQAILDGESETGVTIMYMVDKLDAGDMIAN
HHHHHHCCCCCCEEEEEHHHCCCCCCCCCHHHHHHCCCCCCCEEEEEEEECCCCCCHHHH
TIVPIEETDTVGSLFDKLAVAGSDLLIRTLPAFLEGWIEAVPQDERDVTFAPNISREREQ
CEECCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCCCHHH
IDWTMNGESIYNHIRGMNPFPTAYSTLDGERVKLFMGEKTTGSGQPGEVVRLEEDGFVVA
EEEEECHHHHHHHHCCCCCCCCHHHCCCCCEEEEEECCCCCCCCCCCCEEEEECCCEEEE
TGNDVAIKVTDLQPAGKKRMDGATFMRGAGQKLRIGDRLGGTHERT
ECCCEEEEEECCCCCCCCCCCCHHHHHCCCCEEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA