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The map label for this gene is pyrD [H]

Identifier: 229918570

GI number: 229918570

Start: 2822509

End: 2823435

Strand: Direct

Name: pyrD [H]

Synonym: EAT1b_2857

Alternate gene names: 229918570

Gene position: 2822509-2823435 (Clockwise)

Preceding gene: 229918569

Following gene: 229918571

Centisome position: 94.09

GC content: 53.61

Gene sequence:

>927_bases
ATGAGATTGAATGTCGAGTTACCAGGTCTTCGTTTAAAAAACCCAATTATTCCGGCTTCCGGATGTTTCGGATTTGGAGA
AGAATTCGCGAAACTGTATGACCTCTCCATCTTAGGAGGCATCATGATCAAAGCAGCGACGGAGGAATCGAGATTCGGAA
ATCCGACCCCACGTGTCGCCGAGACGGCACAGGGCATGCTCAACGCGATCGGACTTCAAAATCCAGGTGTCGATGCGATC
ATCGAAGAAAAATTACCATTCCTCTCAACGTTCGACACGGAGATCATCGCCAACGTTGCCGGTTCGACGCCAGATGAATA
CGTGGAAGTCGCCCGTCGAATCAGCGCCGACCCGACGATTAAAGCCATCGAATTGAACATCTCATGCCCGAACGTGAAAT
GTGGGGGCATGCAGTTCGGGACGGACCCGGTAATGGCCGCAGAACTCACGCGACTCGTCAAAGCGGCTTCGAGTAAGCCG
GTCTATGTCAAACTGTCTCCGAACGTCACGTCGATCACGGACATGGCGCGAGCTGTCGAGGCGGCCGGCGCGGACGGCTT
GACGATGATCAACACACTCGTTGGGATGCGAATCGATATCGAGACAGGACGACCGATTTTAGCGAACCGAATCGGTGGGT
TATCTGGTCCGGCCATCAAACCGGTGGCGGTCCGGATGGTATATGAAGTCGCGCAAGCGGTCAACATACCGATTATCGCT
ATGGGCGGGGTTCGCACGGTCGACGATGTGCTTGAGTTCATTTACGCCGGGGCGTCTGCCGTTGCTGTTGGGACGGCAAA
CTTTGAAAATCCATACGTCTGCCAGGAAATCATCGAAGCGTTACCGGCACGACTCGATTTACTCGGAATCGAACATATTT
TGGATGTGAGGGGGAAGGCCTATGCGCAACTTGTATCTCGCCCTTGA

Upstream 100 bases:

>100_bases
GTGGCATCGGTGCTTGTTTTGCCTGTGTCTGTCAAGCACCGGGGGGCTATGTGAAAGTCTGTAGTGACGGTCCGGTATTC
AATGCGGAAGAGGTGCTGTT

Downstream 100 bases:

>100_bases
CGTGGAAACGCGGGACGAAGCGTTTCATTTGTTGAAACGATTTTCAAACCGACCGGCTGTTAAAGTCGGGATGGAACTCT
TTTATCGGGAAGGCGCACGC

Product: dihydroorotate dehydrogenase family protein

Products: NA

Alternate protein names: DHOdehase; DHOD; DHODase; Dihydroorotate oxidase [H]

Number of amino acids: Translated: 308; Mature: 308

Protein sequence:

>308_residues
MRLNVELPGLRLKNPIIPASGCFGFGEEFAKLYDLSILGGIMIKAATEESRFGNPTPRVAETAQGMLNAIGLQNPGVDAI
IEEKLPFLSTFDTEIIANVAGSTPDEYVEVARRISADPTIKAIELNISCPNVKCGGMQFGTDPVMAAELTRLVKAASSKP
VYVKLSPNVTSITDMARAVEAAGADGLTMINTLVGMRIDIETGRPILANRIGGLSGPAIKPVAVRMVYEVAQAVNIPIIA
MGGVRTVDDVLEFIYAGASAVAVGTANFENPYVCQEIIEALPARLDLLGIEHILDVRGKAYAQLVSRP

Sequences:

>Translated_308_residues
MRLNVELPGLRLKNPIIPASGCFGFGEEFAKLYDLSILGGIMIKAATEESRFGNPTPRVAETAQGMLNAIGLQNPGVDAI
IEEKLPFLSTFDTEIIANVAGSTPDEYVEVARRISADPTIKAIELNISCPNVKCGGMQFGTDPVMAAELTRLVKAASSKP
VYVKLSPNVTSITDMARAVEAAGADGLTMINTLVGMRIDIETGRPILANRIGGLSGPAIKPVAVRMVYEVAQAVNIPIIA
MGGVRTVDDVLEFIYAGASAVAVGTANFENPYVCQEIIEALPARLDLLGIEHILDVRGKAYAQLVSRP
>Mature_308_residues
MRLNVELPGLRLKNPIIPASGCFGFGEEFAKLYDLSILGGIMIKAATEESRFGNPTPRVAETAQGMLNAIGLQNPGVDAI
IEEKLPFLSTFDTEIIANVAGSTPDEYVEVARRISADPTIKAIELNISCPNVKCGGMQFGTDPVMAAELTRLVKAASSKP
VYVKLSPNVTSITDMARAVEAAGADGLTMINTLVGMRIDIETGRPILANRIGGLSGPAIKPVAVRMVYEVAQAVNIPIIA
MGGVRTVDDVLEFIYAGASAVAVGTANFENPYVCQEIIEALPARLDLLGIEHILDVRGKAYAQLVSRP

Specific function: Unknown

COG id: COG0167

COG function: function code F; Dihydroorotate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily [H]

Homologues:

Organism=Homo sapiens, GI119943098, Length=223, Percent_Identity=34.9775784753363, Blast_Score=117, Evalue=1e-26,
Organism=Homo sapiens, GI45006951, Length=329, Percent_Identity=27.6595744680851, Blast_Score=85, Evalue=1e-16,
Organism=Escherichia coli, GI87082059, Length=322, Percent_Identity=27.9503105590062, Blast_Score=106, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI71984108, Length=206, Percent_Identity=32.0388349514563, Blast_Score=98, Evalue=6e-21,
Organism=Caenorhabditis elegans, GI17509475, Length=320, Percent_Identity=27.8125, Blast_Score=65, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6322633, Length=299, Percent_Identity=30.4347826086957, Blast_Score=97, Evalue=3e-21,
Organism=Drosophila melanogaster, GI24640763, Length=207, Percent_Identity=32.8502415458937, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI18858217, Length=207, Percent_Identity=32.8502415458937, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI281361352, Length=320, Percent_Identity=30.9375, Blast_Score=92, Evalue=4e-19,
Organism=Drosophila melanogaster, GI17137316, Length=320, Percent_Identity=30.9375, Blast_Score=92, Evalue=4e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR005720
- InterPro:   IPR012135
- InterPro:   IPR001295 [H]

Pfam domain/function: PF01180 DHO_dh [H]

EC number: =1.3.3.1 [H]

Molecular weight: Translated: 32679; Mature: 32679

Theoretical pI: Translated: 4.70; Mature: 4.70

Prosite motif: PS00911 DHODEHASE_1 ; PS00912 DHODEHASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLNVELPGLRLKNPIIPASGCFGFGEEFAKLYDLSILGGIMIKAATEESRFGNPTPRVA
CEEECCCCCCEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHEEEECCHHCCCCCCCHHH
ETAQGMLNAIGLQNPGVDAIIEEKLPFLSTFDTEIIANVAGSTPDEYVEVARRISADPTI
HHHHHHHHHHCCCCCCCCHHHHHCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCE
KAIELNISCPNVKCGGMQFGTDPVMAAELTRLVKAASSKPVYVKLSPNVTSITDMARAVE
EEEEEEEECCCCEECCEECCCCCHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHH
AAGADGLTMINTLVGMRIDIETGRPILANRIGGLSGPAIKPVAVRMVYEVAQAVNIPIIA
HCCCCCHHHHHHHHCCEEEECCCCCHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCEEE
MGGVRTVDDVLEFIYAGASAVAVGTANFENPYVCQEIIEALPARLDLLGIEHILDVRGKA
ECCCCCHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHH
YAQLVSRP
HHHHHCCC
>Mature Secondary Structure
MRLNVELPGLRLKNPIIPASGCFGFGEEFAKLYDLSILGGIMIKAATEESRFGNPTPRVA
CEEECCCCCCEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHEEEECCHHCCCCCCCHHH
ETAQGMLNAIGLQNPGVDAIIEEKLPFLSTFDTEIIANVAGSTPDEYVEVARRISADPTI
HHHHHHHHHHCCCCCCCCHHHHHCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCE
KAIELNISCPNVKCGGMQFGTDPVMAAELTRLVKAASSKPVYVKLSPNVTSITDMARAVE
EEEEEEEECCCCEECCEECCCCCHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHH
AAGADGLTMINTLVGMRIDIETGRPILANRIGGLSGPAIKPVAVRMVYEVAQAVNIPIIA
HCCCCCHHHHHHHHCCEEEECCCCCHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCEEE
MGGVRTVDDVLEFIYAGASAVAVGTANFENPYVCQEIIEALPARLDLLGIEHILDVRGKA
ECCCCCHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHH
YAQLVSRP
HHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA