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The map label for this gene is pyrC [H]

Identifier: 229918566

GI number: 229918566

Start: 2816251

End: 2817531

Strand: Direct

Name: pyrC [H]

Synonym: EAT1b_2853

Alternate gene names: 229918566

Gene position: 2816251-2817531 (Clockwise)

Preceding gene: 229918565

Following gene: 229918567

Centisome position: 93.88

GC content: 53.08

Gene sequence:

>1281_bases
ATGATACTTCAAAACGCGACATGGTATGACAAGGGAACGAAGCGCACGACAAACATTCACGTGAAAGACGGAAAGATCGA
ATCACTCGACTATAAAGGGGAGACCGCGGGACGAGAAATCCTCGATGCGACAGGTTATCTGCTCGCACCAGGACTCGTCG
ATGTCCACGTCCACTTGCGTGAACCAGGTGGCGAGGCGAAAGAGACGATTCGGACGGGAACGATGGCTGCCGCGGCAGGC
GGGTTCACGACCATCTGCTCGATGCCGAACACGAGACCGGTTCCAGACAATCGCGAAACAATGGACGTCCTCCTTCAAAA
AATCGAACAAGACGCGGTCGTACGCGTCCTGCCTTACGCCGCTATCACGAAACGACAGCTCGGTGAAGAACAGGTCGACA
TGGAATCGCTCGCAGATGCCTTCGCCTTTACGGATGACGGGGTCGGTGTCCAATCGGCGGCGATGATGCGACAAGCCATG
CGTGAAGCGAAACGATTGAACAAAGCAGTCGTCGCCCACTGTGAGGACAATACGTTGAAGGCCGGATCGGTCCACGAGGG
CAAATTCAGTGAGGCGCATGGCATTCAAGGAATTCCGAGCCTTGCGGAGAGCATCCATATCGCTCGCGACGTGTTGATCG
CTGAAGAGACTGGATGTCATTATCATGTCTGTCACGTCTCATCCCGCCAATCGGTTCGTGTCATTCGGGATGCGAAACGA
GCCGGCATTCACGTGACTGCAGAAGTGACGCCGCATCATCTCGTCTTGAGTGAGGATGATATTCCGGGACTCGATGCAAA
CTTCAAGATGAATCCACCGCTACGAAGTGAGGATGATCGACAGGCCCTCCTTGAGGGATTATTTGACGGGACGATCGATA
TGATCGCGACGGACCATGCTCCCCATACAGCAGAAGAAAAGGCACAAGGGATAGAGCGGGCTCCGTTTGGGATTACCGGT
TTCGAGACGGCTCTTCCACTTCTCTACACGACATTCGTGAAGACAGGCATCATGGAGGAGTATCAGTTGCTCGACTGGAT
GACGAAACGTCCGAGCGACGTATTCGGTTTATCAAGAGGGGAACTGAAAGTTGGGACGGATGCGGACCTGATTCTCATCG
ATACGGAAACGTTTCGGACGGTCGATCCTACGACATTTTATTCAAAAGGAAAGAATACACCGTTCGCAGGGGAAAAGCTT
GTCGGATGGCCGGTCATGACGATGGTCGGTGGCGAAATTGTATATAAGGGGCGATTTGATGAAACGAACATTATGGCTTG
A

Upstream 100 bases:

>100_bases
GAAGTCTGATCGAACATGAACGGTCACGCATCTTCCCACAAATGAAGAATGGGGTGTACGCCCGGATGAGCATCTTAAAT
CGAGCATTAGGAGGACAACA

Downstream 100 bases:

>100_bases
AGATGGAATGAAATTTGTCGGTAAAGGATTCGGGGCACCGGCTGATACGATGGGGGAAGTCGTCTTCCAGACAGGAATGA
CAGGATACCAAGAAATCTTA

Product: dihydroorotase, multifunctional complex type

Products: NA

Alternate protein names: DHOase [H]

Number of amino acids: Translated: 426; Mature: 426

Protein sequence:

>426_residues
MILQNATWYDKGTKRTTNIHVKDGKIESLDYKGETAGREILDATGYLLAPGLVDVHVHLREPGGEAKETIRTGTMAAAAG
GFTTICSMPNTRPVPDNRETMDVLLQKIEQDAVVRVLPYAAITKRQLGEEQVDMESLADAFAFTDDGVGVQSAAMMRQAM
REAKRLNKAVVAHCEDNTLKAGSVHEGKFSEAHGIQGIPSLAESIHIARDVLIAEETGCHYHVCHVSSRQSVRVIRDAKR
AGIHVTAEVTPHHLVLSEDDIPGLDANFKMNPPLRSEDDRQALLEGLFDGTIDMIATDHAPHTAEEKAQGIERAPFGITG
FETALPLLYTTFVKTGIMEEYQLLDWMTKRPSDVFGLSRGELKVGTDADLILIDTETFRTVDPTTFYSKGKNTPFAGEKL
VGWPVMTMVGGEIVYKGRFDETNIMA

Sequences:

>Translated_426_residues
MILQNATWYDKGTKRTTNIHVKDGKIESLDYKGETAGREILDATGYLLAPGLVDVHVHLREPGGEAKETIRTGTMAAAAG
GFTTICSMPNTRPVPDNRETMDVLLQKIEQDAVVRVLPYAAITKRQLGEEQVDMESLADAFAFTDDGVGVQSAAMMRQAM
REAKRLNKAVVAHCEDNTLKAGSVHEGKFSEAHGIQGIPSLAESIHIARDVLIAEETGCHYHVCHVSSRQSVRVIRDAKR
AGIHVTAEVTPHHLVLSEDDIPGLDANFKMNPPLRSEDDRQALLEGLFDGTIDMIATDHAPHTAEEKAQGIERAPFGITG
FETALPLLYTTFVKTGIMEEYQLLDWMTKRPSDVFGLSRGELKVGTDADLILIDTETFRTVDPTTFYSKGKNTPFAGEKL
VGWPVMTMVGGEIVYKGRFDETNIMA
>Mature_426_residues
MILQNATWYDKGTKRTTNIHVKDGKIESLDYKGETAGREILDATGYLLAPGLVDVHVHLREPGGEAKETIRTGTMAAAAG
GFTTICSMPNTRPVPDNRETMDVLLQKIEQDAVVRVLPYAAITKRQLGEEQVDMESLADAFAFTDDGVGVQSAAMMRQAM
REAKRLNKAVVAHCEDNTLKAGSVHEGKFSEAHGIQGIPSLAESIHIARDVLIAEETGCHYHVCHVSSRQSVRVIRDAKR
AGIHVTAEVTPHHLVLSEDDIPGLDANFKMNPPLRSEDDRQALLEGLFDGTIDMIATDHAPHTAEEKAQGIERAPFGITG
FETALPLLYTTFVKTGIMEEYQLLDWMTKRPSDVFGLSRGELKVGTDADLILIDTETFRTVDPTTFYSKGKNTPFAGEKL
VGWPVMTMVGGEIVYKGRFDETNIMA

Specific function: Involved In The Anaerobic Utilization Of Allantoin. [C]

COG id: COG0044

COG function: function code F; Dihydroorotase and related cyclic amidohydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHOase family. Type 2 subfamily [H]

Homologues:

Organism=Homo sapiens, GI18105007, Length=369, Percent_Identity=32.520325203252, Blast_Score=157, Evalue=1e-38,
Organism=Homo sapiens, GI4503375, Length=434, Percent_Identity=25.3456221198157, Blast_Score=103, Evalue=4e-22,
Organism=Homo sapiens, GI19923821, Length=439, Percent_Identity=24.373576309795, Blast_Score=97, Evalue=3e-20,
Organism=Homo sapiens, GI4503051, Length=444, Percent_Identity=24.5495495495495, Blast_Score=92, Evalue=1e-18,
Organism=Homo sapiens, GI62422571, Length=444, Percent_Identity=24.5495495495495, Blast_Score=90, Evalue=3e-18,
Organism=Homo sapiens, GI4503377, Length=432, Percent_Identity=24.3055555555556, Blast_Score=90, Evalue=4e-18,
Organism=Homo sapiens, GI4503379, Length=428, Percent_Identity=23.1308411214953, Blast_Score=82, Evalue=1e-15,
Organism=Escherichia coli, GI1786722, Length=433, Percent_Identity=27.4826789838337, Blast_Score=177, Evalue=8e-46,
Organism=Escherichia coli, GI87082175, Length=447, Percent_Identity=24.8322147651007, Blast_Score=108, Evalue=5e-25,
Organism=Caenorhabditis elegans, GI193204318, Length=421, Percent_Identity=30.8788598574822, Blast_Score=147, Evalue=8e-36,
Organism=Caenorhabditis elegans, GI17539558, Length=443, Percent_Identity=24.3792325056433, Blast_Score=97, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI71989490, Length=448, Percent_Identity=22.9910714285714, Blast_Score=92, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI86575075, Length=438, Percent_Identity=23.2876712328767, Blast_Score=82, Evalue=4e-16,
Organism=Saccharomyces cerevisiae, GI6322218, Length=399, Percent_Identity=28.5714285714286, Blast_Score=141, Evalue=2e-34,
Organism=Drosophila melanogaster, GI24642586, Length=371, Percent_Identity=31.266846361186, Blast_Score=146, Evalue=3e-35,
Organism=Drosophila melanogaster, GI18859883, Length=208, Percent_Identity=31.25, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI17137462, Length=435, Percent_Identity=22.9885057471264, Blast_Score=91, Evalue=2e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR004722
- InterPro:   IPR002195
- InterPro:   IPR011059 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: =3.5.2.3 [H]

Molecular weight: Translated: 46764; Mature: 46764

Theoretical pI: Translated: 5.22; Mature: 5.22

Prosite motif: PS00482 DIHYDROOROTASE_1 ; PS00483 DIHYDROOROTASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MILQNATWYDKGTKRTTNIHVKDGKIESLDYKGETAGREILDATGYLLAPGLVDVHVHLR
CCCCCCCCCCCCCCEEEEEEEECCCEEECCCCCCHHHHHHHHHCCCEECCCEEEEEEEEE
EPGGEAKETIRTGTMAAAAGGFTTICSMPNTRPVPDNRETMDVLLQKIEQDAVVRVLPYA
CCCCHHHHHHHHCCHHHHCCCCCEEECCCCCCCCCCCHHHHHHHHHHHHHHHHEEHHHHH
AITKRQLGEEQVDMESLADAFAFTDDGVGVQSAAMMRQAMREAKRLNKAVVAHCEDNTLK
HHHHHHCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCHHEEEECCCCCEE
AGSVHEGKFSEAHGIQGIPSLAESIHIARDVLIAEETGCHYHVCHVSSRQSVRVIRDAKR
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHEEEECCCCEEEEEECCCCCHHHHHHHHHH
AGIHVTAEVTPHHLVLSEDDIPGLDANFKMNPPLRSEDDRQALLEGLFDGTIDMIATDHA
CCEEEEEECCCCEEEEECCCCCCCCCCEEECCCCCCCCHHHHHHHHHHCCCEEEEEECCC
PHTAEEKAQGIERAPFGITGFETALPLLYTTFVKTGIMEEYQLLDWMTKRPSDVFGLSRG
CCCHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCC
ELKVGTDADLILIDTETFRTVDPTTFYSKGKNTPFAGEKLVGWPVMTMVGGEIVYKGRFD
CEEECCCCCEEEEECCCCCCCCCCHHHCCCCCCCCCCCCEECCHHHHHCCCEEEEECCCC
ETNIMA
CCCCCC
>Mature Secondary Structure
MILQNATWYDKGTKRTTNIHVKDGKIESLDYKGETAGREILDATGYLLAPGLVDVHVHLR
CCCCCCCCCCCCCCEEEEEEEECCCEEECCCCCCHHHHHHHHHCCCEECCCEEEEEEEEE
EPGGEAKETIRTGTMAAAAGGFTTICSMPNTRPVPDNRETMDVLLQKIEQDAVVRVLPYA
CCCCHHHHHHHHCCHHHHCCCCCEEECCCCCCCCCCCHHHHHHHHHHHHHHHHEEHHHHH
AITKRQLGEEQVDMESLADAFAFTDDGVGVQSAAMMRQAMREAKRLNKAVVAHCEDNTLK
HHHHHHCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCHHEEEECCCCCEE
AGSVHEGKFSEAHGIQGIPSLAESIHIARDVLIAEETGCHYHVCHVSSRQSVRVIRDAKR
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHEEEECCCCEEEEEECCCCCHHHHHHHHHH
AGIHVTAEVTPHHLVLSEDDIPGLDANFKMNPPLRSEDDRQALLEGLFDGTIDMIATDHA
CCEEEEEECCCCEEEEECCCCCCCCCCEEECCCCCCCCHHHHHHHHHHCCCEEEEEECCC
PHTAEEKAQGIERAPFGITGFETALPLLYTTFVKTGIMEEYQLLDWMTKRPSDVFGLSRG
CCCHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCC
ELKVGTDADLILIDTETFRTVDPTTFYSKGKNTPFAGEKLVGWPVMTMVGGEIVYKGRFD
CEEECCCCCEEEEECCCCCCCCCCHHHCCCCCCCCCCCCEECCHHHHHCCCEEEEECCCC
ETNIMA
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA