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The map label for this gene is phr [H]

Identifier: 229918519

GI number: 229918519

Start: 2773798

End: 2775150

Strand: Direct

Name: phr [H]

Synonym: EAT1b_2806

Alternate gene names: 229918519

Gene position: 2773798-2775150 (Clockwise)

Preceding gene: 229918518

Following gene: 229918521

Centisome position: 92.46

GC content: 48.34

Gene sequence:

>1353_bases
ATGAGACGAATATGTTGGTTCCGTTCAGATTTTAGACTGACCGATAATCATATGTTACACCGTGTATTGAAAGATATGGA
GGAAGGCGATGACCTAGACTTCGTCTTTTGGTTGAATCCGAAATACTGTCACCCATTCGAAGTGCGGCATGACTATTTCT
TCTCGACGATGCGAACGTTCATGGATGATTTAGAAGCGAAAGGGTTAGGGCTTCGTGTCCTCGTCGCGGAGACGGAGGAT
GCGTTCGTGAAACAGCTCGGCGAGATGGATGTGCTCTATTTTAATGCGGAGTATGTGGAACCGTTCAAACAGCGGGATGA
CCGTGTGATTGAAGCACTTAGTGAAGATGTAAAGGTAGTGCGACTTTTAGATCGGCATCTGTTTCATCCCGATGCGTTCC
GTACAAAAAGTGGCGATCCCTATAAGGTGTTCACCCCGTTCAAAAAAGCGGCGTATGCCGAACAGCCACCTGCACCATAT
GAGGTTGATGTCAATCGTTTATCTCAGTACATCCGTTCAAAGAATGAACAACCGAGTGAACTGAAAGAGCTCTTCAAGCG
ATGTAAACGTGAATGGAAAGGGCTAGGGGAAACGGAAGCGAAGAAGCGATTGACCCGCTTCGTCAATGACCGCATGGTCG
ATTATGACGAGAAGCGTGACATTCCGAGCATCGCCGGGACGAGTCGACTATCTCCTTATTTACGGACAGGTGTGTTGTCG
ATTCGCACCATCACCGAACAAGTGTTGTCGGCGAGGCAATCAAAAGGGCGCGACACGTATTACGATGAGCTGTTGTGGCG
CGAATTTTATTACATGGTCATGGCAAAGTTCCACGGATTGAAAGATCAACCGTTCAATGATAAATACAAGTCGATTGAAT
GGGAGGACAATGAAGAGCAGTTCGAAAAGTGGTGTAACGGGGAAACCGGGTATCCAATCGTCGACGCGGCGATGCGTCAG
TTGAACGAGACCGGGTGGATGCACAACCGCCTACGCATGATTGTCGCATCTTTCCTATCGAAACATCTCCTTCTCGATTG
GCGAAAAGGAGAACGATATTTCGAACAAAAGCTGATCGATTATGAGGCAGCGTCGAATATCGGGGGATGGCAATGGGCGG
CCTCTGTCGGGACGGACGCTGTTCCATATTTCCGTATTTTCAATCCGACGACGCAATCCGAACGATTTGACCCTGACGGA
ACGTTCATCCGGAAGTATGTGCCGGAGCTGAAACATGTATCAGATAAATCGATTCACTTTCCAGACCCGTCAGAGCGAGA
CGACTATGCCATGCCACTCGTCGATCATAAAGAAGCGAGAGAGCGTGCGCTCGAACGATTTAAAGCATTGTAA

Upstream 100 bases:

>100_bases
AAGGCGACACAATACAAAGTGACGACTTGTTGATTGAATTTGTATAATCAAAAGAAGCATAGCGCGCTATGCTTCTTTTT
TGTAGATGGGAGTGGAGATC

Downstream 100 bases:

>100_bases
ACTAAAAAAGCGCCGCGGCGCTTTTTTGTTTGGTTATCCGTTCATATTTTTCAATTGTGCCCCGTCTTGTCGCGCTGTCG
ACCGGTACGCGTGATAAGAG

Product: Deoxyribodipyrimidine photo-lyase

Products: NA

Alternate protein names: DNA photolyase; Photoreactivating enzyme [H]

Number of amino acids: Translated: 450; Mature: 450

Protein sequence:

>450_residues
MRRICWFRSDFRLTDNHMLHRVLKDMEEGDDLDFVFWLNPKYCHPFEVRHDYFFSTMRTFMDDLEAKGLGLRVLVAETED
AFVKQLGEMDVLYFNAEYVEPFKQRDDRVIEALSEDVKVVRLLDRHLFHPDAFRTKSGDPYKVFTPFKKAAYAEQPPAPY
EVDVNRLSQYIRSKNEQPSELKELFKRCKREWKGLGETEAKKRLTRFVNDRMVDYDEKRDIPSIAGTSRLSPYLRTGVLS
IRTITEQVLSARQSKGRDTYYDELLWREFYYMVMAKFHGLKDQPFNDKYKSIEWEDNEEQFEKWCNGETGYPIVDAAMRQ
LNETGWMHNRLRMIVASFLSKHLLLDWRKGERYFEQKLIDYEAASNIGGWQWAASVGTDAVPYFRIFNPTTQSERFDPDG
TFIRKYVPELKHVSDKSIHFPDPSERDDYAMPLVDHKEARERALERFKAL

Sequences:

>Translated_450_residues
MRRICWFRSDFRLTDNHMLHRVLKDMEEGDDLDFVFWLNPKYCHPFEVRHDYFFSTMRTFMDDLEAKGLGLRVLVAETED
AFVKQLGEMDVLYFNAEYVEPFKQRDDRVIEALSEDVKVVRLLDRHLFHPDAFRTKSGDPYKVFTPFKKAAYAEQPPAPY
EVDVNRLSQYIRSKNEQPSELKELFKRCKREWKGLGETEAKKRLTRFVNDRMVDYDEKRDIPSIAGTSRLSPYLRTGVLS
IRTITEQVLSARQSKGRDTYYDELLWREFYYMVMAKFHGLKDQPFNDKYKSIEWEDNEEQFEKWCNGETGYPIVDAAMRQ
LNETGWMHNRLRMIVASFLSKHLLLDWRKGERYFEQKLIDYEAASNIGGWQWAASVGTDAVPYFRIFNPTTQSERFDPDG
TFIRKYVPELKHVSDKSIHFPDPSERDDYAMPLVDHKEARERALERFKAL
>Mature_450_residues
MRRICWFRSDFRLTDNHMLHRVLKDMEEGDDLDFVFWLNPKYCHPFEVRHDYFFSTMRTFMDDLEAKGLGLRVLVAETED
AFVKQLGEMDVLYFNAEYVEPFKQRDDRVIEALSEDVKVVRLLDRHLFHPDAFRTKSGDPYKVFTPFKKAAYAEQPPAPY
EVDVNRLSQYIRSKNEQPSELKELFKRCKREWKGLGETEAKKRLTRFVNDRMVDYDEKRDIPSIAGTSRLSPYLRTGVLS
IRTITEQVLSARQSKGRDTYYDELLWREFYYMVMAKFHGLKDQPFNDKYKSIEWEDNEEQFEKWCNGETGYPIVDAAMRQ
LNETGWMHNRLRMIVASFLSKHLLLDWRKGERYFEQKLIDYEAASNIGGWQWAASVGTDAVPYFRIFNPTTQSERFDPDG
TFIRKYVPELKHVSDKSIHFPDPSERDDYAMPLVDHKEARERALERFKAL

Specific function: Involved in repair of UV radiation-induced DNA damage. Catalyzes the light-dependent monomerization (300-600 nm) of cyclobutyl pyrimidine dimers (in cis-syn configuration), which are formed between adjacent bases on the same DNA strand upon exposure to ul

COG id: COG0415

COG function: function code L; Deoxyribodipyrimidine photolyase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 DNA photolyase domain [H]

Homologues:

Organism=Homo sapiens, GI4758072, Length=488, Percent_Identity=27.2540983606557, Blast_Score=162, Evalue=6e-40,
Organism=Homo sapiens, GI188536100, Length=486, Percent_Identity=28.3950617283951, Blast_Score=151, Evalue=1e-36,
Organism=Homo sapiens, GI188536103, Length=418, Percent_Identity=29.1866028708134, Blast_Score=140, Evalue=2e-33,
Organism=Escherichia coli, GI1786926, Length=469, Percent_Identity=38.3795309168444, Blast_Score=275, Evalue=4e-75,
Organism=Saccharomyces cerevisiae, GI6324962, Length=385, Percent_Identity=33.7662337662338, Blast_Score=217, Evalue=3e-57,
Organism=Drosophila melanogaster, GI17137248, Length=454, Percent_Identity=29.0748898678414, Blast_Score=159, Evalue=5e-39,
Organism=Drosophila melanogaster, GI24585455, Length=454, Percent_Identity=29.0748898678414, Blast_Score=159, Evalue=5e-39,
Organism=Drosophila melanogaster, GI24648152, Length=470, Percent_Identity=27.4468085106383, Blast_Score=137, Evalue=1e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002081
- InterPro:   IPR018394
- InterPro:   IPR006050
- InterPro:   IPR005101
- InterPro:   IPR014729 [H]

Pfam domain/function: PF00875 DNA_photolyase; PF03441 FAD_binding_7 [H]

EC number: =4.1.99.3 [H]

Molecular weight: Translated: 53572; Mature: 53572

Theoretical pI: Translated: 6.53; Mature: 6.53

Prosite motif: PS00394 DNA_PHOTOLYASES_1_1 ; PS00691 DNA_PHOTOLYASES_1_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRRICWFRSDFRLTDNHMLHRVLKDMEEGDDLDFVFWLNPKYCHPFEVRHDYFFSTMRTF
CCCEEEECCCCCCCHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHH
MDDLEAKGLGLRVLVAETEDAFVKQLGEMDVLYFNAEYVEPFKQRDDRVIEALSEDVKVV
HHHHHCCCCCEEEEEECCHHHHHHHHCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHH
RLLDRHLFHPDAFRTKSGDPYKVFTPFKKAAYAEQPPAPYEVDVNRLSQYIRSKNEQPSE
HHHHHHHCCCCCCCCCCCCCEEEECCHHHHHCCCCCCCCCCCCHHHHHHHHHCCCCCHHH
LKELFKRCKREWKGLGETEAKKRLTRFVNDRMVDYDEKRDIPSIAGTSRLSPYLRTGVLS
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCHHHCCCCCCCCCHHCCHHHHHHHHH
IRTITEQVLSARQSKGRDTYYDELLWREFYYMVMAKFHGLKDQPFNDKYKSIEWEDNEEQ
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHCCCCCCCCHHH
FEKWCNGETGYPIVDAAMRQLNETGWMHNRLRMIVASFLSKHLLLDWRKGERYFEQKLID
HHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YEAASNIGGWQWAASVGTDAVPYFRIFNPTTQSERFDPDGTFIRKYVPELKHVSDKSIHF
HHHHCCCCCHHHHHHCCCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCC
PDPSERDDYAMPLVDHKEARERALERFKAL
CCCCCCCCCCCCCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure
MRRICWFRSDFRLTDNHMLHRVLKDMEEGDDLDFVFWLNPKYCHPFEVRHDYFFSTMRTF
CCCEEEECCCCCCCHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHH
MDDLEAKGLGLRVLVAETEDAFVKQLGEMDVLYFNAEYVEPFKQRDDRVIEALSEDVKVV
HHHHHCCCCCEEEEEECCHHHHHHHHCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHH
RLLDRHLFHPDAFRTKSGDPYKVFTPFKKAAYAEQPPAPYEVDVNRLSQYIRSKNEQPSE
HHHHHHHCCCCCCCCCCCCCEEEECCHHHHHCCCCCCCCCCCCHHHHHHHHHCCCCCHHH
LKELFKRCKREWKGLGETEAKKRLTRFVNDRMVDYDEKRDIPSIAGTSRLSPYLRTGVLS
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCHHHCCCCCCCCCHHCCHHHHHHHHH
IRTITEQVLSARQSKGRDTYYDELLWREFYYMVMAKFHGLKDQPFNDKYKSIEWEDNEEQ
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHCCCCCCCCHHH
FEKWCNGETGYPIVDAAMRQLNETGWMHNRLRMIVASFLSKHLLLDWRKGERYFEQKLID
HHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YEAASNIGGWQWAASVGTDAVPYFRIFNPTTQSERFDPDGTFIRKYVPELKHVSDKSIHF
HHHHCCCCCHHHHHHCCCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCC
PDPSERDDYAMPLVDHKEARERALERFKAL
CCCCCCCCCCCCCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7678007 [H]