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The map label for this gene is ctaB [H]

Identifier: 229918521

GI number: 229918521

Start: 2776423

End: 2777346

Strand: Direct

Name: ctaB [H]

Synonym: EAT1b_2808

Alternate gene names: 229918521

Gene position: 2776423-2777346 (Clockwise)

Preceding gene: 229918519

Following gene: 229918522

Centisome position: 92.55

GC content: 47.51

Gene sequence:

>924_bases
ATGACAAAAGTCAACCCAGGGATGATGGTAGATGTAGAGTATACAGAATCAACGTCATTCCGAGATTACGTCGCCTTAGC
GAAAATGGGAATCGTTCGCGCCAACCTGTTGTTGGTGTTTGCAGGATTCTTCGTGGCAGCGACGTACCAGAGCGATACGC
CAGTCCTTTACTTGTTTGAAGTTTGGCCACAGCTCTTATTAACGATGTTAGGAAGCGCACTCGTGATTTCGGGGAGTTGT
TACCTAAACAACTTTGTGGACCGAGATATCGATTACTTAATGGATCGTACGGACAATCGACCGAGTGTAACCGGCAAGAT
TTCAGGAGAGAAGATTCTACTCCTTGGATTGACACAACTTGCAATCGGAACACTTCTTTTGCTCCTTGTATCGTACGTCG
CCGCAGTATTCGGTTTAATCGGGGCATTTTTTTATGTCGTGATTTATACGATGTGGCTGAAGCGTACGAGTACGCTCAAT
ACGGTCGTCGGTAGTATTTCAGGAGCCGTTCCACCGCTCATCGGTTGGGCAGCACTCGATCCGACACTTCATATCGATGC
GTGGCTCATGTTCCTTGTCATGTTCTTATGGCAACCACCACACTTTCTGGCGCTCGCCATGCGACGGACGGAAGAGTATC
GAGCGGCAGGCATTCCGATGCTTCCGGTCGTGAACGGATTTGCCATCACGAAACGGCAAATCATCTGGTGGATTGCGACG
CTGATTCCGGCATCGCTCTTATTTATGCACTATGGTCTTGTTTACTTGACAGTCGCAGCCGGTTTAGGGGGCTACTGGTT
GTATCTCGGATTGAAAGGATTCAACGCCGAGGATGAAATTAAGTGGGCAAACAAAATGTTCTTCTATTCATTAATTTATT
TAGTCGTGTGGATTATCGCGCTGATTTTGACAGCACTCTGGTGA

Upstream 100 bases:

>100_bases
AAATATGGTATCTTTGTAGAGAGTTAAGTGTATTTTGTTCATATTGTGTTTTTTCTGTGAAGAGAATGCGAGGATTTCGT
GATTATGTGGGGGGGTCAGT

Downstream 100 bases:

>100_bases
TCGCACTCACTATATAGAAAACCATTACACATCATTTTGGGAGAAAGTGGGGATTGTTGTGAAATCATTTAAGAAGCTTC
TGTTTGGCATCGTCCCGATG

Product: protoheme IX farnesyltransferase

Products: NA

Alternate protein names: Heme B farnesyltransferase; Heme O synthase [H]

Number of amino acids: Translated: 307; Mature: 306

Protein sequence:

>307_residues
MTKVNPGMMVDVEYTESTSFRDYVALAKMGIVRANLLLVFAGFFVAATYQSDTPVLYLFEVWPQLLLTMLGSALVISGSC
YLNNFVDRDIDYLMDRTDNRPSVTGKISGEKILLLGLTQLAIGTLLLLLVSYVAAVFGLIGAFFYVVIYTMWLKRTSTLN
TVVGSISGAVPPLIGWAALDPTLHIDAWLMFLVMFLWQPPHFLALAMRRTEEYRAAGIPMLPVVNGFAITKRQIIWWIAT
LIPASLLFMHYGLVYLTVAAGLGGYWLYLGLKGFNAEDEIKWANKMFFYSLIYLVVWIIALILTALW

Sequences:

>Translated_307_residues
MTKVNPGMMVDVEYTESTSFRDYVALAKMGIVRANLLLVFAGFFVAATYQSDTPVLYLFEVWPQLLLTMLGSALVISGSC
YLNNFVDRDIDYLMDRTDNRPSVTGKISGEKILLLGLTQLAIGTLLLLLVSYVAAVFGLIGAFFYVVIYTMWLKRTSTLN
TVVGSISGAVPPLIGWAALDPTLHIDAWLMFLVMFLWQPPHFLALAMRRTEEYRAAGIPMLPVVNGFAITKRQIIWWIAT
LIPASLLFMHYGLVYLTVAAGLGGYWLYLGLKGFNAEDEIKWANKMFFYSLIYLVVWIIALILTALW
>Mature_306_residues
TKVNPGMMVDVEYTESTSFRDYVALAKMGIVRANLLLVFAGFFVAATYQSDTPVLYLFEVWPQLLLTMLGSALVISGSCY
LNNFVDRDIDYLMDRTDNRPSVTGKISGEKILLLGLTQLAIGTLLLLLVSYVAAVFGLIGAFFYVVIYTMWLKRTSTLNT
VVGSISGAVPPLIGWAALDPTLHIDAWLMFLVMFLWQPPHFLALAMRRTEEYRAAGIPMLPVVNGFAITKRQIIWWIATL
IPASLLFMHYGLVYLTVAAGLGGYWLYLGLKGFNAEDEIKWANKMFFYSLIYLVVWIIALILTALW

Specific function: Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group [H]

COG id: COG0109

COG function: function code O; Polyprenyltransferase (cytochrome oxidase assembly factor)

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ubiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily [H]

Homologues:

Organism=Homo sapiens, GI17921982, Length=165, Percent_Identity=36.3636363636364, Blast_Score=97, Evalue=2e-20,
Organism=Escherichia coli, GI1786631, Length=278, Percent_Identity=36.3309352517986, Blast_Score=174, Evalue=6e-45,
Organism=Caenorhabditis elegans, GI71998235, Length=273, Percent_Identity=28.9377289377289, Blast_Score=79, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6325085, Length=155, Percent_Identity=31.6129032258064, Blast_Score=79, Evalue=1e-15,
Organism=Drosophila melanogaster, GI19921064, Length=234, Percent_Identity=32.0512820512821, Blast_Score=99, Evalue=3e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006369
- InterPro:   IPR000537 [H]

Pfam domain/function: PF01040 UbiA [H]

EC number: 2.5.1.-

Molecular weight: Translated: 34444; Mature: 34313

Theoretical pI: Translated: 7.57; Mature: 7.57

Prosite motif: PS00943 UBIA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKVNPGMMVDVEYTESTSFRDYVALAKMGIVRANLLLVFAGFFVAATYQSDTPVLYLFE
CCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCEEHHHH
VWPQLLLTMLGSALVISGSCYLNNFVDRDIDYLMDRTDNRPSVTGKISGEKILLLGLTQL
HHHHHHHHHHCHHHEEECCHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCEEEEEHHHHH
AIGTLLLLLVSYVAAVFGLIGAFFYVVIYTMWLKRTSTLNTVVGSISGAVPPLIGWAALD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCC
PTLHIDAWLMFLVMFLWQPPHFLALAMRRTEEYRAAGIPMLPVVNGFAITKRQIIWWIAT
CCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCHHHHHCCHHHHHHHHHHHHHH
LIPASLLFMHYGLVYLTVAAGLGGYWLYLGLKGFNAEDEIKWANKMFFYSLIYLVVWIIA
HHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHH
LILTALW
HHHHHCC
>Mature Secondary Structure 
TKVNPGMMVDVEYTESTSFRDYVALAKMGIVRANLLLVFAGFFVAATYQSDTPVLYLFE
CCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCEEHHHH
VWPQLLLTMLGSALVISGSCYLNNFVDRDIDYLMDRTDNRPSVTGKISGEKILLLGLTQL
HHHHHHHHHHCHHHEEECCHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCEEEEEHHHHH
AIGTLLLLLVSYVAAVFGLIGAFFYVVIYTMWLKRTSTLNTVVGSISGAVPPLIGWAALD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCC
PTLHIDAWLMFLVMFLWQPPHFLALAMRRTEEYRAAGIPMLPVVNGFAITKRQIIWWIAT
CCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCHHHHHCCHHHHHHHHHHHHHH
LIPASLLFMHYGLVYLTVAAGLGGYWLYLGLKGFNAEDEIKWANKMFFYSLIYLVVWIIA
HHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHH
LILTALW
HHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA