Click here to switch to the map view.

The map label for this gene is nadC [H]

Identifier: 229918404

GI number: 229918404

Start: 2655821

End: 2656690

Strand: Direct

Name: nadC [H]

Synonym: EAT1b_2689

Alternate gene names: 229918404

Gene position: 2655821-2656690 (Clockwise)

Preceding gene: 229918403

Following gene: 229918405

Centisome position: 88.53

GC content: 52.07

Gene sequence:

>870_bases
ATGAATACGATATACCTACGCGAACAGCTACGTCAGTTCTTGATTGAAGATATCGGGTATGGGGACCTATCGAGTGCGCT
GATTGATGGACAGGACGAGTCGGTCGCAACGATTGTCGCCAAAGAACAGGGCATTTTCTGTGGGAAACCGATCGTAGAAG
AGCTGGCAACCATGCAGCGGCTTGAATTGGTCTCTTGCCAAGAAGACGGGAGAGCGGTGACCCCTGGAGACGAACTCGTC
GTCTTGAGAGGGAAGACGCGCGCGATTTTAGAGACAGAGCGCGTGCTGTTGAATGTCATCCAACATACGAGTGGGATTGC
GACGATGACACGACAGTGCGTGGACGCGTTACATGATGACTCGATTCACGTGACCGATACACGCAAGACGACCCCGGGAC
TGCGGATGATTGAAAAGTACGCCGTACGTGTGGGAGGGGGATACAATCACCGTCTAAGACTCGATGACGCCGTCATGATC
AAAGACAATCATATCGTCGCACTTGGTGGCGTGACGAATGCGATTCAAGTCGCACGAGAACGCGTCGGTCATACGACCCC
GATTGAAGTCGAGGTCGAGTCGTTCGAACAACTGATGGAGGCGGTTCAAGCCGATCCGGACATCGTGATGCTTGATAATC
GGACGCCAGATGAATTGAGAGAATGGGTCCGTCATATACCGACGCACATCAAAATTGAAGTGTCTGGTGGCATCACGCTC
GACACGATTGACGATTATCGAGGCATTCGCATCGATGTCATCTCGCTCGGGCAATTGACTCATTCGGTACGCGCGTTCGA
TTGCAGTTTGAATTTACAAGGAGGAATGAAAGATGCAACTACTCGGAACACTCCCGCCGACGTACGCTAA

Upstream 100 bases:

>100_bases
ACCATGACGAAACACGTGACAAGACAATTAAGTGAACAAACTTTACAACTCGATGCGGCGCGTCTTCTCGCGCAAAGCAT
CCTCGAAATGGAGCGGAATG

Downstream 100 bases:

>100_bases
CCTGTCGGTGGAGGAGATGGAGACTCGGATTCAGGCGGTCAAAGACCGACTCGGGACGCGTCTCTTTTTACCGGCCCATC
ATTATCAAAAAGACGAGGTC

Product: nicotinate-nucleotide pyrophosphorylase

Products: NA

Alternate protein names: General stress protein 70; GSP70; Quinolinate phosphoribosyltransferase [decarboxylating]; QAPRTase [H]

Number of amino acids: Translated: 289; Mature: 289

Protein sequence:

>289_residues
MNTIYLREQLRQFLIEDIGYGDLSSALIDGQDESVATIVAKEQGIFCGKPIVEELATMQRLELVSCQEDGRAVTPGDELV
VLRGKTRAILETERVLLNVIQHTSGIATMTRQCVDALHDDSIHVTDTRKTTPGLRMIEKYAVRVGGGYNHRLRLDDAVMI
KDNHIVALGGVTNAIQVARERVGHTTPIEVEVESFEQLMEAVQADPDIVMLDNRTPDELREWVRHIPTHIKIEVSGGITL
DTIDDYRGIRIDVISLGQLTHSVRAFDCSLNLQGGMKDATTRNTPADVR

Sequences:

>Translated_289_residues
MNTIYLREQLRQFLIEDIGYGDLSSALIDGQDESVATIVAKEQGIFCGKPIVEELATMQRLELVSCQEDGRAVTPGDELV
VLRGKTRAILETERVLLNVIQHTSGIATMTRQCVDALHDDSIHVTDTRKTTPGLRMIEKYAVRVGGGYNHRLRLDDAVMI
KDNHIVALGGVTNAIQVARERVGHTTPIEVEVESFEQLMEAVQADPDIVMLDNRTPDELREWVRHIPTHIKIEVSGGITL
DTIDDYRGIRIDVISLGQLTHSVRAFDCSLNLQGGMKDATTRNTPADVR
>Mature_289_residues
MNTIYLREQLRQFLIEDIGYGDLSSALIDGQDESVATIVAKEQGIFCGKPIVEELATMQRLELVSCQEDGRAVTPGDELV
VLRGKTRAILETERVLLNVIQHTSGIATMTRQCVDALHDDSIHVTDTRKTTPGLRMIEKYAVRVGGGYNHRLRLDDAVMI
KDNHIVALGGVTNAIQVARERVGHTTPIEVEVESFEQLMEAVQADPDIVMLDNRTPDELREWVRHIPTHIKIEVSGGITL
DTIDDYRGIRIDVISLGQLTHSVRAFDCSLNLQGGMKDATTRNTPADVR

Specific function: Involved in the catabolism of quinolinic acid (QA) [H]

COG id: COG0157

COG function: function code H; Nicotinate-nucleotide pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nadC/modD family [H]

Homologues:

Organism=Homo sapiens, GI45269149, Length=254, Percent_Identity=38.1889763779528, Blast_Score=171, Evalue=6e-43,
Organism=Escherichia coli, GI1786299, Length=270, Percent_Identity=39.2592592592593, Blast_Score=164, Evalue=7e-42,
Organism=Saccharomyces cerevisiae, GI6321162, Length=281, Percent_Identity=33.4519572953737, Blast_Score=155, Evalue=6e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR004393
- InterPro:   IPR002638
- InterPro:   IPR022412 [H]

Pfam domain/function: PF01729 QRPTase_C; PF02749 QRPTase_N [H]

EC number: =2.4.2.19 [H]

Molecular weight: Translated: 32119; Mature: 32119

Theoretical pI: Translated: 4.89; Mature: 4.89

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTIYLREQLRQFLIEDIGYGDLSSALIDGQDESVATIVAKEQGIFCGKPIVEELATMQR
CCEEHHHHHHHHHHHHHCCCCCHHHHHCCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHH
LELVSCQEDGRAVTPGDELVVLRGKTRAILETERVLLNVIQHTSGIATMTRQCVDALHDD
HHHHHHCCCCCEECCCCCEEEEECCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCC
SIHVTDTRKTTPGLRMIEKYAVRVGGGYNHRLRLDDAVMIKDNHIVALGGVTNAIQVARE
CEEEEECCCCCCHHHHHHHHHHHCCCCCCCEEEECCEEEEECCCEEEECCCHHHHHHHHH
RVGHTTPIEVEVESFEQLMEAVQADPDIVMLDNRTPDELREWVRHIPTHIKIEVSGGITL
HHCCCCCEEEEHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHCCCEEEEEECCCEEE
DTIDDYRGIRIDVISLGQLTHSVRAFDCSLNLQGGMKDATTRNTPADVR
EECCCCCCCEEEEEEHHHHHHHHEEEEEEEECCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MNTIYLREQLRQFLIEDIGYGDLSSALIDGQDESVATIVAKEQGIFCGKPIVEELATMQR
CCEEHHHHHHHHHHHHHCCCCCHHHHHCCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHH
LELVSCQEDGRAVTPGDELVVLRGKTRAILETERVLLNVIQHTSGIATMTRQCVDALHDD
HHHHHHCCCCCEECCCCCEEEEECCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCC
SIHVTDTRKTTPGLRMIEKYAVRVGGGYNHRLRLDDAVMIKDNHIVALGGVTNAIQVARE
CEEEEECCCCCCHHHHHHHHHHHCCCCCCCEEEECCEEEEECCCEEEECCCHHHHHHHHH
RVGHTTPIEVEVESFEQLMEAVQADPDIVMLDNRTPDELREWVRHIPTHIKIEVSGGITL
HHCCCCCEEEEHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHCCCEEEEEECCCEEE
DTIDDYRGIRIDVISLGQLTHSVRAFDCSLNLQGGMKDATTRNTPADVR
EECCCCCCCEEEEEEHHHHHHHHEEEEEEEECCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377; 8444804; 9298659 [H]