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The map label for this gene is pgcA [H]

Identifier: 229918158

GI number: 229918158

Start: 2395879

End: 2397606

Strand: Direct

Name: pgcA [H]

Synonym: EAT1b_2438

Alternate gene names: 229918158

Gene position: 2395879-2397606 (Clockwise)

Preceding gene: 229918156

Following gene: 229918159

Centisome position: 79.87

GC content: 50.0

Gene sequence:

>1728_bases
ATGACATGGCAACAAACGTATGACCGTTGGAATCAATTCGAAGGGCTCGAGCCGCATTTACGTGTGGAACTCGAAGAACT
CGCAAAAGATGAGACCACGTTAGAAGATGCATTTTATAAGACGCTCGAGTTCGGAACAGGCGGGATGCGTGGAGAAATCG
GACCGGGTGCAAACCGAATGAACGTCTATACGATTCGAAAAGCGTCACAAGGATTTGCTGATTTTATCTCAGCATCAGGG
GAAGAGGCGAAACGTCATGGCGTCGTCATCGCCCATGACTCACGTCATTTTTCGCCCGAGTTTGCGTTAGAGGCAGCGCG
GACATTGGCGTCAAACGGAATCAAAACGTATTTGTTCCCAAGTTTGCGTGCCACACCTGAGTTGTCGTTTGCCGTTCGTC
ATTTAAATGCGTTCGGTGGCATCGTAATCACGGCGAGCCACAACCCGCCGGAATATAACGGGTTCAAGGTATATGGGGCA
GACGGGGGACAGCTTCCACCAGCAGAAGCGGATGAACTCGTGACGTATGTCAATGCGATTGAAGACGAGCTGAAAATTGA
GATTGAAGATGAAGCGGCGCTCCGACAAACGGGGCTACTCCTCACCGTCGACTCATCAGTCGATGAAGCTTATATGGAGG
CACTCCAGTCGATTCGAATCCACCGTGACATACAGGACAGCCCTCTCCGAATTGTCTATTCGCCACTCCACGGGACGGGA
CGCCGTCCGGTCATGGAAGGGCTGAAGGCATATGGATTTGAGCACGTGACCATCGTAGAAGAGCAGGCAGAGCCAGACGG
TGCGTTCCCGACGGTCAGTTATCCGAACCCGGAAGAAAAGGCTGCATTTAAATTAGCGATGGAATACGGGGACCGGGTCG
AGGCTGATTTGCTCATGGCGACGGACCCGGATGCAGACCGTGTCGGCTTAACCGTGCGCGGACGGGACGGGGAATGGTTC
GTCTTGACCGGTAACCAAACGGGTGCGCTATTAATGGAATATATCCTGTCGCAAAAGAGTGAAACAGGTACGTTACCTTC
GAATGGGTTTGTCGCCAAGACGATCGTCACGTCTGAACTCGGTGCTGCGATTGCAAAAGCGTACGGCGTACATCTCGAAA
ATACGTTGACTGGATTCAAGTTCATCGGTGAGAAGATCAAACAATATGAAGAATCAGGCGAATATGAATTCCTCTTTGGG
TATGAAGAAAGCTACGGCTATTTGATTGGAGACTTCTGTCGTGATAAAGATGCCGTTCAGGCTTGTTTACTCGCGGCCGA
GATGGCAGCTTATCATAAACAGCACGGTCGGACGCTTTATGATGCGTTACAGTCGATTTACGAGAAGTATGGATTCTACG
AAGAGTCCTTGCAGTCGATGACGTTAAAAGGAAAAGCTGGTCTCGAGCAAATCGGACGGATGATGGAAGCGTTCCGTGCC
AATCCACCAAAAGAAGTCGGTGGATATGAAGTCGTTCGTTTTGAAGACTATAAGAAACAAGTGGCGACCGACTTACAGTC
CGGTAAATCGGAAACGATTGAATTGCCATCATCAAACGTCTTGAAATTCGTCTTTGCGGACGGTTCGTGGTTCTGTCTTC
GCCCATCTGGAACCGAGCCGAAAATCAAGTTTTATTTCAGTGTGCATGCGGATCGTGCCGAGAAGACGACCGCCAAACGT
GAATCGATTGAAGCGGATGTTATGAAACAAGCGAAAGCGATTGATTGA

Upstream 100 bases:

>100_bases
TAATATCACCTCGAGGTTTCGTTACTCTCATCGTATACAAGATGGAAGCAATTGGCGAGTAATTCGATTGAATTTTTTGA
GGGTGAAAGGGGAATGAATC

Downstream 100 bases:

>100_bases
TGAAGAACATCACTCTAGAAATAGGGTGATGTTTTTTGTTTGACATGAAGACATCGCGCCAGTATGATGAGGATATTGTT
TAAAACCGTGTAATCATATA

Product: phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain I

Products: NA

Alternate protein names: PGM; Alpha-phosphoglucomutase; Glucose phosphomutase [H]

Number of amino acids: Translated: 575; Mature: 574

Protein sequence:

>575_residues
MTWQQTYDRWNQFEGLEPHLRVELEELAKDETTLEDAFYKTLEFGTGGMRGEIGPGANRMNVYTIRKASQGFADFISASG
EEAKRHGVVIAHDSRHFSPEFALEAARTLASNGIKTYLFPSLRATPELSFAVRHLNAFGGIVITASHNPPEYNGFKVYGA
DGGQLPPAEADELVTYVNAIEDELKIEIEDEAALRQTGLLLTVDSSVDEAYMEALQSIRIHRDIQDSPLRIVYSPLHGTG
RRPVMEGLKAYGFEHVTIVEEQAEPDGAFPTVSYPNPEEKAAFKLAMEYGDRVEADLLMATDPDADRVGLTVRGRDGEWF
VLTGNQTGALLMEYILSQKSETGTLPSNGFVAKTIVTSELGAAIAKAYGVHLENTLTGFKFIGEKIKQYEESGEYEFLFG
YEESYGYLIGDFCRDKDAVQACLLAAEMAAYHKQHGRTLYDALQSIYEKYGFYEESLQSMTLKGKAGLEQIGRMMEAFRA
NPPKEVGGYEVVRFEDYKKQVATDLQSGKSETIELPSSNVLKFVFADGSWFCLRPSGTEPKIKFYFSVHADRAEKTTAKR
ESIEADVMKQAKAID

Sequences:

>Translated_575_residues
MTWQQTYDRWNQFEGLEPHLRVELEELAKDETTLEDAFYKTLEFGTGGMRGEIGPGANRMNVYTIRKASQGFADFISASG
EEAKRHGVVIAHDSRHFSPEFALEAARTLASNGIKTYLFPSLRATPELSFAVRHLNAFGGIVITASHNPPEYNGFKVYGA
DGGQLPPAEADELVTYVNAIEDELKIEIEDEAALRQTGLLLTVDSSVDEAYMEALQSIRIHRDIQDSPLRIVYSPLHGTG
RRPVMEGLKAYGFEHVTIVEEQAEPDGAFPTVSYPNPEEKAAFKLAMEYGDRVEADLLMATDPDADRVGLTVRGRDGEWF
VLTGNQTGALLMEYILSQKSETGTLPSNGFVAKTIVTSELGAAIAKAYGVHLENTLTGFKFIGEKIKQYEESGEYEFLFG
YEESYGYLIGDFCRDKDAVQACLLAAEMAAYHKQHGRTLYDALQSIYEKYGFYEESLQSMTLKGKAGLEQIGRMMEAFRA
NPPKEVGGYEVVRFEDYKKQVATDLQSGKSETIELPSSNVLKFVFADGSWFCLRPSGTEPKIKFYFSVHADRAEKTTAKR
ESIEADVMKQAKAID
>Mature_574_residues
TWQQTYDRWNQFEGLEPHLRVELEELAKDETTLEDAFYKTLEFGTGGMRGEIGPGANRMNVYTIRKASQGFADFISASGE
EAKRHGVVIAHDSRHFSPEFALEAARTLASNGIKTYLFPSLRATPELSFAVRHLNAFGGIVITASHNPPEYNGFKVYGAD
GGQLPPAEADELVTYVNAIEDELKIEIEDEAALRQTGLLLTVDSSVDEAYMEALQSIRIHRDIQDSPLRIVYSPLHGTGR
RPVMEGLKAYGFEHVTIVEEQAEPDGAFPTVSYPNPEEKAAFKLAMEYGDRVEADLLMATDPDADRVGLTVRGRDGEWFV
LTGNQTGALLMEYILSQKSETGTLPSNGFVAKTIVTSELGAAIAKAYGVHLENTLTGFKFIGEKIKQYEESGEYEFLFGY
EESYGYLIGDFCRDKDAVQACLLAAEMAAYHKQHGRTLYDALQSIYEKYGFYEESLQSMTLKGKAGLEQIGRMMEAFRAN
PPKEVGGYEVVRFEDYKKQVATDLQSGKSETIELPSSNVLKFVFADGSWFCLRPSGTEPKIKFYFSVHADRAEKTTAKRE
SIEADVMKQAKAID

Specific function: Catalyzes the interconversion between glucose-6- phosphate and alpha-glucose-1-phosphate. This is the first step in the biosynthesis of diglucosyl-diacylglycerol (Glc2-DAG), i.e. the predominant glycolipid found in B.subtilis membrane, which is also used

COG id: COG1109

COG function: function code G; Phosphomannomutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the phosphohexose mutase family [H]

Homologues:

Organism=Homo sapiens, GI63055049, Length=560, Percent_Identity=33.75, Blast_Score=305, Evalue=5e-83,
Organism=Homo sapiens, GI31377548, Length=573, Percent_Identity=30.8900523560209, Blast_Score=263, Evalue=4e-70,
Organism=Homo sapiens, GI21361621, Length=564, Percent_Identity=26.5957446808511, Blast_Score=84, Evalue=3e-16,
Organism=Homo sapiens, GI290463102, Length=518, Percent_Identity=26.4478764478764, Blast_Score=79, Evalue=1e-14,
Organism=Escherichia coli, GI1786904, Length=590, Percent_Identity=25.9322033898305, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1788361, Length=483, Percent_Identity=24.0165631469979, Blast_Score=64, Evalue=3e-11,
Organism=Escherichia coli, GI1789566, Length=456, Percent_Identity=25.4385964912281, Blast_Score=63, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI71993870, Length=565, Percent_Identity=32.7433628318584, Blast_Score=261, Evalue=5e-70,
Organism=Caenorhabditis elegans, GI71993878, Length=297, Percent_Identity=34.3434343434343, Blast_Score=157, Evalue=2e-38,
Organism=Saccharomyces cerevisiae, GI6323934, Length=583, Percent_Identity=30.7032590051458, Blast_Score=214, Evalue=4e-56,
Organism=Drosophila melanogaster, GI20129809, Length=549, Percent_Identity=30.6010928961749, Blast_Score=240, Evalue=2e-63,
Organism=Drosophila melanogaster, GI24651977, Length=518, Percent_Identity=29.7297297297297, Blast_Score=219, Evalue=6e-57,
Organism=Drosophila melanogaster, GI24653722, Length=540, Percent_Identity=30.1851851851852, Blast_Score=216, Evalue=4e-56,
Organism=Drosophila melanogaster, GI17864244, Length=532, Percent_Identity=24.4360902255639, Blast_Score=69, Evalue=8e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005844
- InterPro:   IPR016055
- InterPro:   IPR005845
- InterPro:   IPR005846
- InterPro:   IPR005843
- InterPro:   IPR016066
- InterPro:   IPR005841 [H]

Pfam domain/function: PF02878 PGM_PMM_I; PF02879 PGM_PMM_II; PF02880 PGM_PMM_III; PF00408 PGM_PMM_IV [H]

EC number: =5.4.2.2 [H]

Molecular weight: Translated: 64034; Mature: 63902

Theoretical pI: Translated: 4.67; Mature: 4.67

Prosite motif: PS00710 PGM_PMM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTWQQTYDRWNQFEGLEPHLRVELEELAKDETTLEDAFYKTLEFGTGGMRGEIGPGANRM
CCCHHHHHHHHHCCCCCCHHEEEHHHHCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCE
NVYTIRKASQGFADFISASGEEAKRHGVVIAHDSRHFSPEFALEAARTLASNGIKTYLFP
EEEEEECCCCCHHHHHHCCCCHHHHCCEEEEECCCCCCHHHHHHHHHHHHHCCCEEEECC
SLRATPELSFAVRHLNAFGGIVITASHNPPEYNGFKVYGADGGQLPPAEADELVTYVNAI
CCCCCCCHHHHHHHHHHCCCEEEEECCCCCCCCCEEEECCCCCCCCCCCHHHHHHHHHHH
EDELKIEIEDEAALRQTGLLLTVDSSVDEAYMEALQSIRIHRDIQDSPLRIVYSPLHGTG
CCCEEEEECCHHHHHHCCEEEEECCCHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCC
RRPVMEGLKAYGFEHVTIVEEQAEPDGAFPTVSYPNPEEKAAFKLAMEYGDRVEADLLMA
CCHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEE
TDPDADRVGLTVRGRDGEWFVLTGNQTGALLMEYILSQKSETGTLPSNGFVAKTIVTSEL
CCCCCCCEEEEEECCCCCEEEEECCCCHHHHHHHHHHCCCCCCCCCCCCEEEEHHHHHHH
GAAIAKAYGVHLENTLTGFKFIGEKIKQYEESGEYEFLFGYEESYGYLIGDFCRDKDAVQ
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCEEHHHHCCHHHHH
ACLLAAEMAAYHKQHGRTLYDALQSIYEKYGFYEESLQSMTLKGKAGLEQIGRMMEAFRA
HHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCHHHHHHHEECCCCCCHHHHHHHHHHHHC
NPPKEVGGYEVVRFEDYKKQVATDLQSGKSETIELPSSNVLKFVFADGSWFCLRPSGTEP
CCCCCCCCEEEEEEHHHHHHHHHHHHCCCCCEEECCCCCEEEEEEECCCEEEECCCCCCC
KIKFYFSVHADRAEKTTAKRESIEADVMKQAKAID
EEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TWQQTYDRWNQFEGLEPHLRVELEELAKDETTLEDAFYKTLEFGTGGMRGEIGPGANRM
CCHHHHHHHHHCCCCCCHHEEEHHHHCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCE
NVYTIRKASQGFADFISASGEEAKRHGVVIAHDSRHFSPEFALEAARTLASNGIKTYLFP
EEEEEECCCCCHHHHHHCCCCHHHHCCEEEEECCCCCCHHHHHHHHHHHHHCCCEEEECC
SLRATPELSFAVRHLNAFGGIVITASHNPPEYNGFKVYGADGGQLPPAEADELVTYVNAI
CCCCCCCHHHHHHHHHHCCCEEEEECCCCCCCCCEEEECCCCCCCCCCCHHHHHHHHHHH
EDELKIEIEDEAALRQTGLLLTVDSSVDEAYMEALQSIRIHRDIQDSPLRIVYSPLHGTG
CCCEEEEECCHHHHHHCCEEEEECCCHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCC
RRPVMEGLKAYGFEHVTIVEEQAEPDGAFPTVSYPNPEEKAAFKLAMEYGDRVEADLLMA
CCHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEE
TDPDADRVGLTVRGRDGEWFVLTGNQTGALLMEYILSQKSETGTLPSNGFVAKTIVTSEL
CCCCCCCEEEEEECCCCCEEEEECCCCHHHHHHHHHHCCCCCCCCCCCCEEEEHHHHHHH
GAAIAKAYGVHLENTLTGFKFIGEKIKQYEESGEYEFLFGYEESYGYLIGDFCRDKDAVQ
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCEEHHHHCCHHHHH
ACLLAAEMAAYHKQHGRTLYDALQSIYEKYGFYEESLQSMTLKGKAGLEQIGRMMEAFRA
HHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCHHHHHHHEECCCCCCHHHHHHHHHHHHC
NPPKEVGGYEVVRFEDYKKQVATDLQSGKSETIELPSSNVLKFVFADGSWFCLRPSGTEP
CCCCCCCCEEEEEEHHHHHHHHHHHHCCCCCEEECCCCCEEEEEEECCCEEEECCCCCCC
KIKFYFSVHADRAEKTTAKRESIEADVMKQAKAID
EEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9579061; 9384377; 2127799 [H]