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The map label for this gene is menA [H]

Identifier: 229918096

GI number: 229918096

Start: 2329322

End: 2330221

Strand: Direct

Name: menA [H]

Synonym: EAT1b_2376

Alternate gene names: 229918096

Gene position: 2329322-2330221 (Clockwise)

Preceding gene: 229918089

Following gene: 229918097

Centisome position: 77.65

GC content: 50.0

Gene sequence:

>900_bases
ATGAAACAGAAATCGAAAGGGGCATATTGGCGAATGATTCGCCCGCATACCCTGACCGCAAGCTTTATTCCGGTCTTGCT
CGGGACGTTCATCGTCCTCGATCAAACCGAACTCAAATGGGGACTTTTTCTCGCCATGCTCGTGGCATCGGTCCTTATTC
AAATCGCGACGAACTTATTTAACGAGTATTATGACTACAAGCGTGGTCTTGATCATGAGGGGTCTATCGGGATTGGGGGC
TCCATCGTCCGTGACGGATTTACACCACAGCAAGTACTAGCGATTGCACTTGGCATGTATACGGTCGCAGCACTACTCGG
GCTCTACATTGCGGCATCTACAAGCTGGCATTTGCTTTGGATTGGCGCGCTGTCTATGCTTGTCGGCTACCTATATACCG
GAGGACCGCTCCCGATTGCTTATACGCCGTTCGGTGAAATTGTCGCGGGGTTATTCATGGGATATGTCATCATCGGGATT
GCCGGCTTTATCCAAATCAATACGGTGACGACGGAGTTGCTACTCGTGTCGTTCCCGATGGCCTTGTTGATCGGAGCAAT
CTTACTTGCGAATAACATCCGTGATTTAGATAACGATAAAGAGAATGGCCGAAAAACGATCGCATGTCTAGTCGGTCATC
GACGTGCGGTGTATGTATTGGCAGCGTTCTTTATCGCGGCATTAGTCGGCATCATCGTCGCTGTCATGTTTTATGGCGTC
ACTCCATGGGTCTTGCTGTCACTCTTAACGGTGCCGGTCATGATCCGGGCGATTCAACGATTTTGGCAAAAGGCAGAGCC
AGCCGCATTGATGCCTGCAATGGCGATGACAGCGAAAGTGAACACGCTGTTCGGAGCATGGATGGTCATCGGACTCATCG
TTTCAAGATTTGTGTTGTAA

Upstream 100 bases:

>100_bases
GCCTATGAAATGCTCGGGAAATGATCAAGAATCGAGGATAATGGGCTGGCGTTGACAGATTTTTTCATCGAGACGTAAAC
TAACGAAGGGAGGGAACGAA

Downstream 100 bases:

>100_bases
AAAAGAGGAGGCGTTAACGTGTCAGTCGTAAAAGAAATGCTTGAATTCAATAAACGTTTCGTAGAGGAAAAACAGTACGA
ACCGTTCGTATCTGATAAAT

Product: 1,4-dihydroxy-2-naphthoate octaprenyltransferase

Products: NA

Alternate protein names: DHNA-octaprenyltransferase [H]

Number of amino acids: Translated: 299; Mature: 299

Protein sequence:

>299_residues
MKQKSKGAYWRMIRPHTLTASFIPVLLGTFIVLDQTELKWGLFLAMLVASVLIQIATNLFNEYYDYKRGLDHEGSIGIGG
SIVRDGFTPQQVLAIALGMYTVAALLGLYIAASTSWHLLWIGALSMLVGYLYTGGPLPIAYTPFGEIVAGLFMGYVIIGI
AGFIQINTVTTELLLVSFPMALLIGAILLANNIRDLDNDKENGRKTIACLVGHRRAVYVLAAFFIAALVGIIVAVMFYGV
TPWVLLSLLTVPVMIRAIQRFWQKAEPAALMPAMAMTAKVNTLFGAWMVIGLIVSRFVL

Sequences:

>Translated_299_residues
MKQKSKGAYWRMIRPHTLTASFIPVLLGTFIVLDQTELKWGLFLAMLVASVLIQIATNLFNEYYDYKRGLDHEGSIGIGG
SIVRDGFTPQQVLAIALGMYTVAALLGLYIAASTSWHLLWIGALSMLVGYLYTGGPLPIAYTPFGEIVAGLFMGYVIIGI
AGFIQINTVTTELLLVSFPMALLIGAILLANNIRDLDNDKENGRKTIACLVGHRRAVYVLAAFFIAALVGIIVAVMFYGV
TPWVLLSLLTVPVMIRAIQRFWQKAEPAALMPAMAMTAKVNTLFGAWMVIGLIVSRFVL
>Mature_299_residues
MKQKSKGAYWRMIRPHTLTASFIPVLLGTFIVLDQTELKWGLFLAMLVASVLIQIATNLFNEYYDYKRGLDHEGSIGIGG
SIVRDGFTPQQVLAIALGMYTVAALLGLYIAASTSWHLLWIGALSMLVGYLYTGGPLPIAYTPFGEIVAGLFMGYVIIGI
AGFIQINTVTTELLLVSFPMALLIGAILLANNIRDLDNDKENGRKTIACLVGHRRAVYVLAAFFIAALVGIIVAVMFYGV
TPWVLLSLLTVPVMIRAIQRFWQKAEPAALMPAMAMTAKVNTLFGAWMVIGLIVSRFVL

Specific function: Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to dimethylmenaquinone (DMK). Attaches octaprenylpyrophosphate, a membrane-bound 40-carbon side chain to DHNA. The conversion of DHNA to DMK proceeds in three stages:the removal of the carboxyl group of DHNA

COG id: COG1575

COG function: function code H; 1,4-dihydroxy-2-naphthoate octaprenyltransferase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the menA family [H]

Homologues:

Organism=Homo sapiens, GI7019551, Length=302, Percent_Identity=30.794701986755, Blast_Score=99, Evalue=5e-21,
Organism=Escherichia coli, GI1790365, Length=303, Percent_Identity=27.0627062706271, Blast_Score=107, Evalue=9e-25,
Organism=Drosophila melanogaster, GI17737429, Length=304, Percent_Identity=28.2894736842105, Blast_Score=91, Evalue=9e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004657
- InterPro:   IPR000537 [H]

Pfam domain/function: PF01040 UbiA [H]

EC number: =2.5.1.74 [H]

Molecular weight: Translated: 32708; Mature: 32708

Theoretical pI: Translated: 9.71; Mature: 9.71

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKQKSKGAYWRMIRPHTLTASFIPVLLGTFIVLDQTELKWGLFLAMLVASVLIQIATNLF
CCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHH
NEYYDYKRGLDHEGSIGIGGSIVRDGFTPQQVLAIALGMYTVAALLGLYIAASTSWHLLW
HHHHHHHCCCCCCCCCCCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
IGALSMLVGYLYTGGPLPIAYTPFGEIVAGLFMGYVIIGIAGFIQINTVTTELLLVSFPM
HHHHHHHHHHHHCCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALLIGAILLANNIRDLDNDKENGRKTIACLVGHRRAVYVLAAFFIAALVGIIVAVMFYGV
HHHHHHHHHHHCCHHCCCCCCCCHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHCC
TPWVLLSLLTVPVMIRAIQRFWQKAEPAALMPAMAMTAKVNTLFGAWMVIGLIVSRFVL
CHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKQKSKGAYWRMIRPHTLTASFIPVLLGTFIVLDQTELKWGLFLAMLVASVLIQIATNLF
CCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHH
NEYYDYKRGLDHEGSIGIGGSIVRDGFTPQQVLAIALGMYTVAALLGLYIAASTSWHLLW
HHHHHHHCCCCCCCCCCCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
IGALSMLVGYLYTGGPLPIAYTPFGEIVAGLFMGYVIIGIAGFIQINTVTTELLLVSFPM
HHHHHHHHHHHHCCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALLIGAILLANNIRDLDNDKENGRKTIACLVGHRRAVYVLAAFFIAALVGIIVAVMFYGV
HHHHHHHHHHHCCHHCCCCCCCCHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHCC
TPWVLLSLLTVPVMIRAIQRFWQKAEPAALMPAMAMTAKVNTLFGAWMVIGLIVSRFVL
CHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 7934828; 9384377 [H]