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The map label for this gene is glmS [H]

Identifier: 229917921

GI number: 229917921

Start: 2131597

End: 2133393

Strand: Direct

Name: glmS [H]

Synonym: EAT1b_2199

Alternate gene names: 229917921

Gene position: 2131597-2133393 (Clockwise)

Preceding gene: 229917919

Following gene: 229917922

Centisome position: 71.06

GC content: 54.37

Gene sequence:

>1797_bases
ATGTGTGGAATCGTAGGGATGATCGGACAAGTTGGAACGAAAGAGATTTTATTGAAAGGGCTAGAAAAGCTCGAATATCG
TGGCTATGATTCAGCAGGAATTGCATTAGTCGGTGAAAACGTTCGTACGTTCAAAGAAGTAGGACGAATTCAAGCACTCC
GTGACATCGTACCGGCTGATGCTGAAGGAACGATTGGAATCGGCCACACACGTTGGGCGACACACGGGGTACCGAGCGTG
CCGAACGCCCACCCGCACCAAAGTACGACAGGACGCTTCACGCTCGTGCATAACGGCGTAATCGAGAACGATGAACAATT
GAAAGCCACGCTCGACGTCCCGTTCCTTTCAGAGACGGACACAGAAGTCATCGTCCAGCTCATGGAAAAACACTTCGTCG
AACTCGGCGATGTCGAGGCGGCGTTCCGCAAGACGCTTTCGGACCTCCACGGTTCGTACGCGATCGCGATGATCGACTCA
GAGGACCAAGAACGCCTCTATATCGGGAAGAACAAGTCACCGCTCCTCGTCGGACTCGGGGACGGCACGTTCAACGTCGT
CGCATCAGACGCGATGGCGATGCTCCAGGTGACGGACCAGTACCTCGAGCTCCACGACGGTGAGATCGTCATCCTCACAC
GTGAGGCGGCGACGATTAAGACGCTCGACGGCGAAGTGCTCGAACGCGCGCCATACACGGCCGAGATCGATGCGTCAGAT
ATCGAGAAGGGCACGTACGCGCACTACATGTTGAAAGAGATGGACGAGCAACCGGCCGTCATCCGAAACATCATCCAGCA
CTACCAGAACGAGAACGGTGACATCGAACTCACGGAAGGCGTGCGTGAGCTCGTGTCAGAAGCGGACCGGATCTATATCG
TCGCATGTGGGACGAGCTATAACGCGGGACTCGTCGGAAAAGACATTTTAGAACGCATCGCCGGCATTCCGACAGAAGTG
CACGTTTCTTCTGAATTTGGCTACAACATGCCCCTCTTAAGTGAACATCCGTTGTTCGTCTTCTTATCACAATCTGGTGA
GACAGCGGACAGCCGTGCCGTCCTCGTCGAAGTGAAGAAACGCGGATACAAAGCGCTCACCATGACGAATGTACCGGGTT
CAACGCTCTCACGCGAAGCGAACGAGACGATGCTTCTCCACGCCGGACCAGAGATCGCGGTCGCCTCGACGAAAGCATAC
ACGGCACAGATTGCCGTCCTCGCGATTCTCGCGTACGACATCGCCCGTGCGACAGGGAAAGAATTACCGTTCGACCTGAT
GCCAGAGCTCGCCCGTGTCGCAACCATCATGGACTCGATCATGGCGCAAAAAGAGTTGTTTGAAGATCTTGCGGAGCGCT
ACTTGAAAACGACACCGAACACGTTCTTCATCGGTCGTGGGCTTGACGCTTCTGTCTGTCTCGAAGGAGCGCTCAAAGTA
AAAGAGATTTCGTATATCCAAGCGGAAGGGTACCCAGGTGGGGAACTGAAGCATGGGTCGATTGCCTTGATTGAAGACGG
GACACCGGTCATCGCGCTCATCTCACAACCGAAGACGAACTTGAATATTCGTGGGAACGTCAAAGAAGTCGTCGCCCGTG
GCGCGAACGCCTGTATCATTTCGATGCAAGGCGTGGAACATGAGAATGATGACTTCATCTTGCCGCACGTCGAGCCACTC
TTGGCACCGCTCATCAACGTCTTACCGGTTCAGTTGATGGCATATTACGCGGCGCTCGCTCGTGGATGTGACGTGGACAA
GCCACGTAACTTGGCGAAATCGGTGACAGTGGAATAA

Upstream 100 bases:

>100_bases
AACGTTCGGGTGACCGGGCGGACAAAACGAGACTTGATGACACCACTCAAAAAAGCCCGTTTCCTTTTTCGAGAAATCGA
AGCAAAGAGGAGATTTGTTT

Downstream 100 bases:

>100_bases
ACTGAACATAGTGTAAGGCACCTTTCTTCTGGAGAGGTGCTTTTTACTGCTTGCCGATATCTTTGCCAACAAGCAAAATA
GTAGGAGAAGTAAGCGGTTC

Product: glucosamine--fructose-6-phosphate aminotransferase

Products: NA

Alternate protein names: D-fructose-6-phosphate amidotransferase; GFAT; Glucosamine-6-phosphate synthase; Hexosephosphate aminotransferase; L-glutamine-D-fructose-6-phosphate amidotransferase [H]

Number of amino acids: Translated: 598; Mature: 598

Protein sequence:

>598_residues
MCGIVGMIGQVGTKEILLKGLEKLEYRGYDSAGIALVGENVRTFKEVGRIQALRDIVPADAEGTIGIGHTRWATHGVPSV
PNAHPHQSTTGRFTLVHNGVIENDEQLKATLDVPFLSETDTEVIVQLMEKHFVELGDVEAAFRKTLSDLHGSYAIAMIDS
EDQERLYIGKNKSPLLVGLGDGTFNVVASDAMAMLQVTDQYLELHDGEIVILTREAATIKTLDGEVLERAPYTAEIDASD
IEKGTYAHYMLKEMDEQPAVIRNIIQHYQNENGDIELTEGVRELVSEADRIYIVACGTSYNAGLVGKDILERIAGIPTEV
HVSSEFGYNMPLLSEHPLFVFLSQSGETADSRAVLVEVKKRGYKALTMTNVPGSTLSREANETMLLHAGPEIAVASTKAY
TAQIAVLAILAYDIARATGKELPFDLMPELARVATIMDSIMAQKELFEDLAERYLKTTPNTFFIGRGLDASVCLEGALKV
KEISYIQAEGYPGGELKHGSIALIEDGTPVIALISQPKTNLNIRGNVKEVVARGANACIISMQGVEHENDDFILPHVEPL
LAPLINVLPVQLMAYYAALARGCDVDKPRNLAKSVTVE

Sequences:

>Translated_598_residues
MCGIVGMIGQVGTKEILLKGLEKLEYRGYDSAGIALVGENVRTFKEVGRIQALRDIVPADAEGTIGIGHTRWATHGVPSV
PNAHPHQSTTGRFTLVHNGVIENDEQLKATLDVPFLSETDTEVIVQLMEKHFVELGDVEAAFRKTLSDLHGSYAIAMIDS
EDQERLYIGKNKSPLLVGLGDGTFNVVASDAMAMLQVTDQYLELHDGEIVILTREAATIKTLDGEVLERAPYTAEIDASD
IEKGTYAHYMLKEMDEQPAVIRNIIQHYQNENGDIELTEGVRELVSEADRIYIVACGTSYNAGLVGKDILERIAGIPTEV
HVSSEFGYNMPLLSEHPLFVFLSQSGETADSRAVLVEVKKRGYKALTMTNVPGSTLSREANETMLLHAGPEIAVASTKAY
TAQIAVLAILAYDIARATGKELPFDLMPELARVATIMDSIMAQKELFEDLAERYLKTTPNTFFIGRGLDASVCLEGALKV
KEISYIQAEGYPGGELKHGSIALIEDGTPVIALISQPKTNLNIRGNVKEVVARGANACIISMQGVEHENDDFILPHVEPL
LAPLINVLPVQLMAYYAALARGCDVDKPRNLAKSVTVE
>Mature_598_residues
MCGIVGMIGQVGTKEILLKGLEKLEYRGYDSAGIALVGENVRTFKEVGRIQALRDIVPADAEGTIGIGHTRWATHGVPSV
PNAHPHQSTTGRFTLVHNGVIENDEQLKATLDVPFLSETDTEVIVQLMEKHFVELGDVEAAFRKTLSDLHGSYAIAMIDS
EDQERLYIGKNKSPLLVGLGDGTFNVVASDAMAMLQVTDQYLELHDGEIVILTREAATIKTLDGEVLERAPYTAEIDASD
IEKGTYAHYMLKEMDEQPAVIRNIIQHYQNENGDIELTEGVRELVSEADRIYIVACGTSYNAGLVGKDILERIAGIPTEV
HVSSEFGYNMPLLSEHPLFVFLSQSGETADSRAVLVEVKKRGYKALTMTNVPGSTLSREANETMLLHAGPEIAVASTKAY
TAQIAVLAILAYDIARATGKELPFDLMPELARVATIMDSIMAQKELFEDLAERYLKTTPNTFFIGRGLDASVCLEGALKV
KEISYIQAEGYPGGELKHGSIALIEDGTPVIALISQPKTNLNIRGNVKEVVARGANACIISMQGVEHENDDFILPHVEPL
LAPLINVLPVQLMAYYAALARGCDVDKPRNLAKSVTVE

Specific function: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source [H]

COG id: COG0449

COG function: function code M; Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 SIS domains [H]

Homologues:

Organism=Homo sapiens, GI205277386, Length=683, Percent_Identity=32.2108345534407, Blast_Score=320, Evalue=3e-87,
Organism=Homo sapiens, GI4826742, Length=685, Percent_Identity=32.2627737226277, Blast_Score=319, Evalue=4e-87,
Organism=Escherichia coli, GI1790167, Length=615, Percent_Identity=41.9512195121951, Blast_Score=438, Evalue=1e-124,
Organism=Escherichia coli, GI1788651, Length=239, Percent_Identity=28.0334728033473, Blast_Score=67, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17532899, Length=440, Percent_Identity=34.7727272727273, Blast_Score=222, Evalue=5e-58,
Organism=Caenorhabditis elegans, GI17532897, Length=440, Percent_Identity=34.7727272727273, Blast_Score=222, Evalue=5e-58,
Organism=Caenorhabditis elegans, GI17539970, Length=441, Percent_Identity=33.5600907029478, Blast_Score=221, Evalue=8e-58,
Organism=Saccharomyces cerevisiae, GI6322745, Length=462, Percent_Identity=33.1168831168831, Blast_Score=225, Evalue=1e-59,
Organism=Saccharomyces cerevisiae, GI6323731, Length=429, Percent_Identity=26.3403263403263, Blast_Score=154, Evalue=5e-38,
Organism=Saccharomyces cerevisiae, GI6323730, Length=231, Percent_Identity=33.7662337662338, Blast_Score=103, Evalue=1e-22,
Organism=Drosophila melanogaster, GI21357745, Length=691, Percent_Identity=31.9826338639653, Blast_Score=316, Evalue=2e-86,
Organism=Drosophila melanogaster, GI28573187, Length=273, Percent_Identity=28.9377289377289, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24659598, Length=273, Percent_Identity=27.1062271062271, Blast_Score=68, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000583
- InterPro:   IPR017932
- InterPro:   IPR005855
- InterPro:   IPR001347 [H]

Pfam domain/function: PF00310 GATase_2; PF01380 SIS [H]

EC number: =2.6.1.16 [H]

Molecular weight: Translated: 65155; Mature: 65155

Theoretical pI: Translated: 4.63; Mature: 4.63

Prosite motif: PS00443 GATASE_TYPE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCGIVGMIGQVGTKEILLKGLEKLEYRGYDSAGIALVGENVRTFKEVGRIQALRDIVPAD
CCCHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCEEEECCCHHHHHHHHHHHHHHHHCCCC
AEGTIGIGHTRWATHGVPSVPNAHPHQSTTGRFTLVHNGVIENDEQLKATLDVPFLSETD
CCCCEECCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCEEEEECCCCCCCCC
TEVIVQLMEKHFVELGDVEAAFRKTLSDLHGSYAIAMIDSEDQERLYIGKNKSPLLVGLG
HHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCEEEEEECCCCCCEEEECCCCCCEEEEEC
DGTFNVVASDAMAMLQVTDQYLELHDGEIVILTREAATIKTLDGEVLERAPYTAEIDASD
CCCEEHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCEEEECCHHHHHCCCCEEECCHHH
IEKGTYAHYMLKEMDEQPAVIRNIIQHYQNENGDIELTEGVRELVSEADRIYIVACGTSY
CCCCHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCEEHHHHHHHHHHCCCEEEEEEECCCC
NAGLVGKDILERIAGIPTEVHVSSEFGYNMPLLSEHPLFVFLSQSGETADSRAVLVEVKK
CCCCCCHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCEEEEEECCCCCCCCCEEEEEEHH
RGYKALTMTNVPGSTLSREANETMLLHAGPEIAVASTKAYTAQIAVLAILAYDIARATGK
CCCEEEEEECCCCHHHCCCCCCEEEEECCCCEEEECCHHHHHHHHHHHHHHHHHHHHCCC
ELPFDLMPELARVATIMDSIMAQKELFEDLAERYLKTTPNTFFIGRGLDASVCLEGALKV
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHCCEEE
KEISYIQAEGYPGGELKHGSIALIEDGTPVIALISQPKTNLNIRGNVKEVVARGANACII
EEEEEEEECCCCCCCCCCCCEEEEECCCCEEEEEECCCCCCEECCCHHHHHHCCCCEEEE
SMQGVEHENDDFILPHVEPLLAPLINVLPVQLMAYYAALARGCDVDKPRNLAKSVTVE
EEECCCCCCCCEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHCCCC
>Mature Secondary Structure
MCGIVGMIGQVGTKEILLKGLEKLEYRGYDSAGIALVGENVRTFKEVGRIQALRDIVPAD
CCCHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCEEEECCCHHHHHHHHHHHHHHHHCCCC
AEGTIGIGHTRWATHGVPSVPNAHPHQSTTGRFTLVHNGVIENDEQLKATLDVPFLSETD
CCCCEECCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCEEEEECCCCCCCCC
TEVIVQLMEKHFVELGDVEAAFRKTLSDLHGSYAIAMIDSEDQERLYIGKNKSPLLVGLG
HHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCEEEEEECCCCCCEEEECCCCCCEEEEEC
DGTFNVVASDAMAMLQVTDQYLELHDGEIVILTREAATIKTLDGEVLERAPYTAEIDASD
CCCEEHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCEEEECCHHHHHCCCCEEECCHHH
IEKGTYAHYMLKEMDEQPAVIRNIIQHYQNENGDIELTEGVRELVSEADRIYIVACGTSY
CCCCHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCEEHHHHHHHHHHCCCEEEEEEECCCC
NAGLVGKDILERIAGIPTEVHVSSEFGYNMPLLSEHPLFVFLSQSGETADSRAVLVEVKK
CCCCCCHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCEEEEEECCCCCCCCCEEEEEEHH
RGYKALTMTNVPGSTLSREANETMLLHAGPEIAVASTKAYTAQIAVLAILAYDIARATGK
CCCEEEEEECCCCHHHCCCCCCEEEEECCCCEEEECCHHHHHHHHHHHHHHHHHHHHCCC
ELPFDLMPELARVATIMDSIMAQKELFEDLAERYLKTTPNTFFIGRGLDASVCLEGALKV
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHCCEEE
KEISYIQAEGYPGGELKHGSIALIEDGTPVIALISQPKTNLNIRGNVKEVVARGANACII
EEEEEEEECCCCCCCCCCCCEEEEECCCCEEEEEECCCCCCEECCCHHHHHHCCCCEEEE
SMQGVEHENDDFILPHVEPLLAPLINVLPVQLMAYYAALARGCDVDKPRNLAKSVTVE
EEECCCCCCCCEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12721629 [H]