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The map label for this gene is moaA [H]

Identifier: 229917634

GI number: 229917634

Start: 1873482

End: 1874489

Strand: Direct

Name: moaA [H]

Synonym: EAT1b_1910

Alternate gene names: 229917634

Gene position: 1873482-1874489 (Clockwise)

Preceding gene: 229917633

Following gene: 229917635

Centisome position: 62.45

GC content: 53.27

Gene sequence:

>1008_bases
ATGACACCATGGACCGATCGACGGAGACGACCGTTGGAAGACTTACGCATCTCAGTCATTGATAAATGCAACTTTCGTTG
CCGATACTGCATGCCGGAAGAAGCGTTCCGCCACCACCAATTTTTAAAACGAGATGAGTTGTTATCGTTTGACGAGATCG
AGCGCTTCGTTCGCATCATCGCCCCACACGGCGTGAAAAAAGTGCGTCTGACCGGGGGCGAACCTCTACTCAGGCCGAAT
CTCGATGAACTGATTCGCCGCCTTCGCGCGGTCACGACCATCGAGACTATCGGGTTGACGACGAACGGCGTCTATTTAGA
ACGGATGGCGAAAGTGTTGAAGCAAGCTGGGCTCGACCGGGTCAACGTCAGTCTAGACGCCTTATCGGCCGAGACGTTCG
GGATGATGAACGGACGCGGCACGTCGCCCGAGACGGTATTACGAGGAATCGATGAGGCGAAACGGCAAGGGCTCGAAGTG
AAAGTGAACATGGTCGTCCGAAAAGGCTGGAACGATCATGAAGTCGCCCCTATGGCCGCGTATTTCAAAGAACGGAACAT
CACACTCCGTTACATCGAGTTCATGGATGTCGGCACGGCGAATGAATGGAACGTCGAACATGTCGTGTCGTCTGAATCGA
TTCTTGAGGTGTTGAAACAACGAAATGGATTACTTGAACCGCTTGCACCCGAAACACTAGGAGAAGTCGCGCAACGTTAC
CGTTACACGGATGGGGCGCAAGTTGGCTTCATCTCTTCGGTCAGCCAACCGTTCTGCGGAACGTGTACGCGAGGTCGCCT
ATCGAGTGACGGCAAATGGTACACGTGCCTGTTCGCAGAAGACGGGACCGATATCCGCGAATTGCTCCGCAGTGGGGCGA
GCGATGAATTGATTGCCATGACACTAAAAATGGTATGGGAAGTACGGGAAGACCGCTATTCGGAAGAACGGTCGCGAACT
GGGAGTCGGACGCGAAACCGAATTGAAATGAGTTATATCGGAGGATGA

Upstream 100 bases:

>100_bases
TTACTTGCGCAGCGGTGCTGAGAAGCCGATTCGCTGACAAATCGACGCAGGGACTGTGAGGGTCCCTGCTGTCGTTGATG
GATAGAAAGGATGAACCAAG

Downstream 100 bases:

>100_bases
AGACGATGCAAGCACACAACCATGTACATCAAAACACACAGCGTGTCCGGGCAGCGATTTTGACGATCTCGGATACGCGA
ACACTCGATACGGACGTGTC

Product: molybdenum cofactor biosynthesis protein A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 335; Mature: 334

Protein sequence:

>335_residues
MTPWTDRRRRPLEDLRISVIDKCNFRCRYCMPEEAFRHHQFLKRDELLSFDEIERFVRIIAPHGVKKVRLTGGEPLLRPN
LDELIRRLRAVTTIETIGLTTNGVYLERMAKVLKQAGLDRVNVSLDALSAETFGMMNGRGTSPETVLRGIDEAKRQGLEV
KVNMVVRKGWNDHEVAPMAAYFKERNITLRYIEFMDVGTANEWNVEHVVSSESILEVLKQRNGLLEPLAPETLGEVAQRY
RYTDGAQVGFISSVSQPFCGTCTRGRLSSDGKWYTCLFAEDGTDIRELLRSGASDELIAMTLKMVWEVREDRYSEERSRT
GSRTRNRIEMSYIGG

Sequences:

>Translated_335_residues
MTPWTDRRRRPLEDLRISVIDKCNFRCRYCMPEEAFRHHQFLKRDELLSFDEIERFVRIIAPHGVKKVRLTGGEPLLRPN
LDELIRRLRAVTTIETIGLTTNGVYLERMAKVLKQAGLDRVNVSLDALSAETFGMMNGRGTSPETVLRGIDEAKRQGLEV
KVNMVVRKGWNDHEVAPMAAYFKERNITLRYIEFMDVGTANEWNVEHVVSSESILEVLKQRNGLLEPLAPETLGEVAQRY
RYTDGAQVGFISSVSQPFCGTCTRGRLSSDGKWYTCLFAEDGTDIRELLRSGASDELIAMTLKMVWEVREDRYSEERSRT
GSRTRNRIEMSYIGG
>Mature_334_residues
TPWTDRRRRPLEDLRISVIDKCNFRCRYCMPEEAFRHHQFLKRDELLSFDEIERFVRIIAPHGVKKVRLTGGEPLLRPNL
DELIRRLRAVTTIETIGLTTNGVYLERMAKVLKQAGLDRVNVSLDALSAETFGMMNGRGTSPETVLRGIDEAKRQGLEVK
VNMVVRKGWNDHEVAPMAAYFKERNITLRYIEFMDVGTANEWNVEHVVSSESILEVLKQRNGLLEPLAPETLGEVAQRYR
YTDGAQVGFISSVSQPFCGTCTRGRLSSDGKWYTCLFAEDGTDIRELLRSGASDELIAMTLKMVWEVREDRYSEERSRTG
SRTRNRIEMSYIGG

Specific function: Together with moaC, is involved in the conversion of a guanosine derivative (5'-GTP) into molybdopterin precursor Z [H]

COG id: COG2896

COG function: function code H; Molybdenum cofactor biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the radical SAM superfamily. MoaA family [H]

Homologues:

Organism=Homo sapiens, GI116734668, Length=294, Percent_Identity=37.7551020408163, Blast_Score=195, Evalue=5e-50,
Organism=Homo sapiens, GI22027536, Length=294, Percent_Identity=37.7551020408163, Blast_Score=194, Evalue=6e-50,
Organism=Escherichia coli, GI1786999, Length=333, Percent_Identity=35.7357357357357, Blast_Score=182, Evalue=3e-47,
Organism=Caenorhabditis elegans, GI32566331, Length=318, Percent_Identity=34.5911949685535, Blast_Score=195, Evalue=2e-50,
Organism=Caenorhabditis elegans, GI32566329, Length=314, Percent_Identity=34.7133757961783, Blast_Score=194, Evalue=5e-50,
Organism=Caenorhabditis elegans, GI17561210, Length=314, Percent_Identity=35.031847133758, Blast_Score=192, Evalue=1e-49,
Organism=Drosophila melanogaster, GI28574490, Length=296, Percent_Identity=36.4864864864865, Blast_Score=191, Evalue=8e-49,
Organism=Drosophila melanogaster, GI28574488, Length=296, Percent_Identity=36.4864864864865, Blast_Score=190, Evalue=1e-48,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR006638
- InterPro:   IPR013483
- InterPro:   IPR000385
- InterPro:   IPR010505
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06463 Mob_synth_C; PF04055 Radical_SAM [H]

EC number: NA

Molecular weight: Translated: 38417; Mature: 38285

Theoretical pI: Translated: 8.12; Mature: 8.12

Prosite motif: PS01305 MOAA_NIFB_PQQE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTPWTDRRRRPLEDLRISVIDKCNFRCRYCMPEEAFRHHQFLKRDELLSFDEIERFVRII
CCCCCCCCCCCHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHCCCHHHHHHHHHHH
APHGVKKVRLTGGEPLLRPNLDELIRRLRAVTTIETIGLTTNGVYLERMAKVLKQAGLDR
CCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCE
VNVSLDALSAETFGMMNGRGTSPETVLRGIDEAKRQGLEVKVNMVVRKGWNDHEVAPMAA
EEEEHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCEEEEEEEEECCCCCCCCHHHHH
YFKERNITLRYIEFMDVGTANEWNVEHVVSSESILEVLKQRNGLLEPLAPETLGEVAQRY
HHHHCCCEEEEEEEEECCCCCCCCHHHHHCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHH
RYTDGAQVGFISSVSQPFCGTCTRGRLSSDGKWYTCLFAEDGTDIRELLRSGASDELIAM
CCCCCCCCCCHHHCCCCCCCCCCCCCCCCCCCEEEEEEECCCHHHHHHHHCCCCCHHHHH
TLKMVWEVREDRYSEERSRTGSRTRNRIEMSYIGG
HHHHHHHHHHHHHHHHHHHCCCHHHCEEEEEECCC
>Mature Secondary Structure 
TPWTDRRRRPLEDLRISVIDKCNFRCRYCMPEEAFRHHQFLKRDELLSFDEIERFVRII
CCCCCCCCCCHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHCCCHHHHHHHHHHH
APHGVKKVRLTGGEPLLRPNLDELIRRLRAVTTIETIGLTTNGVYLERMAKVLKQAGLDR
CCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCE
VNVSLDALSAETFGMMNGRGTSPETVLRGIDEAKRQGLEVKVNMVVRKGWNDHEVAPMAA
EEEEHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCEEEEEEEEECCCCCCCCHHHHH
YFKERNITLRYIEFMDVGTANEWNVEHVVSSESILEVLKQRNGLLEPLAPETLGEVAQRY
HHHHCCCEEEEEEEEECCCCCCCCHHHHHCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHH
RYTDGAQVGFISSVSQPFCGTCTRGRLSSDGKWYTCLFAEDGTDIRELLRSGASDELIAM
CCCCCCCCCCHHHCCCCCCCCCCCCCCCCCCCEEEEEEECCCHHHHHHHHCCCCCHHHHH
TLKMVWEVREDRYSEERSRTGSRTRNRIEMSYIGG
HHHHHHHHHHHHHHHHHHHCCCHHHCEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: Fe [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA